Plant Name: Hesperocyparis nevadensis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 9.312E-09 | 2.028E-04 | CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.021E-07 | 5.559E-04 | CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.278E-06 | 5.567E-03 | CYP2C19, CYP2C9, CYP3A4, NPC1, NR0B1 |
| MF | GO:0005215; transporter activity | GO:0005330; dopamine:sodium symporter activity | 1.929E-06 | 6.168E-03 | SLC6A2, SLC6A3 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 2.747E-06 | 7.477E-03 | CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 3.856E-06 | 8.396E-03 | CYP2C9, CYP3A4 |
Showing 1 to 6 of 6 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.103E-03 | 7.070E-03 | CYP2C9; CYP2C19 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.516E-06 | 5.304E-05 | CYP2C9; CYP3A4; CYP2C19 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.212E-03 | 7.070E-03 | CYP2C9; CYP3A4 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.526E-03 | 7.628E-03 | CYP2C9; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.131E-05 | 2.710E-04 | CYP2C9; CYP3A4; CYP2C19 |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 8.152E-03 | 3.170E-02 | SMN2; SMN1 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 3.543E-03 | 1.550E-02 | CYP2C9; CYP2C19 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 2.323E-05 | 2.710E-04 | SLCO1B1; SLCO1B3; CYP3A4 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 3.579E-05 | 3.132E-04 | CYP2C9; CYP3A4; CYP2C19 |
Showing 1 to 9 of 9 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | NR3C1 |
| C00-D49: Neoplasms | Neuroendocrine cancer | C7A | SLC6A2 |
| C00-D49: Neoplasms | Neuroblastoma | C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7 | SLC6A2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; NR3C1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NR3C1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | NR3C1 |
Showing 1 to 10 of 44 entries