CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.838E-06	6.964E-03	CA1, CA12, CA2, CA5A, CA6, CA7, CA9, TP53
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	7.429E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.810E-21	2.136E-16	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.645E-16	1.920E-12	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.421E-14	6.188E-11	CA1, CA12, CA2, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	2.802E-20	1.541E-18	CA12; CA1; CA2; CA5A; CA7; CA6; CA9; CA14

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	SERPINA6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
NA: NA	Obstructive airway diseases	NA	SERPINA6
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
C00-D49: Neoplasms	Renal cancer	C64	CA9
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; CA9
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
J00-J99: Diseases of the respiratory system	Asthma	J45	SERPINA6
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
C00-D49: Neoplasms	Cancer	C00-C96	TP53; CA1; CA9
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1; CA9
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	SERPINA6
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic macular edema	E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9	SERPINA6
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
NA: NA	Edema	NA	CA2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Sideritis brevibracteata

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases