CMAUP Plant Collective Molecular Activities

Plant Name: Magnolia fraseri

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.066E-06	6.324E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.647E-07	6.324E-03	CA12, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	4.066E-06	6.324E-03	ADRA2A, ADRA2C
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.066E-06	6.324E-03	GPBAR1, NR1H4
BP	GO:0065007; biological regulation	GO:0032431; activation of phospholipase A2 activity	8.126E-06	8.524E-03	NMUR2, PLA2G1B
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	8.126E-06	8.524E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	8.126E-06	8.524E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	8.126E-06	8.524E-03	PTPN1, PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	8.939E-07	1.073E-04	CA12; CA7; CA9
hsa05133	Pertussis_Homo sapiens_hsa05133	8.499E-05	5.099E-03	CASP7; CASP1; MAPK1
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	8.956E-04	1.822E-02	MAPK1; ADRA2C; ADRA2A
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	5.040E-04	1.619E-02	PLA2G1B; CYP1A2
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	9.112E-04	1.822E-02	CASP7; MAPK1; HSD17B10
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	5.396E-04	1.619E-02	AKR1B10; GAA
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	2.261E-03	3.015E-02	AKR1B10; PLA2G1B; GAA; CYP1A2; ALDH1A1; HSD17B10
hsa05134	Legionellosis_Homo sapiens_hsa05134	1.810E-03	2.914E-02	CASP7; CASP1
hsa04621	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.943E-03	2.914E-02	CASP1; MAPK1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	2.518E-03	3.022E-02	CYP1A2; ALDH1A1
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	3.791E-03	3.791E-02	NMUR2; ADRA2C; ADRA2A
hsa04520	Adherens junction_Homo sapiens_hsa04520	3.249E-03	3.545E-02	PTPN1; MAPK1
hsa04914	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	5.623E-03	4.303E-02	MAPK1; CDC25B
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	7.157E-03	4.771E-02	ACHE; MAPK1
hsa05132	Salmonella infection_Homo sapiens_hsa05132	4.360E-03	4.025E-02	CASP1; MAPK1
hsa04668	TNF signaling pathway_Homo sapiens_hsa04668	7.033E-03	4.771E-02	CASP7; MAPK1
hsa00564	Glycerophospholipid metabolism_Homo sapiens_hsa00564	5.293E-03	4.303E-02	ACHE; PLA2G1B
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	5.737E-03	4.303E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
NA: NA	Colour dead tissues	NA	PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1; PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
C00-D49: Neoplasms	Renal cancer	C64	CA9
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C; PLA2G1B
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; ADRA2A; ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C; ACHE
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
C00-D49: Neoplasms	Breast cancer	C50	CA9
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C; PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1
C00-D49: Neoplasms	Cancer	C00-C96	CA9; MAPK1; ACHE; CDC25B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; MAPK1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases