CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; HRH3; HRH3; ADRA2A
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C
C00-D49: Neoplasms	Solid tumours	C00-D48	TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; HRH3; HRH3
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C; HRH3
C00-D49: Neoplasms	Prostate cancer	C61	TLR2
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C; HRH3
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HRH3
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HRH3; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HRH3; HRH3
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
C00-D49: Neoplasms	Cancer	C00-C96	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	HRH3; ADRA2A
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	HRH3
G00-G99: Diseases of the nervous system G00-G99	Narcolepsy	G47.4	HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HRH3
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C; HRH3
C00-D49: Neoplasms	Melanoma	C43	TLR2
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Excessive daytime sleepiness	F51.1, G47.1	HRH3
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Obese insulin-resistant disorders	E11	HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C; HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	HRH3
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HRH3
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Diplospora dubia

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases