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Plant Name: Dracaena draco




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 1.280E-12 2.786E-08 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 4.214E-11 4.588E-07 CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 7.325E-10 3.987E-06 CYP1A2, CYP2C9, CYP3A4
MF GO:0005488; binding GO:0019825; oxygen binding 1.255E-08 5.464E-05 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 2.193E-08 6.821E-05 CYP1A2, CYP2C19, CYP2C9
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 4.017E-08 1.093E-04 CYP1A2, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0008202; steroid metabolic process 2.417E-07 5.220E-04 AKR1B1, CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 2.421E-07 5.220E-04 CYP1A2, CYP2C19, CYP2C9
BP GO:0008152; metabolic process GO:0006805; xenobiotic metabolic process 5.492E-07 8.542E-04 CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF GO:0005488; binding GO:0020037; heme binding 8.739E-07 1.189E-03 CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF GO:0003824; catalytic activity GO:0008395; steroid hydroxylase activity 1.084E-06 1.389E-03 CYP2C19, CYP2C9, CYP3A4
MF GO:0005488; binding GO:0005506; iron ion binding 2.131E-06 2.250E-03 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0009820; alkaloid metabolic process 7.417E-06 6.460E-03 CYP1A2, CYP3A4
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 1.750E-09 2.222E-07 CYP2C9; CYP1A2; CYP3A4; CYP2C19
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 6.289E-08 3.993E-06 CYP2C9; CYP1A2; CYP3A4; CYP2C19
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 1.267E-07 5.364E-06 CYP2C9; CYP1A2; CYP3A4; CYP2C19
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 7.059E-06 2.122E-04 CYP2C9; CYP1A2; CYP3A4
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 1.002E-05 2.122E-04 CYP2C9; CYP1A2; CYP3A4
hsa04976 Bile secretion_Homo sapiens_hsa04976 9.218E-06 2.122E-04 SLCO1B1; SLCO1B3; CYP3A4
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 3.731E-05 5.924E-04 CYP2C9; CYP1A2; AKR1B1; CYP2C19; CYP3A4; HSD17B10
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 3.625E-05 5.924E-04 CYP2C9; MAPK1; CYP2C19
hsa04210 Apoptosis_Homo sapiens_hsa04210 7.052E-05 9.951E-04 LMNA; MAPK1; NFKB1
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 5.171E-04 5.662E-03 MAPK1; NFKB1
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 6.117E-04 5.662E-03 CYP2C9; CYP2C19
hsa04621 NOD-like receptor signaling pathway_Homo sapiens_hsa04621 5.171E-04 5.662E-03 MAPK1; NFKB1
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 6.929E-04 5.662E-03 MAPK1; NFKB1
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 8.241E-04 5.662E-03 MAPK1; NFKB1
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 8.470E-04 5.662E-03 MAPK1; NFKB1
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 5.354E-04 5.662E-03 CYP1A2; CYP3A4
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 8.470E-04 5.662E-03 MAPK1; NFKB1
hsa05131 Shigellosis_Homo sapiens_hsa05131 6.722E-04 5.662E-03 MAPK1; NFKB1
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 8.470E-04 5.662E-03 MAPK1; NFKB1
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 1.612E-03 8.344E-03 MAPK1; NFKB1
hsa05215 Prostate cancer_Homo sapiens_hsa05215 1.255E-03 7.247E-03 MAPK1; NFKB1
hsa05133 Pertussis_Homo sapiens_hsa05133 8.938E-04 5.675E-03 MAPK1; NFKB1
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 1.676E-03 8.344E-03 MAPK1; NFKB1
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 1.708E-03 8.344E-03 MAPK1; NFKB1
hsa05132 Salmonella infection_Homo sapiens_hsa05132 1.173E-03 7.093E-03 MAPK1; NFKB1
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 1.774E-03 8.344E-03 MAPK1; NFKB1
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 1.908E-03 8.656E-03 MAPK1; NFKB1
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 1.708E-03 8.344E-03 MAPK1; NFKB1
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 2.192E-03 9.281E-03 MAPK1; NFKB1
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 2.265E-03 9.281E-03 MAPK1; NFKB1
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 2.265E-03 9.281E-03 MAPK1; NFKB1
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 2.732E-03 1.067E-02 MAPK1; NFKB1
hsa05161 Hepatitis B_Homo sapiens_hsa05161 3.330E-03 1.208E-02 MAPK1; NFKB1
hsa05160 Hepatitis C_Homo sapiens_hsa05160 2.773E-03 1.067E-02 MAPK1; NFKB1
hsa05164 Influenza A_Homo sapiens_hsa05164 4.743E-03 1.628E-02 MAPK1; NFKB1
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 4.380E-03 1.545E-02 MAPK1; HSD17B10
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 5.396E-03 1.757E-02 MAPK1; NFKB1
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 6.449E-03 1.998E-02 MAPK1; NFKB1
hsa05152 Tuberculosis_Homo sapiens_hsa05152 4.903E-03 1.638E-02 MAPK1; NFKB1
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 6.089E-03 1.933E-02 MAPK1; NFKB1
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 7.854E-03 2.375E-02 MAPK1; NFKB1
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 9.824E-03 2.901E-02 MAPK1; NFKB1
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 1.315E-02 3.795E-02 MAPK1; NFKB1
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 1.709E-02 4.666E-02 MAPK1; NFKB1
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 1.727E-02 4.666E-02 MAPK1
hsa04320 Dorso-ventral axis formation_Homo sapiens_hsa04320 1.608E-02 4.539E-02 MAPK1
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 1.786E-02 4.725E-02 AKR1B1
hsa00051 Fructose and mannose metabolism_Homo sapiens_hsa00051 1.904E-02 4.934E-02 AKR1B1
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 2.997E-03 1.119E-02 CYP1A2
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 AKR1B1
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 NFKB1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CYP3A4
C00-D49: Neoplasms Solid tumours C00-D48 MAPK1
C00-D49: Neoplasms Cancer C00-C96 MAPK1; NFKB1
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 AKR1B1
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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Developer & Maintainer:
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