Plant Name: Hibiscus syriacus
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| GPBAR1; HTR2B; | |
| GLA; MTOR; HPGD; GFER; HSD17B10; AKR1B10; SCD; ALDH1A1; | |
| TOP1; | |
| CHEK1; | |
| CA12; CA9; CA7; | |
| NR1H4; | |
| KDM4E; | |
| CASP1; CASP7; | |
| HIF1A; TP53; NFKB1; | |
| HTT; LMNA; PMP22; GMNN; HBB; THPO; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | GLA | Alpha-galactosidase A | P06280 | CHEMBL2524 |
| Enzyme_unclassified | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | SCD | Acyl-CoA desaturase | O00767 | CHEMBL5555 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Isomerase | TOP1 | DNA topoisomerase I | P11387 | CHEMBL1781 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | CHEK1 | Serine/threonine-protein kinase Chk1 | O14757 | CHEMBL4630 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Small molecule receptor (family A GPCR) | HTR2B | Serotonin 2b (5-HT2b) receptor | P41595 | CHEMBL1833 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
| Unclassified | GMNN | Geminin | O75496 | CHEMBL1293278 |
| Unclassified | HBB | Hemoglobin beta chain | P68871 | CHEMBL4331 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 9.130E-07 | 6.627E-03 | CA12, CA7, CA9, HBB |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 1.564E-06 | 8.215E-03 | AKR1B10, ALDH1A1, CYP1A2, CYP3A4, GFER, HPGD, HSD17B10, KDM4E, MTOR, SCD |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.038E-06 | 8.215E-03 | CA12, CA7, CA9 |
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 2.762E-06 | 8.591E-03 | CA9, CASP1, HBB, HPGD, HTR2B, MTOR, NFKB1, TOP1, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.739E-06 | 3.233E-04 | CA12; CA7; CA9 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 8.038E-05 | 3.983E-03 | CASP7; LMNA; TP53; NFKB1 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 1.013E-04 | 3.983E-03 | CASP7; CASP1; NFKB1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.667E-04 | 4.306E-03 | CYP1A2; ALDH1A1; CYP3A4 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.824E-04 | 4.306E-03 | TP53; HIF1A; MTOR |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 4.219E-04 | 7.113E-03 | TP53; NFKB1; MTOR |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 4.953E-04 | 7.305E-03 | TP53; NFKB1; MTOR |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 2.549E-04 | 5.012E-03 | CASP7; CASP1; NFKB1 |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 6.468E-04 | 8.481E-03 | HIF1A; NFKB1; MTOR |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 9.600E-04 | 1.097E-02 | TP53; HIF1A; MTOR |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 3.970E-03 | 2.455E-02 | HIF1A; TP53; NFKB1; MTOR |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 3.207E-03 | 2.455E-02 | HPGD; TP53; NFKB1 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 4.492E-03 | 2.455E-02 | TP53; HIF1A; MTOR |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 3.981E-03 | 2.455E-02 | NFKB1; MTOR |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 4.617E-03 | 2.455E-02 | CHEK1; TP53; NFKB1 |
| hsa05014 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 3.200E-03 | 2.455E-02 | CASP1; TP53 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.042E-03 | 1.097E-02 | CYP1A2; CYP3A4 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.116E-03 | 1.097E-02 | AKR1B10; GLA |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 4.402E-03 | 2.455E-02 | HIF1A; MTOR |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 4.259E-03 | 2.455E-02 | AKR1B10; GLA |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 5.146E-03 | 2.455E-02 | TP53; MTOR |
| hsa04621 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 3.981E-03 | 2.455E-02 | CASP1; NFKB1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 4.119E-03 | 2.455E-02 | CYP1A2; CYP3A4 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 5.301E-03 | 2.455E-02 | TP53; NFKB1 |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 8.701E-03 | 2.901E-02 | CHEK1; TP53; NFKB1 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 5.780E-03 | 2.455E-02 | CYP1A2; CYP3A4 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 6.449E-03 | 2.455E-02 | TP53; NFKB1 |
| hsa04623 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 4.993E-03 | 2.455E-02 | CASP1; NFKB1 |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 5.944E-03 | 2.455E-02 | NFKB1; MTOR |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 5.780E-03 | 2.455E-02 | CHEK1; TP53 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.273E-02 | 3.953E-02 | TP53; NFKB1; MTOR |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 6.110E-03 | 2.455E-02 | NR1H4; CYP3A4 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 6.449E-03 | 2.455E-02 | CYP1A2; CYP3A4 |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.204E-02 | 3.840E-02 | HIF1A; MTOR |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 8.850E-03 | 2.901E-02 | TP53; NFKB1 |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.837E-02 | 4.817E-02 | TP53; NFKB1; MTOR |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.416E-02 | 4.178E-02 | CASP7; NFKB1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 8.074E-03 | 2.901E-02 | CYP1A2; CYP3A4 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.392E-02 | 4.178E-02 | NFKB1; MTOR |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.670E-02 | 4.691E-02 | TP53; NFKB1 |
| hsa05132 | Salmonella infection_Homo sapiens_hsa05132 | 8.850E-03 | 2.901E-02 | CASP1; NFKB1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 1.670E-02 | 4.691E-02 | TP53; NFKB1 |
| hsa04152 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.776E-02 | 4.763E-02 | SCD; MTOR |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 1.776E-02 | 4.763E-02 | CHEK1; TP53 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 8.224E-03 | 2.901E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| A00-B99: Certain infectious and parasitic diseases | Irritable bowel syndrome | A09, K58, K59.1 | HTR2B |
| I00-I99: Diseases of the circulatory system | Cerebral infarction | I63 | HTR2B |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TOP1 |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | TOP1; TOP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1 |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | HTR2B |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | TOP1 |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR; TOP1 |
| C00-D49: Neoplasms | Esophageal cancer | C15 | TOP1 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | GPBAR1; NFKB1; SCD |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; TOP1 |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A; HTR2B |
| I00-I99: Diseases of the circulatory system | Coronary heart disease | I25.1 | HTR2B |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Beta thalassemia | D56.1 | HBB |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | HTR2B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | SCD |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR |
| A00-B99: Certain infectious and parasitic diseases | Acquired immune deficiency syndrome | B20 | TOP1 |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Fabry's disease | E75.2 | GLA |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; TP53; MTOR; CA9; NFKB1; TOP1; CHEK1 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | TOP1 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; TOP1 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| C00-D49: Neoplasms | Advanced ovarian cancer | NA | TOP1 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | SCD |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; TP53; MTOR; CA9; TOP1; CHEK1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychoses | F20-F29 | HTR2B |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR; CHEK1 |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | CHEK1 |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | TOP1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | SCD |
| NA: NA | Coronary artery restenosis | NA | MTOR |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; MTOR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | TOP1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; MTOR; CA9; CHEK1 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; TOP1 |
| I00-I99: Diseases of the circulatory system | Congestive heart failure | I50 | HTR2B |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TOP1 |
| C00-D49: Neoplasms | Gastric cancer | C16 | TOP1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR; CHEK1; CHEK1 |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; CA9 |