Plant Name: Ericameria laricifolia
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0007210; serotonin receptor signaling pathway | 2.426E-12 | 1.321E-08 | HTR1A, HTR2B, HTR5A, HTR6, HTR7 |
| BP | GO:0009987; cellular process | GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway | 9.522E-10 | 1.885E-06 | HTR1A, HTR5A, HTR7 |
| BP | Unclassified; | GO:0042310; vasoconstriction | 8.614E-07 | 1.340E-03 | HTR1A, HTR2B, HTR7 |
| BP | GO:0032501; multicellular organismal process | GO:0097746; regulation of blood vessel diameter | 1.106E-06 | 1.505E-03 | DRD1, HTR1A, HTR2B, HTR7 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 6.262E-06 | 5.929E-03 | CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 8.764E-06 | 7.340E-03 | CYP1A2, CYP2D6 |
| MF | GO:0060089; molecular transducer activity | GO:0004993; G-protein coupled serotonin receptor activity | 2.426E-12 | 1.321E-08 | HTR1A, HTR2B, HTR5A, HTR6, HTR7 |
| MF | GO:0005488; binding | GO:0051378; serotonin binding | 4.058E-11 | 1.262E-07 | HTR1A, HTR2B, HTR5A, HTR7 |
Showing 1 to 8 of 8 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.246E-03 | 1.298E-02 | CYP1A2 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 7.927E-04 | 5.136E-03 | CYP1A2; ALDH1A1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 9.986E-04 | 5.136E-03 | CYP2D6; CYP1A2 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 8.928E-04 | 5.136E-03 | CYP2D6; CYP1A2 |
| hsa04020 | Calcium signaling pathway_Homo sapiens_hsa04020 | 6.780E-08 | 8.137E-07 | HTR6; HTR7; HTR2B; DRD1; HTR5A |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 2.578E-04 | 2.321E-03 | HTR6; HTR1A; DRD1 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.058E-08 | 1.904E-07 | HTR6; HTR7; HTR1A; HTR2B; DRD1; HTR5A |
| hsa04540 | Gap junction_Homo sapiens_hsa04540 | 1.447E-03 | 6.510E-03 | HTR2B; DRD1 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.477E-11 | 1.612E-09 | HTR6; HTR7; CYP2D6; HTR1A; HTR2B; HTR5A |
Showing 1 to 9 of 9 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| A00-B99: Certain infectious and parasitic diseases | Irritable bowel syndrome | A09, K58, K59.1 | HTR2B |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Eating disorder | E66, F50, I10-I16, I50 | HTR1A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HTR6 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | DRD1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Female sexual dysfunction | F52 | HTR1A |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | HTR1A |
Showing 1 to 10 of 51 entries