CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.693E-14	1.173E-10	CA1, CA12, CA2, CA4, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.749E-08	1.149E-04	CA1, CA12, CA2, CA4, CA6, CA7, CA9, NR1H4, PTPN1, RORC
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.929E-07	3.510E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.222E-06	4.944E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	5.222E-06	4.944E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	5.222E-06	4.944E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.044E-05	8.682E-03	PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.083E-20	4.535E-16	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.599E-16	4.064E-12	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	5.947E-20	5.114E-18	CA12; CA1; CA2; CA4; CA7; CA6; CA9; CA14
hsa04520	Adherens junction_Homo sapiens_hsa04520	1.189E-04	5.113E-03	PTPN1; ACP1; PTPRF
hsa04931	Insulin resistance_Homo sapiens_hsa04931	3.737E-04	8.692E-03	PTPN1; NFKB1; PTPRF
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	4.043E-04	8.692E-03	CA2; CA4
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	6.913E-04	1.189E-02	AKR1B10; GAA
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	3.214E-03	4.203E-02	RORC; NFKB1
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	4.288E-03	4.203E-02	MAPT; NFKB1; CDC25B
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	4.398E-03	4.203E-02	HSD11B1; AKR1B10; PLA2G1B; GAA; ALPL; HSD17B10
hsa04976	Bile secretion_Homo sapiens_hsa04976	3.822E-03	4.203E-02	CA2; NR1H4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1; NFKB1
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
C00-D49: Neoplasms	Breast cancer	C50	CA9
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
C00-D49: Neoplasms	Renal cancer	C64	CA9
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1; CA4; CA4
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
C00-D49: Neoplasms	Colon cancer	C50	ALPL
NA: NA	Colour dead tissues	NA	PTPN1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; NFKB1; CDC25B
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Solanum sisymbriifolium

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases