CMAUP Plant Collective Molecular Activities

Plant Name: Eschweilera coriacea

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.593E-14	5.646E-10	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.555E-11	3.870E-07	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.604E-09	6.986E-06	CA1, CA12, CA2, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	9.510E-08	1.736E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	2.278E-07	2.918E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	7.726E-07	8.854E-04	ADORA2A, CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.331E-06	1.383E-03	CA1, CA12, CA2, CA7, CA9, CDA, ESR2, PPARA, PPARD
BP	GO:0051179; localization	GO:0015860; purine nucleoside transmembrane transport	2.026E-06	1.838E-03	SLC28A2, SLC28A3
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	2.026E-06	1.838E-03	SLC28A1, SLC28A3
MF	GO:0005215; transporter activity	GO:0015211; purine nucleoside transmembrane transporter activity	2.026E-06	1.838E-03	SLC28A2, SLC28A3
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	6.074E-06	3.933E-03	SLC28A1, SLC28A3
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.074E-06	3.933E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	6.074E-06	3.933E-03	SLC28A1, SLC28A3
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	6.074E-06	3.933E-03	ADORA1, ADORA2A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	5.195E-14	2.649E-12	CA12; CA1; CA2; CA7; CA9; CA14
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	3.583E-05	9.136E-04	CDA; CYP2A6; CYP3A4
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	1.013E-04	1.722E-03	CYP2A6; ALDH1A1; CYP3A4
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	1.615E-04	2.059E-03	ADORA2A; ADORA1; PPARA; TSHR
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	5.673E-04	5.786E-03	ADORA2A; ADORA3; ADORA1; TSHR
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.778E-03	2.361E-02	ADORA1; TSHR
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.184E-03	2.382E-02	CYP2A6; CYP3A4
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	4.184E-03	2.382E-02	PPARA; PPARD
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	4.671E-03	2.382E-02	CYP2A6; CYP3A4
hsa04976	Bile secretion_Homo sapiens_hsa04976	4.425E-03	2.382E-02	CA2; CYP3A4
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	5.857E-03	2.716E-02	CYP2A6; CYP3A4
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.219E-02	4.781E-02	ADORA3; ADORA1
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	6.981E-03	2.967E-02	CYP2A6

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; FAAH
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA2A; ADORA1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADORA2A; ADK; FAAH
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; CDA
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
C00-D49: Neoplasms	Renal cancer	C64	CA9
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA2A; ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1; PPARD
NA: NA	Dyslipidemia	NA	PPARD
NA: NA	Hepatitis C virus infection	NA	ADORA3
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	FAAH
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	FAAH
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1
NA: NA	Edema	NA	CA2
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3; CA1; CA9
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	FAAH
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3; ADORA2A; ADORA1; CA1; CA1
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1; ADORA1
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1
C00-D49: Neoplasms	Breast cancer	C50	CA9
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA2A; ADORA1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA2A; ADORA1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1; ADORA1
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	FAAH
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases