CMAUP Plant Collective Molecular Activities

Plant Name: Sarcococca saligna

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.280E-12	2.786E-08	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	4.214E-11	3.059E-07	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.832E-10	9.972E-07	ADRA2A, ADRA2B, ADRA2C
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	7.325E-10	1.994E-06	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	7.325E-10	1.994E-06	ADRA2A, ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	7.325E-10	1.994E-06	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	5.023E-09	8.413E-06	BCHE, CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	1.024E-08	1.394E-05	ADRA2A, ADRA2B, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	1.024E-08	1.394E-05	ADRA2A, ADRA2B, ADRA2C
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.255E-08	1.607E-05	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.017E-08	4.166E-05	CYP1A2, CYP2C9, CYP3A4
BP	GO:0009987; cellular process	GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway	2.076E-07	1.614E-04	ADRA2A, ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.222E-07	2.150E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	3.538E-07	2.266E-04	ACHE, BCHE
MF	GO:0005488; binding	GO:0020037; heme binding	8.739E-07	4.758E-04	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.061E-06	5.247E-04	CYP2D6, CYP3A4
BP	GO:0065007; biological regulation	GO:0032148; activation of protein kinase B activity	1.084E-06	5.247E-04	ADRA2A, ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.084E-06	5.247E-04	CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.131E-06	9.282E-04	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	Unclassified;	GO:0019229; regulation of vasoconstriction	6.145E-06	2.433E-03	ADRA2A, ADRA2B, ADRA2C
BP	GO:0032501; multicellular organismal process	GO:0070472; regulation of uterine smooth muscle contraction	1.271E-05	4.463E-03	ADRA2B, ADRA2C
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.588E-05	5.402E-03	CYP1A2, CYP2C9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	6.289E-08	1.265E-06	CYP2C9; CYP2D6; CYP1A2; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	7.907E-08	1.265E-06	CYP2C9; CYP2D6; CYP1A2; CYP3A4
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	5.977E-07	6.376E-06	CYP2C9; CYP1A2; CYP3A4
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	7.059E-06	5.647E-05	CYP2C9; CYP1A2; CYP3A4
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.423E-05	9.107E-05	CYP2C9; CYP1A2; CYP3A4
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.190E-04	6.348E-04	ADRA2C; ADRA2B; ADRA2A
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	5.270E-04	2.142E-03	ADRA2C; ADRA2B; ADRA2A
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	5.354E-04	2.142E-03	CYP1A2; CYP3A4
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	1.978E-03	7.013E-03	CYP2C9; CYP2D6
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	2.192E-03	7.013E-03	ESR1; HIF1A
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	6.328E-03	1.687E-02	HIF1A; ESR1
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	2.997E-03	8.718E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C; ESR1
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
NA: NA	Upper abdominal bloating	NA	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; ADRA2A; ESR1; ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C; ADRA2B
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; ESR1; ESR1; ACHE
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A
NA: NA	Menopausal disorder	NA	ESR1
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
C00-D49: Neoplasms	Breast cancer	C50	ESR1; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; ESR1
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1
NA: NA	Postmenopausal disorder	NA	ESR1
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
NA: NA	Gonorrheal vaginitis	NA	ESR1
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
C00-D49: Neoplasms	Prostate cancer	C61	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases