Plant Name: Teucrium pestalozzae
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 5.249E-09 | 3.810E-05 | CA1, CA12, CA13, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.115E-08 | 4.966E-05 | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, HSD11B1, NPC1, NR1H4 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.497E-08 | 5.431E-05 | CA1, CA12, CA13, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 6.483E-07 | 8.823E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 9.178E-07 | 1.052E-03 | ACP1, CDC25B, PTPN1, PTPN2, PTPRF |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 7.088E-06 | 6.431E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 9.415E-06 | 6.714E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 9.558E-06 | 6.714E-03 | GPBAR1, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.297E-11 | 9.356E-07 | CA1, CA12, CA13, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 9.415E-06 | 6.714E-03 | CYP1A1, CYP1A2, CYP1B1 |
Showing 1 to 10 of 12 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.806E-03 | 1.799E-02 | AKR1B10; AKR1B1 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.428E-03 | 1.799E-02 | AKR1B10; AKR1B1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.930E-05 | 4.117E-04 | AKR1B10; GAA; AKR1B1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 3.117E-06 | 1.995E-04 | HSD11B1; CYP1A2; CYP1A1; CYP1B1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 4.640E-05 | 8.484E-04 | CYP1A2; CYP1A1; CYP1B1 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 4.782E-03 | 3.772E-02 | AKR1B10; AKR1B1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.173E-03 | 1.668E-02 | PLA2G1B; CYP1A2 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 5.775E-03 | 4.107E-02 | CYP1A2; CYP1A1 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 7.425E-11 | 9.503E-09 | CA12; CA1; CA7; CA9; CA13 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 7.850E-06 | 2.652E-04 | HSD11B1; CYP1A2; CYP1A1; CYP1B1 |
Showing 1 to 10 of 18 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PLA2G1B |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
Showing 1 to 10 of 78 entries