Plant Name: Toxicodendron vernicifluum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; NPSR1; CXCR1; | |
| DRD4; | |
| AMY1A;AMY1B;AMY1C; RECQL; TDP1; PLA2G1B; CTDSP1; PIK3R1; GLO1; HPGD; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; ALOX12; AKR1B10; NOX4; PYGL; APEX1; POLB; | |
| PTPN1; | |
| ACHE; GAA; | |
| AKT1; MET; CAMK2B; CSNK2A1; DAPK1; AXL; NEK2; FLT3; NEK6; SRC; IGF1R; PTK2; AURKB; CDK2; GSK3B; KDR; CDK1; PIM1; NUAK1; ALK; CDK6; PKN1; | |
| CA12; CA14; CA3; CA5B; CA5A; CA9; CA7; CA4; CA6; CA2; CA1; | |
| AR; | |
| ESRRA; | |
| ESR2; | |
| KDM4E; | |
| MAOA; ALOX5; TYR; XDH; | |
| F10; | |
| MMP13; MMP3; MMP2; MMP9; MMP1; | |
| BACE1; | |
| AHR; STAT6; HIF1A; NFKB1; TP53; | |
| FUT7; | |
| SLC5A1; SLC5A2; SLC5A4; | |
| ABCC1; ABCG2; | |
| LMNA; MCL1; MAPT; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | AMY1A;AMY1B;AMY1C | Salivary alpha-amylase | P04745 | CHEMBL2478 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | CTDSP1 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Q9GZU7 | CHEMBL1795098 |
| Enzyme_unclassified | PIK3R1 | PI3-kinase p85-alpha subunit | P27986 | CHEMBL2506 |
| Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Enzyme_unclassified | PYGL | Liver glycogen phosphorylase | P06737 | CHEMBL2568 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Metallo protease | MMP13 | Matrix metalloproteinase 13 | P45452 | CHEMBL280 |
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Nuclear hormone receptor subfamily 3 group B | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
| Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Oxidoreductase | TYR | Tyrosinase | P14679 | CHEMBL1973 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Peptide receptor (family A GPCR) | CXCR1 | Interleukin-8 receptor A | P25024 | CHEMBL4029 |
| Protein Kinase | AKT1 | Serine/threonine-protein kinase AKT | P31749 | CHEMBL4282 |
| Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Protein Kinase | CAMK2B | CaM kinase II beta | Q13554 | CHEMBL4121 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
| Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Protein Kinase | NEK2 | Serine/threonine-protein kinase NEK2 | P51955 | CHEMBL3835 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | NEK6 | Serine/threonine-protein kinase NEK6 | Q9HC98 | CHEMBL4309 |
| Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | CDK2 | Cyclin-dependent kinase 2 | P24941 | CHEMBL301 |
| Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | NUAK1 | NUAK family SNF1-like kinase 1 | O60285 | CHEMBL5784 |
| Protein Kinase | ALK | ALK tyrosine kinase receptor | Q9UM73 | CHEMBL4247 |
| Protein Kinase | CDK6 | Cyclin-dependent kinase 6 | Q00534 | CHEMBL2508 |
| Protein Kinase | PKN1 | Protein kinase N1 | Q16512 | CHEMBL3384 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Serine protease | F10 | Coagulation factor X | P00742 | CHEMBL244 |
| SLC superfamily of solute carriers | SLC5A1 | Sodium/glucose cotransporter 1 | P13866 | CHEMBL4979 |
| SLC superfamily of solute carriers | SLC5A2 | Sodium/glucose cotransporter 2 | P31639 | CHEMBL3884 |
| SLC superfamily of solute carriers | SLC5A4 | Low affinity sodium-glucose cotransporter | Q9NY91 | CHEMBL1770047 |
| Small molecule receptor (family A GPCR) | DRD4 | Dopamine D4 receptor | P21917 | CHEMBL219 |
| Transcription Factor | AHR | Aryl hydrocarbon receptor | P35869 | CHEMBL3201 |
| Transcription Factor | STAT6 | Signal transducer and activator of transcription 6 | P42226 | CHEMBL5401 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Transferase | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Q11130 | CHEMBL3596077 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.540E-12 | 1.149E-09 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, NOX4 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 3.630E-12 | 2.259E-09 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 4.346E-11 | 2.057E-08 | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, XDH |
| MF | GO:0005488; binding | GO:0020037; heme binding | 6.713E-11 | 3.045E-08 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, MPO, NOX4, SRC |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 7.041E-10 | 2.190E-07 | CYP1A2, CYP2C8, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 8.955E-10 | 2.708E-07 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.057E-09 | 3.111E-07 | AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, ESRRA, GLO1, MMP1, MMP13, MMP2, MMP3, MMP9, PTPN1, TP53 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.652E-09 | 4.671E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 2.721E-09 | 7.314E-07 | CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4 |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 5.793E-09 | 1.417E-06 | ABCC1, ABCG2, AKT1, ALK, AURKB, AXL, CAMK2B, CDK1, CDK2, CDK6, CSNK2A1, DAPK1, FLT3, GSK3B, IGF1R, KDR, MET, NEK2, NEK6, NUAK1, PIM1, PKN1, PTK2, PYGL, RECQL, SRC, TP53 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.048E-08 | 2.401E-06 | CYP1A2, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 2.075E-07 | 3.289E-05 | AKT1, AURKB, CAMK2B, CDK1, CDK2, GSK3B, NEK6, PKN1, SRC |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 3.375E-07 | 5.212E-05 | CYP1A2, CYP2C8, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 5.395E-07 | 7.726E-05 | ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 6.368E-07 | 8.864E-05 | AHR, CSNK2A1, HIF1A, KDR, MAPT |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 7.740E-07 | 1.047E-04 | AKR1B1, APEX1, AXL, CDK1, CYP1B1, STAT6 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 1.221E-06 | 1.546E-04 | ALOX12, ALOX15, ALOX5, HPGD |
| BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 1.382E-06 | 1.710E-04 | HIF1A, MMP1, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| MF | GO:0003824; catalytic activity | GO:0101020; estrogen 16-alpha-hydroxylase activity | 1.377E-06 | 1.710E-04 | CYP1A1, CYP2C8, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004556; alpha-amylase activity | 1.377E-06 | 1.710E-04 | AMY1A, AMY1B, AMY1C |
| MF | Unclassified; | GO:0103025; alpha-amylase activity (releasing maltohexaose) | 1.377E-06 | 1.710E-04 | AMY1A, AMY1B, AMY1C |
| MF | GO:0003824; catalytic activity | GO:0035173; histone kinase activity | 1.590E-06 | 1.913E-04 | AURKB, CDK1, CDK2, PKN1 |
| BP | Unclassified; | GO:0044243; multicellular organismal catabolic process | 2.256E-06 | 2.641E-04 | MMP1, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 2.744E-06 | 3.080E-04 | CYP1A1, CYP2C8, CYP3A4 |
| MF | GO:0005215; transporter activity | GO:0005412; glucose:sodium symporter activity | 2.744E-06 | 3.080E-04 | SLC5A1, SLC5A2, SLC5A4 |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 3.333E-06 | 3.703E-04 | AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, PKN1 |
| BP | GO:0032502; developmental process | GO:0007568; aging | 3.443E-06 | 3.806E-04 | AKT1, APEX1, AURKB, CDK1, CYP1A1, MPO, NOX4, POLB, TP53 |
| BP | Unclassified; | GO:0015758; glucose transport | 4.090E-06 | 4.431E-04 | AKT1, PLA2G1B, SLC5A1, SLC5A2, SLC5A4 |
| BP | Unclassified; | GO:0044259; multicellular organismal macromolecule metabolic process | 5.899E-06 | 5.974E-04 | HIF1A, MMP1, MMP13, MMP2, MMP3, MMP9 |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 5.899E-06 | 5.974E-04 | AR, CYP3A4, ESR2, ESRRA, HSD17B1, NPC1 |
| BP | GO:0065007; biological regulation | GO:0048878; chemical homeostasis | 7.762E-06 | 7.545E-04 | ABCG2, AKR1B1, AKT1, ALOX12, CA12, CA2, CA7, DRD4, HIF1A, MET, NOX4, NPC1, NPSR1, PIK3R1, PLA2G1B, PYGL, TP53 |
| BP | GO:0009987; cellular process | GO:2001243; negative regulation of intrinsic apoptotic signaling pathway | 1.050E-05 | 9.565E-04 | AKT1, HIF1A, MCL1, MMP9, PTPN1, SRC |
| BP | GO:0008152; metabolic process | GO:0016572; histone phosphorylation | 1.309E-05 | 1.139E-03 | AURKB, CDK1, CDK2, PKN1 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 1.309E-05 | 1.139E-03 | AKT1, MAPT, PTPN1, TP53 |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 1.508E-05 | 1.292E-03 | AXL, F10, MET, NOX4, PIK3R1, PTK2, SRC |
| BP | GO:0022610; biological adhesion | GO:0001952; regulation of cell-matrix adhesion | 1.670E-05 | 1.393E-03 | CDK6, GSK3B, KDR, PIK3R1, PTK2, SRC |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 1.670E-05 | 1.393E-03 | AKT1, AR, DAPK1, LMNA, MCL1, SRC |
| BP | GO:0009987; cellular process | GO:2000045; regulation of G1/S transition of mitotic cell cycle | 2.277E-05 | 1.844E-03 | AKT1, APEX1, CDK1, CDK2, CTDSP1, CYP1A1, TP53 |
| BP | GO:0008152; metabolic process | GO:0030574; collagen catabolic process | 2.278E-05 | 1.844E-03 | MMP1, MMP13, MMP2, MMP3, MMP9 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 2.463E-05 | 1.958E-03 | AURKB, CA2, CA7, HIF1A, NEK2, NPC1, NPSR1, PLA2G1B |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 2.707E-05 | 2.090E-03 | APEX1, POLB |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.707E-05 | 2.090E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.707E-05 | 2.090E-03 | ALOX12, ALOX15 |
| BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 3.749E-05 | 2.835E-03 | AXL, KDR, PIK3R1, PTK2, SRC |
| BP | GO:0008152; metabolic process | GO:0006703; estrogen biosynthetic process | 3.820E-05 | 2.849E-03 | CYP19A1, HSD17B1, HSD17B2 |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 3.841E-05 | 2.855E-03 | AURKB, CA2, CA7, CDK6, HIF1A, KDR, NEK2, NPC1, NPSR1, PLA2G1B, SRC |
| BP | GO:0008152; metabolic process | GO:1901575; organic substance catabolic process | 4.645E-05 | 3.382E-03 | ACHE, AKR1B10, AKT1, ALDH1A1, AURKB, BACE1, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FUT7, GAA, GSK3B, HSD17B10, MAOA, PLA2G1B, PYGL, TP53, XDH |
| BP | GO:0009987; cellular process | GO:0022617; extracellular matrix disassembly | 5.868E-05 | 4.134E-03 | MMP1, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0009987; cellular process | GO:2000811; negative regulation of anoikis | 7.395E-05 | 5.080E-03 | MCL1, PTK2, SRC |
| BP | GO:0050896; response to stimulus | GO:0048585; negative regulation of response to stimulus | 7.722E-05 | 5.271E-03 | AKT1, ALOX12, ALOX15, AR, CDK6, CYP19A1, DAPK1, ESR2, GSK3B, HIF1A, IGF1R, LMNA, MCL1, MET, MMP9, NFKB1, PTPN1, SRC, STAT6, XDH |
| BP | GO:0009987; cellular process | GO:0043065; positive regulation of apoptotic process | 7.870E-05 | 5.339E-03 | AKT1, CYP1B1, DAPK1, GSK3B, HPGD, MAPT, MCL1, MMP9, NOX4, SRC, TP53, XDH |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 8.094E-05 | 5.390E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 8.094E-05 | 5.390E-03 | CYP1A1, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 8.094E-05 | 5.390E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 8.094E-05 | 5.390E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors | 8.140E-05 | 5.404E-03 | AKR1B1, AKR1B10, ALDH1A1, XDH |
| BP | GO:0009987; cellular process | GO:0090199; regulation of release of cytochrome c from mitochondria | 8.898E-05 | 5.763E-03 | AKT1, LMNA, MMP9, TP53 |
| BP | GO:0009987; cellular process | GO:0010638; positive regulation of organelle organization | 8.908E-05 | 5.763E-03 | ALOX15, AURKB, GSK3B, HIF1A, KDR, MAPT, MET, MMP9, NEK2, NOX4, SRC, TP53 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 8.946E-05 | 5.763E-03 | CYP2C19, CYP2C8, CYP2C9 |
| BP | GO:0065007; biological regulation | GO:0000187; activation of MAPK activity | 1.054E-04 | 6.709E-03 | ALK, CDK1, DRD4, PKN1, PLA2G1B, PTPN1 |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 1.057E-04 | 6.709E-03 | IGF1R, KDR, PTK2, SRC |
| BP | GO:0008152; metabolic process | GO:2000379; positive regulation of reactive oxygen species metabolic process | 1.093E-04 | 6.922E-03 | AKT1, MAPT, NOX4, TP53, XDH |
| BP | GO:0008152; metabolic process | GO:0031324; negative regulation of cellular metabolic process | 1.104E-04 | 6.970E-03 | AHR, AKT1, APEX1, AR, AURKB, CDK1, CDK2, CSNK2A1, CTDSP1, DAPK1, DRD4, ESR2, ESRRA, GSK3B, HIF1A, IGF1R, MAPT, MCL1, MET, MMP3, MMP9, NFKB1, NPC1, PKN1, PTPN1, SRC, STAT6, TP53, XDH |
| CC | GO:0044464; cell part | GO:0005739; mitochondrion | 1.172E-04 | 7.355E-03 | AKT1, APEX1, CA5A, CA5B, CDK1, CYP1A1, CYP1B1, ESR2, GSK3B, HSD17B10, MAOA, MCL1, MMP2, MPO, NFKB1, NOX4, SRC, TP53 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 1.181E-04 | 7.391E-03 | AHR, AKR1B1, AKR1B10, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, AR, AURKB, CA1, CA2, CA3, CA7, CAMK2B, CDK1, CDK2, CDK6, CSNK2A1, FLT3, GLO1, GSK3B, HIF1A, HPGD, HSD17B1, LMNA, MAPT, MCL1, NEK2, NEK6, NFKB1, PIK3R1, PIM1, PKN1, PLA2G1B, PTK2, PTPN1, PYGL, SRC, STAT6, TP53, TYR, XDH |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.245E-04 | 7.725E-03 | AHR, AR, ESR2, ESRRA |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 1.484E-04 | 9.054E-03 | AHR, AKR1B1, AKT1, ALOX5, APEX1, AR, AURKB, CAMK2B, CDK1, CDK2, CDK6, CSNK2A1, CTDSP1, ESR2, ESRRA, GSK3B, HIF1A, HPGD, LMNA, MCL1, NEK2, NEK6, NFKB1, NUAK1, PIM1, PKN1, POLB, RECQL, SRC, STAT6, TP53 |
| BP | GO:0040007; growth | GO:0040008; regulation of growth | 1.561E-04 | 9.494E-03 | AKT1, ALOX12, AR, CDK1, CSNK2A1, ESR2, HIF1A, MAPT, MPO, PIM1, PTK2, TP53 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 1.613E-04 | 9.704E-03 | CYP1A1, CYP1A2 |
| MF | GO:0005488; binding | GO:0005497; androgen binding | 1.613E-04 | 9.704E-03 | ALDH1A1, AR |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 6.113E-23 | 6.655E-19 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.033E-16 | 7.339E-13 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.197E-15 | 3.680E-12 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.750E-22 | 6.900E-20 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.432E-11 | 1.318E-09 | GSK3B; FLT3; MMP1; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; NFKB1; PTK2; IGF1R; AR; CDK6; CDK2; AKT1; MET; TP53 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 3.164E-10 | 1.456E-08 | PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; PYGL; CYP2C19; CYP3A4; CYP19A1; HSD17B10; FUT7; HSD17B1; ALOX5; HSD17B2; XDH; AMY1A; GAA; AMY1B; AMY1C; TYR; CYP2C9; CYP2C8; AKR1B10; CYP1A2; ALDH1A1; CYP1A1 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 4.667E-10 | 1.718E-08 | CAMK2B; SRC; MMP2; KDR; AKT1; PIK3R1; TP53; HIF1A; MMP9; MET; PTK2; IGF1R |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 9.664E-11 | 5.927E-09 | CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 5.672E-09 | 1.739E-07 | HSD17B1; ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.735E-08 | 3.548E-07 | GSK3B; PIK3R1; PTK2; NFKB1; IGF1R; CDK6; CDK2; KDR; AKT1; PKN1; TP53; MET; MCL1 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.609E-08 | 3.548E-07 | GSK3B; AR; CDK2; AKT1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 2.658E-08 | 4.446E-07 | CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 5.423E-08 | 7.873E-07 | CDK6; SRC; CDK2; AKT1; STAT6; PIK3R1; TP53; MMP9; NFKB1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.652E-08 | 3.548E-07 | HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 2.571E-08 | 4.446E-07 | HPGD; FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 5.562E-08 | 7.873E-07 | MMP1; DAPK1; SRC; MMP2; MMP9; TP53 |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.631E-07 | 3.026E-06 | CDK6; CDK2; AKT1; PIK3R1; TP53; NFKB1; PTK2 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 4.415E-07 | 4.778E-06 | GSK3B; CDK6; CSNK2A1; CDK2; AKT1; PIK3R1; TP53; NFKB1 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 9.266E-07 | 8.974E-06 | CAMK2B; CDK6; AKT1; PIK3R1; TP53; IGF1R |
| hsa04973 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 9.913E-08 | 1.303E-06 | AMY1A; AMY1B; AMY1C; AKT1; PIK3R1; SLC5A1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.892E-07 | 2.321E-06 | CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.594E-06 | 1.275E-05 | CYP2C9; CYP2C8; MAOA; ALOX5; ALOX15; ALOX12; CYP2C19 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 9.266E-07 | 8.974E-06 | CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.110E-06 | 1.022E-05 | FLT3; AKT1; PIK3R1; TP53; MET; HIF1A |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 1.568E-06 | 1.275E-05 | CDK6; AKT1; PIK3R1; TP53; MET; IGF1R |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.704E-06 | 1.306E-05 | GSK3B; SRC; AKT1; PIK3R1; NFKB1; ESR2 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.323E-06 | 1.159E-05 | CYP2C9; CYP2C8; MAOA; CYP1A2; CYP3A4; CYP2C19 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 8.531E-06 | 5.814E-05 | GSK3B; CSNK2A1; CDK2; CDK1; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04510 | Focal adhesion_Homo sapiens_hsa04510 | 8.531E-06 | 5.814E-05 | GSK3B; SRC; KDR; AKT1; PIK3R1; MET; PTK2; IGF1R |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 5.180E-06 | 3.813E-05 | CAMK2B; GSK3B; SRC; AKT1; PIK3R1; PTK2 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 9.500E-06 | 5.827E-05 | POLB; CDK6; SRC; CDK2; CDK1; PIK3R1; TP53; NFKB1 |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.095E-05 | 6.295E-05 | SRC; MMP2; AKT1; PIK3R1; MMP9; ESR2 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.967E-05 | 1.005E-04 | ABCC1; CDK6; PIM1; CYP1B1; TP53; MMP9; MET; NFKB1; MCL1 |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 9.256E-06 | 5.827E-05 | ALK; CDK6; AKT1; PIK3R1; TP53 |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 1.374E-05 | 7.647E-05 | CAMK2B; AKT1; PIK3R1; HIF1A; NFKB1; IGF1R |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.900E-05 | 9.986E-05 | PTPN1; GSK3B; AKT1; PIK3R1; PYGL; NFKB1 |
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 9.256E-06 | 5.827E-05 | AMY1A; AMY1B; GAA; AMY1C; PYGL |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.011E-05 | 5.998E-05 | FLT3; PIM1; AKT1; PIK3R1; NFKB1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.980E-05 | 1.443E-04 | GSK3B; SRC; AKT1; PIK3R1; TP53; HIF1A |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 3.277E-05 | 1.526E-04 | CAMK2B; GSK3B; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04370 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.413E-05 | 7.647E-05 | SRC; KDR; AKT1; PIK3R1; PTK2 |
| hsa04062 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 4.579E-05 | 1.959E-04 | GSK3B; CXCR1; SRC; AKT1; PIK3R1; NFKB1; PTK2 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 7.760E-05 | 3.173E-04 | LMNA; AKT1; PIK3R1; TP53; NFKB1; MCL1 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 2.081E-05 | 1.035E-04 | CDK6; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 1.540E-04 | 5.784E-04 | PLA2G1B; KDR; AKT1; PIK3R1; MET; NFKB1; IGF1R |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 3.401E-05 | 1.526E-04 | CDK6; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.604E-04 | 5.903E-04 | MMP2; PIM1; AKT1; PIK3R1; NFKB1 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.143E-04 | 4.572E-04 | AKT1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.392E-04 | 5.336E-04 | CDK2; CDK1; AKT1; PIK3R1; IGF1R |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 3.401E-05 | 1.526E-04 | CYP2C9; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 3.633E-05 | 1.592E-04 | PTPN1; CSNK2A1; SRC; MET; IGF1R |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.392E-04 | 8.628E-04 | MMP3; AKT1; PIK3R1; MMP9; NFKB1 |
| hsa04114 | Oocyte meiosis_Homo sapiens_hsa04114 | 4.010E-04 | 1.294E-03 | CAMK2B; AR; CDK2; CDK1; IGF1R |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 3.579E-04 | 1.197E-03 | ABCC1; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 7.080E-04 | 1.944E-03 | SRC; KDR; AKT1; PIK3R1; MET; IGF1R |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 4.161E-04 | 1.298E-03 | GSK3B; CDK6; CDK2; CDK1; TP53 |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 4.987E-04 | 1.480E-03 | CAMK2B; GSK3B; MAOA; AKT1; DRD4 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 5.732E-04 | 1.648E-03 | GSK3B; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.243E-03 | 3.364E-03 | PIM1; AKT1; STAT6; PIK3R1; MCL1 |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 7.002E-04 | 1.944E-03 | PTPN1; GSK3B; AKT1; PIK3R1; PYGL |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 1.983E-03 | 5.140E-03 | POLB; GSK3B; AKT1; PIK3R1; TP53; NFKB1 |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 2.482E-03 | 6.257E-03 | CSNK2A1; CDK2; CDK1; TP53; NFKB1 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 1.377E-04 | 5.336E-04 | GSK3B; AKT1; PIK3R1; TP53 |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.427E-03 | 6.202E-03 | CAMK2B; ACHE; AKT1; PIK3R1 |
| hsa05211 | Renal cell carcinoma_Homo sapiens_hsa05211 | 3.473E-04 | 1.183E-03 | AKT1; PIK3R1; MET; HIF1A |
| hsa04750 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.539E-03 | 4.103E-03 | CAMK2B; SRC; ALOX12; PIK3R1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 3.396E-03 | 8.115E-03 | CAMK2B; AKT1; PIK3R1; NFKB1; TSHR |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.914E-03 | 5.031E-03 | GSK3B; AKT1; PIK3R1; NFKB1 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 2.730E-04 | 9.477E-04 | GSK3B; AKT1; PIK3R1; TP53 |
| hsa04144 | Endocytosis_Homo sapiens_hsa04144 | 1.014E-02 | 2.194E-02 | CXCR1; SRC; KDR; MET; IGF1R |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 3.894E-04 | 1.279E-03 | CXCR1; SRC; MET; NFKB1 |
| hsa04662 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 5.105E-04 | 1.491E-03 | GSK3B; AKT1; PIK3R1; NFKB1 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 5.843E-03 | 1.311E-02 | GSK3B; AKT1; PIK3R1; IGF1R |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 7.238E-03 | 1.585E-02 | GSK3B; AKT1; PIK3R1; NFKB1 |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 5.843E-03 | 1.311E-02 | CAMK2B; GSK3B; CSNK2A1; TP53 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 3.027E-03 | 7.330E-03 | ALOX5; AKT1; PIK3R1; NFKB1 |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 4.641E-03 | 1.067E-02 | CDK2; AKT1; PIK3R1; IGF1R |
| hsa04670 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 3.027E-03 | 7.330E-03 | MMP2; PIK3R1; MMP9; PTK2 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 1.044E-02 | 2.207E-02 | BACE1; GSK3B; MAPT; HSD17B10 |
| hsa05164 | Influenza A_Homo sapiens_hsa05164 | 1.198E-02 | 2.435E-02 | GSK3B; AKT1; PIK3R1; NFKB1 |
| hsa05100 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 6.562E-04 | 1.858E-03 | SRC; PIK3R1; MET; PTK2 |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 4.117E-04 | 1.298E-03 | CDK6; CDK2; CDK1; TP53 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 4.592E-04 | 1.386E-03 | CA2; SLC5A1; CYP3A4; ABCG2 |
| hsa05152 | Tuberculosis_Homo sapiens_hsa05152 | 1.269E-02 | 2.538E-02 | CAMK2B; SRC; AKT1; NFKB1 |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.102E-02 | 2.303E-02 | CAMK2B; SRC; MMP2 |
| hsa04611 | Platelet activation_Homo sapiens_hsa04611 | 2.395E-02 | 4.278E-02 | SRC; AKT1; PIK3R1 |
| hsa04916 | Melanogenesis_Homo sapiens_hsa04916 | 1.419E-02 | 2.727E-02 | CAMK2B; GSK3B; TYR |
| hsa04970 | Salivary secretion_Homo sapiens_hsa04970 | 1.037E-02 | 2.207E-02 | AMY1A; AMY1B; AMY1C |
| hsa04152 | AMPK signaling pathway_Homo sapiens_hsa04152 | 2.497E-02 | 4.418E-02 | AKT1; PIK3R1; IGF1R |
| hsa05146 | Amoebiasis_Homo sapiens_hsa05146 | 1.419E-02 | 2.727E-02 | PIK3R1; NFKB1; PTK2 |
| hsa04620 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.657E-02 | 3.049E-02 | AKT1; PIK3R1; NFKB1 |
| hsa04922 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.458E-02 | 2.737E-02 | CAMK2B; AKT1; PYGL |
| hsa04360 | Axon guidance_Homo sapiens_hsa04360 | 2.656E-02 | 4.610E-02 | GSK3B; MET; PTK2 |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.458E-02 | 2.737E-02 | AKT1; PIK3R1; HIF1A |
| hsa05142 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.576E-02 | 2.929E-02 | AKT1; PIK3R1; NFKB1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 4.869E-05 | 2.036E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa04213 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 4.166E-03 | 9.704E-03 | AKT1; PIK3R1; IGF1R |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 2.854E-03 | 7.096E-03 | AKT1; PIK3R1; TSHR |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 3.472E-03 | 8.191E-03 | AKT1; PIK3R1; HIF1A |
| hsa05030 | Cocaine addiction_Homo sapiens_hsa05030 | 2.546E-02 | 4.461E-02 | MAOA; NFKB1 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.262E-02 | 4.081E-02 | CYP3A4; XDH |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 2.081E-02 | 3.792E-02 | ABCC1; ABCG2 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 4.596E-04 | 1.386E-03 | AKR1B10; GAA; AKR1B1 |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.348E-02 | 2.667E-02 | MAOA; TYR |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.135E-02 | 2.346E-02 | AKR1B10; AKR1B1 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 1.204E-02 | 2.435E-02 | POLB; APEX1 |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.423E-02 | 2.727E-02 | AKR1B10; AKR1B1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 5.962E-03 | 1.322E-02 | CA2; CA4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.500E-04 | 8.847E-04 | CYP1A2; XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3 |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; SRC |
| C00-D49: Neoplasms | Female androgenresponsive recurrent mammary cancer | C50 | AR |
| Z00-Z99: Factors influencing health status and contact with health services | Contraception | Z30 | AR |
| I00-I99: Diseases of the circulatory system | Heart disease | I00-I52 | MET |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MPO; ALOX5 |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | SRC |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypogonadism | E23.0, E28.3, E29.1 | AR |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Muscle atrophy | M62.5 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | MPO |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET; IGF1R; KDR |
| NA: NA | Hematopoietic stem cell transplantation | NA | FLT3 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| I00-I99: Diseases of the circulatory system | Coagulation | I80-I82 | F10 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; ACHE |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | F10 |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR |
| H00-H59: Diseases of the eye and adnexa | Choroidal neovascularisation | H35 | ESRRA |
| NA: NA | Christmas disease | NA | F10 |
| K00-K95: Diseases of the digestive system | Chemotherapy-induced mucositis | K12.3 | MET |
| K00-K95: Diseases of the digestive system | Gastrointestinal disease | K00-K93 | ESRRA |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR |
| C00-D49: Neoplasms | Melanoma | C43 | TYR; KDR; KDR |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2; KDR; KDR |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5 |
| C00-D49: Neoplasms | Cancer | C00-C96 | AR; AKT1; MET; MCL1; CSNK2A1; FLT3; FLT3; CA9; MMP2; ACHE; SRC; IGF1R; PTK2; CDK2; GSK3B; HIF1A; CDK1; MMP9; NFKB1; PIM1; TP53; CA1; KDR |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cachexia | R64 | AR; ESRRA |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MMP9 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Attention deficit hyperactivity disorder | F90 | F10 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Male hormonal deficiencies | E20-E35 | AR |
| NA: NA | Male hypogonadism | NA | AR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B; ALOX5 |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | AR; KDR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | ALOX5; MMP13; MMP3; MMP2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PLA2G1B; ABCC1; ESRRA; ALOX5; MMP1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5 |
| C00-D49: Neoplasms | Metastatic prostate cancer | C61 | AR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD4 |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CAMK2B; AKR1B1; PLA2G1B; ESRRA; ALOX5; MMP3; TYR; MMP1 |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5 |
| C00-D49: Neoplasms | Bladder cancer | C67 | AR; CYP19A1 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Blood coagulation disorders | D65-D68 | F10 |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F10 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | ESRRA; DRD4 |
| C00-D49: Neoplasms | Metastasis | C00-C97 | AXL |
| C00-D49: Neoplasms | Mesothelioma | C45 | PTK2 |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | AR; KDR |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | NPSR1 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| N00-N99: Diseases of the genitourinary system | Prostate hyperplasia | N40 | AR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B; ALOX5 |
| C00-D49: Neoplasms | Prostate cancer | C61 | AR; AR; FLT3 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| I00-I99: Diseases of the circulatory system | Prophylaxis of deep vein thrombosis | I80-I82, I80.2 | F10 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | AR; IGF1R |
| NA: NA | HIV infections | NA | AHR |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | SRC |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Erectile dysfunction | F52.2, N48.4 | DRD4 |
| C00-D49: Neoplasms | Renal cancer | C64 | F10; CA9; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; ACHE |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3 |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SRC |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | SLC5A2 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AKT1; MET; FLT3; CA9; MMP2; SRC; IGF1R; PTK2; AURKB; CDK2; HIF1A; MMP9; TP53; KDR; KDR; KDR |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Endocrine disease | E00-E35 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| NA: NA | Edema | NA | CA2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | ESRRA |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MET; AXL; IGF1R; IGF1R; CDK2; KDR |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | MMP2; KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MPO; PLA2G1B; ALOX5; MMP13 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | SLC5A1; SLC5A2; SLC5A2; PTPN1; PTPN1; SLC5A4; NFKB1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1/2 diabetes | E08-E13 | SLC5A4 |
| NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3 |
| NA: NA | Upper abdominal bloating | NA | ACHE |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
| C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3 |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3 |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | AKT1; CA9; HIF1A |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | SLC5A2; MET |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | MMP2 |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| I00-I99: Diseases of the circulatory system | Venous thrombosis | I80-I82 | F10 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Hemophilia | D66-D68 | F10 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Hematology | D50-D77 | F10 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SRC; AURKB; TP53 |
| C00-D49: Neoplasms | Hematologic malignancies | C81-C86 | AKT1 |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | ALOX5; FLT3 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Myocardial reperfusion injury | T86.4 | AKT1 |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | MMP3 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| C00-D49: Neoplasms | Liver cancer | C22 | IGF1R; KDR |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Leukemia | C90-C95 | AKT1; FLT3 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | PTK2; TP53 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA; TYR |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Hormone refractory prostate cancer | C61 | AR |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Breast cancer | C50 | AR; CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; KDR; KDR; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | F10 |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic nephropathy | E11.21 | MMP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| I00-I99: Diseases of the circulatory system | Acute coronary syndrome | I74 | F10 |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; GSK3B |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis in post-menopausal women | M80-M81 | AR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | AR; SRC |
| C00-D49: Neoplasms | Ovarian cancer | C56 | MMP2; KDR; KDR; KDR; KDR |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | SLC5A1; SLC5A2; AKR1B1; PTPN1; SLC5A4; GSK3B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatological disease | L00-L99 | AR; ESRRA |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ESRRA; ALOX5 |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PLA2G1B; ESRRA; ALOX5; ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | AKT1; FLT3; MMP2; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | MPO; MAOA; ACHE |
| I00-I99: Diseases of the circulatory system | Venous thromboembolism | I80-I82 | F10 |
| I00-I99: Diseases of the circulatory system | Angina pectoris | I20 | F10 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Cystic fibrosis | E84 | AR |
| I00-I99: Diseases of the circulatory system | Deep vein thrombosis | I80-I82, I80.2 | F10 |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR |
| C00-D49: Neoplasms | Ocular cancer | C69 | APEX1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| I00-I99: Diseases of the circulatory system | Deep venous clots | I80.2 | F10 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR |
| C00-D49: Neoplasms | AML | NA | FLT3; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Alopecia | L65.9 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAOA; MAPT; ACHE; ACHE; ACHE; GSK3B |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B; ESRRA |
| C00-D49: Neoplasms | Castration-resistant prostate cancer | C61 | AR |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| I00-I99: Diseases of the circulatory system | Thromboembolic disorders | I80-I82 | F10 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | AR; MMP13; ACHE; IGF1R; CDK1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1; ABCC1; ABCC1; XDH |
| C00-D49: Neoplasms | Glioblastoma | NA | FLT3 |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | SRC |
| C00-D49: Neoplasms | Glioma | C71 | KDR |
| NA: NA | GIST | NA | FLT3 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1; ACHE; CA1; CA1 |
| K00-K95: Diseases of the digestive system | Alcoholic hepatitis | K70.1 | AR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET |
| J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R |
| C00-D49: Neoplasms | Multiple myeloma | C90 | AHR; SRC; IGF1R |
| L00-L99: Diseases of the skin and subcutaneous tissue | Melasma | L81.1 | TYR |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R |
| H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R |
| NA: NA | Haemophilia B | NA | F10 |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; CA4; CA2 |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; CA1 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | AR; XDH |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1; TP53; KDR; KDR |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | AR; AR; ESRRA; MMP2 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3; CDK2 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | FLT3; FLT3; AURKB; TP53; TP53 |
| C00-D49: Neoplasms | Advanced prostate cancer | C61 | AR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | F10 |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | F10; ALOX5 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Testosterone deficiency | E29.1 | AR |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; KDR |
| C00-D49: Neoplasms | Thymoma | C37, D15.0 | CDK2 |
| C00-D49: Neoplasms | Colon cancer | C50 | FLT3 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | FLT3; IGF1R; MMP9; TP53; KDR |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | MET |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; KDR |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CAMK2B; MAOA; ACHE; CYP3A4 |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | MMP9 |