Plant Name: Gymnema sylvestre
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CXCR1; NPSR1; NMUR2; | |
| ADRA2C; ADRA2A; DRD4; | |
| PTPN1; | |
| RECQL; PLA2G1B; TDP1; PIK3R1; GLO1; MPO; AKR1B1; HSD17B2; ALOX12; ALOX15; NOX4; HSD17B10; PYGL; POLB; | |
| GAA; ACHE; | |
| SRC; NEK6; DAPK1; AKT1; ALK; CAMK2B; AXL; MET; FLT3; PKN1; CDK1; MAPK1; PIM1; IGF1R; NUAK1; NEK2; KDR; GSK3B; PTK2; AURKB; CSNK2A1; | |
| CA2; CA9; CA12; CA5A; CA7; CA3; CA14; CA5B; CA4; CA6; CA1; | |
| KDM4E; | |
| MAOA; ALOX5; XDH; | |
| BACE1; | |
| MMP13; MMP9; MMP1; MMP3; MMP2; | |
| HIF1A; TP53; NFKB1; STAT6; | |
| ABCG2; ABCC1; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | PYGL | Liver glycogen phosphorylase | P06737 | CHEMBL2568 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | PIK3R1 | PI3-kinase p85-alpha subunit | P27986 | CHEMBL2506 |
| Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Metallo protease | MMP13 | Matrix metalloproteinase 13 | P45452 | CHEMBL280 |
| Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Peptide receptor (family A GPCR) | CXCR1 | Interleukin-8 receptor A | P25024 | CHEMBL4029 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Peptide receptor (family A GPCR) | NMUR2 | Neuromedin-U receptor 2 | Q9GZQ4 | CHEMBL1075144 |
| Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Protein Kinase | NEK6 | Serine/threonine-protein kinase NEK6 | Q9HC98 | CHEMBL4309 |
| Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
| Protein Kinase | AKT1 | Serine/threonine-protein kinase AKT | P31749 | CHEMBL4282 |
| Protein Kinase | ALK | ALK tyrosine kinase receptor | Q9UM73 | CHEMBL4247 |
| Protein Kinase | CAMK2B | CaM kinase II beta | Q13554 | CHEMBL4121 |
| Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | PKN1 | Protein kinase N1 | Q16512 | CHEMBL3384 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Protein Kinase | NUAK1 | NUAK family SNF1-like kinase 1 | O60285 | CHEMBL5784 |
| Protein Kinase | NEK2 | Serine/threonine-protein kinase NEK2 | P51955 | CHEMBL3835 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
| Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Small molecule receptor (family A GPCR) | ADRA2C | Alpha-2c adrenergic receptor | P18825 | CHEMBL1916 |
| Small molecule receptor (family A GPCR) | ADRA2A | Alpha-2a adrenergic receptor | P08913 | CHEMBL1867 |
| Small molecule receptor (family A GPCR) | DRD4 | Dopamine D4 receptor | P21917 | CHEMBL219 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Transcription Factor | STAT6 | Signal transducer and activator of transcription 6 | P42226 | CHEMBL5401 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0005524; ATP binding | 5.345E-11 | 2.425E-08 | ABCC1, ABCG2, AKT1, ALK, AURKB, AXL, CAMK2B, CDK1, CSNK2A1, DAPK1, FLT3, GSK3B, IGF1R, KDR, MAPK1, MET, NEK2, NEK6, NUAK1, PIM1, PKN1, PTK2, PYGL, RECQL, SRC, TP53 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 3.407E-10 | 1.216E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 5.334E-10 | 1.815E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4, NOX4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 8.891E-10 | 2.766E-07 | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4, XDH |
| MF | GO:0005488; binding | GO:0020037; heme binding | 2.300E-09 | 6.262E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4, MPO, NOX4, SRC |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.810E-09 | 7.283E-07 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP13, MMP2, MMP3, MMP9, PTPN1, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004674; protein serine/threonine kinase activity | 3.246E-09 | 8.218E-07 | AKT1, ALK, AURKB, CAMK2B, CDK1, CSNK2A1, DAPK1, GSK3B, MAPK1, NEK2, NEK6, NUAK1, PIM1, PKN1 |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 2.143E-08 | 3.921E-06 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, MAPK1, NEK6, PKN1, SRC |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 2.792E-08 | 5.025E-06 | AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, MAPK1, PKN1 |
| CC | GO:0016020; membrane | GO:0005886; plasma membrane | 3.878E-08 | 6.650E-06 | ABCC1, ABCG2, ACHE, ADRA2A, ADRA2C, AKT1, ALK, ALOX12, ALOX15, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CAMK2B, CSNK2A1, CXCR1, DAPK1, DRD4, FLT3, GAA, GLO1, GSK3B, HSD17B10, IGF1R, KDR, MAPK1, MET, MMP2, NMUR2, NPSR1, PIK3R1, PIM1, PKN1, PTK2, PTPN1, SRC, TDP1 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 5.072E-08 | 8.414E-06 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 1.476E-07 | 2.216E-05 | ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B |
| BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 2.354E-07 | 3.328E-05 | HIF1A, MMP1, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 2.526E-07 | 3.460E-05 | CYP1A2, CYP2C8, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0030168; platelet activation | 3.034E-07 | 4.103E-05 | ADRA2A, ADRA2C, AKT1, AXL, MAPK1, PIK3R1, SRC |
| BP | Unclassified; | GO:0044243; multicellular organismal catabolic process | 4.896E-07 | 6.202E-05 | MMP1, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| MF | GO:0003824; catalytic activity | GO:0101020; estrogen 16-alpha-hydroxylase activity | 6.298E-07 | 7.704E-05 | CYP1A1, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 1.256E-06 | 1.417E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | Unclassified; | GO:0044259; multicellular organismal macromolecule metabolic process | 1.297E-06 | 1.448E-04 | HIF1A, MMP1, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.397E-06 | 1.553E-04 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0065007; biological regulation | GO:0000187; activation of MAPK activity | 1.792E-06 | 1.941E-04 | ALK, CDK1, DRD4, MAPK1, PKN1, PLA2G1B, PTPN1 |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 3.122E-06 | 3.176E-04 | ADRA2A, AURKB, CA2, CA7, HIF1A, KDR, MAPK1, NEK2, NPSR1, PLA2G1B, SRC |
| BP | GO:0051179; localization | GO:0046903; secretion | 3.509E-06 | 3.473E-04 | ALOX5, AXL, CA2, CA9, CXCR1, DRD4, GAA, HIF1A, MAPK1, MMP9, MPO, NFKB1, NMUR2, PLA2G1B, PYGL, XDH |
| MF | GO:0005488; binding | GO:0051379; epinephrine binding | 3.496E-06 | 3.473E-04 | ADRA2A, ADRA2C, DRD4 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 3.598E-06 | 3.545E-04 | AURKB, CA2, CA7, HIF1A, MAPK1, NEK2, NPSR1, PLA2G1B |
| BP | GO:0032502; developmental process | GO:0007568; aging | 4.230E-06 | 4.075E-04 | AKT1, AURKB, CDK1, CYP1A1, MPO, NOX4, POLB, TP53 |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 4.701E-06 | 4.509E-04 | AKR1B1, AXL, CDK1, CYP1B1, STAT6 |
| BP | GO:0008152; metabolic process | GO:0030574; collagen catabolic process | 6.445E-06 | 5.636E-04 | MMP1, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0009987; cellular process | GO:0071276; cellular response to cadmium ion | 7.125E-06 | 6.132E-04 | AKT1, CYP1A2, MAPK1, MMP9 |
| BP | GO:0065007; biological regulation | GO:0032148; activation of protein kinase B activity | 1.041E-05 | 8.782E-04 | ADRA2A, ADRA2C, AKT1, SRC |
| BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 1.068E-05 | 8.978E-04 | AXL, KDR, PIK3R1, PTK2, SRC |
| BP | GO:0008152; metabolic process | GO:0008610; lipid biosynthetic process | 1.315E-05 | 1.068E-03 | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B2, PIK3R1, PLA2G1B |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.358E-05 | 1.095E-03 | CYP1A2, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 1.358E-05 | 1.095E-03 | CYP1A2, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 1.610E-05 | 1.256E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 1.610E-05 | 1.256E-03 | ALOX12, ALOX15 |
| BP | GO:0009987; cellular process | GO:0022617; extracellular matrix disassembly | 1.683E-05 | 1.304E-03 | MMP1, MMP13, MMP2, MMP3, MMP9 |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 2.394E-05 | 1.767E-03 | FLT3, GSK3B, HIF1A, MAPK1, NEK6, NFKB1, PIK3R1, PIM1, PKN1, SRC, TP53 |
| BP | GO:0008152; metabolic process | GO:0031331; positive regulation of cellular catabolic process | 2.997E-05 | 2.161E-03 | ADRA2A, AKT1, CDK1, DAPK1, GSK3B, HIF1A, KDR, PTK2, PTPN1 |
| BP | GO:0009987; cellular process | GO:0090199; regulation of release of cytochrome c from mitochondria | 3.232E-05 | 2.285E-03 | AKT1, LMNA, MMP9, TP53 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 3.415E-05 | 2.391E-03 | ALOX12, ALOX15, ALOX5 |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 3.464E-05 | 2.411E-03 | AXL, MET, NOX4, PIK3R1, PTK2, SRC |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 3.846E-05 | 2.625E-03 | IGF1R, KDR, PTK2, SRC |
| BP | GO:0009987; cellular process | GO:2001243; negative regulation of intrinsic apoptotic signaling pathway | 4.114E-05 | 2.779E-03 | AKT1, HIF1A, MMP9, PTPN1, SRC |
| BP | GO:0065007; biological regulation | GO:1904355; positive regulation of telomere capping | 4.135E-05 | 2.779E-03 | AURKB, MAPK1, NEK2 |
| MF | GO:0003824; catalytic activity | GO:0035173; histone kinase activity | 4.135E-05 | 2.779E-03 | AURKB, CDK1, PKN1 |
| BP | GO:0065007; biological regulation | GO:0042593; glucose homeostasis | 4.458E-05 | 2.951E-03 | ADRA2A, AKT1, HIF1A, NOX4, PIK3R1, PYGL |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 4.817E-05 | 3.131E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 4.817E-05 | 3.131E-03 | CYP1A1, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 4.817E-05 | 3.131E-03 | ALOX12, ALOX15 |
| MF | GO:0060089; molecular transducer activity | GO:0004938; alpha2-adrenergic receptor activity | 4.817E-05 | 3.131E-03 | ADRA2A, ADRA2C |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 4.817E-05 | 3.131E-03 | ALOX12, ALOX15 |
| CC | GO:0044464; cell part | GO:0005739; mitochondrion | 4.844E-05 | 3.139E-03 | AKT1, CA5A, CA5B, CDK1, CYP1A1, CYP1B1, GSK3B, HSD17B10, MAOA, MAPK1, MMP2, MPO, NFKB1, NOX4, SRC, TP53 |
| BP | GO:0065007; biological regulation | GO:0098771; inorganic ion homeostasis | 5.237E-05 | 3.374E-03 | ABCG2, CA12, CA2, CA7, DRD4, HIF1A, MAPK1, NMUR2, NPSR1, PLA2G1B, TP53 |
| BP | GO:0002376; immune system process | GO:0048534; hematopoietic or lymphoid organ development | 5.861E-05 | 3.732E-03 | FLT3, HIF1A, KDR, MAPK1, PKN1, POLB |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 6.348E-05 | 3.995E-03 | AKT1, HIF1A, LMNA, SRC, TP53 |
| BP | GO:0008152; metabolic process | GO:0005977; glycogen metabolic process | 6.675E-05 | 4.189E-03 | AKT1, GAA, GSK3B, PYGL |
| BP | GO:0008152; metabolic process | GO:0044283; small molecule biosynthetic process | 6.788E-05 | 4.247E-03 | AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, MPO, PLA2G1B |
| MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 7.598E-05 | 4.660E-03 | AKR1B1, CYP19A1, CYP1A2, NOX4, XDH |
| BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 7.995E-05 | 4.876E-03 | CYP1A1, POLB, TP53 |
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 8.509E-05 | 5.175E-03 | AKT1, CYP1A1, CYP1B1, FLT3, MAPK1, NFKB1, NOX4, SRC |
| BP | GO:0008152; metabolic process | GO:0097164; ammonium ion metabolic process | 9.433E-05 | 5.658E-03 | ACHE, AKR1B1, CSNK2A1, DRD4, MAOA, PLA2G1B |
| BP | GO:0065007; biological regulation | GO:0032431; activation of phospholipase A2 activity | 9.608E-05 | 5.670E-03 | NMUR2, PLA2G1B |
| BP | GO:0065007; biological regulation | GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | 9.608E-05 | 5.670E-03 | ADRA2A, ADRA2C |
| BP | GO:0009987; cellular process | GO:0032811; negative regulation of epinephrine secretion | 9.608E-05 | 5.670E-03 | ADRA2A, ADRA2C |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 9.608E-05 | 5.670E-03 | CYP1A1, CYP1A2 |
| MF | GO:0003824; catalytic activity | GO:0004222; metalloendopeptidase activity | 1.023E-04 | 5.990E-03 | MMP1, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0009987; cellular process | GO:0032461; positive regulation of protein oligomerization | 1.058E-04 | 6.123E-03 | MMP1, MMP3, TP53 |
| BP | GO:0051179; localization | GO:0050482; arachidonic acid secretion | 1.058E-04 | 6.123E-03 | DRD4, NMUR2, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 1.058E-04 | 6.123E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0065007; biological regulation | GO:0048872; homeostasis of number of cells | 1.066E-04 | 6.142E-03 | AXL, FLT3, HIF1A, PKN1, POLB |
| BP | GO:0051179; localization | GO:0051222; positive regulation of protein transport | 1.358E-04 | 7.642E-03 | ACHE, CDK1, GSK3B, HIF1A, MAPK1, PIK3R1, PLA2G1B, SRC, TP53 |
| BP | GO:0032502; developmental process | GO:0051094; positive regulation of developmental process | 1.421E-04 | 7.953E-03 | ADRA2C, AKT1, ALOX12, AXL, CA2, CAMK2B, CDK1, CYP1B1, HIF1A, KDR, LMNA, NFKB1, PIM1, SRC, STAT6 |
| BP | GO:0008152; metabolic process | GO:0006706; steroid catabolic process | 1.540E-04 | 8.470E-03 | CYP19A1, CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0051122; hepoxilin biosynthetic process | 1.597E-04 | 8.630E-03 | ALOX12, ALOX15 |
| MF | GO:0005488; binding | GO:0051380; norepinephrine binding | 1.597E-04 | 8.630E-03 | ADRA2A, DRD4 |
| BP | GO:0008152; metabolic process | GO:0045913; positive regulation of carbohydrate metabolic process | 1.647E-04 | 8.815E-03 | AKT1, HIF1A, NFKB1, SRC |
| BP | GO:0051179; localization | GO:0043269; regulation of ion transport | 1.648E-04 | 8.815E-03 | ADRA2A, AKT1, CA2, CA7, CAMK2B, DAPK1, DRD4, MMP9, NPSR1, PLA2G1B |
| BP | GO:0051179; localization | GO:1900182; positive regulation of protein localization to nucleus | 1.821E-04 | 9.624E-03 | AKT1, CDK1, MAPK1, PIK3R1, SRC |
| MF | GO:0005488; binding | GO:0002039; p53 binding | 1.843E-04 | 9.693E-03 | GSK3B, HIF1A, NUAK1, TP53 |
| BP | GO:0002376; immune system process | GO:0002684; positive regulation of immune system process | 1.900E-04 | 9.946E-03 | AKT1, AXL, CA2, HIF1A, MAPK1, MMP2, NFKB1, PIK3R1, PLA2G1B, PTK2, SRC, STAT6, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.005E-24 | 5.553E-20 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.539E-17 | 8.379E-14 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.480E-16 | 4.508E-13 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0045862; positive regulation of proteolysis | 1.916E-04 | 1.000E-02 | ADRA2A, AKT1, CDK1, DAPK1, GSK3B, PTK2, SRC, XDH |
| BP | GO:0008152; metabolic process | GO:0016572; histone phosphorylation | 1.930E-04 | 1.000E-02 | AURKB, CDK1, PKN1 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 1.930E-04 | 1.000E-02 | AKT1, PTPN1, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.847E-23 | 3.362E-21 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.020E-12 | 9.279E-11 | CAMK2B; SRC; MMP2; PIK3R1; HIF1A; MMP9; PTK2; IGF1R; KDR; AKT1; MAPK1; TP53; MET |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 3.150E-11 | 1.911E-09 | GSK3B; FLT3; MMP1; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; NFKB1; PTK2; IGF1R; AKT1; MAPK1; MET; TP53 |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 2.106E-10 | 9.583E-09 | MMP1; DAPK1; SRC; MMP2; MAPK1; MMP9; TP53 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 7.514E-09 | 2.735E-07 | FLT3; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 8.464E-08 | 1.229E-06 | GSK3B; KDR; AKT1; MAPK1; PIK3R1; PKN1; TP53; MET; PTK2; NFKB1; IGF1R |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 4.011E-08 | 1.043E-06 | ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 5.559E-08 | 1.124E-06 | GSK3B; AKT1; MAPK1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 4.744E-08 | 1.079E-06 | CAMK2B; GSK3B; SRC; AKT1; MAPK1; PIK3R1; PTK2 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 3.391E-08 | 1.029E-06 | FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R |
| hsa04510 | Focal adhesion_Homo sapiens_hsa04510 | 9.141E-08 | 1.229E-06 | GSK3B; SRC; KDR; AKT1; MAPK1; PIK3R1; MET; PTK2; IGF1R |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 8.964E-08 | 1.229E-06 | FLT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 1.013E-07 | 1.229E-06 | SRC; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1 |
| hsa04370 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.355E-07 | 1.541E-06 | SRC; KDR; AKT1; MAPK1; PIK3R1; PTK2 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 1.991E-07 | 2.013E-06 | CAMK2B; AKT1; MAPK1; PIK3R1; TP53; IGF1R |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 1.531E-07 | 1.639E-06 | CAMK2B; AKT1; MAPK1; PIK3R1; HIF1A; NFKB1; IGF1R |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 9.967E-08 | 1.229E-06 | CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 3.388E-07 | 3.245E-06 | AKT1; MAPK1; PIK3R1; TP53; MET; IGF1R |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 3.685E-07 | 3.353E-06 | GSK3B; SRC; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 3.887E-07 | 3.369E-06 | GSK3B; SRC; AKT1; MAPK1; PIK3R1; TP53; HIF1A |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 4.359E-07 | 3.449E-06 | CAMK2B; GSK3B; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04062 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 6.743E-07 | 5.113E-06 | GSK3B; CXCR1; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PTK2 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 8.743E-08 | 1.229E-06 | CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 4.342E-07 | 3.449E-06 | PTPN1; CSNK2A1; SRC; MAPK1; MET; IGF1R |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 2.733E-06 | 1.776E-05 | MMP2; PIM1; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 2.883E-06 | 1.809E-05 | PLA2G1B; KDR; AKT1; MAPK1; PIK3R1; MET; NFKB1; IGF1R |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 2.431E-06 | 1.702E-05 | SRC; MMP2; AKT1; MAPK1; PIK3R1; MMP9 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 4.261E-06 | 2.451E-05 | PTPN1; GSK3B; AKT1; PIK3R1; PYGL; NFKB1 |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 4.492E-06 | 2.478E-05 | MMP3; AKT1; MAPK1; PIK3R1; MMP9; NFKB1 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 1.784E-06 | 1.299E-05 | GSK3B; AKT1; MAPK1; PIK3R1; TP53 |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 2.591E-06 | 1.746E-05 | ALK; AKT1; MAPK1; PIK3R1; TP53 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.987E-06 | 2.670E-05 | CYP2C8; MAOA; ALOX5; ALOX15; MAPK1; ALOX12 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.392E-05 | 6.179E-05 | GSK3B; CSNK2A1; CDK1; AKT1; PIK3R1; TP53; NFKB1 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 4.309E-06 | 2.451E-05 | GSK3B; AKT1; MAPK1; PIK3R1; TP53 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.531E-05 | 6.481E-05 | POLB; SRC; CDK1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 7.429E-06 | 3.654E-05 | ABCC1; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 1.340E-05 | 6.096E-05 | GSK3B; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 1.521E-05 | 6.481E-05 | GSK3B; CSNK2A1; AKT1; PIK3R1; TP53; NFKB1 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 5.879E-06 | 2.972E-05 | AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.910E-05 | 7.093E-05 | PLA2G1B; MAOA; GAA; ALOX15; AKR1B1; ALOX12; PYGL; CYP3A4; CYP19A1; HSD17B10; CYP2C8; ALOX5; HSD17B2; CYP1A2; CYP1A1; XDH |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 4.309E-06 | 2.451E-05 | CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 1.794E-05 | 6.947E-05 | LMNA; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.845E-05 | 6.995E-05 | SRC; KDR; AKT1; MAPK1; PIK3R1; MET; IGF1R |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 9.674E-06 | 4.514E-05 | AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04662 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 9.674E-06 | 4.514E-05 | GSK3B; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa05211 | Renal cell carcinoma_Homo sapiens_hsa05211 | 5.879E-06 | 2.972E-05 | AKT1; MAPK1; PIK3R1; MET; HIF1A |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 2.050E-05 | 7.462E-05 | ABCC1; PIM1; CYP1B1; MAPK1; TP53; MMP9; MET; NFKB1 |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.722E-05 | 6.947E-05 | PTPN1; GSK3B; AKT1; MAPK1; PIK3R1; PYGL |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 7.355E-05 | 2.434E-04 | CAMK2B; ACHE; AKT1; MAPK1; PIK3R1 |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 4.054E-05 | 1.392E-04 | CDK1; AKT1; MAPK1; PIK3R1; IGF1R |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 3.317E-05 | 1.161E-04 | AKT1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.710E-05 | 6.947E-05 | CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 5.391E-05 | 1.817E-04 | GSK3B; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.156E-05 | 7.694E-05 | AKT1; PIK3R1; TP53; NFKB1; PTK2 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 9.830E-05 | 3.139E-04 | ALOX5; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.496E-04 | 4.463E-04 | CAMK2B; GSK3B; MAOA; AKT1; DRD4 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 2.341E-04 | 6.657E-04 | GSK3B; AKT1; MAPK1; PIK3R1; IGF1R |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 5.139E-04 | 1.375E-03 | POLB; GSK3B; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 4.936E-04 | 1.341E-03 | AKT1; MAPK1; PIK3R1; ADRA2C; ADRA2A |
| hsa05164 | Influenza A_Homo sapiens_hsa05164 | 6.105E-04 | 1.587E-03 | GSK3B; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa05152 | Tuberculosis_Homo sapiens_hsa05152 | 6.593E-04 | 1.667E-03 | CAMK2B; SRC; AKT1; MAPK1; NFKB1 |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 4.424E-04 | 1.220E-03 | CAMK2B; SRC; MMP2; MAPK1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.087E-03 | 2.638E-03 | CAMK2B; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04750 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 5.857E-04 | 1.545E-03 | CAMK2B; SRC; ALOX12; PIK3R1 |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 6.562E-04 | 1.667E-03 | AKT1; MAPK1; PIK3R1; HIF1A |
| hsa04620 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 7.868E-04 | 1.935E-03 | AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04611 | Platelet activation_Homo sapiens_hsa04611 | 1.327E-03 | 3.137E-03 | SRC; AKT1; MAPK1; PIK3R1 |
| hsa05142 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 7.325E-04 | 1.826E-03 | AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04114 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.368E-03 | 3.192E-03 | CAMK2B; CDK1; MAPK1; IGF1R |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 8.843E-05 | 2.874E-04 | AKT1; MAPK1; PIK3R1; HIF1A |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.773E-03 | 4.034E-03 | AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 1.823E-03 | 4.095E-03 | AKT1; MAPK1; PIK3R1; IGF1R |
| hsa04670 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.173E-03 | 2.810E-03 | MMP2; PIK3R1; MMP9; PTK2 |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 2.313E-03 | 5.013E-03 | CAMK2B; GSK3B; CSNK2A1; TP53 |
| hsa04360 | Axon guidance_Homo sapiens_hsa04360 | 1.539E-03 | 3.545E-03 | GSK3B; MAPK1; MET; PTK2 |
| hsa04144 | Endocytosis_Homo sapiens_hsa04144 | 3.430E-03 | 6.784E-03 | CXCR1; SRC; KDR; MET; IGF1R |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 2.434E-03 | 5.151E-03 | CXCR1; AKT1; MAPK1; PIK3R1 |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.442E-04 | 4.450E-04 | CXCR1; SRC; MET; NFKB1 |
| hsa04261 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.687E-03 | 5.575E-03 | CAMK2B; AKT1; MAPK1; PIK3R1 |
| hsa05100 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 2.453E-04 | 6.869E-04 | SRC; PIK3R1; MET; PTK2 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.889E-03 | 5.907E-03 | GSK3B; AKT1; PIK3R1; NFKB1 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 3.399E-03 | 6.784E-03 | PIM1; AKT1; STAT6; PIK3R1 |
| hsa04921 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 3.399E-03 | 6.784E-03 | CAMK2B; SRC; MAPK1; PIK3R1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.900E-04 | 5.488E-04 | CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.210E-04 | 3.796E-04 | CYP2C8; CYP1A2; CYP1A1; CYP3A4 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 4.229E-03 | 8.188E-03 | BACE1; GSK3B; MAPK1; HSD17B10 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.527E-04 | 4.482E-04 | CYP2C8; MAOA; CYP1A2; CYP3A4 |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 5.937E-03 | 1.091E-02 | CSNK2A1; CDK1; TP53; NFKB1 |
| hsa04810 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 9.813E-03 | 1.717E-02 | SRC; MAPK1; PIK3R1; PTK2 |
| hsa04060 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 2.001E-02 | 3.113E-02 | CXCR1; FLT3; KDR; MET |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 1.765E-02 | 2.817E-02 | AKT1; MAPK1; TP53; NFKB1 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 2.310E-02 | 3.474E-02 | NMUR2; ADRA2C; ADRA2A; DRD4 |
| hsa04152 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.263E-02 | 2.148E-02 | AKT1; PIK3R1; IGF1R |
| hsa04530 | Tight junction_Homo sapiens_hsa04530 | 1.711E-02 | 2.755E-02 | CSNK2A1; SRC; AKT1 |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 1.263E-02 | 2.148E-02 | GSK3B; CDK1; TP53 |
| hsa04916 | Melanogenesis_Homo sapiens_hsa04916 | 7.035E-03 | 1.255E-02 | CAMK2B; GSK3B; MAPK1 |
| hsa04666 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 5.757E-03 | 1.069E-02 | AKT1; MAPK1; PIK3R1 |
| hsa04922 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 7.231E-03 | 1.278E-02 | CAMK2B; AKT1; PYGL |
| hsa05146 | Amoebiasis_Homo sapiens_hsa05146 | 7.035E-03 | 1.255E-02 | PIK3R1; NFKB1; PTK2 |
| hsa04540 | Gap junction_Homo sapiens_hsa04540 | 4.936E-03 | 9.358E-03 | SRC; CDK1; MAPK1 |
| hsa04664 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 2.384E-03 | 5.104E-03 | AKT1; MAPK1; PIK3R1 |
| hsa05132 | Salmonella infection_Homo sapiens_hsa05132 | 4.629E-03 | 8.869E-03 | MAPK1; PKN1; NFKB1 |
| hsa04213 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 2.004E-03 | 4.447E-03 | AKT1; PIK3R1; IGF1R |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.758E-05 | 6.947E-05 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 2.696E-03 | 5.575E-03 | CA2; CYP3A4; ABCG2 |
| hsa05131 | Shigellosis_Homo sapiens_hsa05131 | 2.095E-03 | 4.594E-03 | SRC; MAPK1; NFKB1 |
| hsa05140 | Leishmaniasis_Homo sapiens_hsa05140 | 3.302E-02 | 4.732E-02 | MAPK1; NFKB1 |
| hsa04971 | Gastric acid secretion_Homo sapiens_hsa04971 | 3.385E-02 | 4.813E-02 | CAMK2B; CA2 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 3.469E-02 | 4.894E-02 | MAPK1; NFKB1 |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 3.057E-02 | 4.415E-02 | AKT1; NFKB1 |
| hsa04720 | Long-term potentiation_Homo sapiens_hsa04720 | 2.742E-02 | 4.058E-02 | CAMK2B; MAPK1 |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.977E-02 | 4.334E-02 | CDK1; TP53 |
| hsa05031 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.820E-02 | 4.138E-02 | CAMK2B; MAOA |
| hsa04730 | Long-term depression_Homo sapiens_hsa04730 | 2.297E-02 | 3.474E-02 | MAPK1; IGF1R |
| hsa05321 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.666E-02 | 3.977E-02 | STAT6; NFKB1 |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 2.018E-02 | 3.113E-02 | AKT1; PIK3R1 |
| hsa04621 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.087E-02 | 3.191E-02 | MAPK1; NFKB1 |
| hsa05217 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.951E-02 | 3.088E-02 | GSK3B; TP53 |
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.018E-02 | 3.113E-02 | GAA; PYGL |
| hsa05030 | Cocaine addiction_Homo sapiens_hsa05030 | 1.569E-02 | 2.549E-02 | MAOA; NFKB1 |
| hsa04930 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.508E-02 | 2.473E-02 | MAPK1; PIK3R1 |
| hsa04973 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.334E-02 | 2.227E-02 | AKT1; PIK3R1 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.391E-02 | 2.301E-02 | CYP3A4; XDH |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 1.278E-02 | 2.153E-02 | ABCC1; ABCG2 |
| hsa04960 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.013E-02 | 1.757E-02 | MAPK1; PIK3R1 |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 5.694E-03 | 1.068E-02 | MAPK1; TP53 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 6.086E-03 | 1.108E-02 | GAA; AKR1B1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 3.602E-03 | 7.050E-03 | CA2; CA4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.490E-04 | 4.463E-04 | CYP1A2; XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | SRC |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | GSK3B; SRC |
| C00-D49: Neoplasms | Ovarian cancer | C56 | MMP2; KDR; KDR; KDR; KDR |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | ADRA2C; PLA2G1B; ALOX5; ALOX5 |
| I00-I99: Diseases of the circulatory system | Heart disease | I00-I52 | MET |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE |
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3 |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | MPO; MAOA; ACHE |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | FLT3; AKT1; MMP2; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MMP13; CDK1; ADRA2C; ADRA2A; ACHE; IGF1R |
| K00-K95: Diseases of the digestive system | Peptic ulcer | K25-K27 | ADRA2C |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | ADRA2C; MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ADRA2C; MAOA; GSK3B; ACHE; ACHE; ACHE |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | ADRA2C; PLA2G1B |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | ALOX5 |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MMP9 |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5 |
| J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3 |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | ADRA2C; MAOA |
| C00-D49: Neoplasms | Breast cancer | C50 | FLT3; FLT3; CYP19A1; CA9; CDK1; KDR; KDR; KDR; IGF1R |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | SRC |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR |
| C00-D49: Neoplasms | Glioblastoma | NA | FLT3 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | XDH; AKR1B1; ABCC1; ABCC1 |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR |
| C00-D49: Neoplasms | Cancer | C00-C96 | FLT3; FLT3; AKT1; HIF1A; TP53; MET; CA9; CDK1; MAPK1; MMP9; NFKB1; PIM1; MMP2; KDR; GSK3B; ACHE; SRC; PTK2; CA1; IGF1R; CSNK2A1 |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; SRC |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic nephropathy | E11.21 | MMP1; ADRA2C |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| NA: NA | Edema | NA | CA2 |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | FLT3; FLT3; TP53; TP53; AURKB |
| C00-D49: Neoplasms | Multiple myeloma | C90 | SRC; IGF1R |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | MPO |
| G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R |
| I00-I99: Diseases of the circulatory system | Hypotension | I95 | ADRA2C |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD4 |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ADRA2C; ACHE |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA |
| L00-L99: Diseases of the skin and subcutaneous tissue | Erythema | L51-L54 | ADRA2C |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Erectile dysfunction | F52.2, N48.4 | DRD4 |
| I00-I99: Diseases of the circulatory system | Hypertension | I10-I16 | ADRA2C |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | MMP2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | MET |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Fibromyalgia | M79.7 | ADRA2C |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | FLT3; TP53; MMP9; KDR; IGF1R |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| C00-D49: Neoplasms | Colon cancer | C50 | FLT3 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET; KDR; IGF1R |
| NA: NA | Hematopoietic stem cell transplantation | NA | FLT3 |
| C00-D49: Neoplasms | Hematologic malignancies | C81-C86 | AKT1 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; SRC; AURKB |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | ADRA2C; CA4; CA4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; AKR1B1; GSK3B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ALOX5 |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Contusion | S36.220S | ADRA2C |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B; ALOX5 |
| C00-D49: Neoplasms | AML | NA | FLT3; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | IGF1R |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | DRD4 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | MMP2 |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | MET |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | AKT1; HIF1A; CA9 |
| H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CAMK2B; MMP1; AKR1B1; MMP3; PLA2G1B; ALOX5 |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5 |
| NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B; ALOX5 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; PTK2 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | FLT3; AKT1 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Liver cancer | C22 | KDR; IGF1R |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; AKR1B1; KDR; KDR |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH; ADRA2C |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | FLT3; AKT1; HIF1A; TP53; MET; CA9; MAPK1; MMP9; MMP2; KDR; KDR; KDR; SRC; PTK2; IGF1R; AURKB |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Myocardial reperfusion injury | T86.4 | AKT1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Attention deficit hyperactivity disorder | F90 | ADRA2A |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SRC |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3 |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Sexual dysfunction | F52 | ADRA2A |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | MMP1; PLA2G1B; ABCC1; ALOX5 |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MMP13; MPO; PLA2G1B; ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1; ADRA2C; ACHE; CA1; CA1 |
| NA: NA | GIST | NA | FLT3 |
| C00-D49: Neoplasms | Glioma | C71 | KDR |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | SRC |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR |
| C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3 |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | FLT3; ALOX5 |
| C00-D49: Neoplasms | Prostate cancer | C61 | FLT3 |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | MMP3 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| C00-D49: Neoplasms | Metastasis | C00-C97 | AXL |
| C00-D49: Neoplasms | Mesothelioma | C45 | PTK2 |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; NFKB1 |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; KDR |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2; KDR; KDR |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | MMP9 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; KDR |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
| NA: NA | Upper abdominal bloating | NA | ACHE |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; ADRA2C |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | MMP2; KDR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | AXL; MET; KDR; IGF1R; IGF1R |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Male sexual disorders | F52 | ADRA2C |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; ACHE; CA4 |
| H00-H59: Diseases of the eye and adnexa | Ocular disease | H00-H59 | ADRA2C |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | ADRA2C; NPSR1 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; CA1 |
| K00-K95: Diseases of the digestive system | Chemotherapy-induced mucositis | K12.3 | MET |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | MMP13; MMP3; MMP2; ALOX5 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CAMK2B; CYP3A4; MAOA; ACHE |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MPO; ALOX5 |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | SRC |