CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	OPRD1;
Protein Kinase	AURKB; AURKA; KDR;
Lyase	CA14; CA7; CA5A; CA6; CA12; CA9; CA5B;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.594E-14	2.001E-10	CA12, CA5A, CA5B, CA6, CA7, CA9
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	4.177E-06	8.268E-03	AURKA, AURKB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.541E-20	1.207E-15	CA12, CA14, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.274E-16	3.564E-12	CA12, CA14, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	1.312E-19	2.755E-18	CA12; CA5B; CA5A; CA7; CA6; CA9; CA14
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	3.000E-04	3.150E-03	CYP1A1; CYP1B1
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	4.694E-04	3.286E-03	CYP1A1; CYP1B1
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	6.316E-04	3.316E-03	CYP1A1; CYP1B1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	9.986E-04	4.194E-03	CYP1A1; CYP1B1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.258E-03	4.402E-03	CYP1A1; CYP1B1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; KDR; KDR; KDR
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA
C00-D49: Neoplasms	Liver cancer	C22	KDR
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKB; AURKA; CA9; KDR; KDR; KDR
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; KDR
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; CA9; KDR
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR
C00-D49: Neoplasms	Glioma	C71	KDR
C00-D49: Neoplasms	Renal cancer	C64	CA9; KDR
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1
C00-D49: Neoplasms	Breast cancer	C50	CA9; KDR; KDR; KDR
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; KDR
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR
C00-D49: Neoplasms	AML	NA	KDR
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1
C00-D49: Neoplasms	Thyroid cancer	C73	KDR
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR; KDR
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1
C00-D49: Neoplasms	Gastric cancer	C16	KDR; KDR
NA: NA	Acute nonspecific diarrhea	NA	OPRD1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; AURKA
C00-D49: Neoplasms	Melanoma	C43	KDR; KDR
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Senecio integerrimus

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases