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Plant Name: Corydalis rhizoma




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
FFAR1; FFAR4; HTR7; ADRA1A; HTR2A; DRD4; DRD1; DRD2; HTR1A;
Peptide receptor (family A GPCR)
TSHR; NPSR1; CXCR1;
Enzyme_unclassified
TDP1; PLA2G1B; BLM; FAAH; RECQL; TERT; PIK3R1; GLO1; HPGD; MPO; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALOX12; NOX4; PYGL; POLB;
Protein Kinase
AKT1; MET; CAMK2B; CSNK2A1; DAPK1; AXL; FLT3; NEK6; PKN1; NEK2; SRC; IGF1R; PTK2; AURKB; GSK3B; CDK1; PIM1; NUAK1; ALK; KDR;
Lyase
CA12; CA5B; CA3; CA14; CA7; CA5A; CA4; CA6; CA2; CA9; CA1;
Nuclear hormone receptor subfamily 1 group A
THRB;
Nuclear hormone receptor subfamily 1 group C
PPARA; PPARG; PPARD;
Nuclear hormone receptor subfamily 3 group A
ESR1; ESR2;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; XDH;
Metallo protease
MMP13; MMP3; MMP2; MMP9;
Serine protease
ELANE;
Aspartic protease
BACE1;
Transcription Factor
STAT6; HIF1A; NFKB1; TP53;
Bromodomain
CREBBP;
ATP-binding cassette
ABCC1; ABCG2;
Unclassified
LMNA; FABP5; MAPT; FABP3; F3; HTT;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP19A1; CYP1A2; CYP2C19; CYP2C9; CYP2D6; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Bromodomain CREBBP CREB-binding protein Q92793 CHEMBL5747
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Showing 1 to 10 of 99 entries
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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO TypeGO CategoryEnriched GO Termsp-ValueAdjusted p-ValueEnriched Genes
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 3.211E-12 1.110E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 1.908E-11 5.541E-09 CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 7.928E-10 1.439E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 2.458E-09 3.965E-07 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 2.458E-09 3.965E-07 CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4
BP Unclassified; GO:2000021; regulation of ion homeostasis 1.143E-07 1.290E-05 CA2, CA7, DRD1, DRD2, HTR2A, HTT, KDR, NPSR1, PLA2G1B, SRC
BP Unclassified; GO:0032846; positive regulation of homeostatic process 2.474E-07 2.482E-05 AURKB, CA2, CA7, DRD1, DRD2, HIF1A, HTT, NEK2, NPSR1, PLA2G1B
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 4.882E-07 4.543E-05 ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B
BP Unclassified; GO:0032844; regulation of homeostatic process 9.220E-07 8.194E-05 AURKB, CA2, CA7, DRD1, DRD2, HIF1A, HTR2A, HTT, KDR, NEK2, NPSR1, PLA2G1B, SRC
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 1.061E-06 9.241E-05 AKT1, HIF1A, LMNA, PPARD, SRC, TERT, TP53
Showing 1 to 10 of 118 entries
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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway IDPathway Namep-ValueAdjusted p-ValueEnriched Genes
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 4.149E-07 4.927E-06 CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 2.402E-04 7.736E-04 CYP1A2; XDH
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 4.502E-05 1.989E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 2.312E-08 5.491E-07 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 8.381E-11 3.432E-09 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 1.752E-05 9.512E-05 CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP3A4
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 2.976E-22 5.654E-20 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 1.644E-06 1.487E-05 CYP2C9; CYP2D6; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 4.931E-08 1.041E-06 CYP2C9; CYP2C8; MAOA; CYP2D6; CYP1A2; CYP3A4; CYP2C19
hsa00983 Drug metabolism - other enzymes_Homo sapiens_hsa00983 2.180E-02 3.944E-02 CYP3A4; XDH
Showing 1 to 10 of 108 entries
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Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease CategoryDisease NameICD10 CodeLinked Targets
A00-B99: Certain infectious and parasitic diseases Trematode infection B66.9 ESR1
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
A00-B99: Certain infectious and parasitic diseases Septic shock A41.9 ELANE
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9; DRD2
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
A00-B99: Certain infectious and parasitic diseases Malaria B54 CYP2D6
Showing 1 to 10 of 295 entries
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Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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