Plant Name: Rhaponticum uniflorum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 6.247E-07 | 6.371E-03 | ACP1, PTPN1, PTPN2, PTPRF |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.463E-06 | 6.371E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 1.463E-06 | 6.371E-03 | GPBAR1, NR1H4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 1.719E-05 | 4.297E-04 | PTPN1; ACP1; PTPRF |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 1.100E-03 | 1.375E-02 | CA2; NR1H4 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 2.566E-03 | 2.138E-02 | PTPN1; PTPRF |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 4.132E-03 | 2.582E-02 | PTPN1; PTPRF |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 6.252E-03 | 3.126E-02 | SMN2; SMN1 |
| hsa04710 | Circadian rhythm_Homo sapiens_hsa04710 | 2.080E-02 | 4.763E-02 | RORC |
| hsa04966 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.874E-02 | 4.763E-02 | CA2 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.599E-02 | 4.763E-02 | CA2 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 2.080E-02 | 4.763E-02 | AKR1B10 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.184E-02 | 4.763E-02 | CA2 |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.492E-02 | 4.791E-02 | AKR1B10 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 2.218E-02 | 4.763E-02 | AKR1B10 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 2.286E-02 | 4.763E-02 | POLB |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1 |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2 |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| NA: NA | Edema | NA | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |