CMAUP Plant Collective Molecular Activities

Plant Name: Datura stramonium

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	9.340E-11	1.849E-07	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.708E-09	3.099E-06	CA12, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.256E-08	8.777E-05	CA12, CA2, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.662E-07	1.905E-04	CA12, CA2, CA7, CA9
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	7.753E-07	6.835E-04	BLM, CA2, CA9, CASP1, CASP7, CYP1A2, HPGD, NFKB1
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	3.358E-06	2.521E-03	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	2.608E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004435; phosphatidylinositol phospholipase C activity	3.685E-06	2.608E-03	CHRM1, CHRM3, CHRM5
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	1.181E-05	6.431E-03	BLM, CA9, CASP1, HPGD, HTR2C, NFKB1, POLB
BP	GO:0032501; multicellular organismal process	GO:0046541; saliva secretion	1.236E-05	6.563E-03	CHRM1, CHRM3
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	1.176E-15	1.280E-11	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	1.176E-15	1.280E-11	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	7.050E-15	5.117E-11	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.294E-08	5.758E-07	CHRM2; CHRM3; CHRM1; CHRM4; CHRM5; HTR2C; ADRA1D
hsa04020	Calcium signaling pathway_Homo sapiens_hsa04020	3.236E-08	9.601E-07	CHRM2; CHRM3; CHRM1; CHRM5; HTR2C; ADRA1D
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	1.175E-07	2.613E-06	CHRM2; CHRM3; CHRM1; CHRM4; CHRM5
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	2.588E-09	2.303E-07	CA12; CA2; CA7; CA9
hsa04810	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	3.039E-06	5.409E-05	CHRM2; CHRM3; CHRM1; CHRM4; CHRM5
hsa05134	Legionellosis_Homo sapiens_hsa05134	2.920E-05	4.332E-04	CASP7; CASP1; NFKB1
hsa05133	Pertussis_Homo sapiens_hsa05133	7.410E-05	9.421E-04	CASP7; CASP1; NFKB1
hsa04210	Apoptosis_Homo sapiens_hsa04210	4.690E-04	5.217E-03	CASP7; LMNA; NFKB1
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	1.300E-03	1.285E-02	CHRM2; CHRM1; NFKB1
hsa04971	Gastric acid secretion_Homo sapiens_hsa04971	2.974E-03	2.036E-02	CHRM3; CA2
hsa04621	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.777E-03	1.582E-02	CASP1; NFKB1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	2.304E-03	1.709E-02	CYP1A2; ALDH1A1
hsa04623	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.234E-03	1.709E-02	CASP1; NFKB1
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	5.949E-03	2.941E-02	CHRM2; CHRM1; NFKB1
hsa04970	Salivary secretion_Homo sapiens_hsa04970	4.269E-03	2.533E-02	CHRM3; ADRA1D
hsa05132	Salmonella infection_Homo sapiens_hsa05132	3.992E-03	2.533E-02	CASP1; NFKB1
hsa04668	TNF signaling pathway_Homo sapiens_hsa04668	6.444E-03	3.019E-02	CASP7; NFKB1
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	4.948E-03	2.752E-02	CHRM3; CA2
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	5.488E-03	2.873E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
NA: NA	Uveitis	NA	CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRM4
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2; CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRM4; CHRM4
NA: NA	Gastritis	NA	CHRM4
NA: NA	Excessive sweating	NA	CHRM1
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CHRM1; ADRA1D; CHRM3; CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	ADRA1D
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1
NA: NA	Dysuria	NA	CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR2C; HTR2C
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1
NA: NA	Edema	NA	CA2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fecal incontinence	R15	ADRA1D
J00-J99: Diseases of the respiratory system	Asthma	J45	CHRM2
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	CHRM4
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HTR2C
H00-H59: Diseases of the eye and adnexa	Acquired nystagmus	H55	CHRM4
NA: NA	Abdominal stomach pain	NA	CHRM1
NA: NA	Addiction	NA	CHRM2
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3; CHRM4
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	CHRM5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	CHRM4
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1
NA: NA	Functional bowel syndrome	NA	CHRM1
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	ADRA1D
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	CHRM1; CHRM2; CHRM3; CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3
NA: NA	Vomiting	NA	CHRM4
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR2C
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA1D; CHRM4
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1
C00-D49: Neoplasms	Cancer	C00-C96	CA9; NFKB1
NA: NA	Spasms	NA	CHRM3
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	CHRM4; CHRM4
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; CHRM4
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	ADRA1D
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	CHRM2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2C
NA: NA	Moderate and severe psychomotor agitation	NA	CHRM4
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C
N00-N99: Diseases of the genitourinary system	Benign prostatic hyperplasia	N40	ADRA1D
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3
C00-D49: Neoplasms	Breast cancer	C50	CA9
NA: NA	Schizoaffective disorders	NA	CHRM1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	HTR2C
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	CHRM1; CHRM3; CHRM4; CHRM5
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3
C00-D49: Neoplasms	Renal cancer	C64	CA9
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2; CHRM4; CHRM4; CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nocturia	R35	CHRM4
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2
NA: NA	Dystonia	NA	CHRM1
NA: NA	Peptic ulcer disease	NA	CHRM4
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	CHRM4
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	CHRM1; CHRM1; CHRM2; CHRM4
C00-D49: Neoplasms	Pediatric cancer	C00-C96	ADRA1D
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	CHRM1; CHRM5
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5
NA: NA	Urgency	NA	CHRM4
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5
NA: NA	Suprapubic pain	NA	CHRM4
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM4; CHRM5
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR2C
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CHRM3; HTR2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Organophosphate poisoning	T60.0	CHRM4
H00-H59: Diseases of the eye and adnexa	Produce mydriasis and cycloplegia for diagnostic purposes	H57.04	CHRM4
NA: NA	Primary insomnia	NA	HTR2C
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	ADRA1D
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	ADRA1D
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM1; CHRM1; CHRM5; HTR2C
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CHRM1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	CHRM1; CHRM5; HTR2C
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM1; CHRM4; CHRM4; CHRM5
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1
I00-I99: Diseases of the circulatory system	Heart failure	I50	CHRM2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR2C; HTR2C
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; ADRA1D; CHRM2; CHRM3; CHRM5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Urinary retention	R33	CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	CHRM4; HTR2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADRA1D; HTR2C
H00-H59: Diseases of the eye and adnexa	Mydriasis diagnosis	H57.0	CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases