Plant Name: Polymnia uvedalia
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 7.744E-11 | 1.686E-06 | CA12, CA2, CA4, CA7 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.321E-09 | 2.411E-05 | CA12, CA2, CA4, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 7.636E-09 | 4.157E-05 | CA12, CA2, CA4, CA7 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 8.842E-07 | 2.751E-03 | CA2, CA7 |
| BP | GO:0065007; biological regulation | GO:0042592; homeostatic process | 2.210E-06 | 4.930E-03 | AKR1B1, CA12, CA2, CA7, GAA, P4HB, POLB |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.174E-10 | 3.523E-09 | CA12; CA2; CA4; CA7 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 6.914E-05 | 1.037E-03 | CA2; CA4 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.186E-04 | 1.186E-03 | GAA; AKR1B1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 3.402E-03 | 2.551E-02 | MAOA; GAA; AKR1B1; ALPI |
| hsa00340 | Histidine metabolism_Homo sapiens_hsa00340 | 1.312E-02 | 4.669E-02 | MAOA |
| hsa00360 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 9.313E-03 | 4.656E-02 | MAOA |
| hsa04966 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.475E-02 | 4.669E-02 | CA2 |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.909E-02 | 4.669E-02 | MAOA |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.179E-02 | 4.669E-02 | MAOA |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.963E-02 | 4.669E-02 | AKR1B1 |
| hsa00260 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.179E-02 | 4.669E-02 | MAOA |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.746E-02 | 4.669E-02 | AKR1B1 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 1.801E-02 | 4.669E-02 | POLB |
| hsa00790 | Folate biosynthesis_Homo sapiens_hsa00790 | 7.675E-03 | 4.605E-02 | ALPI |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | MAOA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; CA4 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | AKR1B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAOA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | MAOA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| NA: NA | Edema | NA | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2 |