Plant Name: Geum japonicum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.372E-07 | 2.988E-03 | CA12, CA4, CA7 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 6.247E-07 | 5.113E-03 | ACP1, PTPN1, PTPN2, PTPRF |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.463E-06 | 6.371E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 1.463E-06 | 6.371E-03 | GPBAR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.134E-06 | 7.744E-03 | CA12, CA4, CA7 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 2.924E-06 | 9.097E-03 | PTPN1, PTPN2 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.944E-06 | 9.543E-03 | CA12, CA4, CA7 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.846E-07 | 3.877E-06 | CA12; CA4; CA7 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 1.719E-05 | 1.805E-04 | PTPN1; ACP1; PTPRF |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 7.355E-04 | 5.148E-03 | HSD11B1; CYP1B1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.162E-03 | 6.102E-03 | HSD11B1; CYP1B1 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 2.566E-03 | 8.981E-03 | PTPN1; PTPRF |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.464E-03 | 6.147E-03 | HSD11B1; CYP1B1 |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 4.132E-03 | 1.239E-02 | PTPN1; PTPRF |
| hsa04710 | Circadian rhythm_Homo sapiens_hsa04710 | 2.080E-02 | 4.234E-02 | RORC |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.765E-02 | 4.466E-02 | CYP1B1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.599E-02 | 4.196E-02 | CA4 |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.492E-02 | 4.360E-02 | AKR1B10 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 2.080E-02 | 4.234E-02 | AKR1B10 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 2.218E-02 | 4.234E-02 | AKR1B10 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1 |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4; HSD11B1 |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |