CMAUP Plant Collective Molecular Activities

Plant Name: Alpinia flabellata

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.121E-06	5.774E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.121E-06	5.774E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	2.121E-06	5.774E-03	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.061E-06	5.774E-03	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.061E-06	5.774E-03	ADRA2A, ADRA2C
BP	GO:0032501; multicellular organismal process	GO:0019233; sensory perception of pain	4.217E-06	7.063E-03	CNR1, CNR2, MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	3.596E-07	3.704E-05	CNR2; CNR1; NMUR2; ADRA2C; ADRA2A
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.190E-04	4.559E-03	MAPK1; ADRA2C; ADRA2A
hsa05216	Thyroid cancer_Homo sapiens_hsa05216	1.328E-04	4.559E-03	RXRA; MAPK1
hsa05223	Non-small cell lung cancer_Homo sapiens_hsa05223	4.992E-04	1.028E-02	RXRA; MAPK1
hsa05219	Bladder cancer_Homo sapiens_hsa05219	2.671E-04	6.878E-03	MMP2; MAPK1
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	1.495E-03	1.612E-02	RXRA; MMP2; MAPK1
hsa04912	GnRH signaling pathway_Homo sapiens_hsa04912	1.312E-03	1.612E-02	MMP2; MAPK1
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.612E-03	1.612E-02	MMP2; MAPK1
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	1.550E-03	1.612E-02	MMP2; MAPK1
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	1.943E-03	1.612E-02	ACHE; MAPK1
hsa04723	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.612E-03	1.612E-02	CNR1; MAPK1
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	1.978E-03	1.612E-02	ALOX5; MAPK1
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	2.192E-03	1.612E-02	ALOX5; MAPK1
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	2.192E-03	1.612E-02	RXRA; MAPK1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	2.773E-03	1.904E-02	RXRA; MAPK1
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	6.328E-03	3.902E-02	MMP2; MAPK1
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	6.449E-03	3.902E-02	POLB; MAPK1
hsa04015	Rap1 signaling pathway_Homo sapiens_hsa04015	6.820E-03	3.902E-02	CNR1; MAPK1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	CNR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5; MMP2
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anorexia	F50.0-F50.1	CNR1
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; CNR1; ADRA2A; CNR2; ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	CNR1
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
C00-D49: Neoplasms	Ovarian cancer	C56	CNR1; MMP2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	CNR1
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5; CNR2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5; CNR2
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C; CNR1; CNR1; CNR1; CNR1; CNR1; CNR1
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP2; MAPK1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	CNR1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	CNR1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR1; CNR2
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	CNR1; CNR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5; CNR2
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CNR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C; CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	CNR1; CNR1; CNR1
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
C00-D49: Neoplasms	Cancer	C00-C96	MMP2; MAPK1; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CNR1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chemotherapy-induced nausea	R11	CNR1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C; ALOX5; ALOX5
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	CNR1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	CNR1
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases