Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
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GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.506E-08 | 4.961E-05 | CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.393E-28 | 3.032E-24 | CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 2.748E-06 | 3.325E-03 | CA2, CA7 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.137E-22 | 1.237E-18 | CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 8.341E-21 | 4.540E-17 | CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|
hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 6.363E-28 | 2.481E-26 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA7; CA6; CA9; CA14 |
hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 1.232E-03 | 2.403E-02 | CASP7; CASP1 |
hsa05133 | Pertussis_Homo sapiens_hsa05133 | 2.277E-03 | 2.960E-02 | CASP7; CASP1 |
hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 4.741E-03 | 4.623E-02 | XDH |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
---|---|---|---|
C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; HIF1A |
I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; HIF1A |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
NA: NA | Edema | NA | CA2 |
I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH |
G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | XDH |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2 |
C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9; HIF1A |
C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |