CMAUP Plant Collective Molecular Activities

Plant Name: Salvia miltiorrhiza

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CHRM1; CHRM3; CHRM5; HTR2C; DRD4; HRH3; ADRA2A; ADRA2B; HTR2A; HTR6; GPBAR1;
Peptide receptor (family A GPCR)	TSHR; NPSR1; CXCR1;
Enzyme_unclassified	RECQL; PLA2G1B; TDP1; BLM; ALPI; CES1; CTDSP1; TERT; PKM; PIK3R1; GLO1; HSD11B1; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; AKR1B10; ALDH1A1; ALOX12; NOX4; TNKS; PARP1; TNKS2; PYGL; APEX1; POLB; CES2; CD38; AOX1;
Protein Phosphatase	PTPN1; PTPN11; PTPN6; CDC25B; PTPRF; PTPN2; ACP1;
Hydrolase	ACHE; MGAM; GAA;
Voltage-gated calcium channel	CACNA1C;
Potassium channels	KCNH2;
Protein Kinase	PKN1; MET; CAMK2B; CSNK2A1; AKT1; DAPK1; NEK2; FLT3; ABL1; SRC; IGF1R; AURKB; GSK3B; CDK1; MAPK1; EGFR; PIM1; NUAK1; ALK; PTK2; AXL; NEK6; KDR;
Lyase	CA12; CA14; CA7; CA3; CA5B; CA1; CA9; CA4; CA6; CA2; CA5A;
Nuclear hormone receptor subfamily 3 group C	AR;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Lysine demethylase	KDM4E;
Oxidoreductase	MAOA; ALOX5; TYR; XDH;
Metallo protease	MMP13; MMP12; MMP3; MMP2; MMP9; MMP1;
Aspartic protease	BACE1;
Transcription Factor	AHR; STAT6; STAT3; HIF1A; NFKB1; TP53;
ATP-binding cassette	ABCC1; ABCG2;
SLC superfamily of solute carriers	SLC6A4; SLC6A2; SLC6A3; SLCO1B3; SLCO1B1;
Unclassified	LMNA; MAPT; SIGMAR1; MCL1; THPO; HTT; RAB9A; NPC1; APAF1; APP; TTR;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	TBXAS1; CYP2D6; CYP19A1; CYP1A2; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C8	Cytochrome P450 2C8	P10632	CHEMBL3721
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Cytochrome P450 family 5	TBXAS1	Thromboxane-A synthase	P24557	CHEMBL1835
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	PIK3R1	PI3-kinase p85-alpha subunit	P27986	CHEMBL2506
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	MPO	Myeloperoxidase	P05164	CHEMBL2439
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	PARP1	Poly [ADP-ribose] polymerase-1	P09874	CHEMBL3105
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Enzyme_unclassified	PYGL	Liver glycogen phosphorylase	P06737	CHEMBL2568
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	CES2	Carboxylesterase 2	O00748	CHEMBL3180
Enzyme_unclassified	CD38	Lymphocyte differentiation antigen CD38	P28907	CHEMBL4660
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALPI	Intestinal alkaline phosphatase	P09923	CHEMBL5573
Enzyme_unclassified	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Enzyme_unclassified	CTDSP1	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Q9GZU7	CHEMBL1795098
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Hydrolase	MGAM	Maltase-glucoamylase	O43451	CHEMBL2074
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP13	Matrix metalloproteinase 13	P45452	CHEMBL280
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP3	Matrix metalloproteinase 3	P08254	CHEMBL283
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Peptide receptor (family A GPCR)	CXCR1	Interleukin-8 receptor A	P25024	CHEMBL4029
Potassium channels	KCNH2	HERG	Q12809	CHEMBL240
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Protein Kinase	AKT1	Serine/threonine-protein kinase AKT	P31749	CHEMBL4282
Protein Kinase	DAPK1	Death-associated protein kinase 1	P53355	CHEMBL2558
Protein Kinase	NEK2	Serine/threonine-protein kinase NEK2	P51955	CHEMBL3835
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	ABL1	Tyrosine-protein kinase ABL	P00519	CHEMBL1862
Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	GSK3B	Glycogen synthase kinase-3 beta	P49841	CHEMBL262
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	NUAK1	NUAK family SNF1-like kinase 1	O60285	CHEMBL5784
Protein Kinase	ALK	ALK tyrosine kinase receptor	Q9UM73	CHEMBL4247
Protein Kinase	PTK2	Focal adhesion kinase 1	Q05397	CHEMBL2695
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	NEK6	Serine/threonine-protein kinase NEK6	Q9HC98	CHEMBL4309
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	PKN1	Protein kinase N1	Q16512	CHEMBL3384
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	CAMK2B	CaM kinase II beta	Q13554	CHEMBL4121
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN11	Protein-tyrosine phosphatase 2C	Q06124	CHEMBL3864
Protein Phosphatase	PTPN6	Protein-tyrosine phosphatase 1C	P29350	CHEMBL3166
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
SLC superfamily of solute carriers	SLC6A4	Serotonin transporter	P31645	CHEMBL228
SLC superfamily of solute carriers	SLC6A2	Norepinephrine transporter	P23975	CHEMBL222
SLC superfamily of solute carriers	SLC6A3	Dopamine transporter	Q01959	CHEMBL238
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Small molecule receptor (family A GPCR)	HRH3	Histamine H3 receptor	Q9Y5N1	CHEMBL264
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	STAT6	Signal transducer and activator of transcription 6	P42226	CHEMBL5401
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	APAF1	Apoptotic protease-activating factor 1	O14727	CHEMBL1795093
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487
Unclassified	TTR	Transthyretin	P02766	CHEMBL3194
Voltage-gated calcium channel	CACNA1C	Voltage-gated L-type calcium channel alpha-1C subunit	Q13936	CHEMBL1940

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.355E-12	4.738E-10	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, NOX4
MF	GO:0005488; binding	GO:0020037; heme binding	2.393E-12	4.738E-10	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, MPO, NOX4, PTGS1, SRC, TBXAS1
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.690E-12	7.175E-10	ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, TBXAS1, XDH
MF	Unclassified;	GO:0004872; receptor activity	8.359E-12	1.507E-09	ADRA2A, ADRA2B, AHR, ALK, AR, AXL, CHRM1, CHRM3, CHRM5, CXCR1, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FFAR1, FFAR4, FLT3, GPBAR1, HPGD, HRH3, HTR2A, HTR2C, HTR6, IGF1R, KCNH2, KDR, MET, NPC1, NPSR1, NR1H4, NR1I2, PPARA, PPARD, PPARG, PTPN6, PTPRF, RORC, SIGMAR1, TSHR
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.354E-11	2.340E-09	AHR, AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR1I2, PIM1, PPARA, PPARD, PPARG, RORC, SRC, STAT3
BP	Unclassified;	GO:0032846; positive regulation of homeostatic process	4.980E-11	8.032E-09	ABL1, AURKB, CA2, CA7, EGFR, HIF1A, HTT, MAPK1, NEK2, NPC1, NPSR1, NR1H4, PLA2G1B, STAT3, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.355E-11	8.512E-09	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.984E-10	2.751E-08	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.325E-10	3.164E-08	CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4, NR1I2
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.503E-10	5.837E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	6.872E-10	8.600E-08	AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR1I2, PPARA, PPARD, PPARG, RORC, SRC
MF	GO:0005488; binding	GO:0005496; steroid binding	1.967E-09	2.315E-07	AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NPC1, NR1H4, RORC
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.201E-09	4.441E-07	CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP	GO:0065007; biological regulation	GO:0042593; glucose homeostasis	6.940E-09	6.901E-07	ADRA2A, AKT1, FFAR1, HIF1A, NOX4, NR1H4, PIK3R1, PPARG, PTPN11, PTPN2, PYGL, STAT3
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	7.451E-09	7.342E-07	AR, CDK1, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR1I2, PPARA, PPARD, PPARG, RORC
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.285E-08	1.222E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.566E-08	1.476E-06	ABL1, CA2, CA7, CACNA1C, HTR2A, HTR2C, HTT, KDR, NPSR1, PARP1, PLA2G1B, PTPN6, SRC
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.517E-08	2.256E-06	CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4
MF	Unclassified;	GO:0032403; protein complex binding	2.811E-08	2.488E-06	ABL1, ACHE, ADRA2A, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP13, MMP9, PIK3R1, PKM, PPARA, PTPN1, PTPN11, PTPN2, PTPRF, SLC6A3, SLC6A4, SRC, TSHR
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	7.581E-08	6.046E-06	ABL1, ALOX15, APP, EGFR, FFAR4, HTR2A, HTR2C, KDR, NOX4, PTPN11, SRC, THPO
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	1.174E-07	9.066E-06	ABL1, AHR, AKR1B1, AKT1, ALOX5, APEX1, AR, AURKB, BLM, CAMK2B, CDC25B, CDK1, CSNK2A1, CTDSP1, ESR1, ESR2, ESRRA, ESRRB, FABP5, GSK3B, HIF1A, HPGD, HTT, LMNA, MAPK1, MCL1, NEK2, NEK6, NFKB1, NR1H4, NR1I2, NUAK1, PARP1, PIM1, PKN1, POLB, PPARA, PPARD, PPARG, PTPN11, PTPN2, RECQL, RORC, SMN1, SMN2, SRC, STAT3, STAT6, TERT, TNKS, TP53
BP	GO:0065007; biological regulation	GO:1904355; positive regulation of telomere capping	1.903E-07	1.405E-05	AURKB, MAPK1, NEK2, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0018107; peptidyl-threonine phosphorylation	2.306E-07	1.674E-05	AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, MAPK1, PKN1, TNKS
BP	GO:0009987; cellular process	GO:0030168; platelet activation	2.836E-07	2.012E-05	ADRA2A, ADRA2B, AKT1, AXL, MAPK1, PIK3R1, PTPN11, PTPN6, SRC
MF	Unclassified;	GO:0099600; transmembrane receptor activity	2.863E-07	2.017E-05	ADRA2A, ADRA2B, ALK, AXL, CHRM1, CHRM3, CHRM5, CXCR1, DRD4, EGFR, FFAR1, FFAR4, FLT3, GPBAR1, HPGD, HRH3, HTR2A, HTR2C, HTR6, IGF1R, KDR, MET, NPC1, NPSR1, PPARG, PTPN6, PTPRF, SIGMAR1, TSHR
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	3.038E-07	2.127E-05	ABCC1, ADRA2A, ADRA2B, ALK, APP, AXL, BACE1, CHRM1, CHRM3, CHRM5, DRD4, FFAR1, FFAR4, FLT3, HRH3, HTR2A, HTR2C, HTR6, IGF1R, KDR, MET, NPC1, NPSR1, PTPRF, SIGMAR1, SLC6A2, SLC6A3, SLC6A4, SLCO1B1, SLCO1B3, TSHR
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.626E-07	2.452E-05	ABCC1, ADRA2A, CA2, CA4, CA9, CHRM3, EGFR, HPGD, SLCO1B1, SLCO1B3, TSHR
MF	GO:0005215; transporter activity	GO:0005330; dopamine:sodium symporter activity	5.268E-07	3.424E-05	SLC6A2, SLC6A3, SLC6A4
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	6.188E-07	3.928E-05	ABL1, AKR1B1, APEX1, AXL, CDK1, CYP1B1, STAT6
MF	GO:0005488; binding	GO:0005524; ATP binding	8.409E-07	5.217E-05	ABCC1, ABCG2, ABL1, AKT1, ALK, APAF1, AURKB, AXL, BLM, CAMK2B, CDK1, CSNK2A1, DAPK1, EGFR, FLT3, GSK3B, IGF1R, KDR, MAPK1, MET, NEK2, NEK6, NUAK1, PIM1, PKM, PKN1, PTK2, PYGL, RECQL, SRC, TP53
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	1.002E-06	6.079E-05	AKT1, AURKB, CAMK2B, CDK1, GSK3B, MAPK1, NEK6, PKN1, SRC, TNKS
BP	Unclassified;	GO:0044243; multicellular organismal catabolic process	2.130E-06	1.169E-04	MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	2.136E-06	1.169E-04	ABL1, EGFR, IGF1R, KDR, PTK2, SRC
MF	GO:0005488; binding	GO:0070405; ammonium ion binding	2.130E-06	1.169E-04	ACHE, CHRM3, DRD4, HTR2A, HTR2C, SLC6A3, SLC6A4
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	2.448E-06	1.313E-04	HIF1A, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP	GO:0065007; biological regulation	GO:0000187; activation of MAPK activity	2.593E-06	1.387E-04	ADRA2B, ALK, CDK1, DRD4, MAPK1, PKN1, PLA2G1B, PTPN1, PTPN11
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	2.800E-06	1.484E-04	AXL, CDK1, CSNK2A1, EGFR, FLT3, PKM, PPARG
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	2.812E-06	1.486E-04	AKT1, MAPT, PTPN1, SLC6A3, TP53
CC	GO:0044464; cell part	GO:0005829; cytosol	2.893E-06	1.519E-04	ABL1, ACP1, AHR, AKR1B1, AKR1B10, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, AOX1, APAF1, APP, AR, AURKB, BLM, CA1, CA2, CA3, CA7, CAMK2B, CDC25B, CDK1, CES1, CSNK2A1, FABP3, FABP5, FLT3, GLO1, GSK3B, HIF1A, HPGD, HSD17B1, HTR2A, HTT, LMNA, MAPK1, MAPT, MCL1, NEK2, NEK6, NFKB1, PIK3R1, PIM1, PKM, PKN1, PLA2G1B, PPARG, PTK2, PTPN1, PTPN11, PTPN2, PTPN6, PYGL, RAB9A, SLC6A4, SMN1, SMN2, SRC, STAT3, STAT6, TNKS, TNKS2, TP53, TYR, XDH
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	4.287E-06	2.141E-04	AXL, EGFR, MET, NOX4, PIK3R1, PTK2, PTPN11, SRC, THPO
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	4.514E-06	2.234E-04	CYP19A1, FFAR4, NFKB1, NR1H4, PPARA, PPARD, PPARG, PTPN2
MF	GO:0003824; catalytic activity	GO:0004674; protein serine/threonine kinase activity	4.506E-06	2.234E-04	AKT1, ALK, AURKB, CAMK2B, CDK1, CSNK2A1, DAPK1, EGFR, GSK3B, MAPK1, NEK2, NEK6, NUAK1, PIM1, PKN1
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	4.767E-06	2.322E-04	AKT1, CYP1A2, EGFR, MAPK1, MMP9
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	4.767E-06	2.322E-04	ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B
CC	GO:0016020; membrane	GO:0045121; membrane raft	5.101E-06	2.468E-04	APP, BACE1, EGFR, HTR2A, KDR, MAPK1, NPC1, SLC6A2, SLC6A3, SLC6A4, SRC, STAT6
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	5.206E-06	2.502E-04	CHRM1, CHRM3, CHRM5
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	5.206E-06	2.502E-04	CYP1A1, CYP2C8, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	5.206E-06	2.502E-04	CHRM1, CHRM3, CHRM5
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	5.613E-06	2.646E-04	AHR, CSNK2A1, HIF1A, KDR, MAPT
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	6.431E-06	2.973E-04	HIF1A, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP	GO:0008152; metabolic process	GO:0010907; positive regulation of glucose metabolic process	6.572E-06	3.032E-04	AKT1, ESRRB, PPARA, PTPN2, SRC
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	7.085E-06	3.207E-04	ALOX12, ALOX15, ALOX5, HPGD
BP	GO:0008152; metabolic process	GO:1903580; positive regulation of ATP metabolic process	7.655E-06	3.430E-04	CDK1, ESRRB, HIF1A, HTR2A, STAT3
BP	GO:0065007; biological regulation	GO:0032212; positive regulation of telomere maintenance via telomerase	7.655E-06	3.430E-04	AURKB, MAPK1, NEK2, TNKS, TNKS2
BP	GO:0050896; response to stimulus	GO:0032355; response to estradiol	7.900E-06	3.525E-04	CD38, CYP1A2, EGFR, ESR1, ESRRA, HPGD, SLC6A4, STAT3
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	1.035E-05	4.436E-04	CHRM1, CHRM3, CHRM5
BP	GO:0023052; signaling	GO:0051583; dopamine uptake involved in synaptic transmission	1.035E-05	4.436E-04	SLC6A2, SLC6A3, SLC6A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.035E-05	4.436E-04	CYP1A1, CYP2C8, CYP3A4
BP	GO:0008152; metabolic process	GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation	1.225E-05	5.158E-04	ABL1, ADRA2A, ADRA2B, FLT3, HTR2A, PTPN1, SRC, STAT3, TP53
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	1.457E-05	6.031E-04	MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.631E-05	6.665E-04	ACP1, CDC25B, PTPN1, PTPN11, PTPN2, PTPN6, PTPRF
MF	GO:0098772; molecular function regulator	GO:0030235; nitric-oxide synthase regulator activity	1.800E-05	7.219E-04	AKT1, EGFR, ESR1
MF	GO:0005488; binding	GO:0001223; transcription coactivator binding	1.839E-05	7.347E-04	AHR, ESR1, PPARA, TERT
BP	GO:0008152; metabolic process	GO:0031331; positive regulation of cellular catabolic process	2.136E-05	8.382E-04	ADRA2A, AKT1, CDK1, DAPK1, ESRRB, GSK3B, HIF1A, HTR2A, HTT, KDR, PPARA, PTK2, PTPN1
MF	GO:0005488; binding	GO:0002039; p53 binding	2.236E-05	8.696E-04	BLM, GSK3B, HIF1A, HTT, NUAK1, TP53
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	2.250E-05	8.730E-04	AKT1, HIF1A, LMNA, PPARD, SRC, TERT, TP53
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	2.257E-05	8.730E-04	CYP1A1, POLB, PPARG, TP53
BP	Unclassified;	GO:0032845; negative regulation of homeostatic process	2.354E-05	9.042E-04	ADRA2A, CD38, HTR2A, HTR2C, PARP1, SRC, TNKS, TNKS2
MF	GO:0005488; binding	GO:0042803; protein homodimerization activity	2.543E-05	9.631E-04	ABCG2, ACHE, ADRA2A, AKT1, AOX1, BLM, CAMK2B, FLT3, HPGD, KCNH2, MAPT, MCL1, NFKB1, PYGL, SLC6A4, STAT3, TERT, TYR, XDH
BP	GO:0008152; metabolic process	GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter	2.741E-05	1.031E-03	HIF1A, STAT3, TERT, TP53
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	2.741E-05	1.031E-03	HPGD, MMP2, MMP9, TERT
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.798E-05	1.045E-03	AKR1B1, AKR1B10, ALDH1A1, AOX1, XDH
BP	GO:0032501; multicellular organismal process	GO:0060020; Bergmann glial cell differentiation	2.863E-05	1.057E-03	ABL1, MAPK1, PTPN11
BP	GO:0009987; cellular process	GO:1903376; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	2.863E-05	1.057E-03	HIF1A, MCL1, PARP1
MF	GO:0005488; binding	GO:0051379; epinephrine binding	2.863E-05	1.057E-03	ADRA2A, ADRA2B, DRD4
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	2.863E-05	1.057E-03	ACP1, PTPN11, PTPN2
MF	GO:0140110; transcription regulator activity	GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	3.069E-05	1.123E-03	AR, ESR1, ESRRA, ESRRB, HIF1A, NFKB1, NR1H4, NR1I2, PARP1, PPARA, STAT3, STAT6, TP53
BP	GO:0008152; metabolic process	GO:0042136; neurotransmitter biosynthetic process	3.486E-05	1.255E-03	ACHE, AKT1, CYP1B1, SLC6A3, SLC6A4
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	3.859E-05	1.380E-03	ABL1, GSK3B, MAPT, MCL1, PARP1, TP53
BP	GO:0002376; immune system process	GO:0043312; neutrophil degranulation	4.052E-05	1.432E-03	ALOX5, APAF1, CXCR1, FABP5, GAA, MAPK1, MGAM, MMP9, MPO, NFKB1, PKM, PTPN6, PYGL, TTR
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	4.269E-05	1.480E-03	APP, EGFR, MAPT
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	4.269E-05	1.480E-03	BLM, RECQL, TP53
BP	Unclassified;	GO:0003056; regulation of vascular smooth muscle contraction	4.269E-05	1.480E-03	ADRA2B, CHRM1, CHRM3
MF	GO:0005488; binding	GO:0032052; bile acid binding	4.269E-05	1.480E-03	NR1H4, PLA2G1B, PYGL
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	4.465E-05	1.543E-03	MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	4.554E-05	1.564E-03	CA3, CDK1, HPGD, POLB, SLC6A3, STAT3, TP53
MF	GO:0005488; binding	GO:0001085; RNA polymerase II transcription factor binding	4.554E-05	1.564E-03	AHR, AR, ESR1, GSK3B, PPARA, STAT3, TP53
BP	GO:0008152; metabolic process	GO:0009299; mRNA transcription	4.651E-05	1.588E-03	HIF1A, PPARD, STAT3, TP53
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	4.755E-05	1.620E-03	NR1H4, PIK3R1, PTPN1, PTPN2, SRC
BP	GO:0050896; response to stimulus	GO:1901655; cellular response to ketone	5.144E-05	1.736E-03	AKR1B1, AKT1, AR, EGFR, PPARG, SRC
MF	GO:0005488; binding	GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding	5.558E-05	1.842E-03	AHR, AR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, NFKB1, NR1H4, NR1I2, PARP1, PPARA, RORC, STAT3, STAT6, TP53
BP	GO:0002376; immune system process	GO:0002521; leukocyte differentiation	5.611E-05	1.854E-03	ABL1, AXL, FLT3, GLO1, MMP9, PARP1, PIK3R1, PPARG, PTPN2, RORC
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.922E-05	1.951E-03	CAMK2B, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, EGFR, FAAH, HSD11B1, HSD17B2, NOX4, PTGS1, RAB9A, SIGMAR1, TBXAS1
BP	GO:0008152; metabolic process	GO:0051974; negative regulation of telomerase activity	6.062E-05	1.991E-03	PPARG, SRC, TP53
BP	GO:0051179; localization	GO:0042908; xenobiotic transport	6.062E-05	1.991E-03	ABCC1, ABCG2, NR1I2
BP	GO:0065007; biological regulation	GO:1904357; negative regulation of telomere maintenance via telomere lengthening	6.372E-05	2.065E-03	PARP1, SRC, TNKS, TNKS2
BP	GO:0050896; response to stimulus	GO:1904646; cellular response to amyloid-beta	6.372E-05	2.065E-03	APP, GSK3B, IGF1R, PARP1
MF	GO:0003824; catalytic activity	GO:0033764; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	6.372E-05	2.065E-03	HSD11B1, HSD17B1, HSD17B10, HSD17B2
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	6.565E-05	2.093E-03	PTPN11, PTPN6
BP	GO:0009987; cellular process	GO:0007208; phospholipase C-activating serotonin receptor signaling pathway	6.565E-05	2.093E-03	HTR2A, HTR2C
BP	GO:0008152; metabolic process	GO:0009115; xanthine catabolic process	6.565E-05	2.093E-03	AOX1, XDH
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	6.565E-05	2.093E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	6.565E-05	2.093E-03	ALOX12, ALOX15
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	6.565E-05	2.093E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	6.565E-05	2.093E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	6.565E-05	2.093E-03	HTR2A, HTR2C
CC	GO:0044464; cell part	GO:0034774; secretory granule lumen	6.531E-05	2.093E-03	ALOX5, APAF1, APP, FABP5, MAPK1, MPO, NFKB1, PKM, PTPN6, PYGL, TTR
BP	GO:0065007; biological regulation	GO:0060249; anatomical structure homeostasis	6.783E-05	2.153E-03	AKR1B1, APEX1, BLM, GAA, HIF1A, NOX4, PARP1, PTPN11, SRC, TERT
BP	GO:0008152; metabolic process	GO:0046320; regulation of fatty acid oxidation	7.387E-05	2.331E-03	AKT1, FABP3, PPARA, PPARG
BP	GO:0032501; multicellular organismal process	GO:0060736; prostate gland growth	8.286E-05	2.567E-03	AR, CYP19A1, ESR1
MF	GO:0005488; binding	GO:0043560; insulin receptor substrate binding	8.286E-05	2.567E-03	IGF1R, PIK3R1, PTPN11
MF	GO:0005488; binding	GO:0034452; dynactin binding	8.286E-05	2.567E-03	GSK3B, HTT, MAPT
BP	GO:0032501; multicellular organismal process	GO:0051241; negative regulation of multicellular organismal process	9.024E-05	2.756E-03	ALOX12, APP, AXL, CD38, CTDSP1, EGFR, FFAR4, GSK3B, HIF1A, LMNA, NFKB1, NR1H4, PIK3R1, PPARD, PPARG, PTK2, PTPN11, PTPN2, SLC6A4, STAT3, TERT, XDH
MF	GO:0005488; binding	GO:0030971; receptor tyrosine kinase binding	9.100E-05	2.775E-03	PIK3R1, PTPN1, PTPN11, PTPN2, TP53
BP	GO:0008152; metabolic process	GO:2000379; positive regulation of reactive oxygen species metabolic process	9.293E-05	2.818E-03	AKT1, EGFR, MAPT, NOX4, TP53, XDH
BP	GO:0032502; developmental process	GO:0045596; negative regulation of cell differentiation	1.065E-04	3.180E-03	APP, CTDSP1, EGFR, ESRRB, GSK3B, MAPK1, PIK3R1, PPARA, PPARD, PPARG, PTK2, PTPN2, SLC6A4, STAT3, TERT, XDH
BP	GO:0008283; cell proliferation	GO:0033598; mammary gland epithelial cell proliferation	1.098E-04	3.274E-03	ESR1, MAPK1, STAT6
BP	GO:0009987; cellular process	GO:0045600; positive regulation of fat cell differentiation	1.170E-04	3.460E-03	AKT1, HTR2A, HTR2C, PPARD, PPARG
BP	GO:0009987; cellular process	GO:2001243; negative regulation of intrinsic apoptotic signaling pathway	1.255E-04	3.682E-03	AKT1, HIF1A, MCL1, MMP9, PTPN1, SRC
CC	GO:0044464; cell part	GO:0005739; mitochondrion	1.394E-04	4.068E-03	ABL1, AKT1, APEX1, CA5A, CA5B, CDK1, CYP1A1, CYP1B1, CYP2D6, ESR2, GSK3B, HSD17B10, MAOA, MAPK1, MCL1, MMP2, MPO, NFKB1, NOX4, PARP1, PKM, PTPN11, SRC, TP53
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	1.419E-04	4.115E-03	CYP19A1, HSD17B1, HSD17B2
BP	GO:0009987; cellular process	GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response	1.419E-04	4.115E-03	PIK3R1, PTPN1, PTPN2
BP	Unclassified;	GO:0045907; positive regulation of vasoconstriction	1.430E-04	4.131E-03	AKT1, CD38, EGFR, HTR2A
BP	GO:0051179; localization	GO:0042307; positive regulation of protein import into nucleus	1.490E-04	4.285E-03	APP, CDK1, EGFR, MAPK1, PARP1, PIK3R1
BP	GO:0065007; biological regulation	GO:0032148; activation of protein kinase B activity	1.611E-04	4.603E-03	ADRA2A, ADRA2B, AKT1, SRC
BP	GO:0065007; biological regulation	GO:0051091; positive regulation of DNA binding transcription factor activity	1.713E-04	4.857E-03	AKT1, ALK, APP, AR, ESR1, ESR2, NFKB1, PLA2G1B, PPARG
BP	GO:0032501; multicellular organismal process	GO:0050767; regulation of neurogenesis	1.763E-04	4.961E-03	ABL1, ADRA2B, AKT1, APP, CAMK2B, CDK1, CTDSP1, GSK3B, HIF1A, MAPT, PPARG, PTK2, PTPRF, SLC6A4, STAT3, TERT
MF	GO:0005215; transporter activity	GO:0005319; lipid transporter activity	1.776E-04	4.989E-03	ABCC1, ABCG2, FABP3, HTT, NPC1, SLCO1B1, SLCO1B3
BP	GO:0032502; developmental process	GO:0060065; uterus development	1.795E-04	5.025E-03	CYP19A1, ESR1, SRC
MF	GO:0005488; binding	GO:0001784; phosphotyrosine residue binding	1.807E-04	5.052E-03	ABL1, MAPK1, PIK3R1, PTPN6
BP	GO:0032502; developmental process	GO:0009653; anatomical structure morphogenesis	1.892E-04	5.263E-03	ABL1, APP, AR, AXL, CA2, CA9, CACNA1C, CYP1B1, EGFR, ESR1, GAA, HIF1A, HPGD, MAPK1, MET, MMP13, MMP2, NOX4, POLB, PTK2, PTPN11, SLC6A4, SRC, STAT6
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.959E-04	5.325E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0000023; maltose metabolic process	1.959E-04	5.325E-03	GAA, MGAM
BP	GO:0002376; immune system process	GO:0001922; B-1 B cell homeostasis	1.959E-04	5.325E-03	ABL1, HIF1A
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.959E-04	5.325E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.959E-04	5.325E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	1.959E-04	5.325E-03	CYP1A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.959E-04	5.325E-03	ALOX12, ALOX15
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.959E-04	5.325E-03	ADRA2A, ADRA2B
MF	GO:0003824; catalytic activity	GO:0032450; maltose alpha-glucosidase activity	1.959E-04	5.325E-03	GAA, MGAM
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.959E-04	5.325E-03	ALOX12, ALOX15
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.959E-04	5.325E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	1.959E-04	5.325E-03	CES1, CES2
BP	GO:0050896; response to stimulus	GO:0009612; response to mechanical stimulus	1.981E-04	5.378E-03	AKT1, EGFR, HTR2A, MPO, NFKB1, PPARG, PTPN11, SRC
BP	GO:0009987; cellular process	GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling	1.995E-04	5.402E-03	FLT3, KDR, PPARD, PTK2, PTPN6
BP	GO:0065007; biological regulation	GO:0045124; regulation of bone resorption	2.020E-04	5.445E-03	CA2, CD38, EGFR, SRC
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	2.039E-04	5.489E-03	APP, AR, CYP1B1, FABP3, LMNA, NOX4, PKN1, PPARD, PPARG, PTPN2, PTPN6, SLC6A4, STAT3, TERT, TP53, XDH
BP	GO:0040011; locomotion	GO:0014910; regulation of smooth muscle cell migration	2.141E-04	5.728E-03	APEX1, NOX4, PPARD, SRC, TERT
BP	GO:0032501; multicellular organismal process	GO:0040014; regulation of multicellular organism growth	2.141E-04	5.728E-03	APP, PTPN11, SLC6A3, STAT3, TNKS2
MF	GO:0005488; binding	GO:0046982; protein heterodimerization activity	2.168E-04	5.793E-03	ADRA2A, AHR, AXL, EGFR, HIF1A, MCL1, NFKB1, PIK3R1, PPARD, PPARG, TP53, TTR, TYR
BP	GO:0051179; localization	GO:0070198; protein localization to chromosome, telomeric region	2.231E-04	5.924E-03	TERT, TNKS, TNKS2
BP	GO:0050896; response to stimulus	GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway	2.231E-04	5.924E-03	MAPK1, PTPN1, STAT3
BP	GO:0050896; response to stimulus	GO:2001275; positive regulation of glucose import in response to insulin stimulus	2.231E-04	5.924E-03	NR1H4, PIK3R1, PTPN11
BP	GO:0009987; cellular process	GO:0045742; positive regulation of epidermal growth factor receptor signaling pathway	2.251E-04	5.963E-03	ADRA2A, ADRA2B, AKT1, MMP9
BP	GO:0009987; cellular process	GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage	2.296E-04	6.061E-03	ABL1, MCL1, PIK3R1, POLB, TP53
BP	GO:0023052; signaling	GO:0032024; positive regulation of insulin secretion	2.296E-04	6.061E-03	CD38, FFAR1, HIF1A, NR1H4, PPARD
BP	GO:0008152; metabolic process	GO:0000122; negative regulation of transcription from RNA polymerase II promoter	2.302E-04	6.068E-03	AR, AURKB, ESR1, ESR2, ESRRA, MMP12, NFKB1, NR1H4, PARP1, PPARA, PPARD, PPARG, PTPN2, RORC, STAT3, STAT6, TP53
CC	GO:0043226; organelle	GO:0016604; nuclear body	2.389E-04	6.291E-03	ABL1, AOX1, APEX1, AR, BLM, HIF1A, LMNA, MAPT, NEK6, NR1I2, RORC, SMN1, SMN2, TERT, TNKS, TP53
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	2.533E-04	6.631E-03	AKR1B1, AOX1, CYP19A1, CYP1A2, NOX4, XDH
BP	GO:0008152; metabolic process	GO:0044283; small molecule biosynthetic process	2.554E-04	6.672E-03	AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, MPO, PKM, PLA2G1B, PTGS1
BP	GO:0009987; cellular process	GO:1901992; positive regulation of mitotic cell cycle phase transition	2.632E-04	6.822E-03	APEX1, APP, CDK1, CYP1A1, TERT
CC	GO:0044464; cell part	GO:0048471; perinuclear region of cytoplasm	2.626E-04	6.822E-03	ABL1, ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HTT, KCNH2, NOX4, NPC1, PPARG, SRC, TNKS2, TYR
BP	GO:0032502; developmental process	GO:0045766; positive regulation of angiogenesis	2.682E-04	6.935E-03	ABL1, ALOX12, CYP1B1, HIF1A, KDR, STAT3, TERT
BP	GO:0009987; cellular process	GO:2000811; negative regulation of anoikis	2.729E-04	7.017E-03	MCL1, PTK2, SRC
BP	GO:0050896; response to stimulus	GO:0070920; regulation of production of small RNA involved in gene silencing by RNA	2.729E-04	7.017E-03	EGFR, ESR1, TERT
BP	GO:0009987; cellular process	GO:0048010; vascular endothelial growth factor receptor signaling pathway	3.003E-04	7.630E-03	AXL, KDR, PIK3R1, PTK2, SRC
BP	GO:0002376; immune system process	GO:0061515; myeloid cell development	3.057E-04	7.721E-03	APP, PTPN11, PTPN6, SRC
BP	GO:0065007; biological regulation	GO:0051101; regulation of DNA binding	3.236E-04	8.117E-03	MMP9, NEK2, PARP1, PPARA, PPARG, TNKS
BP	GO:0050896; response to stimulus	GO:0033189; response to vitamin A	3.295E-04	8.199E-03	CYP1A1, PPARD, PPARG
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	3.295E-04	8.199E-03	CYP2C19, CYP2C8, CYP2C9
MF	GO:0003824; catalytic activity	GO:0035173; histone kinase activity	3.295E-04	8.199E-03	AURKB, CDK1, PKN1
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	3.556E-04	8.759E-03	MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP	GO:0065007; biological regulation	GO:0032431; activation of phospholipase A2 activity	3.897E-04	9.335E-03	EGFR, PLA2G1B
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	3.897E-04	9.335E-03	ADRA2A, ADRA2B
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	3.897E-04	9.335E-03	ADRA2A, ADRA2B
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	3.897E-04	9.335E-03	TNKS, TNKS2
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	3.897E-04	9.335E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.897E-04	9.335E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	3.897E-04	9.335E-03	ESR1, ESR2
MF	GO:0005488; binding	GO:0005497; androgen binding	3.897E-04	9.335E-03	ALDH1A1, AR
MF	GO:0003824; catalytic activity	GO:0004558; alpha-1,4-glucosidase activity	3.897E-04	9.335E-03	GAA, MGAM
BP	GO:0008152; metabolic process	GO:0051000; positive regulation of nitric-oxide synthase activity	3.930E-04	9.373E-03	AKT1, HIF1A, TERT
BP	GO:0008152; metabolic process	GO:0045821; positive regulation of glycolytic process	3.930E-04	9.373E-03	ESRRB, HIF1A, HTR2A
BP	Unclassified;	GO:0051279; regulation of release of sequestered calcium ion into cytosol	4.105E-04	9.673E-03	ABL1, CACNA1C, HTT, NPSR1, PTPN6
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	4.105E-04	9.673E-03	ALOX15, EGFR, PPARA, PPARD, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.516E-21	2.072E-17	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.017E-15	1.046E-12	ALPI, AR, BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, NR1H4, NR1I2, PARP1, PPARA, PPARD, PPARG, PTPN1, RORC, TNKS, TP53
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.370E-14	1.379E-11	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	Unclassified;	GO:0032844; regulation of homeostatic process	1.061E-13	3.079E-11	ABL1, ADRA2A, AURKB, CA2, CA7, CACNA1C, CD38, EGFR, HIF1A, HTR2A, HTR2C, HTT, KDR, MAPK1, NEK2, NPC1, NPSR1, NR1H4, PARP1, PLA2G1B, PTPN6, SRC, STAT3, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.998E-13	5.304E-11	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	5.810E-20	1.179E-17	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	4.758E-16	4.830E-14	APP; MAOA; ALOX15; HTR2C; ALOX12; CACNA1C; HTR2A; CYP2C19; SLC6A4; PTGS1; CYP2C9; CYP2C8; HTR6; CYP2D6; ALOX5; MAPK1
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	3.388E-14	2.292E-12	CAMK2B; SRC; MMP2; STAT3; PTPN11; PIK3R1; HIF1A; ESR1; MMP9; PTK2; EGFR; IGF1R; KDR; AKT1; MAPK1; PTPN6; TP53; MET
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	5.625E-12	2.855E-10	GSK3B; FLT3; MMP1; DAPK1; MMP2; STAT3; PIK3R1; HIF1A; MMP9; EGFR; NFKB1; PTK2; IGF1R; AR; ABL1; AKT1; MAPK1; PPARG; MET; TP53; PPARD
hsa04520	Adherens junction_Homo sapiens_hsa04520	3.109E-10	1.262E-08	PTPN1; CSNK2A1; SRC; MAPK1; PTPN6; ACP1; MET; PTPRF; EGFR; IGF1R
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.278E-09	3.707E-08	CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; TBXAS1; ALOX12; CYP2C19; PTGS1
hsa05219	Bladder cancer_Homo sapiens_hsa05219	9.244E-10	3.128E-08	MMP1; DAPK1; SRC; MMP2; MAPK1; MMP9; TP53; EGFR
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	7.560E-09	1.395E-07	PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; PYGL; CYP2C19; CYP3A4; CYP19A1; HSD17B10; PTGS1; HSD11B1; HSD17B1; ALOX5; HSD17B2; CD38; AOX1; XDH; MGAM; GAA; TYR; CYP2C9; CYP2C8; PKM; AKR1B10; TBXAS1; CYP1A2; ALDH1A1; CYP1A1; ALPI; CES1
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	5.016E-09	1.018E-07	GSK3B; SRC; STAT3; AKT1; MAPK1; PIK3R1; ESR1; NFKB1; ESR2
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	2.606E-09	5.877E-08	PKM; FLT3; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A; EGFR
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	1.438E-08	2.279E-07	FLT3; STAT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PPARD
hsa04931	Insulin resistance_Homo sapiens_hsa04931	1.459E-08	2.279E-07	PTPN1; GSK3B; STAT3; AKT1; PTPN11; PIK3R1; PYGL; PPARA; NFKB1; PTPRF
hsa05215	Prostate cancer_Homo sapiens_hsa05215	3.345E-08	4.243E-07	GSK3B; AR; AKT1; MAPK1; PIK3R1; TP53; EGFR; NFKB1; IGF1R
hsa04012	ErbB signaling pathway_Homo sapiens_hsa04012	2.735E-08	3.702E-07	CAMK2B; GSK3B; SRC; ABL1; AKT1; MAPK1; PIK3R1; EGFR; PTK2
hsa04630	Jak-STAT signaling pathway_Homo sapiens_hsa04630	4.895E-08	5.845E-07	THPO; STAT3; PIM1; AKT1; AOX1; PTPN6; STAT6; PTPN11; PIK3R1; PTPN2; MCL1
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	2.168E-09	5.502E-08	CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	8.521E-08	9.104E-07	SRC; MMP2; AKT1; MAPK1; PIK3R1; ESR1; MMP9; EGFR; ESR2
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.657E-08	2.402E-07	HSD11B1; HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	2.296E-07	2.000E-06	CAMK2B; CHRM3; ACHE; CHRM1; CHRM5; AKT1; MAPK1; PIK3R1; CACNA1C
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.203E-07	1.168E-06	CAMK2B; STAT3; AKT1; MAPK1; PIK3R1; HIF1A; EGFR; NFKB1; IGF1R
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	6.718E-08	7.577E-07	CYP2C9; CYP2C8; MAOA; CYP2D6; CYP1A2; AOX1; CYP3A4; CYP2C19
hsa05161	Hepatitis B_Homo sapiens_hsa05161	2.364E-07	2.000E-06	APAF1; SRC; STAT3; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	5.223E-07	3.927E-06	GSK3B; CHRM1; PIK3R1; PTK2; EGFR; NFKB1; IGF1R; KDR; AKT1; MAPK1; PKN1; TP53; MET; MCL1
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.852E-07	1.709E-06	HPGD; FLT3; MMP3; PPARG; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	6.609E-07	4.792E-06	ABCC1; STAT3; MMP9; EGFR; NFKB1; CDC25B; PIM1; ABL1; CYP1B1; MAPK1; TP53; MET; MCL1
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	4.474E-07	3.494E-06	CAMK2B; GSK3B; ABL1; AKT1; MAPK1; PTPN11; PIK3R1; TP53; NFKB1
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.209E-07	1.168E-06	HSD17B1; ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R
hsa04020	Calcium signaling pathway_Homo sapiens_hsa04020	1.623E-06	9.301E-06	CAMK2B; CHRM3; HTR6; CHRM1; CHRM5; HTR2C; CD38; CACNA1C; HTR2A; EGFR
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	2.627E-07	2.133E-06	HSD11B1; CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19
hsa04210	Apoptosis_Homo sapiens_hsa04210	1.640E-06	9.301E-06	APAF1; PARP1; LMNA; AKT1; MAPK1; PIK3R1; TP53; NFKB1; MCL1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	1.068E-06	6.774E-06	GSK3B; STAT3; AKT1; MAPK1; PIK3R1; PPARA; TP53; EGFR; NFKB1
hsa05214	Glioma_Homo sapiens_hsa05214	7.634E-07	5.166E-06	CAMK2B; AKT1; MAPK1; PIK3R1; TP53; EGFR; IGF1R
hsa04014	Ras signaling pathway_Homo sapiens_hsa04014	1.851E-06	9.890E-06	PLA2G1B; KDR; ABL1; AKT1; MAPK1; PTPN11; PIK3R1; MET; EGFR; NFKB1; IGF1R
hsa05212	Pancreatic cancer_Homo sapiens_hsa05212	8.484E-07	5.556E-06	STAT3; AKT1; MAPK1; PIK3R1; TP53; EGFR; NFKB1
hsa05218	Melanoma_Homo sapiens_hsa05218	1.402E-06	8.624E-06	AKT1; MAPK1; PIK3R1; TP53; MET; EGFR; IGF1R
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	3.997E-06	2.029E-05	CAMK2B; HTR6; CHRM1; AKT1; MAPK1; PIK3R1; CACNA1C; PPARA; NFKB1; TSHR
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	7.634E-07	5.166E-06	CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; AOX1; CYP3A4
hsa04510	Focal adhesion_Homo sapiens_hsa04510	4.566E-06	2.207E-05	GSK3B; SRC; KDR; AKT1; MAPK1; PIK3R1; MET; PTK2; EGFR; IGF1R
hsa05220	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.695E-06	9.301E-06	ABL1; AKT1; MAPK1; PTPN11; PIK3R1; TP53; NFKB1
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	4.249E-06	2.104E-05	GSK3B; SRC; AKT1; MAPK1; PIK3R1; TP53; ESR1; HIF1A
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.237E-05	5.460E-05	CHRM3; HTR6; CHRM1; HRH3; CHRM5; HTR2C; HTR2A; ADRA2B; ADRA2A; DRD4; TSHR
hsa05162	Measles_Homo sapiens_hsa05162	1.214E-05	5.460E-05	GSK3B; CSNK2A1; STAT3; AKT1; RAB9A; PIK3R1; TP53; NFKB1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.695E-06	9.301E-06	HSD11B1; CYP2C9; CYP2D6; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.490E-05	6.171E-05	MMP2; STAT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1
hsa04062	Chemokine signaling pathway_Homo sapiens_hsa04062	1.736E-05	6.777E-05	GSK3B; CXCR1; SRC; STAT3; AKT1; MAPK1; PIK3R1; NFKB1; PTK2
hsa05169	Epstein-Barr virus infection_Homo sapiens_hsa05169	3.193E-05	1.179E-04	GSK3B; CSNK2A1; STAT3; CDK1; AKT1; CD38; PIK3R1; TP53; NFKB1
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	3.584E-05	1.299E-04	POLB; PKM; SRC; STAT3; CDK1; MAPK1; PIK3R1; TP53; NFKB1
hsa05213	Endometrial cancer_Homo sapiens_hsa05213	3.212E-06	1.672E-05	GSK3B; AKT1; MAPK1; PIK3R1; TP53; EGFR
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	5.547E-05	1.976E-04	BACE1; APP; GSK3B; APAF1; MAPK1; CACNA1C; MAPT; HSD17B10
hsa04370	VEGF signaling pathway_Homo sapiens_hsa04370	8.267E-06	3.814E-05	SRC; KDR; AKT1; MAPK1; PIK3R1; PTK2
hsa05223	Non-small cell lung cancer_Homo sapiens_hsa05223	4.993E-06	2.357E-05	ALK; AKT1; MAPK1; PIK3R1; TP53; EGFR
hsa05211	Renal cell carcinoma_Homo sapiens_hsa05211	1.310E-05	5.657E-05	AKT1; MAPK1; PTPN11; PIK3R1; MET; HIF1A
hsa04728	Dopaminergic synapse_Homo sapiens_hsa04728	7.208E-05	2.439E-04	CAMK2B; GSK3B; MAOA; AKT1; CACNA1C; SLC6A3; DRD4
hsa04662	B cell receptor signaling pathway_Homo sapiens_hsa04662	2.345E-05	8.817E-05	GSK3B; AKT1; MAPK1; PTPN6; PIK3R1; NFKB1
hsa04910	Insulin signaling pathway_Homo sapiens_hsa04910	1.153E-04	3.656E-04	PTPN1; GSK3B; AKT1; MAPK1; PIK3R1; PYGL; PTPRF
hsa04912	GnRH signaling pathway_Homo sapiens_hsa04912	8.178E-05	2.722E-04	CAMK2B; SRC; MMP2; MAPK1; CACNA1C; EGFR
hsa05120	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.558E-05	6.323E-05	CXCR1; SRC; PTPN11; MET; EGFR; NFKB1
hsa04550	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.317E-04	3.931E-04	GSK3B; ESRRB; STAT3; AKT1; MAPK1; PIK3R1; IGF1R
hsa04750	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.235E-04	3.797E-04	CAMK2B; SRC; HTR2C; ALOX12; PIK3R1; HTR2A
hsa04015	Rap1 signaling pathway_Homo sapiens_hsa04015	2.679E-04	7.450E-04	SRC; KDR; AKT1; MAPK1; PIK3R1; MET; EGFR; IGF1R
hsa04211	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	9.798E-05	3.157E-04	AKT1; PPARG; PIK3R1; TP53; NFKB1; IGF1R
hsa04914	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.235E-04	3.797E-04	CDK1; AKT1; MAPK1; PIK3R1; CDC25B; IGF1R
hsa05222	Small cell lung cancer_Homo sapiens_hsa05222	5.957E-05	2.085E-04	APAF1; AKT1; PIK3R1; TP53; NFKB1; PTK2
hsa04921	Oxytocin signaling pathway_Homo sapiens_hsa04921	2.544E-04	7.173E-04	CAMK2B; SRC; CD38; MAPK1; PIK3R1; CACNA1C; EGFR
hsa04810	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	2.946E-04	8.083E-04	CHRM3; CHRM1; SRC; CHRM5; MAPK1; PIK3R1; PTK2; EGFR
hsa04540	Gap junction_Homo sapiens_hsa04540	6.779E-05	2.332E-04	SRC; CDK1; HTR2C; MAPK1; HTR2A; EGFR
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	1.695E-05	6.746E-05	FABP3; FABP5; MMP1; PPARG; PPARA; PPARD
hsa04668	TNF signaling pathway_Homo sapiens_hsa04668	2.325E-04	6.649E-04	MMP3; AKT1; MAPK1; PIK3R1; MMP9; NFKB1
hsa04976	Bile secretion_Homo sapiens_hsa04976	1.999E-05	7.656E-05	SLCO1B1; CA2; SLCO1B3; NR1H4; CYP3A4; ABCG2
hsa04660	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.712E-04	5.037E-04	GSK3B; AKT1; MAPK1; PTPN6; PIK3R1; NFKB1
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	9.347E-04	2.314E-03	AKT1; MAPK1; MAPT; CACNA1C; TP53; EGFR; NFKB1; CDC25B
hsa04611	Platelet activation_Homo sapiens_hsa04611	4.063E-04	1.071E-03	SRC; TBXAS1; AKT1; MAPK1; PIK3R1; PTGS1
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	3.398E-04	9.199E-04	ALOX5; STAT3; AKT1; MAPK1; PIK3R1; NFKB1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	3.719E-04	9.934E-04	ABCC1; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04072	Phospholipase D signaling pathway_Homo sapiens_hsa04072	9.729E-04	2.362E-03	CXCR1; AKT1; MAPK1; PTPN11; PIK3R1; EGFR
hsa04068	FoxO signaling pathway_Homo sapiens_hsa04068	6.423E-04	1.610E-03	STAT3; AKT1; MAPK1; PIK3R1; EGFR; IGF1R
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	2.074E-03	4.575E-03	AKT1; MAPK1; PIK3R1; CACNA1C; ADRA2B; ADRA2A
hsa04922	Glucagon signaling pathway_Homo sapiens_hsa04922	1.209E-03	2.853E-03	CAMK2B; PKM; AKT1; PYGL; PPARA
hsa05152	Tuberculosis_Homo sapiens_hsa05152	2.851E-03	6.014E-03	CAMK2B; APAF1; SRC; AKT1; MAPK1; NFKB1
hsa05231	Choline metabolism in cancer_Homo sapiens_hsa05231	1.209E-03	2.853E-03	AKT1; MAPK1; PIK3R1; HIF1A; EGFR
hsa05166	HTLV-I infection_Homo sapiens_hsa05166	4.340E-03	8.638E-03	POLB; GSK3B; TERT; AKT1; PIK3R1; TP53; NFKB1
hsa04114	Oocyte meiosis_Homo sapiens_hsa04114	2.874E-03	6.014E-03	CAMK2B; AR; CDK1; MAPK1; IGF1R
hsa04261	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	6.291E-03	1.205E-02	CAMK2B; AKT1; MAPK1; PIK3R1; CACNA1C
hsa04670	Leukocyte transendothelial migration_Homo sapiens_hsa04670	2.401E-03	5.184E-03	MMP2; PTPN11; PIK3R1; MMP9; PTK2
hsa04310	Wnt signaling pathway_Homo sapiens_hsa04310	5.294E-03	1.024E-02	CAMK2B; GSK3B; CSNK2A1; TP53; PPARD
hsa04932	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	6.836E-03	1.285E-02	GSK3B; AKT1; PIK3R1; PPARA; NFKB1
hsa04380	Osteoclast differentiation_Homo sapiens_hsa04380	3.889E-03	7.817E-03	AKT1; MAPK1; PPARG; PIK3R1; NFKB1
hsa04144	Endocytosis_Homo sapiens_hsa04144	1.663E-02	2.791E-02	CXCR1; SRC; KDR; MET; EGFR; IGF1R
hsa04110	Cell cycle_Homo sapiens_hsa04110	2.976E-03	6.164E-03	GSK3B; ABL1; CDK1; TP53; CDC25B
hsa05164	Influenza A_Homo sapiens_hsa05164	1.243E-02	2.214E-02	GSK3B; AKT1; MAPK1; PIK3R1; NFKB1
hsa04920	Adipocytokine signaling pathway_Homo sapiens_hsa04920	2.244E-04	6.507E-04	STAT3; AKT1; PTPN11; PPARA; NFKB1
hsa05168	Herpes simplex infection_Homo sapiens_hsa05168	1.548E-02	2.663E-02	CSNK2A1; CDK1; PTPN11; TP53; NFKB1
hsa04360	Axon guidance_Homo sapiens_hsa04360	3.298E-03	6.744E-03	GSK3B; ABL1; MAPK1; MET; PTK2
hsa04060	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.840E-02	3.037E-02	CXCR1; THPO; FLT3; KDR; MET; EGFR
hsa04152	AMPK signaling pathway_Homo sapiens_hsa04152	1.658E-02	2.791E-02	AKT1; PPARG; PIK3R1; IGF1R
hsa04650	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.190E-02	3.474E-02	MAPK1; PTPN6; PTPN11; PIK3R1
hsa04620	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	9.777E-03	1.756E-02	AKT1; MAPK1; PIK3R1; NFKB1
hsa05210	Colorectal cancer_Homo sapiens_hsa05210	1.262E-04	3.823E-04	GSK3B; AKT1; MAPK1; PIK3R1; TP53
hsa05142	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	9.159E-03	1.675E-02	AKT1; MAPK1; PIK3R1; NFKB1
hsa04916	Melanogenesis_Homo sapiens_hsa04916	8.000E-03	1.476E-02	CAMK2B; GSK3B; MAPK1; TYR
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	6.942E-03	1.293E-02	CHRM3; CA2; PLA2G1B; CD38
hsa04911	Insulin secretion_Homo sapiens_hsa04911	4.521E-03	8.910E-03	CAMK2B; CHRM3; FFAR1; CACNA1C
hsa04640	Hematopoietic cell lineage_Homo sapiens_hsa04640	3.207E-02	4.970E-02	THPO; FLT3; CD38
hsa05132	Salmonella infection_Homo sapiens_hsa05132	3.025E-02	4.723E-02	MAPK1; PKN1; NFKB1
hsa05100	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	3.322E-03	6.744E-03	SRC; PIK3R1; MET; PTK2
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	1.474E-05	6.171E-05	MAOA; CYP1A2; CYP1A1; AOX1; CYP1B1
hsa05031	Amphetamine addiction_Homo sapiens_hsa05031	1.908E-03	4.256E-03	CAMK2B; MAOA; CACNA1C; SLC6A3
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	1.266E-03	2.955E-03	AKT1; MAPK1; PIK3R1; HIF1A
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	1.978E-02	3.212E-02	MAPK1; PTPN6; NFKB1
hsa04664	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.639E-02	2.791E-02	AKT1; MAPK1; PIK3R1
hsa04971	Gastric acid secretion_Homo sapiens_hsa04971	2.050E-02	3.302E-02	CAMK2B; CHRM3; CA2
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	9.773E-04	2.362E-03	AKT1; PIK3R1; TSHR; PTGS1
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.706E-03	3.848E-03	STAT3; RORC; STAT6; NFKB1
hsa04720	Long-term potentiation_Homo sapiens_hsa04720	1.514E-02	2.627E-02	CAMK2B; MAPK1; CACNA1C
hsa05131	Shigellosis_Homo sapiens_hsa05131	1.706E-03	3.848E-03	SRC; ABL1; MAPK1; NFKB1
hsa04115	p53 signaling pathway_Homo sapiens_hsa04115	1.704E-02	2.836E-02	APAF1; CDK1; TP53
hsa04213	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.394E-02	2.440E-02	AKT1; PIK3R1; IGF1R
hsa04930	Type II diabetes mellitus_Homo sapiens_hsa04930	5.435E-04	1.397E-03	PKM; MAPK1; PIK3R1; CACNA1C
hsa00500	Starch and sucrose metabolism_Homo sapiens_hsa00500	9.706E-03	1.756E-02	MGAM; GAA; PYGL
hsa05030	Cocaine addiction_Homo sapiens_hsa05030	6.713E-03	1.274E-02	MAOA; NFKB1; SLC6A3
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	4.614E-04	1.201E-03	CYP3A4; XDH; CES2; CES1
hsa04973	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	5.290E-03	1.024E-02	MGAM; AKT1; PIK3R1
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	8.542E-05	2.797E-04	MGAM; AKR1B10; GAA; AKR1B1
hsa05216	Thyroid cancer_Homo sapiens_hsa05216	1.493E-03	3.443E-03	MAPK1; PPARG; TP53
hsa04320	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.890E-02	3.094E-02	MAPK1; EGFR
hsa00040	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.241E-02	4.984E-02	AKR1B10; AKR1B1
hsa00051	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.604E-02	4.097E-02	AKR1B10; AKR1B1
hsa00350	Tyrosine metabolism_Homo sapiens_hsa00350	2.583E-03	5.520E-03	MAOA; AOX1; TYR
hsa03410	Base excision repair_Homo sapiens_hsa03410	2.178E-03	4.755E-03	POLB; PARP1; APEX1
hsa00760	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.164E-02	3.459E-02	AOX1; CD38
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.390E-02	2.440E-02	CA2; CA4
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	6.029E-04	1.530E-03	CYP1A2; XDH

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
K00-K95: Diseases of the digestive system	Alcoholic hepatitis	K70.1	AR
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR
C00-D49: Neoplasms	Melanoma	C43	TERT; EGFR; PARP1; TYR; KDR; KDR
NA: NA	Menopausal disorder	NA	ESR1
NA: NA	Male hypogonadism	NA	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Male hormonal deficiencies	E20-E35	AR
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR; PARP1
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	CACNA1C
I00-I99: Diseases of the circulatory system	Cardiomyopathy	I42.0	TTR
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
C00-D49: Neoplasms	Mesothelioma	C45	PTK2
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CAMK2B; AKR1B1; PLA2G1B; ESRRA; ALOX5; MMP3; TYR; MMP1
NA: NA	Schizoaffective disorders	NA	CHRM1
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA; TYR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B; ABCC1; ESRRA; ALOX5; MMP1
NA: NA	Appetite suppressant	NA	SLC6A4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	AR; ESRRA
C00-D49: Neoplasms	Glioma	C71	ABL1; EGFR; EGFR; KDR; APP
NA: NA	Gonorrheal vaginitis	NA	ESR1
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	EGFR; KDR
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE; APP
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM1; CHRM1; CHRM5; ESRRA; HTR2A; HTR2A; HTR2C; SLC6A4; HTR6; HRH3; HRH3; DRD4
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
A00-B99: Certain infectious and parasitic diseases	Acquired immune deficiency syndrome	B20	MGAM
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	AR; AR; ESRRA; MMP2; ESR1
NA: NA	Abdominal stomach pain	NA	CHRM1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis in post-menopausal women	M80-M81	AR
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	TTR amyloidosis	E85	TTR
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
C00-D49: Neoplasms	Lymphoma	C81-C86	AKT1; CA9; HIF1A; EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA; MAOA; SLC6A2; HTR2C; HTR2C; SLC6A4; SLC6A4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depression	F32, F33	SLC6A4
C00-D49: Neoplasms	Bladder cancer	C67	AR; CYP19A1; EGFR
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT; FLT3; FLT3; AURKB; TP53; TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep maintenance insomnia	F51.0, G47.0	HTR2A
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR2A; HRH3
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
C00-D49: Neoplasms	Urethral cancer	NA	EGFR
C00-D49: Neoplasms	Hematological malignancies	C81-C86	CD38; SRC; AURKB; TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA; MGAM
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	AR; IGF1R; ESR1; ESR1
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR
NA: NA	Spasms	NA	CHRM3
C00-D49: Neoplasms	Solid tumours	C00-D48	AKT1; MET; PKM; FLT3; CA9; ABL1; MMP2; SRC; IGF1R; PTK2; STAT3; AURKB; HIF1A; MAPK1; MMP9; EGFR; TP53; KDR; KDR; KDR
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
C00-D49: Neoplasms	Tumors	C00-D48	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	TBXAS1; PTPN1; PTPN1; HSD11B1; NFKB1; GPBAR1; PPARD; MGAM
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
I00-I99: Diseases of the circulatory system	Heart failure	I50	AR; XDH; SLC6A2
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1; TERT; EGFR; EGFR; EGFR; TP53; KDR; KDR
A00-B99: Certain infectious and parasitic diseases	HCV infection	B17.1, B18.2	MMP3
C00-D49: Neoplasms	Recurrent epithelial ovarian or primary peritoneal cancer	C78	PARP1
C00-D49: Neoplasms	Leukemia	C90-C95	AKT1; FLT3; ABL1; ESR1
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	PTK2; TP53
C00-D49: Neoplasms	Liver cancer	C22	TERT; IGF1R; KDR
G00-G99: Diseases of the nervous system G00-G99	Narcolepsy	G47.4	HRH3
S00-T88: Injury, poisoning and certain other consequences of external causes	Myocardial reperfusion injury	T86.4	AKT1
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	MMP3; PARP1
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
N00-N99: Diseases of the genitourinary system	Nephritis	N00-N19, N25-N29	TBXAS1
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5; FLT3; STAT3; EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B; ALOX5
C00-D49: Neoplasms	Prostate cancer	C61	AR; AR; TERT; FLT3; ABL1; EGFR; ESR1
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	TBXAS1
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	TBXAS1; ALOX5
I00-I99: Diseases of the circulatory system	Heart arrhythmia	I47-I49	CACNA1C
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R
C00-D49: Neoplasms	Lung cancer	C33-C34	ABL1; MMP2; EGFR
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	HRH3; APP
C00-D49: Neoplasms	Metastatic prostate cancer	C61	AR
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	CHRM5; ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR2C; DRD4
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR2A
NA: NA	Menopausal staging	NA	SLC6A4
C00-D49: Neoplasms	CLL	NA	FLT3
C00-D49: Neoplasms	Glioblastoma multiforme	C71	SRC; EGFR; EGFR
C00-D49: Neoplasms	Glioblastoma	NA	FLT3
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3
NA: NA	Geographic retinal atrophy	NA	APP
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1; CHRM1; CHRM3; CA1; CA1; ACHE; HTR2A
NA: NA	GIST	NA	FLT3
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1; ABCC1; ABCC1; XDH
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; CA2
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	TBXAS1
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory skin condition	L00-L99	PARP1
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3; ABL1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	SLC6A4
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; IGF1R; EGFR; EGFR; AXL; KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Obese insulin-resistant disorders	E11	HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	ESRRA; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	ESRRA; EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM1; CHRM5
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	CHRM1; CHRM5; NPSR1; HTR2C; HTR6; HRH3; ESR1; APP
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA; CHRM1; ADRA2B; SLC6A4; SLC6A4
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT; ACHE; HTR6
C00-D49: Neoplasms	Neuroendocrine cancer	C7A	SLC6A2
C00-D49: Neoplasms	Renal cancer	C64	CA9; KDR
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3; ALOX5
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	CES1; PPARD; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Smoking cessation	F17.2	SLC6A4
C00-D49: Neoplasms	Intestinal cancer	NA	ABL1
I00-I99: Diseases of the circulatory system	Ischemic stroke	I61-I63	MMP3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	CHRM1; CHRM5; MAPT; ACHE; HTR6; HRH3
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	TBXAS1
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	AR; HTR2A; KDR; MGAM
C00-D49: Neoplasms	Castration-resistant prostate cancer	C61	AR
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
NA: NA	Addiction	NA	HTR2A
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	SRC
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	AR; ESRRA
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1; PTPN1; HSD11B1; HSD11B1; GSK3B; HTR2A; HTR2C; MGAM
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1; HTR6; HRH3; HRH3
A00-B99: Certain infectious and parasitic diseases	Dengue fever	A90	MGAM
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ESRRA; ALOX5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Hyperglycemia	R73.9	MGAM
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	AR; KDR
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1; CA4; CA4
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE; CA4; CA2
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3
C00-D49: Neoplasms	Ocular cancer	C69	APEX1
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3; ABL1; CES1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	AR; ESR1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
NA: NA	HIV infections	NA	AHR
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2; KDR; KDR
C00-D49: Neoplasms	Pancreatic cancer	C25	AKT1; TERT; FLT3; MMP2; EGFR; KDR
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	AR; CHRM3; PKM; MMP13; ACHE; IGF1R; CDK1; ADRA2A; SLC6A2; HTR2C; SLC6A4; HRH3; HRH3; ESR1
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MPO; MAOA; CHRM1; CHRM1; ACHE; SLC6A4
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	HTR2A
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1; SRC
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	HTR2C
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	ABL1
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	CES1
G00-G99: Diseases of the nervous system G00-G99	Permanent and transient stroke	G45.9, I61-I63	PARP1
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; STAT3; KDR
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Hematologic malignancies	C81-C86	AKT1
I00-I99: Diseases of the circulatory system	Hemorrhoids	I84	HTR2A
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3
C00-D49: Neoplasms	Ovarian cancer	C56	TERT; MMP2; EGFR; EGFR; PARP1; KDR; KDR; KDR; KDR
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3
C00-D49: Neoplasms	Osteosarcoma	C40-C41	SRC; GSK3B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	AR; SRC; ESR1
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3
H00-H59: Diseases of the eye and adnexa	Corneal ulcers	H16.0	MMP3
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	AR; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR; KDR
C00-D49: Neoplasms	Advanced prostate cancer	C61	AR; ESR1
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR
NA: NA	Dyslipidemia	NA	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1; CA2
NA: NA	Dystonia	NA	CHRM1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HRH3
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	AR; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	ABL1; ABL1; SRC
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	AR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	SLC6A2
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
C00-D49: Neoplasms	Colon cancer	C50	FLT3; EGFR
C00-D49: Neoplasms	Colorectal cancer	C18-C21	FLT3; IGF1R; MMP9; EGFR; EGFR; TP53; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA; ADRA2B; HTR2A; HTR2C; HRH3
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	HTR6
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	AR
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	PARP1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5; HSD11B1; MMP12; CES1; PPARD
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B; CES1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
J00-J99: Diseases of the respiratory system	Asthma	J45	TBXAS1; PLA2G1B; ESRRA; ALOX5; ALOX5; MMP12
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5
NA: NA	Primary insomnia	NA	HTR2C
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA; CHRM1; CHRM3; MAPT; ACHE; ACHE; ACHE; GSK3B; HTR6; HTR6; HTR6; HRH3; HRH3; APP
L00-L99: Diseases of the skin and subcutaneous tissue	Alopecia	L65.9	AR
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B; ALOX5
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5; PLA2G1B; ESRRA; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5
C00-D49: Neoplasms	AML	NA	FLT3; KDR
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	DRD4
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
A00-B99: Certain infectious and parasitic diseases	Infections disease	A00-B99	MPO
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA; HTR2A; HTR2C; SLC6A4
NA: NA	Chemotherapyinduced emesis	NA	SLC6A4
C00-D49: Neoplasms	Cancer	C00-C96	AR; AKT1; MET; CD38; MCL1; CSNK2A1; CA1; FLT3; FLT3; CA9; ABL1; MMP2; ACHE; SRC; IGF1R; PTK2; STAT3; GSK3B; HIF1A; CDK1; MAPK1; MMP9; NFKB1; EGFR; PIM1; PARP1; CDC25B; SLC6A4; TP53; ESR1; ESR1; KDR; APP
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cancer pain	R52, G89	SLC6A2
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	TTR; APP
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
NA: NA	Excessive sweating	NA	CHRM1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Excessive daytime sleepiness	F51.1, G47.1	HRH3
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5; MMP13; MMP3; MMP2
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR; KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Testosterone deficiency	E29.1	AR
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	AR
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle atrophy	M62.5	AR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle disease	M60-M63	MGAM
C00-D49: Neoplasms	Multiple myeloma	C90	AHR; TERT; CD38; SRC; IGF1R; STAT3
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	MPO; ESR1; ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	HRH3
NA: NA	Myalgia	NA	SLC6A4
NA: NA	Depressive disorders	NA	SLC6A4
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM3; CHRM5
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR2A; CYP2D6; SLC6A4
H00-H59: Diseases of the eye and adnexa	Choroidal neovascularisation	H35	ESRRA
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	TBXAS1; CACNA1C
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CAMK2B; MAOA; ACHE; SLC6A2; HTR2A; HTR2C; HTR6; HTR6; HRH3; CYP3A4
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12
C00-D49: Neoplasms	Female androgenresponsive recurrent mammary cancer	C50	AR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	SLC6A2
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	SLC6A4
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM5
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT; HTR2A; HRH3; PPARD
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP
I00-I99: Diseases of the circulatory system	Cerebrovascular disorders	I60-I69	PARP1
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	SLC6A2; HTR2A; SLC6A4; SLC6A4
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET
NA: NA	Functional bowel syndrome	NA	CHRM1
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5; RAB9A
C00-D49: Neoplasms	Gastric cancer	C16	EGFR; EGFR; KDR; KDR
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	SLC6A4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
NA: NA	Postmenopausal disorder	NA	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA; SLC6A2; SLC6A2; SLC6A2; SLC6A2; HTR2A; HTR2C; SLC6A4; SLC6A4; SLC6A4
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9
N00-N99: Diseases of the genitourinary system	Vasomotor symptoms	N95.1	SLC6A4
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MPO; CHRM1; CHRM3; CHRM5; ALOX5; MMP12; MMP12
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR
NA: NA	Chronic low back pain	NA	SLC6A4
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
C00-D49: Neoplasms	Metastasis	C00-C97	AXL
NA: NA	Colour dead tissues	NA	PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1; CES1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A; SLC6A2; SLC6A2; SLC6A4; HRH3
C00-D49: Neoplasms	Neuroblastoma	C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7	SLC6A2
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MPO; PLA2G1B; ALOX5; MMP13; MMP12; SLC6A4
C00-D49: Neoplasms	Breast cancer	C50	AR; TERT; CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; EGFR; EGFR; EGFR; ESR1; ESR1; KDR; KDR; KDR
G00-G99: Diseases of the nervous system G00-G99	Brain ischaemia	G45.9, I67.8	PARP1
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT; SRC; EGFR; EGFR; ESR1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases