CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa05212	Pancreatic cancer_Homo sapiens_hsa05212	5.558E-06	4.946E-04	STAT3; TP53; NFKB1
hsa04210	Apoptosis_Homo sapiens_hsa04210	5.316E-05	1.072E-03	LMNA; TP53; NFKB1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	4.562E-05	1.072E-03	STAT3; TP53; NFKB1
hsa05162	Measles_Homo sapiens_hsa05162	4.876E-05	1.072E-03	STAT3; TP53; NFKB1
hsa05161	Hepatitis B_Homo sapiens_hsa05161	6.024E-05	1.072E-03	STAT3; TP53; NFKB1
hsa05169	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.578E-04	1.833E-03	STAT3; TP53; NFKB1
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	1.648E-04	1.833E-03	STAT3; TP53; NFKB1
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	3.133E-04	3.099E-03	MAPT; TP53; NFKB1
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	4.317E-04	3.704E-03	STAT3; NFKB1
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.108E-04	1.643E-03	CYP3A4; CYP2C19
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	4.897E-04	3.704E-03	STAT3; TP53; NFKB1
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	5.613E-04	3.704E-03	STAT3; NFKB1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	5.613E-04	3.704E-03	ALDH1A1; CYP3A4
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	6.883E-04	3.704E-03	STAT3; NFKB1
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	1.138E-03	4.731E-03	STAT3; TP53; NFKB1
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	6.323E-04	3.704E-03	CYP3A4; CYP2C19
hsa05220	Chronic myeloid leukemia_Homo sapiens_hsa05220	7.075E-04	3.704E-03	TP53; NFKB1
hsa04920	Adipocytokine signaling pathway_Homo sapiens_hsa04920	6.507E-04	3.704E-03	STAT3; NFKB1
hsa05215	Prostate cancer_Homo sapiens_hsa05215	1.049E-03	4.669E-03	TP53; NFKB1
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.348E-03	5.197E-03	STAT3; NFKB1
hsa05222	Small cell lung cancer_Homo sapiens_hsa05222	9.802E-04	4.591E-03	TP53; NFKB1
hsa04211	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.169E-03	4.731E-03	TP53; NFKB1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	8.917E-04	4.409E-03	CYP3A4; CYP2C19
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.402E-03	5.197E-03	STAT3; NFKB1
hsa04931	Insulin resistance_Homo sapiens_hsa04931	1.568E-03	5.581E-03	STAT3; NFKB1
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	1.833E-03	6.024E-03	STAT3; NFKB1
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.895E-03	6.024E-03	TP53; NFKB1
hsa04630	Jak-STAT signaling pathway_Homo sapiens_hsa04630	3.255E-03	9.989E-03	THPO; STAT3
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.895E-03	6.024E-03	TP53; NFKB1
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	5.309E-03	1.432E-02	STAT3; TP53
hsa04062	Chemokine signaling pathway_Homo sapiens_hsa04062	4.524E-03	1.258E-02	STAT3; NFKB1
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	4.200E-03	1.246E-02	TP53; NFKB1
hsa05168	Herpes simplex infection_Homo sapiens_hsa05168	4.431E-03	1.258E-02	TP53; NFKB1
hsa05166	HTLV-I infection_Homo sapiens_hsa05166	8.443E-03	2.210E-02	TP53; NFKB1
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	1.440E-02	3.560E-02	TP53; NFKB1
hsa05216	Thyroid cancer_Homo sapiens_hsa05216	1.584E-02	3.810E-02	TP53
hsa04614	Renin-angiotensin system_Homo sapiens_hsa04614	1.258E-02	3.199E-02	CMA1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
I00-I99: Diseases of the circulatory system	Heart failure	I50	CMA1
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
NA: NA	Gram-positive bacterial infection	NA	CMA1
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3
C00-D49: Neoplasms	Multiple myeloma	C90	STAT3
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CMA1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	STAT3
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	CMA1
C00-D49: Neoplasms	Solid tumours	C00-D48	STAT3; TP53
C00-D49: Neoplasms	Cancer	C00-C96	STAT3; NFKB1; TP53
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: vernonia cinerea

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases