Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
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GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
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MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.516E-11 | 4.981E-08 | CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2 |
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.942E-08 | 4.271E-05 | CYP2C19, CYP2C9, CYP2D6 |
MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 6.917E-08 | 9.413E-05 | CYP2A6, CYP2C19, CYP2C9, CYP2D6 |
BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 3.222E-07 | 3.340E-04 | CYP2A6, CYP2C19, CYP2C9 |
MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 9.919E-07 | 8.000E-04 | CYP2A6, CYP2C19, CYP2C9 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.094E-34 | 2.383E-30 | CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.996E-27 | 5.439E-23 | CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.295E-25 | 1.250E-21 | CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.934E-06 | 1.504E-03 | CYP2A6, CYP2C19, CYP2C9 |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 4.066E-06 | 3.053E-03 | CA2, CA7 |
BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 9.152E-06 | 5.694E-03 | CYP2A6, CYP2C19, CYP2C9, CYP2D6, NPC1 |
MF | GO:0005488; binding | GO:0020037; heme binding | 1.477E-05 | 8.937E-03 | CYP2A6, CYP2C19, CYP2C9, CYP2D6 |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
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hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 9.792E-34 | 7.148E-32 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14; CA13 |
hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.093E-06 | 3.990E-05 | CYP2C9; CYP2A6; CYP2D6; CYP2C19 |
hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 7.840E-05 | 1.908E-03 | CYP2C9; CYP2A6; CYP2D6 |
hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.109E-04 | 2.024E-03 | CYP2C9; CYP2A6; CYP2C19 |
hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.790E-04 | 3.837E-03 | CYP2C9; CYP2D6; CYP2C19 |
hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 2.294E-03 | 2.042E-02 | CYP2C9; CYP2C19 |
hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 3.154E-04 | 3.837E-03 | CA2; CA4 |
hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 5.040E-04 | 5.256E-03 | CYP2C9; CYP2C19 |
hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 3.079E-03 | 2.248E-02 | NFKB1; ESR2 |
hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 2.518E-03 | 2.042E-02 | CYP2C9; CYP2A6 |
hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 5.737E-03 | 3.808E-02 | CYP2A6 |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
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H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE |
K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; ACHE; CA4 |
NA: NA | Upper abdominal bloating | NA | ACHE |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; CYP2D6 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
NA: NA | Edema | NA | CA2 |
A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE |
A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9 |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE |
I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9; NFKB1; ACHE |
C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; ACHE; ACHE |
C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1; ACHE |
A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE |
C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE |
NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1; ACHE |