CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	9.078E-05	6.264E-03	HTR6; CYP2D6; CYP2C19
hsa05214	Glioma_Homo sapiens_hsa05214	1.212E-03	2.354E-02	TP53; MTOR
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.287E-03	2.354E-02	TP53; MTOR
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.364E-03	2.354E-02	CYP2D6; CYP2C19
hsa05215	Prostate cancer_Homo sapiens_hsa05215	2.256E-03	2.889E-02	TP53; MTOR
hsa04211	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	2.513E-03	2.889E-02	TP53; MTOR
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	3.924E-03	3.868E-02	TP53; MTOR
hsa04210	Apoptosis_Homo sapiens_hsa04210	5.475E-03	4.722E-02	LMNA; TP53

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR6
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MTOR
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MTOR
C00-D49: Neoplasms	Cancer	C00-C96	MTOR; TP53
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	MTOR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HTR6
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR6; HTR6
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR6; HTR6; HTR6; MAPT
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	ODC1; TP53
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Organ rejection	D89.8, T86	MTOR
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
C00-D49: Neoplasms	Lymphoma	C81-C86	MTOR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	HTR6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR6; MAPT
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
C00-D49: Neoplasms	Bladder cancer	C67	MTOR
C00-D49: Neoplasms	Multiple myeloma	C90	MTOR; MTOR
C00-D49: Neoplasms	Solid tumours	C00-D48	MTOR; TP53
C00-D49: Neoplasms	Solid tumors	NA	MTOR
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
A00-B99: Certain infectious and parasitic diseases	Burns and burn infection	A00-B99	ODC1
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR6
C00-D49: Neoplasms	Sarcoma	C81-C86	MTOR
A00-B99: Certain infectious and parasitic diseases	African trypanosomiasis	B56	ODC1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	HTR6; MAPT
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR6
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MTOR
C00-D49: Neoplasms	Renal cancer	C64	MTOR
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Pancreatic cancer	C25	MTOR
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Transplant rejection	D89.8, T86	MTOR
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
NA: NA	Coronary artery restenosis	NA	MTOR
C00-D49: Neoplasms	Advanced kidney cancer	C64	MTOR

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Glycosmis montana

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases