Plant Name: Radula voluta
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.745E-09 | 2.989E-05 | CYP1A2, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 3.014E-08 | 2.188E-04 | CYP1A2, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 3.678E-07 | 8.899E-04 | BCHE, CYP1A2, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 8.842E-07 | 1.750E-03 | CYP2D6, CYP3A4 |
| BP | GO:0023052; signaling | GO:0050805; negative regulation of synaptic transmission | 5.617E-06 | 7.644E-03 | ACHE, BCHE, DRD1 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 2.418E-07 | 8.899E-04 | CYP1A2, CYP2D6, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 2.948E-07 | 8.899E-04 | ACHE, BCHE |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 1.768E-06 | 2.961E-03 | CYP1A2, CYP3A4 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.924E-06 | 2.993E-03 | CYP1A2, CYP2D6, CYP3A4 |
Showing 1 to 9 of 9 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 4.470E-04 | 4.135E-03 | CYP1A2; CYP3A4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.747E-03 | 1.452E-02 | CYP1A2 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.108E-04 | 1.366E-03 | CYP1A2; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 5.613E-04 | 4.154E-03 | CYP1A2; CYP3A4 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 7.538E-06 | 1.394E-04 | CYP2D6; CYP1A2; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 6.357E-06 | 1.394E-04 | CYP2D6; CYP1A2; CYP3A4 |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 3.843E-03 | 1.777E-02 | SMN2; SMN1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 8.917E-04 | 5.499E-03 | CYP1A2; CYP3A4 |
Showing 1 to 8 of 8 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; ACHE |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | DRD1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychiatric disorder | F01-F99 | DRD1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD1 |
Showing 1 to 10 of 39 entries