CMAUP Plant Collective Molecular Activities

Plant Name: Holarrhena pubescens

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.463E-06	8.083E-03	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	1.485E-06	8.083E-03	HIF1A, MAPT, NR3C1
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.924E-06	9.645E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.924E-06	9.645E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0045761; regulation of adenylate cyclase activity	4.224E-06	9.645E-03	ADRA2A, HRH3, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	8.885E-07	6.397E-05	HRH3; ADRA2C; NR3C1; ADRA2A; TSHR

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; NFKB1; NR3C1
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
NA: NA	Non-infectious rhinitis	NA	NR3C1
E00-E89: Endocrine, nutritional and metabolic diseases	Obese insulin-resistant disorders	E11	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HRH3; NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HRH3; HRH3
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C; HRH3
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	NR3C1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	NR3C1
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; HIF1A; NR3C1
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C; HRH3; NR3C1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; MAPT; HRH3; HRH3
S00-T88: Injury, poisoning and certain other consequences of external causes	Spinal cord injury	S14, S24, S34	NR3C1
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1
S00-T88: Injury, poisoning and certain other consequences of external causes	Skin allergies	T78.4	NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT; HRH3
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	NR3C1; NR3C1; NR3C1
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT; HRH3; DAO
G00-G99: Diseases of the nervous system G00-G99	Duchenne muscular dystrophy	G71.0	NR3C1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	SERPINA6; NR3C1
L00-L99: Diseases of the skin and subcutaneous tissue	Eczema	L20-L30	NR3C1
NA: NA	Colour dead tissues	NA	PTPN1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	HRH3
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	NR3C1
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HRH3
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
NA: NA	Corticosteroid-responsive inflammation	NA	NR3C1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C; PTPN1; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Excessive daytime sleepiness	F51.1, G47.1	HRH3
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HRH3; HRH3
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A; HRH3
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	NR3C1
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C; SERPINA6; NR3C1; NR3C1; NR3C1; NR3C1
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C; NR3C1
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C
NA: NA	Obstructive airway diseases	NA	SERPINA6
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic macular edema	E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9	SERPINA6
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	SERPINA6
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	HRH3
H60-H95: Diseases of the ear and mastoid process	Otitis externa	H60	NR3C1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C; NR3C1
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; ADRA2A; HRH3; HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
G00-G99: Diseases of the nervous system G00-G99	Narcolepsy	G47.4	HRH3

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases