CMAUP Plant Collective Molecular Activities

Plant Name: Tinospora crispa

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	RECQL; TDP1; PKM; GLO1; ALOX12; HSD17B1; AKR1B1; HSD17B10; ALOX15; NOX4; USP2; TNKS; PARP1; TNKS2; CD38; POLB;
Hydrolase	ACHE;
Chloride channel	CFTR;
Protein Kinase	GSK3B; SYK; FLT3; CDK6; CSNK2A1;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 3 group C	AR;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Oxidoreductase	ALOX5; MAOA; PTGS2; XDH;
Lysine demethylase	KDM4E;
Metallo protease	MMP9; MMP12; MMP2;
Transcription Factor	HIF1A; TP53;
ATP-binding cassette	ABCG2; ABCC1;
Unclassified	NPC1; LMNA; TTR; MAPT; THPO; APP;
Methyl-lysine/arginine binding protein	L3MBTL1; SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Chloride channel	CFTR	Cystic fibrosis transmembrane conductance regulator	P13569	CHEMBL4051
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	PARP1	Poly [ADP-ribose] polymerase-1	P09874	CHEMBL3105
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Enzyme_unclassified	CD38	Lymphocyte differentiation antigen CD38	P28907	CHEMBL4660
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	GSK3B	Glycogen synthase kinase-3 beta	P49841	CHEMBL262
Protein Kinase	SYK	Tyrosine-protein kinase SYK	P43405	CHEMBL2599
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK6	Cyclin-dependent kinase 6	Q00534	CHEMBL2508
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	TTR	Transthyretin	P02766	CHEMBL3194
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.377E-10	6.187E-07	ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.754E-09	1.993E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.042E-09	3.059E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	8.567E-09	4.055E-06	AR, CA12, CA2, CA4, CA7, ESR1, ESR2, GLO1, L3MBTL1, MMP12, MMP2, MMP9, PARP1, TNKS, TP53
BP	Unclassified;	GO:0032844; regulation of homeostatic process	1.104E-08	5.095E-06	CA2, CA7, CD38, CDK6, CFTR, HIF1A, NPC1, PARP1, PTGS2, SYK, TNKS, TNKS2
MF	GO:0005488; binding	GO:0042802; identical protein binding	1.719E-08	6.792E-06	ABCG2, ACHE, APP, CD38, CSNK2A1, ESR1, ESR2, FLT3, L3MBTL1, MAPT, MMP9, PARP1, PKM, PTGS2, SMN1, SMN2, TP53, TTR, USP2, XDH
BP	Unclassified;	GO:0032846; positive regulation of homeostatic process	1.936E-08	7.136E-06	CA2, CA7, CFTR, HIF1A, NPC1, PTGS2, SYK, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	2.996E-08	9.886E-06	ABCC1, ALOX12, ALOX15, ALOX5, SYK
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.077E-08	2.381E-05	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0020037; heme binding	9.550E-08	2.446E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4, PTGS2
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	1.208E-07	3.057E-05	ALOX12, ALOX15, ALOX5, PTGS2
BP	GO:0008152; metabolic process	GO:0016579; protein deubiquitination	1.372E-07	3.284E-05	AR, CFTR, ESR1, HIF1A, POLB, TNKS, TNKS2, TP53, USP2
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.860E-07	4.355E-05	CA12, CA2, CA4, CA7, CFTR
MF	GO:0005488; binding	GO:0005496; steroid binding	1.974E-07	4.526E-05	AR, CYP3A4, ESR1, ESR2, HSD17B1, NPC1
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.881E-06	5.185E-04	CA2, CA7, CFTR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.881E-06	5.185E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0048545; response to steroid hormone	3.575E-06	6.035E-04	AR, CA2, CD38, FLT3, NPC1, PARP1, PTGS2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.740E-06	6.265E-04	CA12, CA2, CA4, CA7
BP	GO:0032501; multicellular organismal process	GO:0060736; prostate gland growth	3.953E-06	6.472E-04	AR, CYP19A1, ESR1
BP	GO:0008152; metabolic process	GO:2000379; positive regulation of reactive oxygen species metabolic process	6.789E-06	1.020E-03	MAPT, NOX4, PTGS2, TP53, XDH
CC	GO:0016020; membrane	GO:0016020; membrane	8.144E-06	1.190E-03	ABCC1, ABCG2, ACHE, ALOX12, ALOX15, ALOX5, APP, AR, CA12, CA2, CA4, CD38, CFTR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FLT3, GLO1, GSK3B, HSD17B10, L3MBTL1, LMNA, MAOA, MAPT, MMP2, NOX4, NPC1, PARP1, PTGS2, RECQL, SYK, TDP1, TNKS, TNKS2, TSHR, USP2
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	8.556E-06	1.202E-03	ALOX12, ALOX15
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	8.556E-06	1.202E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	8.556E-06	1.202E-03	ALOX12, ALOX15
BP	GO:0050896; response to stimulus	GO:1901654; response to ketone	1.383E-05	1.827E-03	AKR1B1, AR, CD38, CFTR, CSNK2A1, PARP1
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	1.654E-05	2.094E-03	AKR1B1, CYP19A1, CYP1A2, NOX4, XDH
BP	GO:0009987; cellular process	GO:0080135; regulation of cellular response to stress	1.798E-05	2.263E-03	APP, CDK6, GSK3B, HIF1A, MAPT, PARP1, PTGS2, SYK, TP53, XDH
BP	GO:0050896; response to stimulus	GO:0010332; response to gamma radiation	1.930E-05	2.388E-03	NOX4, PARP1, POLB, TP53
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.562E-05	2.952E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	2.562E-05	2.952E-03	ALOX15, PTGS2
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.562E-05	2.952E-03	CYP1A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.562E-05	2.952E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.562E-05	2.952E-03	ALOX12, ALOX15
BP	GO:0065007; biological regulation	GO:0044093; positive regulation of molecular function	3.024E-05	3.394E-03	APP, AR, CFTR, ESR1, ESR2, FLT3, GSK3B, HIF1A, MAPT, MMP9, NOX4, PARP1, SYK, TNKS, TSHR, XDH
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	3.120E-05	3.440E-03	CYP1A1, POLB, TP53
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.120E-05	3.440E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019899; enzyme binding	3.479E-05	3.733E-03	APP, AR, CFTR, CYP1A1, CYP1A2, CYP3A4, ESR1, ESR2, GSK3B, HIF1A, MAPT, PARP1, POLB, PTGS2, SYK, TNKS2, TP53, USP2
BP	GO:0008152; metabolic process	GO:0016125; sterol metabolic process	3.753E-05	3.929E-03	APP, CFTR, CYP19A1, CYP1B1, NPC1
BP	GO:0008152; metabolic process	GO:0031324; negative regulation of cellular metabolic process	4.003E-05	4.140E-03	APP, AR, CD38, CSNK2A1, ESR1, ESR2, GSK3B, HIF1A, L3MBTL1, MAPT, MMP12, MMP9, NPC1, PARP1, PTGS2, TNKS, TNKS2, TP53, USP2, XDH
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.138E-05	4.250E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0030154; cell differentiation	4.571E-05	4.651E-03	AR, CDK6, CYP1A1, ESR1, FLT3, GLO1, GSK3B, HIF1A, MAPT, MMP2, MMP9, NOX4, PARP1, PTGS2, THPO, TP53
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	5.114E-05	4.971E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	5.114E-05	4.971E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	5.114E-05	4.971E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	5.114E-05	4.971E-03	CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0031334; positive regulation of protein complex assembly	5.165E-05	4.976E-03	ALOX15, ESR1, GSK3B, MAPT, PARP1, TP53
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	6.036E-05	5.666E-03	CYP19A1, CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0003950; NAD+ ADP-ribosyltransferase activity	6.036E-05	5.666E-03	PARP1, TNKS, TNKS2
BP	GO:0050896; response to stimulus	GO:0032870; cellular response to hormone stimulus	6.459E-05	5.988E-03	AR, ESR1, FLT3, NPC1, PARP1, PKM, TSHR
BP	GO:0009987; cellular process	GO:0050714; positive regulation of protein secretion	6.573E-05	6.039E-03	ACHE, CD38, CFTR, HIF1A, MMP12, SYK
BP	GO:0032501; multicellular organismal process	GO:0010575; positive regulation of vascular endothelial growth factor production	6.777E-05	6.123E-03	CYP1B1, HIF1A, PTGS2
BP	GO:0065007; biological regulation	GO:1904357; negative regulation of telomere maintenance via telomere lengthening	6.777E-05	6.123E-03	PARP1, TNKS, TNKS2
BP	GO:0050896; response to stimulus	GO:1904646; cellular response to amyloid-beta	6.777E-05	6.123E-03	APP, GSK3B, PARP1
BP	GO:0050896; response to stimulus	GO:0014074; response to purine-containing compound	7.029E-05	6.325E-03	APP, CFTR, NOX4, PTGS2, TP53
BP	GO:0008152; metabolic process	GO:0051186; cofactor metabolic process	7.130E-05	6.389E-03	ABCC1, AKR1B1, CD38, CYP1A1, CYP1A2, GLO1, PKM, PTGS2
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	7.376E-05	6.556E-03	ALOX15, GSK3B, HIF1A, MAPT, MMP9, NOX4, TNKS, TNKS2, TP53
BP	GO:0008283; cell proliferation	GO:0048661; positive regulation of smooth muscle cell proliferation	7.463E-05	6.606E-03	AKR1B1, MMP2, MMP9, PTGS2
BP	GO:0008152; metabolic process	GO:0072330; monocarboxylic acid biosynthetic process	7.497E-05	6.610E-03	ALOX12, ALOX15, CYP1A1, PKM, PTGS2
BP	GO:0008152; metabolic process	GO:0008209; androgen metabolic process	7.574E-05	6.623E-03	CYP19A1, CYP3A4, ESR1
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	7.854E-05	6.835E-03	GSK3B, MAPT, PARP1, TP53
BP	GO:0050896; response to stimulus	GO:0048585; negative regulation of response to stimulus	8.144E-05	7.018E-03	ALOX12, ALOX15, AR, CDK6, CYP19A1, ESR1, ESR2, GSK3B, HIF1A, LMNA, MMP12, MMP9, PTGS2, XDH
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	8.507E-05	7.180E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	8.507E-05	7.180E-03	CYP1A1, CYP3A4
MF	GO:0005488; binding	GO:0008013; beta-catenin binding	1.004E-04	8.220E-03	AR, CSNK2A1, ESR1, GSK3B
BP	GO:0009987; cellular process	GO:2001242; regulation of intrinsic apoptotic signaling pathway	1.021E-04	8.327E-03	HIF1A, MMP9, PARP1, PTGS2, TP53
BP	GO:0002376; immune system process	GO:0002682; regulation of immune system process	1.098E-04	8.852E-03	ALOX15, APP, CA2, CD38, CDK6, CYP19A1, ESR1, HIF1A, L3MBTL1, MMP12, MMP2, SYK, THPO, TP53
BP	GO:0032501; multicellular organismal process	GO:0051240; positive regulation of multicellular organismal process	1.144E-04	9.062E-03	ALOX12, APP, AR, CA2, CD38, CYP1B1, HIF1A, MAPT, MMP12, MMP9, PARP1, PTGS2, SYK, THPO
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	1.149E-04	9.062E-03	AKR1B1, CYP19A1, CYP1A2, NOX4, XDH
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	1.137E-04	9.062E-03	CSNK2A1, HIF1A, MAPT
BP	GO:0009987; cellular process	GO:0043410; positive regulation of MAPK cascade	1.201E-04	9.373E-03	ALOX15, APP, AR, FLT3, NOX4, SYK, THPO, XDH
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	1.208E-04	9.398E-03	HIF1A, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0070212; protein poly-ADP-ribosylation	1.274E-04	9.713E-03	PARP1, TNKS
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.274E-04	9.713E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.274E-04	9.713E-03	CYP1A2, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	5.896E-09	8.549E-07	HSD17B1; ALOX5; CYP1A1; CYP1B1; PTGS2; CYP19A1
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.476E-08	1.070E-06	HSD17B1; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	1.694E-06	4.094E-05	AR; GSK3B; CDK6; FLT3; MMP2; PTGS2; HIF1A; TP53; MMP9
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	1.306E-06	3.786E-05	MAOA; ALOX15; AKR1B1; ALOX12; PTGS2; CYP3A4; CYP19A1; HSD17B10; PKM; HSD17B1; ALOX5; CYP1A2; CYP1A1; CD38; XDH
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	7.751E-07	2.810E-05	APP; MAOA; ALOX5; ALOX15; ALOX12; PTGS2
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	1.372E-07	6.632E-06	CA12; CA2; CA4; CA7
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	5.018E-06	9.096E-05	MAOA; CYP1A2; CYP1A1; CYP1B1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	3.627E-06	7.514E-05	CYP1A2; CYP1A1; CYP1B1; CYP3A4; PTGS2
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.924E-05	4.711E-04	ALOX5; ALOX15; ALOX12; PTGS2
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	3.975E-05	5.764E-04	PKM; FLT3; TP53; HIF1A
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.573E-05	6.735E-04	CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04976	Bile secretion_Homo sapiens_hsa04976	4.997E-05	6.586E-04	CA2; CYP3A4; CFTR; ABCG2
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	1.959E-04	1.671E-03	ABCC1; CDK6; CYP1B1; PTGS2; TP53; MMP9
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	1.825E-04	1.653E-03	MMP2; ESR1; MMP9; ESR2
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	2.797E-04	1.929E-03	MMP2; TP53; HIF1A; ESR1; MMP9
hsa05169	Epstein-Barr virus infection_Homo sapiens_hsa05169	2.734E-04	1.929E-03	GSK3B; SYK; CSNK2A1; CD38; TP53
hsa04064	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.433E-04	1.385E-03	SYK; CSNK2A1; PARP1; PTGS2
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	2.927E-04	1.929E-03	POLB; CDK6; PKM; SYK; TP53
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	3.573E-04	2.253E-03	GSK3B; TP53; ESR1; HIF1A
hsa05162	Measles_Homo sapiens_hsa05162	6.112E-04	3.692E-03	GSK3B; CDK6; CSNK2A1; TP53
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	7.609E-05	8.220E-04	CYP1A2; ALOX15; CYP3A4
hsa05219	Bladder cancer_Homo sapiens_hsa05219	2.167E-04	1.745E-03	MMP2; MMP9; TP53
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	1.342E-03	6.948E-03	APP; GSK3B; MAPT; HSD17B10
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	1.139E-03	6.115E-03	GSK3B; ESR1; ESR2
hsa02010	ABC transporters_Homo sapiens_hsa02010	2.675E-04	1.929E-03	ABCC1; CFTR; ABCG2
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	8.458E-04	4.906E-03	CYP1A2; CYP1A1; CYP3A4
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.006E-03	5.612E-03	MAOA; CYP1A2; CYP3A4
hsa05215	Prostate cancer_Homo sapiens_hsa05215	2.095E-03	9.494E-03	GSK3B; AR; TP53
hsa05222	Small cell lung cancer_Homo sapiens_hsa05222	1.900E-03	9.390E-03	CDK6; PTGS2; TP53
hsa04640	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.029E-03	9.489E-03	THPO; FLT3; CD38
hsa04210	Apoptosis_Homo sapiens_hsa04210	7.455E-03	2.882E-02	PARP1; LMNA; TP53
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	2.599E-03	1.142E-02	CA2; CD38; CFTR
hsa04110	Cell cycle_Homo sapiens_hsa04110	5.334E-03	2.210E-02	GSK3B; CDK6; TP53
hsa05161	Hepatitis B_Homo sapiens_hsa05161	8.362E-03	3.031E-02	CDK6; TP53; MMP9
hsa04310	Wnt signaling pathway_Homo sapiens_hsa04310	7.751E-03	2.882E-02	GSK3B; CSNK2A1; TP53
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	1.615E-02	4.778E-02	GSK3B; CDK6; SYK; TP53
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.470E-02	4.565E-02	FLT3; TP53; MMP9
hsa05214	Glioma_Homo sapiens_hsa05214	1.480E-02	4.565E-02	CDK6; TP53
hsa05223	Non-small cell lung cancer_Homo sapiens_hsa05223	1.114E-02	3.670E-02	CDK6; TP53
hsa05213	Endometrial cancer_Homo sapiens_hsa05213	9.658E-03	3.416E-02	GSK3B; TP53
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.114E-02	3.670E-02	PTGS2; TSHR
hsa05210	Colorectal cancer_Homo sapiens_hsa05210	1.353E-02	4.358E-02	GSK3B; TP53
hsa05212	Pancreatic cancer_Homo sapiens_hsa05212	1.523E-02	4.601E-02	CDK6; TP53
hsa05218	Melanoma_Homo sapiens_hsa05218	1.749E-02	4.972E-02	CDK6; TP53
hsa05217	Basal cell carcinoma_Homo sapiens_hsa05217	1.076E-02	3.670E-02	GSK3B; TP53
hsa04115	p53 signaling pathway_Homo sapiens_hsa04115	1.657E-02	4.805E-02	CDK6; TP53
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	7.622E-03	2.882E-02	CYP3A4; XDH
hsa00620	Pyruvate metabolism_Homo sapiens_hsa00620	5.807E-03	2.339E-02	PKM; GLO1
hsa03410	Base excision repair_Homo sapiens_hsa03410	3.981E-03	1.698E-02	POLB; PARP1
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.943E-03	9.390E-03	CA2; CA4
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	7.937E-05	8.220E-04	CYP1A2; XDH

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	AR; CFTR
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53; AKR1B1
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
I00-I99: Diseases of the circulatory system	Heart failure	I50	AR; XDH
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5; MMP2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA; PTGS2; PTGS2
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	AR
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP; TTR
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1; PTGS2; PTGS2; PTGS2; PTGS2
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	SYK
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
L00-L99: Diseases of the skin and subcutaneous tissue	Alopecia	L65.9	AR
NA: NA	Menopausal disorder	NA	ESR1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; APP
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; MAPT
NA: NA	Rheumatold arthritis	NA	PTGS2; PTGS2; PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	AR
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5; SYK; AKR1B1; PTGS2; PTGS2; PTGS2; PTGS2
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	AR; AR; ESR1; MMP2
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; MAOA
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
NA: NA	Edema	NA	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	AR
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1; PTGS2
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE; APP
C00-D49: Neoplasms	Metastatic prostate cancer	C61	AR
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53; FLT3; MMP9
C00-D49: Neoplasms	Castration-resistant prostate cancer	C61	AR
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	AR
I00-I99: Diseases of the circulatory system	Cardiomyopathy	I42.0	TTR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5; ALOX5; SYK; SYK; MMP12; PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5; PTGS2; PTGS2; ABCC1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5; MMP12
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	PARP1
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
NA: NA	Upper abdominal bloating	NA	ACHE
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5; PTGS2
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory skin condition	L00-L99	PARP1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5; SYK; MMP12; PTGS2
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	AR
C00-D49: Neoplasms	Cancer	C00-C96	AR; GSK3B; SYK; HIF1A; TP53; FLT3; FLT3; MMP9; ACHE; ESR1; ESR1; PARP1; MMP2; PTGS2; CD38; APP; CSNK2A1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; ACHE; CA4
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	SYK; ESR1
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Melanoma	C43	PARP1
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	TTR amyloidosis	E85	TTR
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	PARP1
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP
G00-G99: Diseases of the nervous system G00-G99	Brain ischaemia	G45.9, I67.8	PARP1
C00-D49: Neoplasms	Breast cancer	C50	AR; CYP19A1; FLT3; FLT3; ESR1; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5; FLT3
C00-D49: Neoplasms	Prostate cancer	C61	AR; AR; FLT3; ESR1
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	AR
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3; ESR1
NA: NA	Gonorrheal vaginitis	NA	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH; AKR1B1; PTGS2; ABCC1; ABCC1
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
C00-D49: Neoplasms	Bladder cancer	C67	AR; CYP19A1
C00-D49: Neoplasms	B-cell lymphoma	C85.1	SYK
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	GSK3B; AKR1B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
C00-D49: Neoplasms	Advanced prostate cancer	C61	AR; ESR1
C00-D49: Neoplasms	Pancreatic cancer	C25	FLT3; MMP2; PTGS2
C00-D49: Neoplasms	CLL	NA	FLT3
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5; MMP12; MMP12
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	SYK
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
A00-B99: Certain infectious and parasitic diseases	HIV-associated diarrhoea	A09	CFTR
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	PARP1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
I00-I99: Diseases of the circulatory system	Cerebrovascular disorders	I60-I69	PARP1
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis in post-menopausal women	M80-M81	AR
C00-D49: Neoplasms	Osteosarcoma	C40-C41	GSK3B
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH
C00-D49: Neoplasms	Glioma	C71	APP
C00-D49: Neoplasms	Female androgenresponsive recurrent mammary cancer	C50	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	AR; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53; FLT3; FLT3
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	AR; ESR1
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	AR; ESR1; ESR1
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	AR; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; MAPT
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3
C00-D49: Neoplasms	Recurrent epithelial ovarian or primary peritoneal cancer	C78	PARP1
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3
NA: NA	Joint and muscular pain	NA	PTGS2
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2
C00-D49: Neoplasms	Colon cancer	C50	FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE; CYP3A4; MAOA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Hematological malignancies	C81-C86	SYK; TP53; CD38
E00-E89: Endocrine, nutritional and metabolic diseases	Testosterone deficiency	E29.1	AR
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5; SYK
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
K00-K95: Diseases of the digestive system	Alcoholic hepatitis	K70.1	AR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1
NA: NA	Postmenopausal disorder	NA	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Solid tumours	C00-D48	SYK; HIF1A; TP53; FLT3; MMP9; MMP2; PKM
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GSK3B; ACHE; ACHE; ACHE; MAOA; PTGS2; MAPT; APP
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5; SYK
C00-D49: Neoplasms	AML	NA	FLT3
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
G00-G99: Diseases of the nervous system G00-G99	Permanent and transient stroke	G45.9, I61-I63	PARP1
C00-D49: Neoplasms	Multiple myeloma	C90	CD38
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP
NA: NA	GIST	NA	FLT3
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1
NA: NA	Geographic retinal atrophy	NA	APP
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3
C00-D49: Neoplasms	Glioblastoma	NA	FLT3
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	AR; ACHE; ESR1; PTGS2; PTGS2; PTGS2; PTGS2; PKM
C00-D49: Neoplasms	Ovarian cancer	C56	PARP1; MMP2
A00-B99: Certain infectious and parasitic diseases	Diarrhea	A09, K59.1	CFTR
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle atrophy	M62.5	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Male hormonal deficiencies	E20-E35	AR
NA: NA	Male hypogonadism	NA	AR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA; MAOA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	AR; ESR1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases