CMAUP Plant Collective Molecular Activities

Plant Name: Cinnamomum cassia

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.038E-09	2.259E-06	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, TP53
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	8.569E-08	1.244E-04	CA2, CA4, CA9, SLCO1B1, SLCO1B3, TSHR
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.742E-31	2.121E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	4.510E-03	CA2, CA7
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	5.410E-06	4.908E-03	BCL2, MAPT, TP53
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.376E-24	5.853E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.465E-22	1.342E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	6.016E-30	6.197E-28	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa05014	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	3.044E-05	1.568E-03	BCL2; MAPK14; TP53
hsa04976	Bile secretion_Homo sapiens_hsa04976	8.225E-05	2.824E-03	SLCO1B1; CA2; SLCO1B3
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	3.889E-04	6.675E-03	BCL2; MAPK14; TP53
hsa04210	Apoptosis_Homo sapiens_hsa04210	6.101E-04	8.977E-03	LMNA; BCL2; TP53
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	3.889E-04	6.675E-03	BCL2; MAPK14; TP53
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.438E-04	6.675E-03	CA2; CA4
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	1.782E-03	2.039E-02	MAPK14; TP53; MET
hsa05169	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.757E-03	2.039E-02	BCL2; MAPK14; TP53
hsa05210	Colorectal cancer_Homo sapiens_hsa05210	2.497E-03	2.502E-02	BCL2; TP53
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	3.401E-03	2.502E-02	MAPT; MAPK14; TP53
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	2.909E-03	2.502E-02	TP53; MET
hsa05120	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	2.995E-03	2.502E-02	MAPK14; MET
hsa05218	Melanoma_Homo sapiens_hsa05218	3.260E-03	2.502E-02	TP53; MET
hsa05215	Prostate cancer_Homo sapiens_hsa05215	5.071E-03	3.155E-02	BCL2; TP53
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	5.208E-03	3.155E-02	BCL2; TP53; MET
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	6.482E-03	3.709E-02	BCL2; MAPK14
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	7.625E-03	4.134E-02	BCL2; TP53; MET
hsa05222	Small cell lung cancer_Homo sapiens_hsa05222	4.743E-03	3.155E-02	BCL2; TP53
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	8.752E-03	4.507E-02	BCL2; MAPK14

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2; CA9
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MAPK14
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
NA: NA	Edema	NA	CA2
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET
C00-D49: Neoplasms	Prostate cancer	C61	BCL2
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; TP53; CA9
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MAPK14
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	MAPK14; MAPK14
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HCAR2
C00-D49: Neoplasms	Renal cancer	C64	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
NA: NA	Rheumatold arthritis	NA	MAPK14
NA: NA	Acute respiratory distress syndrome	NA	MAPK14
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MAPK14
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MAPK14
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	MAPK14
NA: NA	Inflammatory diseases	NA	MAPK14
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
C00-D49: Neoplasms	Cancer	C00-C96	BCL2; BCL2; MET; TP53; CA1; CA9; MAPK14
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HCAR2
C00-D49: Neoplasms	Breast cancer	C50	BCL2; CA9
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2; MAPK14
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	MAPK14
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases