Plant Name: Eleutherococcus giraldii
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 2.165E-09 | 6.734E-06 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 1.289E-07 | 1.477E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 2.646E-07 | 2.505E-04 | FABP3, FFAR1, PPARG, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 1.140E-06 | 8.006E-04 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 2.431E-06 | 1.357E-03 | FABP3, PPARA, PPARG, TLR2 |
| MF | Unclassified; | GO:0004872; receptor activity | 3.348E-06 | 1.823E-03 | FFAR1, FFAR4, HPGD, PPARA, PPARD, PPARG, TLR2, TSHR |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 4.872E-06 | 2.526E-03 | PPARA, PPARG |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 5.475E-06 | 2.622E-03 | PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 7.305E-06 | 3.001E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 7.305E-06 | 3.001E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 7.305E-06 | 3.001E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 7.305E-06 | 3.001E-03 | FABP3, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 9.620E-06 | 3.809E-03 | PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 2.148E-05 | 7.544E-03 | ALOX15, PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 2.188E-05 | 7.562E-03 | HPGD, PPARG |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 2.673E-05 | 8.687E-03 | PPARA, PPARD |
| BP | GO:0051179; localization | GO:0060099; regulation of phagocytosis, engulfment | 2.673E-05 | 8.687E-03 | ALOX15, PPARG |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 2.844E-05 | 8.976E-03 | LMNA, PPARA, PPARD, TLR2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Melanoma | C43 | TLR2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TLR2 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARD; PPARD; PPARG |
| C00-D49: Neoplasms | Cancer | C00-C96 | TLR2 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | PPARG |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Nicotine dependence | F17 | PPARG |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | PPARD |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PPARG; PPARG |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | PPARG |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; PPARD; PPARG; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PPARG |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PPARG |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Radiation sickness | T66 | TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| NA: NA | Dyslipidemia | NA | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PPARG |