CMAUP Plant Collective Molecular Activities

Plant Name: Cinnamomum camphora

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Transient receptor potential channel	TRPA1;
Protein Kinase	PRKCE; PRKCB; MAPK1; PRKCH; PRKCG; PRKCD; PRKCA; PRKCQ;
Oxidoreductase	PTGS1;
Enzyme_unclassified	ALOX15;
Transcription Factor	TP53;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PRKCE	Protein kinase C epsilon	Q02156	CHEMBL3582
Protein Kinase	PRKCB	Protein kinase C beta	P05771	CHEMBL3045
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	PRKCH	Protein kinase C eta	P24723	CHEMBL3616
Protein Kinase	PRKCG	Protein kinase C gamma	P05129	CHEMBL2938
Protein Kinase	PRKCD	Protein kinase C delta	Q05655	CHEMBL2996
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Kinase	PRKCQ	Protein kinase C theta	Q04759	CHEMBL3920
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	5.442E-13	3.950E-09	MAPK1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ
MF	GO:0003824; catalytic activity	GO:0004699; calcium-independent protein kinase C activity	5.662E-10	2.466E-06	PRKCD, PRKCE, PRKCH
MF	GO:0003824; catalytic activity	GO:0004698; calcium-dependent protein kinase C activity	2.264E-09	7.041E-06	PRKCA, PRKCB, PRKCG
BP	GO:0009987; cellular process	GO:0034351; negative regulation of glial cell apoptotic process	3.162E-08	5.485E-05	PRKCA, PRKCD, PRKCH
BP	GO:0009987; cellular process	GO:0090330; regulation of platelet aggregation	4.583E-07	3.992E-04	PRKCA, PRKCD, PRKCQ
BP	GO:0008152; metabolic process	GO:0035408; histone H3-T6 phosphorylation	7.290E-07	5.474E-04	PRKCA, PRKCB
MF	GO:0003824; catalytic activity	GO:0035403; histone kinase activity (H3-T6 specific)	7.290E-07	5.474E-04	PRKCA, PRKCB
MF	GO:0005488; binding	GO:0005524; ATP binding	1.206E-06	7.297E-04	MAPK1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, TP53
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	2.265E-06	1.050E-03	PRKCB, PRKCD, PRKCQ
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.370E-06	1.699E-03	CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0007077; mitotic nuclear envelope disassembly	7.333E-06	2.457E-03	LMNA, PRKCA, PRKCB
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.091E-05	3.086E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	1.366E-05	3.668E-03	ALOX15, CYP1A2, PTGS1
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.527E-05	3.779E-03	CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0050861; positive regulation of B cell receptor signaling pathway	1.527E-05	3.779E-03	PRKCB, PRKCH
BP	GO:0008152; metabolic process	GO:0051054; positive regulation of DNA metabolic process	3.057E-05	5.641E-03	MAPK1, PRKCD, PRKCG, PRKCQ
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	3.181E-05	5.772E-03	LMNA, MAPK1, PRKCA, PRKCH, PRKCQ, PTGS1, TP53, TSHR
CC	GO:0016020; membrane	GO:0005886; plasma membrane	3.711E-05	6.465E-03	ALOX15, MAPK1, MAPT, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, TRPA1, TSHR
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.787E-05	7.779E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	4.787E-05	7.779E-03	CYP1A2, CYP3A4
BP	GO:0065007; biological regulation	GO:0044093; positive regulation of molecular function	5.100E-05	8.047E-03	MAPK1, MAPT, PRKCB, PRKCD, PRKCE, PRKCH, PRKCQ, TSHR
BP	GO:0008152; metabolic process	GO:0032930; positive regulation of superoxide anion generation	6.593E-05	9.571E-03	MAPT, PRKCD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04750	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	5.820E-15	8.206E-13	PRKCG; PRKCH; TRPA1; PRKCB; PRKCE; PRKCD; PRKCA; PRKCQ
hsa04270	Vascular smooth muscle contraction_Homo sapiens_hsa04270	3.080E-14	2.172E-12	PRKCG; PRKCH; PRKCB; PRKCE; PRKCD; MAPK1; PRKCA; PRKCQ
hsa04530	Tight junction_Homo sapiens_hsa04530	1.234E-11	5.801E-10	PRKCG; PRKCH; PRKCB; PRKCE; PRKCD; PRKCA; PRKCQ
hsa04666	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.019E-10	3.593E-09	PRKCG; PRKCB; PRKCE; PRKCD; MAPK1; PRKCA
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	3.171E-10	8.941E-09	PRKCG; PRKCB; ALOX15; MAPK1; PRKCA; PTGS1
hsa05223	Non-small cell lung cancer_Homo sapiens_hsa05223	8.645E-10	1.741E-08	PRKCG; PRKCB; MAPK1; PRKCA; TP53
hsa05214	Glioma_Homo sapiens_hsa05214	1.861E-09	3.280E-08	PRKCG; PRKCB; MAPK1; PRKCA; TP53
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	4.823E-10	1.133E-08	PRKCG; PRKCB; PRKCE; MAPK1; PRKCA; TP53
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.753E-08	2.746E-07	PRKCB; PRKCE; PRKCD; MAPK1; PRKCA
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	4.457E-08	5.237E-07	PRKCG; PRKCB; MAPK1; PRKCA; MAPT; TP53
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	3.838E-08	4.920E-07	PRKCG; PRKCB; MAPK1; PRKCA; TP53
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	1.100E-07	1.124E-06	PRKCG; PRKCB; PRKCE; MAPK1; PRKCA; TP53
hsa05161	Hepatitis B_Homo sapiens_hsa05161	1.116E-07	1.124E-06	PRKCG; PRKCB; MAPK1; PRKCA; TP53
hsa04960	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.884E-08	4.067E-07	PRKCG; PRKCB; MAPK1; PRKCA
hsa04730	Long-term depression_Homo sapiens_hsa04730	1.691E-07	1.491E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	1.691E-07	1.491E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04370	VEGF signaling pathway_Homo sapiens_hsa04370	1.809E-07	1.500E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	5.747E-07	3.858E-06	PRKCG; PRKCB; MAPK1; PRKCA; TP53
hsa04925	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	5.708E-07	3.858E-06	PRKCG; PRKCB; PRKCE; PRKCA
hsa04720	Long-term potentiation_Homo sapiens_hsa04720	2.492E-07	1.952E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04918	Thyroid hormone synthesis_Homo sapiens_hsa04918	3.351E-07	2.487E-06	PRKCG; PRKCB; PRKCA; TSHR
hsa04012	ErbB signaling pathway_Homo sapiens_hsa04012	7.613E-07	4.879E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04912	GnRH signaling pathway_Homo sapiens_hsa04912	9.122E-07	5.359E-06	PRKCB; PRKCD; MAPK1; PRKCA
hsa04713	Circadian entrainment_Homo sapiens_hsa04713	1.084E-06	6.115E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04916	Melanogenesis_Homo sapiens_hsa04916	1.332E-06	6.981E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa05231	Choline metabolism in cancer_Homo sapiens_hsa05231	1.386E-06	6.981E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04540	Gap junction_Homo sapiens_hsa04540	7.971E-07	4.887E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04723	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.386E-06	6.981E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	2.023E-06	8.913E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.500E-06	7.291E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04931	Insulin resistance_Homo sapiens_hsa04931	1.881E-06	8.555E-06	PRKCB; PRKCE; PRKCD; PRKCQ
hsa04724	Glutamatergic synapse_Homo sapiens_hsa04724	2.250E-06	9.615E-06	PRKCG; PRKCB; MAPK1; PRKCA
hsa04650	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	4.414E-06	1.778E-05	PRKCG; PRKCB; MAPK1; PRKCA
hsa04310	Wnt signaling pathway_Homo sapiens_hsa04310	5.395E-06	2.113E-05	PRKCG; PRKCB; PRKCA; TP53
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	1.527E-05	5.384E-05	PRKCG; PRKCB; MAPK1; PRKCA; TP53
hsa04921	Oxytocin signaling pathway_Homo sapiens_hsa04921	8.237E-06	3.056E-05	PRKCG; PRKCB; MAPK1; PRKCA
hsa04510	Focal adhesion_Homo sapiens_hsa04510	2.169E-05	7.458E-05	PRKCG; PRKCB; MAPK1; PRKCA
hsa04015	Rap1 signaling pathway_Homo sapiens_hsa04015	2.573E-05	8.437E-05	PRKCG; PRKCB; MAPK1; PRKCA
hsa04014	Ras signaling pathway_Homo sapiens_hsa04014	3.425E-05	1.073E-04	PRKCG; PRKCB; MAPK1; PRKCA
hsa04971	Gastric acid secretion_Homo sapiens_hsa04971	3.185E-05	1.021E-04	PRKCG; PRKCB; PRKCA
hsa05031	Amphetamine addiction_Homo sapiens_hsa05031	2.363E-05	7.932E-05	PRKCG; PRKCB; PRKCA
hsa04911	Insulin secretion_Homo sapiens_hsa04911	4.826E-05	1.479E-04	PRKCG; PRKCB; PRKCA
hsa04210	Apoptosis_Homo sapiens_hsa04210	2.124E-04	5.349E-04	LMNA; MAPK1; TP53
hsa04727	GABAergic synapse_Homo sapiens_hsa04727	5.353E-05	1.606E-04	PRKCG; PRKCB; PRKCA
hsa05032	Morphine addiction_Homo sapiens_hsa05032	5.917E-05	1.703E-04	PRKCG; PRKCB; PRKCA
hsa04970	Salivary secretion_Homo sapiens_hsa04970	5.537E-05	1.626E-04	PRKCG; PRKCB; PRKCA
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.347E-04	3.517E-04	PRKCD; MAPK1; TP53
hsa04070	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	7.380E-05	2.040E-04	PRKCG; PRKCB; PRKCA
hsa05146	Amoebiasis_Homo sapiens_hsa05146	7.838E-05	2.125E-04	PRKCG; PRKCB; PRKCA
hsa04728	Dopaminergic synapse_Homo sapiens_hsa04728	1.669E-04	4.278E-04	PRKCG; PRKCB; PRKCA
hsa05164	Influenza A_Homo sapiens_hsa05164	4.091E-04	9.946E-04	PRKCB; MAPK1; PRKCA
hsa04020	Calcium signaling pathway_Homo sapiens_hsa04020	4.443E-04	1.062E-03	PRKCG; PRKCB; PRKCA
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	6.940E-05	1.957E-04	PRKCG; PRKCB; PRKCA
hsa04670	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.282E-04	3.410E-04	PRKCG; PRKCB; PRKCA
hsa04062	Chemokine signaling pathway_Homo sapiens_hsa04062	4.966E-04	1.167E-03	PRKCB; PRKCD; MAPK1
hsa04961	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	8.082E-06	3.056E-05	PRKCG; PRKCB; PRKCA
hsa04930	Type II diabetes mellitus_Homo sapiens_hsa04930	8.616E-06	3.115E-05	PRKCE; PRKCD; MAPK1
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	2.797E-03	4.931E-03	MAPK1; PRKCA; TP53
hsa05143	African trypanosomiasis_Homo sapiens_hsa05143	3.283E-06	1.361E-05	PRKCG; PRKCB; PRKCA
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	1.822E-02	2.763E-02	CYP1A2; ALOX15; CYP3A4; PTGS1
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	1.285E-02	1.969E-02	MAPK1; TP53
hsa04611	Platelet activation_Homo sapiens_hsa04611	4.727E-03	7.935E-03	MAPK1; PTGS1
hsa05162	Measles_Homo sapiens_hsa05162	5.839E-03	9.573E-03	PRKCQ; TP53
hsa04072	Phospholipase D signaling pathway_Homo sapiens_hsa04072	6.522E-03	1.057E-02	MAPK1; PRKCA
hsa04261	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	6.877E-03	1.102E-02	MAPK1; PRKCA
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	8.681E-03	1.375E-02	PRKCE; MAPK1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	5.591E-03	9.275E-03	MAPK1; TP53
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	1.214E-02	1.882E-02	MAPK1; TSHR
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	8.781E-03	1.376E-02	MAPK1; MAPT
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	3.143E-03	5.471E-03	PRKCD; MAPK1
hsa04660	T cell receptor signaling pathway_Homo sapiens_hsa04660	3.461E-03	5.952E-03	MAPK1; PRKCQ
hsa05215	Prostate cancer_Homo sapiens_hsa05215	2.550E-03	4.609E-03	MAPK1; TP53
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.839E-06	8.555E-06	CYP1A2; ALOX15; CYP3A4
hsa04664	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.499E-03	3.019E-03	MAPK1; PRKCA
hsa04064	NF-kappa B signaling pathway_Homo sapiens_hsa04064	2.780E-03	4.931E-03	PRKCB; PRKCQ
hsa05218	Melanoma_Homo sapiens_hsa05218	1.633E-03	3.197E-03	MAPK1; TP53
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.455E-03	2.974E-03	MAPK1; TP53
hsa05212	Pancreatic cancer_Homo sapiens_hsa05212	1.413E-03	2.929E-03	MAPK1; TP53
hsa05220	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.725E-03	3.200E-03	MAPK1; TP53
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	1.725E-03	3.200E-03	PRKCB; MAPK1
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.019E-03	2.281E-03	TSHR; PTGS1
hsa04662	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.725E-03	3.200E-03	PRKCB; MAPK1
hsa05210	Colorectal cancer_Homo sapiens_hsa05210	1.248E-03	2.666E-03	MAPK1; TP53
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	2.170E-03	3.973E-03	CYP1A2; CYP3A4
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	1.371E-03	2.884E-03	CYP1A2; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.725E-03	3.200E-03	CYP1A2; CYP3A4
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.543E-03	3.064E-03	CYP1A2; CYP3A4
hsa05213	Endometrial cancer_Homo sapiens_hsa05213	8.795E-04	2.000E-03	MAPK1; TP53
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.248E-03	2.666E-03	ALOX15; PTGS1
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.093E-03	2.408E-03	CYP1A2; CYP3A4
hsa05219	Bladder cancer_Homo sapiens_hsa05219	5.469E-04	1.264E-03	MAPK1; TP53
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	3.347E-02	4.917E-02	CYP1A2
hsa05020	Prion diseases_Homo sapiens_hsa05020	2.935E-02	4.356E-02	MAPK1
hsa05216	Thyroid cancer_Homo sapiens_hsa05216	2.724E-04	6.738E-04	MAPK1; TP53
hsa04320	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.271E-02	3.407E-02	MAPK1
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	4.243E-03	7.208E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1; TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1
NA: NA	Rheumatold arthritis	NA	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
C00-D49: Neoplasms	Central nervous system tumors	NA	PRKCB
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Renal transplantation	D89.8	PRKCB
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
C00-D49: Neoplasms	Cancer	C00-C96	PRKCB; MAPK1; TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
C00-D49: Neoplasms	Brain cancer	C71, D33	PRKCB
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1; PRKCQ
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
I00-I99: Diseases of the circulatory system	Acute myocardial infarction	I21-I22	PRKCD
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1
I00-I99: Diseases of the circulatory system	Ischemic reperfusion injury	I00-I99	PRKCE
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	PRKCB
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
C00-D49: Neoplasms	Lymphoma	C81-C86	PRKCB
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1; TRPA1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	PRKCE
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1
NA: NA	Reperfusion injury and heart attacks	NA	PRKCD
NA: NA	Miosis during ocular surgery	NA	PTGS1
C00-D49: Neoplasms	Glioblastoma multiforme	C71	PRKCB

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases