CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.745E-09	2.989E-05	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	3.014E-08	2.188E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.678E-07	8.899E-04	BCHE, CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.418E-07	8.899E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	2.948E-07	8.899E-04	ACHE, BCHE
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	8.842E-07	1.750E-03	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.768E-06	2.961E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.924E-06	2.993E-03	CYP1A2, CYP2D6, CYP3A4
BP	GO:0023052; signaling	GO:0050805; negative regulation of synaptic transmission	5.617E-06	7.644E-03	ACHE, BCHE, DRD1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	6.357E-06	1.394E-04	CYP2D6; CYP1A2; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	7.538E-06	1.394E-04	CYP2D6; CYP1A2; CYP3A4
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.108E-04	1.366E-03	CYP1A2; CYP3A4
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	4.470E-04	4.135E-03	CYP1A2; CYP3A4
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	5.613E-04	4.154E-03	CYP1A2; CYP3A4
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	8.917E-04	5.499E-03	CYP1A2; CYP3A4
hsa03013	RNA transport_Homo sapiens_hsa03013	3.843E-03	1.777E-02	SMN2; SMN1
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	2.747E-03	1.452E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1; ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1; ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1; ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; ACHE
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; ACHE; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Zamia spiralis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases