CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	8.485E-07	9.188E-03	ACP1, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.688E-06	9.188E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.688E-06	9.188E-03	GPBAR1, NR1H4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04520	Adherens junction_Homo sapiens_hsa04520	2.143E-05	5.143E-04	PTPN1; ACP1; PTPRF
hsa04976	Bile secretion_Homo sapiens_hsa04976	1.266E-03	1.520E-02	ABCB1; NR1H4
hsa04931	Insulin resistance_Homo sapiens_hsa04931	2.950E-03	2.360E-02	PTPN1; PTPRF
hsa04910	Insulin signaling pathway_Homo sapiens_hsa04910	4.746E-03	2.847E-02	PTPN1; PTPRF

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1
C00-D49: Neoplasms	Solid tumours	C00-D48	ABCB1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
C00-D49: Neoplasms	Cancer	C00-C96	ABCB1
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	ELANE; ELANE; ELANE
J00-J99: Diseases of the respiratory system	Pulmonary disease	J00-J99	ELANE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
J00-J99: Diseases of the respiratory system	Mucolytic	J00-J99	ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ELANE; ELANE
NA: NA	Acute respiratory distress syndrome	NA	ELANE; ELANE; ELANE
J00-J99: Diseases of the respiratory system	Pulmonary emphysema	J43	ELANE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ELANE
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ELANE
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	ABCB1
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
NA: NA	Myocardial ischaemia-reperfusion injury	NA	ELANE
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	ELANE; ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ELANE
J00-J99: Diseases of the respiratory system	Asthma	J45	ELANE
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1
C00-D49: Neoplasms	Ovarian cancer	C56	ABCB1
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
NA: NA	Colour dead tissues	NA	PTPN1
J00-J99: Diseases of the respiratory system	Bronchiectasis	J47, Q33.4	ELANE
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Betula davurica

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases