Plant Name: Cleome pungens
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 7.744E-11 | 1.686E-06 | CA12, CA2, CA4, CA7 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.321E-09 | 2.411E-05 | CA12, CA2, CA4, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 7.636E-09 | 4.157E-05 | CA12, CA2, CA4, CA7 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 8.842E-07 | 2.139E-03 | CA2, CA7 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.606E-06 | 5.158E-03 | CA2, CA4, SLCO1B1, SLCO1B3 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.174E-10 | 2.231E-09 | CA12; CA2; CA4; CA7 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 6.931E-06 | 6.584E-05 | SLCO1B1; CA2; SLCO1B3 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 6.914E-05 | 4.379E-04 | CA2; CA4 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.186E-04 | 5.635E-04 | GAA; AKR1B1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.689E-02 | 4.258E-02 | GAA; AKR1B1; ALPI |
| hsa04966 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.475E-02 | 3.390E-02 | CA2 |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.909E-02 | 3.390E-02 | MIF |
| hsa00360 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 9.313E-03 | 2.949E-02 | MIF |
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 3.038E-02 | 4.341E-02 | GAA |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.963E-02 | 3.390E-02 | AKR1B1 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.746E-02 | 3.390E-02 | AKR1B1 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 3.198E-02 | 4.341E-02 | AKR1B1 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 1.801E-02 | 3.390E-02 | POLB |
| hsa00790 | Folate biosynthesis_Homo sapiens_hsa00790 | 7.675E-03 | 2.917E-02 | ALPI |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MIF |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | MIF |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; CA4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| NA: NA | Edema | NA | CA2 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | AKR1B1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Refractory autoimmune diseases | D84.9, M35.9 | MIF |