Plant Name: Berberis floribunda
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; NPSR1; CXCR1; | |
| DRD4; | |
| RECQL; TDP1; PLA2G1B; BLM; ALPI; CTDSP1; PIK3R1; GLO1; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALOX12; NOX4; TNKS; PARP1; TNKS2; PYGL; POLB; AOX1; CD38; | |
| MGAM; GAA; | |
| NEK6; PKN1; AKT1; MET; CAMK2B; CSNK2A1; DAPK1; NEK2; FLT3; ABL1; SRC; IGF1R; PTK2; AURKB; GSK3B; CDK1; MAPK1; EGFR; PIM1; NUAK1; ALK; AXL; KDR; | |
| CA14; CA3; CA7; CA5A; CA1; CA9; CA4; CA6; CA2; CA12; | |
| AR; | |
| ESRRB; ESRRA; | |
| PPARA; PPARD; | |
| ESR1; ESR2; | |
| KDM4E; | |
| MAOA; ALOX5; TYR; XDH; | |
| MMP13; MMP12; MMP3; MMP2; MMP9; | |
| BACE1; | |
| AHR; STAT6; HIF1A; NFKB1; TP53; | |
| ABCC1; ABCG2; | |
| SLCO1B3; SLCO1B1; | |
| LMNA; MAPT; THPO; RAB9A; NPC1; APP; TTR; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Cytochrome P450 family 5 | TBXAS1 | Thromboxane-A synthase | P24557 | CHEMBL1835 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | ALPI | Intestinal alkaline phosphatase | P09923 | CHEMBL5573 |
| Enzyme_unclassified | CTDSP1 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Q9GZU7 | CHEMBL1795098 |
| Enzyme_unclassified | PIK3R1 | PI3-kinase p85-alpha subunit | P27986 | CHEMBL2506 |
| Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Enzyme_unclassified | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Enzyme_unclassified | TNKS | Tankyrase-1 | O95271 | CHEMBL6164 |
| Enzyme_unclassified | PARP1 | Poly [ADP-ribose] polymerase-1 | P09874 | CHEMBL3105 |
| Enzyme_unclassified | TNKS2 | Tankyrase-2 | Q9H2K2 | CHEMBL6154 |
| Enzyme_unclassified | PYGL | Liver glycogen phosphorylase | P06737 | CHEMBL2568 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | AOX1 | Aldehyde oxidase | Q06278 | CHEMBL3257 |
| Enzyme_unclassified | CD38 | Lymphocyte differentiation antigen CD38 | P28907 | CHEMBL4660 |
| Hydrolase | MGAM | Maltase-glucoamylase | O43451 | CHEMBL2074 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Metallo protease | MMP13 | Matrix metalloproteinase 13 | P45452 | CHEMBL280 |
| Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Nuclear hormone receptor subfamily 3 group B | ESRRB | Estrogen-related receptor beta | O95718 | CHEMBL3751 |
| Nuclear hormone receptor subfamily 3 group B | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
| Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Oxidoreductase | TYR | Tyrosinase | P14679 | CHEMBL1973 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Peptide receptor (family A GPCR) | CXCR1 | Interleukin-8 receptor A | P25024 | CHEMBL4029 |
| Protein Kinase | NEK6 | Serine/threonine-protein kinase NEK6 | Q9HC98 | CHEMBL4309 |
| Protein Kinase | PKN1 | Protein kinase N1 | Q16512 | CHEMBL3384 |
| Protein Kinase | AKT1 | Serine/threonine-protein kinase AKT | P31749 | CHEMBL4282 |
| Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Protein Kinase | CAMK2B | CaM kinase II beta | Q13554 | CHEMBL4121 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
| Protein Kinase | NEK2 | Serine/threonine-protein kinase NEK2 | P51955 | CHEMBL3835 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | ABL1 | Tyrosine-protein kinase ABL | P00519 | CHEMBL1862 |
| Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | EGFR | Epidermal growth factor receptor erbB1 | P00533 | CHEMBL203 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | NUAK1 | NUAK family SNF1-like kinase 1 | O60285 | CHEMBL5784 |
| Protein Kinase | ALK | ALK tyrosine kinase receptor | Q9UM73 | CHEMBL4247 |
| Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Small molecule receptor (family A GPCR) | DRD4 | Dopamine D4 receptor | P21917 | CHEMBL219 |
| Transcription Factor | AHR | Aryl hydrocarbon receptor | P35869 | CHEMBL3201 |
| Transcription Factor | STAT6 | Signal transducer and activator of transcription 6 | P42226 | CHEMBL5401 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
| Unclassified | TTR | Transthyretin | P02766 | CHEMBL3194 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.156E-13 | 1.562E-10 | CA1, CA12, CA2, CA3, CA4, CA5A, CA6, CA7, CA9 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 3.087E-13 | 1.562E-10 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, MPO, NOX4, SRC, TBXAS1 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 5.474E-12 | 1.779E-09 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.973E-11 | 7.895E-09 | CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 3.194E-11 | 8.281E-09 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2D6, CYP3A4 |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 1.531E-10 | 3.436E-08 | ABCG2, AKT1, ALK, AOX1, APP, BLM, CAMK2B, CD38, CSNK2A1, DAPK1, DRD4, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MAPK1, MAPT, MET, MMP9, NFKB1, PARP1, PYGL, RAB9A, SMN1, SMN2, STAT6, TP53, TTR, TYR, XDH |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 4.212E-10 | 8.188E-08 | ABL1, AURKB, CA2, CA7, EGFR, HIF1A, MAPK1, NEK2, NPC1, NPSR1, PLA2G1B, TNKS, TNKS2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 9.242E-10 | 1.597E-07 | CYP1A2, CYP2C8, CYP2C9, CYP3A4 |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 1.163E-09 | 1.934E-07 | ABL1, AURKB, CA2, CA7, CD38, EGFR, HIF1A, KDR, MAPK1, NEK2, NPC1, NPSR1, PARP1, PLA2G1B, SRC, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.346E-09 | 2.171E-07 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 1.424E-09 | 2.258E-07 | ABCC1, ABCG2, ABL1, AKT1, ALK, AURKB, AXL, BLM, CAMK2B, CDK1, CSNK2A1, DAPK1, EGFR, FLT3, GSK3B, IGF1R, KDR, MAPK1, MET, NEK2, NEK6, NUAK1, PIM1, PKN1, PTK2, PYGL, RECQL, SRC, TP53 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 3.821E-09 | 5.299E-07 | CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 3.821E-09 | 5.299E-07 | CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 1.245E-08 | 1.558E-06 | AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, MAPK1, PKN1, TNKS |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 2.716E-08 | 3.080E-06 | AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NPC1 |
| BP | GO:0065007; biological regulation | GO:1904355; positive regulation of telomere capping | 2.920E-08 | 3.277E-06 | AURKB, MAPK1, NEK2, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 2.967E-08 | 3.313E-06 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, MAPK1, NEK6, PKN1, SRC, TNKS |
| MF | GO:0003824; catalytic activity | GO:0004674; protein serine/threonine kinase activity | 3.380E-08 | 3.755E-06 | AKT1, ALK, AURKB, CAMK2B, CDK1, CSNK2A1, DAPK1, EGFR, GSK3B, MAPK1, NEK2, NEK6, NUAK1, PIM1, PKN1 |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 2.367E-07 | 2.156E-05 | ABL1, EGFR, IGF1R, KDR, PTK2, SRC |
| BP | GO:0009987; cellular process | GO:0071276; cellular response to cadmium ion | 7.533E-07 | 6.053E-05 | AKT1, CYP1A2, EGFR, MAPK1, MMP9 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 7.533E-07 | 6.053E-05 | ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 8.888E-07 | 7.038E-05 | AHR, CSNK2A1, HIF1A, KDR, MAPT |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 1.149E-06 | 8.747E-05 | ABL1, AKR1B1, AXL, CDK1, CYP1B1, STAT6 |
| BP | GO:0065007; biological regulation | GO:0032212; positive regulation of telomere maintenance via telomerase | 1.217E-06 | 9.235E-05 | AURKB, MAPK1, NEK2, TNKS, TNKS2 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 1.579E-06 | 1.181E-04 | ABL1, AHR, AKR1B1, AKT1, ALOX5, AR, AURKB, BLM, CAMK2B, CDK1, CSNK2A1, CTDSP1, ESR1, ESR2, ESRRA, ESRRB, GSK3B, HIF1A, LMNA, MAPK1, NEK2, NEK6, NFKB1, NUAK1, PARP1, PIM1, PKN1, POLB, PPARA, PPARD, RECQL, SMN1, SMN2, SRC, STAT6, TNKS, TP53 |
| MF | GO:0003824; catalytic activity | GO:0101020; estrogen 16-alpha-hydroxylase activity | 1.686E-06 | 1.249E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 2.171E-06 | 1.571E-04 | HIF1A, MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 2.213E-06 | 1.590E-04 | AXL, EGFR, MET, NOX4, PIK3R1, PTK2, SRC, THPO |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 3.246E-06 | 2.209E-04 | AR, CDK1, ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD |
| BP | Unclassified; | GO:0044243; multicellular organismal catabolic process | 3.336E-06 | 2.263E-04 | MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 3.358E-06 | 2.264E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0031334; positive regulation of protein complex assembly | 4.846E-06 | 3.140E-04 | ALOX15, ESR1, GSK3B, MAPT, MET, MMP3, PARP1, SRC, TP53 |
| MF | GO:0098772; molecular function regulator | GO:0030235; nitric-oxide synthase regulator activity | 5.853E-06 | 3.749E-04 | AKT1, EGFR, ESR1 |
| MF | GO:0005488; binding | GO:0042562; hormone binding | 8.118E-06 | 4.938E-04 | AR, EGFR, HSD17B1, IGF1R, PIK3R1, TTR |
| BP | Unclassified; | GO:0044259; multicellular organismal macromolecule metabolic process | 8.688E-06 | 5.255E-04 | HIF1A, MMP12, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0032502; developmental process | GO:0048638; regulation of developmental growth | 9.745E-06 | 5.830E-04 | ABL1, AKT1, APP, AR, CDK1, MAPT, PIM1, PPARD, PTK2, TNKS2 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 9.850E-06 | 5.876E-04 | ABCC1, CA2, CA4, CA9, EGFR, SLCO1B1, SLCO1B3, TSHR |
| BP | GO:0008152; metabolic process | GO:0045944; positive regulation of transcription from RNA polymerase II promoter | 1.015E-05 | 6.041E-04 | AHR, AKT1, APP, AR, EGFR, ESR1, ESRRA, ESRRB, HIF1A, MET, MMP12, NFKB1, PARP1, PIK3R1, PLA2G1B, PPARA, STAT6, TNKS, TP53 |
| BP | GO:0008152; metabolic process | GO:2000379; positive regulation of reactive oxygen species metabolic process | 1.130E-05 | 6.614E-04 | AKT1, EGFR, MAPT, NOX4, TP53, XDH |
| BP | GO:0002376; immune system process | GO:0002684; positive regulation of immune system process | 1.194E-05 | 6.954E-04 | ABL1, AKT1, APP, AXL, CA2, CD38, HIF1A, MAPK1, MMP12, MMP2, NFKB1, PIK3R1, PLA2G1B, PTK2, SRC, STAT6, THPO, TP53 |
| BP | GO:0032501; multicellular organismal process | GO:2000026; regulation of multicellular organismal development | 1.339E-05 | 7.715E-04 | ABL1, AKT1, ALOX12, APP, AR, AXL, CA2, CAMK2B, CDK1, CTDSP1, CYP1B1, EGFR, ESR1, ESRRA, GSK3B, HIF1A, KDR, MAPT, PIK3R1, PIM1, PPARD, PTK2, SRC, STAT6, THPO, XDH |
| BP | GO:0032501; multicellular organismal process | GO:0048143; astrocyte activation | 1.393E-05 | 7.943E-04 | APP, EGFR, MAPT |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 1.393E-05 | 7.943E-04 | BLM, RECQL, TP53 |
| BP | GO:0065007; biological regulation | GO:1904357; negative regulation of telomere maintenance via telomere lengthening | 1.469E-05 | 8.308E-04 | PARP1, SRC, TNKS, TNKS2 |
| BP | GO:0050896; response to stimulus | GO:1904646; cellular response to amyloid-beta | 1.469E-05 | 8.308E-04 | APP, GSK3B, IGF1R, PARP1 |
| BP | GO:0009987; cellular process | GO:0070374; positive regulation of ERK1 and ERK2 cascade | 1.496E-05 | 8.394E-04 | ABL1, ALOX15, APP, EGFR, KDR, NOX4, SRC, THPO |
| BP | GO:0051179; localization | GO:0034502; protein localization to chromosome | 1.960E-05 | 1.062E-03 | AURKB, CDK1, ESR1, TNKS, TNKS2 |
| BP | Unclassified; | GO:2000021; regulation of ion homeostasis | 2.213E-05 | 1.164E-03 | ABL1, CA2, CA7, KDR, NPSR1, PARP1, PLA2G1B, SRC |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 2.585E-05 | 1.334E-03 | AKT1, HIF1A, LMNA, PPARD, SRC, TP53 |
| BP | GO:0032501; multicellular organismal process | GO:0060736; prostate gland growth | 2.715E-05 | 1.381E-03 | AR, CYP19A1, ESR1 |
| BP | GO:0008152; metabolic process | GO:0009115; xanthine catabolic process | 3.097E-05 | 1.536E-03 | AOX1, XDH |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 3.097E-05 | 1.536E-03 | ALOX12, ALOX15 |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 3.097E-05 | 1.536E-03 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 3.097E-05 | 1.536E-03 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0030574; collagen catabolic process | 3.149E-05 | 1.555E-03 | MMP12, MMP13, MMP2, MMP3, MMP9 |
| MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 3.202E-05 | 1.574E-03 | AKR1B1, AOX1, CYP19A1, CYP1A2, NOX4, XDH |
| BP | GO:0008152; metabolic process | GO:0010907; positive regulation of glucose metabolic process | 3.338E-05 | 1.622E-03 | AKT1, ESRRB, PPARA, SRC |
| BP | GO:0008283; cell proliferation | GO:0033598; mammary gland epithelial cell proliferation | 3.605E-05 | 1.744E-03 | ESR1, MAPK1, STAT6 |
| CC | GO:0043226; organelle | GO:0044454; nuclear chromosome part | 4.255E-05 | 2.023E-03 | AR, AURKB, BLM, CDK1, CSNK2A1, ESR1, PARP1, PPARD, STAT6, TNKS, TNKS2, TP53 |
| MF | GO:0005488; binding | GO:0002039; p53 binding | 4.513E-05 | 2.136E-03 | BLM, GSK3B, HIF1A, NUAK1, TP53 |
| BP | GO:0008152; metabolic process | GO:0006703; estrogen biosynthetic process | 4.667E-05 | 2.202E-03 | CYP19A1, HSD17B1, HSD17B2 |
| BP | GO:0032502; developmental process | GO:0007568; aging | 4.671E-05 | 2.202E-03 | AKT1, AURKB, CDK1, CYP1A1, MPO, NOX4, POLB, TP53 |
| BP | GO:0065007; biological regulation | GO:0045124; regulation of bone resorption | 4.743E-05 | 2.221E-03 | CA2, CD38, EGFR, SRC |
| MF | GO:0005488; binding | GO:0001085; RNA polymerase II transcription factor binding | 4.788E-05 | 2.233E-03 | AHR, AR, ESR1, GSK3B, PPARA, TP53 |
| BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 5.171E-05 | 2.394E-03 | AXL, KDR, PIK3R1, PTK2, SRC |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 5.178E-05 | 2.394E-03 | CAMK2B, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, EGFR, HSD17B2, NOX4, RAB9A, TBXAS1 |
| BP | GO:0009987; cellular process | GO:0050714; positive regulation of protein secretion | 5.272E-05 | 2.427E-03 | ABL1, CD38, EGFR, HIF1A, MMP12, PLA2G1B, PPARD, SRC |
| BP | GO:0032502; developmental process | GO:0060065; uterus development | 5.916E-05 | 2.667E-03 | CYP19A1, ESR1, SRC |
| BP | GO:0023052; signaling | GO:0050806; positive regulation of synaptic transmission | 6.064E-05 | 2.728E-03 | APP, CA2, CA7, DRD4, EGFR, MAPK1 |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 6.708E-05 | 2.957E-03 | AXL, CDK1, CSNK2A1, EGFR, FLT3 |
| BP | GO:0008283; cell proliferation | GO:0048661; positive regulation of smooth muscle cell proliferation | 6.708E-05 | 2.957E-03 | AKR1B1, AKT1, EGFR, MMP2, MMP9 |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 7.142E-05 | 3.104E-03 | ALOX15, EGFR, PPARA, PPARD, TP53 |
| BP | GO:0009987; cellular process | GO:1901216; positive regulation of neuron death | 7.142E-05 | 3.104E-03 | ABL1, GSK3B, MAPT, PARP1, TP53 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 7.587E-05 | 3.284E-03 | ABL1, AHR, AKR1B1, AKT1, ALOX12, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BLM, CA1, CA2, CA3, CA7, CAMK2B, CDK1, CSNK2A1, FLT3, GLO1, GSK3B, HIF1A, HSD17B1, LMNA, MAPK1, MAPT, NEK2, NEK6, NFKB1, PIK3R1, PIM1, PKN1, PLA2G1B, PTK2, PYGL, RAB9A, SMN1, SMN2, SRC, STAT6, TNKS, TNKS2, TP53, TYR, XDH |
| BP | GO:0009987; cellular process | GO:0022617; extracellular matrix disassembly | 8.076E-05 | 3.475E-03 | MMP12, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0050896; response to stimulus | GO:0001101; response to acid chemical | 8.189E-05 | 3.517E-03 | AKR1B1, AKT1, CD38, EGFR, HSD17B2, KDR, MMP2, SRC, TP53 |
| BP | GO:0009987; cellular process | GO:0010639; negative regulation of organelle organization | 8.585E-05 | 3.651E-03 | AKT1, LMNA, MAPT, MET, NEK2, PARP1, SRC, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 9.028E-05 | 3.805E-03 | ALOX12, ALOX15, ALOX5 |
| BP | GO:0050896; response to stimulus | GO:1901655; cellular response to ketone | 9.100E-05 | 3.811E-03 | AKR1B1, AKT1, AR, EGFR, SRC |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 9.258E-05 | 3.811E-03 | CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0000023; maltose metabolic process | 9.258E-05 | 3.811E-03 | GAA, MGAM |
| BP | GO:0002376; immune system process | GO:0001922; B-1 B cell homeostasis | 9.258E-05 | 3.811E-03 | ABL1, HIF1A |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 9.258E-05 | 3.811E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 9.258E-05 | 3.811E-03 | CYP1A1, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 9.258E-05 | 3.811E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0032450; maltose alpha-glucosidase activity | 9.258E-05 | 3.811E-03 | GAA, MGAM |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 9.258E-05 | 3.811E-03 | ALOX12, ALOX15 |
| CC | GO:0044464; cell part | GO:0005739; mitochondrion | 9.179E-05 | 3.811E-03 | ABL1, AKT1, CA5A, CDK1, CYP1A1, CYP1B1, CYP2D6, ESR2, GSK3B, HSD17B10, MAOA, MAPK1, MMP2, MPO, NFKB1, NOX4, PARP1, SRC, TP53 |
| BP | GO:0050896; response to stimulus | GO:0033273; response to vitamin | 9.648E-05 | 3.949E-03 | CYP1A1, EGFR, PPARD, TP53, TYR |
| MF | GO:0140110; transcription regulator activity | GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | 9.924E-05 | 4.047E-03 | AR, ESR1, ESRRA, ESRRB, HIF1A, NFKB1, PARP1, PPARA, STAT6, TP53 |
| BP | GO:0032501; multicellular organismal process | GO:0043536; positive regulation of blood vessel endothelial cell migration | 1.056E-04 | 4.267E-03 | ABL1, AKT1, HIF1A, KDR |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 1.092E-04 | 4.378E-03 | CYP2C19, CYP2C8, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0035173; histone kinase activity | 1.092E-04 | 4.378E-03 | AURKB, CDK1, PKN1 |
| BP | GO:0009987; cellular process | GO:0090199; regulation of release of cytochrome c from mitochondria | 1.154E-04 | 4.603E-03 | AKT1, LMNA, MMP9, TP53 |
| MF | GO:0003824; catalytic activity | GO:0016614; oxidoreductase activity, acting on CH-OH group of donors | 1.159E-04 | 4.613E-03 | AKR1B1, AOX1, HSD17B1, HSD17B10, HSD17B2, XDH |
| BP | GO:0065007; biological regulation | GO:0000187; activation of MAPK activity | 1.526E-04 | 5.944E-03 | ALK, CDK1, DRD4, MAPK1, PKN1, PLA2G1B |
| BP | GO:0022414; reproductive process | GO:0001892; embryonic placenta development | 1.808E-04 | 6.847E-03 | EGFR, ESRRB, HIF1A |
| MF | GO:0005488; binding | GO:0001223; transcription coactivator binding | 1.808E-04 | 6.847E-03 | AHR, ESR1, PPARA |
| BP | GO:0065007; biological regulation | GO:0032431; activation of phospholipase A2 activity | 1.845E-04 | 6.867E-03 | EGFR, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0070213; protein auto-ADP-ribosylation | 1.845E-04 | 6.867E-03 | TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 1.845E-04 | 6.867E-03 | CYP1A1, CYP1A2 |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 1.845E-04 | 6.867E-03 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0004558; alpha-1,4-glucosidase activity | 1.845E-04 | 6.867E-03 | GAA, MGAM |
| BP | GO:0032502; developmental process | GO:0002009; morphogenesis of an epithelium | 1.864E-04 | 6.927E-03 | AR, CA2, CA9, EGFR, ESR1, HIF1A, MET, SRC |
| BP | GO:0009987; cellular process | GO:0051983; regulation of chromosome segregation | 1.934E-04 | 7.151E-03 | AURKB, CSNK2A1, NEK2, NEK6, TNKS |
| BP | GO:0008152; metabolic process | GO:0016579; protein deubiquitination | 1.956E-04 | 7.219E-03 | AR, CDK1, ESR1, HIF1A, POLB, TNKS, TNKS2, TP53 |
| MF | GO:0005488; binding | GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding | 2.064E-04 | 7.529E-03 | AHR, AR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, NFKB1, PARP1, PPARA, STAT6, TP53 |
| BP | GO:0009987; cellular process | GO:0032872; regulation of stress-activated MAPK cascade | 2.068E-04 | 7.531E-03 | AKT1, APP, EGFR, IGF1R, MAPK1, PKN1, XDH |
| BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 2.101E-04 | 7.588E-03 | CYP1A1, POLB, TP53 |
| BP | GO:0008152; metabolic process | GO:0044247; cellular polysaccharide catabolic process | 2.101E-04 | 7.588E-03 | GAA, MGAM, PYGL |
| BP | GO:0008152; metabolic process | GO:0009251; glucan catabolic process | 2.101E-04 | 7.588E-03 | GAA, MGAM, PYGL |
| BP | GO:0022610; biological adhesion | GO:0051893; regulation of focal adhesion assembly | 2.357E-04 | 8.400E-03 | ABL1, KDR, PTK2, SRC |
| BP | GO:0050896; response to stimulus | GO:0010332; response to gamma radiation | 2.357E-04 | 8.400E-03 | NOX4, PARP1, POLB, TP53 |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 2.416E-04 | 8.578E-03 | APP, BACE1, EGFR, KDR, MAPK1, NPC1, SRC, STAT6 |
| BP | GO:0008152; metabolic process | GO:0045740; positive regulation of DNA replication | 2.531E-04 | 8.861E-03 | CDK1, EGFR, IGF1R, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 2.775E-04 | 9.560E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 2.821E-04 | 9.689E-03 | AKT1, AR, DAPK1, LMNA, SRC |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 5.716E-20 | 1.750E-16 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA6, CA7, CA9 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.374E-14 | 1.215E-11 | ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, TBXAS1, XDH |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 3.829E-14 | 2.606E-11 | ALPI, AR, BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP12, MMP13, MMP2, MMP3, MMP9, PARP1, PPARA, PPARD, TNKS, TP53 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.130E-14 | 2.725E-11 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA6, CA7, CA9 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 5.285E-14 | 3.288E-11 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, NOX4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.592E-19 | 5.029E-17 | CA12; CA1; CA3; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 2.841E-13 | 2.756E-11 | CAMK2B; SRC; MMP2; PIK3R1; HIF1A; ESR1; MMP9; PTK2; EGFR; IGF1R; KDR; AKT1; MAPK1; TP53; MET |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 4.250E-12 | 2.749E-10 | GSK3B; FLT3; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; EGFR; NFKB1; PTK2; IGF1R; AR; ABL1; AKT1; MAPK1; MET; TP53; PPARD |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.934E-10 | 1.915E-08 | CYP2C9; APP; CYP2C8; CYP2D6; MAOA; ALOX5; ALOX15; MAPK1; ALOX12; CYP2C19 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.235E-09 | 3.422E-08 | GSK3B; AR; AKT1; MAPK1; PIK3R1; TP53; EGFR; NFKB1; IGF1R |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.005E-09 | 3.251E-08 | CAMK2B; GSK3B; SRC; ABL1; AKT1; MAPK1; PIK3R1; EGFR; PTK2 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.476E-09 | 3.579E-08 | CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; TBXAS1; ALOX12; CYP2C19 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.556E-10 | 7.547E-09 | CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19 |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 3.216E-09 | 5.672E-08 | SRC; MMP2; AKT1; MAPK1; PIK3R1; ESR1; MMP9; EGFR; ESR2 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 7.442E-09 | 1.031E-07 | PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; PYGL; CYP2C19; CYP3A4; CYP19A1; HSD17B10; HSD17B1; ALOX5; HSD17B2; CD38; AOX1; XDH; MGAM; GAA; TYR; CYP2C9; CYP2C8; TBXAS1; CYP1A2; CYP1A1; ALPI |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 2.784E-09 | 5.402E-08 | FLT3; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A; EGFR |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 2.126E-09 | 4.582E-08 | DAPK1; SRC; MMP2; MAPK1; MMP9; TP53; EGFR |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 4.997E-09 | 7.457E-08 | GSK3B; SRC; AKT1; MAPK1; PIK3R1; ESR1; NFKB1; ESR2 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 3.538E-09 | 5.719E-08 | CYP2C9; CYP2C8; MAOA; CYP2D6; CYP1A2; AOX1; CYP3A4; CYP2C19 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 9.075E-09 | 1.174E-07 | HSD17B1; ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 2.329E-08 | 2.824E-07 | FLT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PPARD |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 5.919E-08 | 6.379E-07 | CAMK2B; AKT1; MAPK1; PIK3R1; TP53; EGFR; IGF1R |
| hsa04510 | Focal adhesion_Homo sapiens_hsa04510 | 1.449E-07 | 1.339E-06 | GSK3B; SRC; KDR; AKT1; MAPK1; PIK3R1; MET; PTK2; EGFR; IGF1R |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 8.647E-08 | 8.829E-07 | CAMK2B; AKT1; MAPK1; PIK3R1; HIF1A; EGFR; NFKB1; IGF1R |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 3.205E-07 | 2.487E-06 | GSK3B; KDR; AKT1; MAPK1; PIK3R1; PKN1; TP53; MET; PTK2; EGFR; NFKB1; IGF1R |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 1.101E-07 | 1.068E-06 | AKT1; MAPK1; PIK3R1; TP53; MET; EGFR; IGF1R |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.637E-08 | 3.009E-07 | HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.489E-07 | 2.195E-06 | GSK3B; SRC; AKT1; MAPK1; PIK3R1; TP53; ESR1; HIF1A |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 2.833E-07 | 2.390E-06 | CAMK2B; GSK3B; ABL1; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 4.269E-07 | 3.067E-06 | PLA2G1B; KDR; ABL1; AKT1; MAPK1; PIK3R1; MET; EGFR; NFKB1; IGF1R |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 5.772E-07 | 3.862E-06 | FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 6.235E-07 | 4.032E-06 | GSK3B; AKT1; MAPK1; PIK3R1; PPARA; TP53; EGFR; NFKB1 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 1.265E-06 | 7.671E-06 | SRC; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.998E-07 | 2.424E-06 | CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 3.586E-07 | 2.676E-06 | GSK3B; AKT1; MAPK1; PIK3R1; TP53; EGFR |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 5.620E-07 | 3.862E-06 | ALK; AKT1; MAPK1; PIK3R1; TP53; EGFR |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 4.814E-06 | 2.395E-05 | ABCC1; PIM1; ABL1; CYP1B1; MAPK1; TP53; MMP9; MET; EGFR; NFKB1 |
| hsa04370 | VEGF signaling pathway_Homo sapiens_hsa04370 | 9.403E-07 | 5.885E-06 | SRC; KDR; AKT1; MAPK1; PIK3R1; PTK2 |
| hsa04062 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 7.976E-06 | 3.868E-05 | GSK3B; CXCR1; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PTK2 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.505E-06 | 8.590E-06 | AKT1; MAPK1; PIK3R1; TP53; EGFR; NFKB1 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 1.096E-05 | 5.064E-05 | PARP1; LMNA; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.399E-05 | 6.312E-05 | GSK3B; CSNK2A1; CDK1; AKT1; CD38; PIK3R1; TP53; NFKB1 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 2.736E-06 | 1.434E-05 | ABL1; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 9.067E-06 | 4.290E-05 | GSK3B; CSNK2A1; AKT1; RAB9A; PIK3R1; TP53; NFKB1 |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.917E-05 | 8.264E-05 | SRC; KDR; AKT1; MAPK1; PIK3R1; MET; EGFR; IGF1R |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.802E-05 | 7.947E-05 | MMP2; PIM1; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.375E-06 | 8.081E-06 | CYP2C9; CYP2C8; CYP1A2; CYP1A1; AOX1; CYP3A4 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 2.964E-06 | 1.513E-05 | CSNK2A1; SRC; MAPK1; MET; EGFR; IGF1R |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.736E-06 | 1.434E-05 | CYP2C9; CYP2D6; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 2.781E-05 | 1.148E-04 | GSK3B; AKT1; PIK3R1; PYGL; PPARA; NFKB1 |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.929E-05 | 1.160E-04 | MMP3; AKT1; MAPK1; PIK3R1; MMP9; NFKB1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.037E-04 | 3.659E-04 | CAMK2B; AKT1; MAPK1; PIK3R1; PPARA; NFKB1; TSHR |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.248E-04 | 4.247E-04 | POLB; SRC; CDK1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 4.782E-05 | 1.750E-04 | ABCC1; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.217E-04 | 4.216E-04 | GSK3B; ESRRB; AKT1; MAPK1; PIK3R1; IGF1R |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 2.178E-04 | 6.761E-04 | THPO; PIM1; AKT1; AOX1; STAT6; PIK3R1 |
| hsa04921 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 2.178E-04 | 6.761E-04 | CAMK2B; SRC; CD38; MAPK1; PIK3R1; EGFR |
| hsa04662 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 4.692E-05 | 1.750E-04 | GSK3B; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 2.119E-05 | 8.937E-05 | GSK3B; AKT1; MAPK1; PIK3R1; TP53 |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.907E-04 | 6.165E-04 | CDK1; AKT1; MAPK1; PIK3R1; IGF1R |
| hsa05211 | Renal cell carcinoma_Homo sapiens_hsa05211 | 2.877E-05 | 1.160E-04 | AKT1; MAPK1; PIK3R1; MET; HIF1A |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.345E-04 | 4.500E-04 | CAMK2B; SRC; MMP2; MAPK1; EGFR |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.029E-04 | 3.659E-04 | AKT1; PIK3R1; TP53; NFKB1; PTK2 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.568E-04 | 5.155E-04 | AKT1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 3.031E-04 | 8.910E-04 | BACE1; APP; GSK3B; MAPK1; MAPT; HSD17B10 |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 2.196E-04 | 6.761E-04 | AKT1; MAPK1; PIK3R1; HIF1A; EGFR |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 3.327E-05 | 1.291E-04 | CXCR1; SRC; MET; EGFR; NFKB1 |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.517E-04 | 7.629E-04 | GSK3B; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 4.102E-05 | 1.561E-04 | SLCO1B1; CA2; SLCO1B3; CYP3A4; ABCG2 |
| hsa04611 | Platelet activation_Homo sapiens_hsa04611 | 5.254E-04 | 1.456E-03 | SRC; TBXAS1; AKT1; MAPK1; PIK3R1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.368E-06 | 1.312E-05 | MAOA; CYP1A2; CYP1A1; AOX1; CYP1B1 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 4.511E-04 | 1.268E-03 | ALOX5; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04114 | Oocyte meiosis_Homo sapiens_hsa04114 | 5.453E-04 | 1.490E-03 | CAMK2B; AR; CDK1; MAPK1; IGF1R |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 7.773E-04 | 2.011E-03 | AKT1; MAPK1; PIK3R1; EGFR; IGF1R |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 6.771E-04 | 1.775E-03 | CAMK2B; GSK3B; MAOA; AKT1; DRD4 |
| hsa04360 | Axon guidance_Homo sapiens_hsa04360 | 6.308E-04 | 1.676E-03 | GSK3B; ABL1; MAPK1; MET; PTK2 |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.043E-03 | 2.561E-03 | CAMK2B; GSK3B; CSNK2A1; TP53; PPARD |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.110E-03 | 2.692E-03 | CXCR1; AKT1; MAPK1; PIK3R1; EGFR |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 9.480E-04 | 2.358E-03 | GSK3B; AKT1; MAPK1; PIK3R1; PYGL |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.371E-03 | 3.243E-03 | GSK3B; AKT1; PIK3R1; PPARA; NFKB1 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 2.623E-03 | 5.655E-03 | AKT1; MAPK1; MAPT; TP53; EGFR; NFKB1 |
| hsa05164 | Influenza A_Homo sapiens_hsa05164 | 2.613E-03 | 5.655E-03 | GSK3B; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04144 | Endocytosis_Homo sapiens_hsa04144 | 2.834E-03 | 5.911E-03 | CXCR1; SRC; KDR; MET; EGFR; IGF1R |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 2.780E-03 | 5.911E-03 | POLB; GSK3B; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04060 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 3.172E-03 | 6.478E-03 | CXCR1; THPO; FLT3; KDR; MET; EGFR |
| hsa05152 | Tuberculosis_Homo sapiens_hsa05152 | 2.812E-03 | 5.911E-03 | CAMK2B; SRC; AKT1; MAPK1; NFKB1 |
| hsa04750 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.968E-03 | 4.545E-03 | CAMK2B; SRC; ALOX12; PIK3R1 |
| hsa04916 | Melanogenesis_Homo sapiens_hsa04916 | 2.119E-03 | 4.835E-03 | CAMK2B; GSK3B; MAPK1; TYR |
| hsa04922 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 2.197E-03 | 4.956E-03 | CAMK2B; AKT1; PYGL; PPARA |
| hsa04620 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.619E-03 | 5.655E-03 | AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa05142 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 2.444E-03 | 5.449E-03 | AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04810 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 6.124E-03 | 1.153E-02 | SRC; MAPK1; PIK3R1; PTK2; EGFR |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 3.093E-03 | 6.383E-03 | CAMK2B; AKT1; MAPK1; PIK3R1 |
| hsa04261 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 8.517E-03 | 1.559E-02 | CAMK2B; AKT1; MAPK1; PIK3R1 |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 5.725E-03 | 1.100E-02 | AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04540 | Gap junction_Homo sapiens_hsa04540 | 1.324E-03 | 3.170E-03 | SRC; CDK1; MAPK1; EGFR |
| hsa05100 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 8.438E-04 | 2.154E-03 | SRC; PIK3R1; MET; PTK2 |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.804E-02 | 2.990E-02 | CSNK2A1; CDK1; TP53; NFKB1 |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 4.593E-03 | 9.000E-03 | GSK3B; ABL1; CDK1; TP53 |
| hsa04670 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 3.851E-03 | 7.623E-03 | MMP2; PIK3R1; MMP9; PTK2 |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 3.107E-04 | 8.997E-04 | AKT1; MAPK1; PIK3R1; HIF1A |
| hsa04152 | AMPK signaling pathway_Homo sapiens_hsa04152 | 2.966E-02 | 4.641E-02 | AKT1; PIK3R1; IGF1R |
| hsa05131 | Shigellosis_Homo sapiens_hsa05131 | 4.226E-04 | 1.206E-03 | SRC; ABL1; MAPK1; NFKB1 |
| hsa05146 | Amoebiasis_Homo sapiens_hsa05146 | 1.696E-02 | 2.836E-02 | PIK3R1; NFKB1; PTK2 |
| hsa04666 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.398E-02 | 2.380E-02 | AKT1; MAPK1; PIK3R1 |
| hsa04972 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.522E-02 | 2.567E-02 | CA2; PLA2G1B; CD38 |
| hsa04064 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.398E-02 | 2.380E-02 | CSNK2A1; PARP1; NFKB1 |
| hsa04640 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.206E-02 | 2.107E-02 | THPO; FLT3; CD38 |
| hsa05132 | Salmonella infection_Homo sapiens_hsa05132 | 1.133E-02 | 1.998E-02 | MAPK1; PKN1; NFKB1 |
| hsa04664 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 5.950E-03 | 1.132E-02 | AKT1; MAPK1; PIK3R1 |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 6.448E-03 | 1.203E-02 | AKT1; PPARA; NFKB1 |
| hsa04213 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 5.024E-03 | 9.746E-03 | AKT1; PIK3R1; IGF1R |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 3.448E-03 | 6.896E-03 | AKT1; PIK3R1; TSHR |
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 3.448E-03 | 6.896E-03 | MGAM; GAA; PYGL |
| hsa05030 | Cocaine addiction_Homo sapiens_hsa05030 | 2.881E-02 | 4.545E-02 | MAOA; NFKB1 |
| hsa04973 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.843E-03 | 4.307E-03 | MGAM; AKT1; PIK3R1 |
| hsa04930 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 2.773E-02 | 4.410E-02 | MAPK1; PIK3R1 |
| hsa00280 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.773E-02 | 4.410E-02 | AOX1; HSD17B10 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.563E-02 | 4.143E-02 | CYP3A4; XDH |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 2.358E-02 | 3.845E-02 | ABCC1; ABCG2 |
| hsa04960 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.880E-02 | 3.091E-02 | MAPK1; PIK3R1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 5.591E-04 | 1.506E-03 | MGAM; GAA; AKR1B1 |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 8.838E-04 | 2.227E-03 | MAOA; AOX1; TYR |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 1.067E-02 | 1.898E-02 | MAPK1; TP53 |
| hsa04320 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 9.286E-03 | 1.684E-02 | MAPK1; EGFR |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 1.368E-02 | 2.369E-02 | POLB; PARP1 |
| hsa00760 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.067E-02 | 1.898E-02 | AOX1; CD38 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 6.788E-03 | 1.254E-02 | CA2; CA4 |
| hsa00750 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.197E-02 | 4.962E-02 | AOX1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.859E-04 | 8.532E-04 | CYP1A2; XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | AR; IGF1R; ESR1; ESR1 |
| C00-D49: Neoplasms | Hormone refractory prostate cancer | C61 | AR; ESR1 |
| NA: NA | HIV infections | NA | AHR |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | TBXAS1; ALOX5 |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | NPSR1; ESR1; APP |
| C00-D49: Neoplasms | Colon cancer | C50 | FLT3; EGFR |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | FLT3; IGF1R; MMP9; EGFR; EGFR; TP53; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatological disease | L00-L99 | AR; ESRRA |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Hyperglycemia | R73.9 | MGAM |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| Z00-Z99: Factors influencing health status and contact with health services | Hormone replacement therapy | Z79.890 | ESR1 |
| C00-D49: Neoplasms | Gastric cancer | C16 | EGFR; EGFR; KDR; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | MET |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Female sexual dysfunction | F52 | ESR1 |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3 |
| Z00-Z99: Factors influencing health status and contact with health services | Contraception | Z30 | AR; ESR1 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD; ESR1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | AR; AKT1; MET; CSNK2A1; CA1; FLT3; FLT3; CA9; ABL1; MMP2; SRC; IGF1R; PTK2; GSK3B; HIF1A; CDK1; MAPK1; MMP9; NFKB1; EGFR; PIM1; PARP1; CD38; TP53; ESR1; ESR1; KDR; APP |
| C00-D49: Neoplasms | Female androgenresponsive recurrent mammary cancer | C50 | AR |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR |
| NA: NA | Postmenopausal disorder | NA | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | MGAM; GAA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Erectile dysfunction | F52.2, N48.4 | DRD4 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | AR; XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypogonadism | E23.0, E28.3, E29.1 | AR; ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| C00-D49: Neoplasms | Hematologic malignancies | C81-C86 | AKT1 |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | AR; MGAM; KDR |
| C00-D49: Neoplasms | Castration-resistant prostate cancer | C61 | AR |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Testosterone deficiency | E29.1 | AR |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | TBXAS1 |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| N00-N99: Diseases of the genitourinary system | Infertility | N97.0 | ESR1 |
| H00-H59: Diseases of the eye and adnexa | Age related macular degeneration | H35.3 | APP |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | MMP9 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | ESR1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5 |
| N00-N99: Diseases of the genitourinary system | Atrophic vaginitis | N95.2 | ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Muscle disease | M60-M63 | MGAM |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Muscle atrophy | M62.5 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | MPO; ESR1; ESR1 |
| G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R |
| H00-H59: Diseases of the eye and adnexa | Macular degeneration | H35.3 | APP |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | AKT1; CA9; HIF1A; EGFR |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | AR; KDR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AKT1; MET; FLT3; CA9; ABL1; MMP2; SRC; IGF1R; PTK2; AURKB; HIF1A; MAPK1; MMP9; EGFR; TP53; KDR; KDR; KDR |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | EGFR; PARP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Endocrine disease | E00-E35 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| G00-G99: Diseases of the nervous system G00-G99 | Ataxia telangiectasia | G11.3 | PARP1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PLA2G1B; ABCC1; ESRRA; ALOX5 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthralgia | M25.5 | ESR1 |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Female hypogonadism | E23, E28 | ESR1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| A00-B99: Certain infectious and parasitic diseases | Acquired immune deficiency syndrome | B20 | MGAM |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | AR; AR; ESRRA; MMP2; ESR1 |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cachexia | R64 | AR; ESRRA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | ABL1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CAMK2B; AKR1B1; PLA2G1B; ESRRA; ALOX5; MMP3; TYR |
| I00-I99: Diseases of the circulatory system | Heart disease | I00-I52 | MET |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | ESRRA; DRD4 |
| I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | TBXAS1 |
| I00-I99: Diseases of the circulatory system | Cardiomyopathy | I42.0 | TTR |
| C00-D49: Neoplasms | Recurrent epithelial ovarian or primary peritoneal cancer | C78 | PARP1 |
| Z00-Z99: Factors influencing health status and contact with health services | Oral contraceptive | Z30 | ESR1 |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Osteopetrosis | Q78.2 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Female infertility due to anovulation | N97.0 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Female infertility | N97.0 | ESR1; ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | ESRRA |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5 |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| C00-D49: Neoplasms | Ovarian cancer | C56 | MMP2; EGFR; EGFR; PARP1; KDR; KDR; KDR; KDR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis in post-menopausal women | M80-M81 | AR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | AR; SRC; ESR1 |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Vulnerary | S00-T98 | EGFR |
| C00-D49: Neoplasms | Bladder cancer | C67 | AR; CYP19A1; EGFR |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; KDR |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Brain ischaemia | G45.9, I67.8 | PARP1 |
| C00-D49: Neoplasms | Breast cancer | C50 | AR; CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; EGFR; EGFR; EGFR; ESR1; ESR1; KDR; KDR; KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Brain injury | S09.90 | APP |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | SRC; EGFR; EGFR; ESR1 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | AR; MMP13; IGF1R; CDK1; ESR1 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | AKT1; FLT3; MMP2; EGFR; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | MPO; MAOA |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; SRC |
| C00-D49: Neoplasms | Refractory breast cancer | C50 | EGFR |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | ABL1; ABL1; SRC |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | EGFR |
| NA: NA | Hematopoietic stem cell transplantation | NA | FLT3 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B; ALOX5 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4; CA2 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Atrophy | M62.571 | ESR1 |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; GSK3B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD4 |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Male hormonal deficiencies | E20-E35 | AR |
| NA: NA | Dyslipidemia | NA | PPARD |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA1; CA2 |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT |
| I00-I99: Diseases of the circulatory system | Cerebrovascular disorders | I60-I69 | PARP1 |
| C00-D49: Neoplasms | Malignant tumor | C00-C75, C7A, C7B | EGFR |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Prostate cancer | C61 | AR; AR; FLT3; ABL1; EGFR; ESR1 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | ALOX5; FLT3; EGFR |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3; ABL1 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; PPARD |
| I00-I99: Diseases of the circulatory system | Cerebral amyloid angiopathy | I68.0 | APP |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3 |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SRC |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | TTR amyloidosis | E85 | TTR |
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
| G00-G99: Diseases of the nervous system G00-G99 | Permanent and transient stroke | G45.9, I61-I63 | PARP1 |
| K00-K95: Diseases of the digestive system | Chemotherapy-induced mucositis | K12.3 | MET |
| H00-H59: Diseases of the eye and adnexa | Choroidal neovascularisation | H35 | ESRRA |
| C00-D49: Neoplasms | Metastasis | C00-C97 | AXL |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Diabetic foot ulcer | L88-L89 | EGFR |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | FLT3; FLT3; AURKB; TP53; TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARD; PPARD |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MET; IGF1R; IGF1R; EGFR; EGFR; AXL; KDR |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | MMP2; KDR |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | TBXAS1 |
| C00-D49: Neoplasms | Inflammatory breast cancer | C50 | EGFR |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MPO; PLA2G1B; ALOX5; MMP13; MMP12 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6; CA2 |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MMP9 |
| C00-D49: Neoplasms | Urethral cancer | NA | EGFR |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5 |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2; KDR; KDR |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; KDR |
| C00-D49: Neoplasms | Advanced prostate cancer | C61 | AR; ESR1 |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR |
| C00-D49: Neoplasms | Advanced cancers | C00-C96 | EGFR |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ESRRA; ALOX5 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA |
| A00-B99: Certain infectious and parasitic diseases | Dengue fever | A90 | MGAM |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1; MGAM; GSK3B |
| C00-D49: Neoplasms | Intestinal cancer | NA | ABL1 |
| C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3 |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3; ABL1 |
| N00-N99: Diseases of the genitourinary system | Post-menopausal vaginal atrophy | N95.2 | ESR1 |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | ABL1; MMP2; EGFR |
| C00-D49: Neoplasms | Locally advanced head and neck cancer | C07-C14, C32, C33 | EGFR |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | MET |
| N00-N99: Diseases of the genitourinary system | Vagina disease | N76.0 | ESR1 |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | TBXAS1; PLA2G1B; ESRRA; ALOX5; ALOX5; MMP12 |
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ESR1 |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Cystic fibrosis | E84 | AR |
| N00-N99: Diseases of the genitourinary system | Irregularities | N92.6 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | TBXAS1; MGAM; NFKB1; PPARD |
| N00-N99: Diseases of the genitourinary system | Nephritis | N00-N19, N25-N29 | TBXAS1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Myocardial reperfusion injury | T86.4 | AKT1 |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | MMP3; PARP1 |
| C00-D49: Neoplasms | Liver cancer | C22 | IGF1R; KDR |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Leukemia | C90-C95 | AKT1; FLT3; ABL1; ESR1 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | PTK2; TP53 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR |
| H00-H59: Diseases of the eye and adnexa | Eye disorders | H00-H59 | ESR1 |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA; TYR |
| K00-K95: Diseases of the digestive system | Gastrointestinal disease | K00-K93 | ESRRA; EGFR |
| C00-D49: Neoplasms | AML | NA | FLT3; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Alopecia | L65.9 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAOA; MAPT; GSK3B; APP |
| E00-E89: Endocrine, nutritional and metabolic diseases | Estrogen deficiency | E28.39 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Prostate hyperplasia | N40 | AR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | ALOX5; MMP13; MMP3; MMP2 |
| NA: NA | Menopausal disorder | NA | ESR1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Melasma | L81.1 | TYR |
| C00-D49: Neoplasms | Melanoma | C43 | EGFR; PARP1; TYR; KDR; KDR |
| NA: NA | Geographic retinal atrophy | NA | APP |
| NA: NA | GIST | NA | FLT3 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1; CA1; CA1 |
| C00-D49: Neoplasms | Glioblastoma | NA | FLT3 |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | SRC; EGFR; EGFR |
| C00-D49: Neoplasms | Glioma | C71 | ABL1; EGFR; EGFR; KDR; APP |
| J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3 |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET |
| K00-K95: Diseases of the digestive system | Alcoholic hepatitis | K70.1 | AR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA |
| C00-D49: Neoplasms | Esophageal cancer | C15 | EGFR |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B; ESRRA |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B; ALOX5 |
| NA: NA | Male hypogonadism | NA | AR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R |
| C00-D49: Neoplasms | Multiple myeloma | C90 | AHR; SRC; IGF1R; CD38 |
| G00-G99: Diseases of the nervous system G00-G99 | Diagnostic imaging | G30, I73.9 | APP |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R |
| H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR |
| I00-I99: Diseases of the circulatory system | Angina pectoris | I20 | TBXAS1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CAMK2B; MAOA; CYP3A4 |
| I00-I99: Diseases of the circulatory system | Aortic aneurysm | I71 | MMP12 |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| NA: NA | Edema | NA | CA2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| C00-D49: Neoplasms | Carcinoma | D00-D09 | ESR1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5; MMP12; PPARD |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | EGFR; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| C00-D49: Neoplasms | Metastatic prostate cancer | C61 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Mild to moderate alzheimer disease | G30 | APP |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | APP |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Head and neck squamous cell carcinoma | C44 | EGFR |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1; EGFR; EGFR; EGFR; TP53; KDR; KDR |
| NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Dyspareunia | N94.1 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Amyloidosis | E85 | APP; TTR |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5; RAB9A |
| C00-D49: Neoplasms | Mesothelioma | C45 | PTK2 |
| N00-N99: Diseases of the genitourinary system | Menopause symptoms | N95.0 | ESR1; ESR1 |
| N00-N99: Diseases of the genitourinary system | Menorrhagia | N92.0 | ESR1 |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| NA: NA | Gonorrheal vaginitis | NA | ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1; ABCC1; ABCC1; XDH |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SRC; AURKB; CD38; TP53 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET; IGF1R; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory skin condition | L00-L99 | PARP1 |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MPO; ALOX5; MMP12; MMP12 |