CMAUP Plant Collective Molecular Activities

Plant Name: Elephantopus mollis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	RECQL; ALPL; TDP1; TERT; PKM; PGD; GFER; HSD17B10; ALDH1A1; POLB;
Hydrolase	GAA;
Miscellaneous ion channel	BCL2;
Protein Kinase	MET; MAPK14; DYRK1A;
Lyase	CA2; CA1; CA12; CA9; CA3; CA14; CA5B; CA5A; CA4; CA6; CA7;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Lysine demethylase	KDM4E;
Oxidoreductase	PTGS1;
Aspartic protease	BACE1;
Cysteine protease	CASP1; CASP7;
Metallo protease	MMP2; MMP14;
Transcription Factor	NFKB1;
DNA methyltransferase	DNMT1;
ATP-binding cassette	ABCB1;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	HTT; RAB9A; NPC1; MAPT; MITF; PAX8; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
DNA methyltransferase	DNMT1	DNA (cytosine-5)-methyltransferase 1	P26358	CHEMBL1993
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP14	Matrix metalloproteinase 14	P50281	CHEMBL3869
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	MAPK14	MAP kinase p38 alpha	Q16539	CHEMBL260
Protein Kinase	DYRK1A	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Q13627	CHEMBL2292
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	MITF	Microphthalmia-associated transcription factor	O75030	CHEMBL1741165
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.050E-10	1.098E-06	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR2, MMP14, MMP2, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.778E-27	1.911E-22	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	1.260E-06	1.247E-03	ALPL, APP, BCL2, CA2, CA9, CASP1, CASP7, CYP1A2, MMP14, NFKB1, NPC1
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	1.707E-06	1.568E-03	ABCB1, CA2, CA7
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	4.096E-06	3.185E-03	ALPL, BCL2, CA2, CA9, CYP1A2, MMP14, NFKB1, NPC1, PAX8, PKM
BP	GO:0065007; biological regulation	GO:0010952; positive regulation of peptidase activity	4.395E-06	3.300E-03	APP, CASP1, CASP7, MAPK14, MAPT, MMP14
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.811E-05	9.852E-03	CA2, CA7
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	1.811E-05	9.852E-03	BCL2, NR1H4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.687E-20	5.103E-16	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.983E-19	3.476E-15	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	APP
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PKM; PTGS1
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
NA: NA	Acute respiratory distress syndrome	NA	MAPK14
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Soft tissue sarcoma	C00-D49	DNMT1
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MAPK14
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2; MAPK14
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2; TERT
C00-D49: Neoplasms	Renal cancer	C64	CA9
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	APP
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1
NA: NA	Inflammatory diseases	NA	MAPK14
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MAPK14; PTGS1
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	ABCB1; MET; DNMT1
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	MAPK14
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	MAPK14; PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1; MET
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2; PTGS1
NA: NA	Rheumatold arthritis	NA	MAPK14; PTGS1
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT; DNMT1; DNMT1
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	DNMT1; DNMT1
C00-D49: Neoplasms	Colon cancer	C50	ALPL
C00-D49: Neoplasms	Solid tumours	C00-D48	ABCB1; MET; CA9; MMP2; MMP14; PKM
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	MAPK14; MAPK14
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT; APP
NA: NA	Miosis during ocular surgery	NA	PTGS1
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2; CA9
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1
C00-D49: Neoplasms	Tumors	C00-D48	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MAPK14
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1
C00-D49: Neoplasms	Prostate cancer	C61	BCL2; TERT
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT
C00-D49: Neoplasms	Breast cancer	C50	BCL2; CA9; TERT
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1; MAPK14
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
C00-D49: Neoplasms	Melanoma	C43	TERT
C00-D49: Neoplasms	Cancer	C00-C96	BCL2; BCL2; ABCB1; MET; CA1; CA9; MAPK14; NFKB1; MMP2; DNMT1; APP
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET
C00-D49: Neoplasms	Glioma	C71	APP
C00-D49: Neoplasms	Glioblastoma multiforme	C71	DNMT1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
NA: NA	Geographic retinal atrophy	NA	APP
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT; MMP2
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP
NA: NA	Edema	NA	CA2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2; PTGS1
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Liver cancer	C22	TERT
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	DNMT1
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2
C00-D49: Neoplasms	Ovarian cancer	C56	ABCB1; TERT; MMP2
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases