CMAUP Plant Collective Molecular Activities

Plant Name: Pedicularis procera

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.135E-13	9.299E-10	CA1, CA12, CA2, CA4, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.929E-06	3.500E-03	CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.870E-06	3.500E-03	ALPI, CA1, CA12, CA2, CA4, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.929E-06	3.500E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	3.856E-06	4.939E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	3.856E-06	4.939E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	5.159E-06	6.241E-03	ADRA2A, AKR1B1, CA12, CA2, CA7, MAPK1, NMUR2
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	9.631E-06	8.388E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.690E-19	8.035E-15	CA1, CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.172E-15	1.576E-11	CA1, CA12, CA14, CA2, CA4, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	8.735E-19	9.084E-17	CA12; CA1; CA2; CA4; CA7; CA9; CA14
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	2.956E-04	7.686E-03	MAPK1; ADRA2C; ADRA2A
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.503E-04	7.686E-03	CA2; CA4
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	2.576E-04	7.686E-03	GAA; AKR1B1
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.288E-03	2.678E-02	NMUR2; ADRA2C; ADRA2A

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; MAPK1
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
NA: NA	Edema	NA	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C; CA1; CA1; AKR1B1; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
NA: NA	Upper abdominal bloating	NA	ACHE
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; MAPK1; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4; ACHE
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C; CA4; CA4
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; ADRA2A; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
C00-D49: Neoplasms	Renal cancer	C64	CA9
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
C00-D49: Neoplasms	Breast cancer	C50	CA9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases