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Plant Name: Terminalia chebula




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
GPR35; FFAR1; FFAR4; ADRA2B;
Peptide receptor (family A GPCR)
TSHR;
Enzyme_unclassified
TDP1; BLM; GLA; FAAH; RECQL; TERT; PKM; HKDC1; GLO1; HPGD; AKR1B1; HSD17B10; ALOX15; ALDH1A1; ALOX12; GFER; NOX4; USP2; TNKS; PARP1; TNKS2; APEX1; POLB; CD38;
Phosphodiesterase 5
PDE5A;
Protein Phosphatase
DUSP3;
Hydrolase
GAA;
Isomerase
TOP1;
Protein Kinase
AKT1; MET; GSK3B; CSNK2A1; FLT3; SRC; IGF1R; PTK2; BRAF; AURKB; AURKA; FLT4; EPHB4; MAP3K8; TEK; PDGFRB; INSR; PLK4; MAPK1; MAPK14; MAPK3; ERBB2; EGFR; NUAK1; LCK; FYN; KDR; PLK1;
Lyase
CA12; CA3; CA14; CA5B; CA5A; CA1; CA9; CA13; CA7; CA4; CA6; CA2;
Nuclear hormone receptor subfamily 1 group I
NR1I2;
Nuclear hormone receptor subfamily 1 group C
PPARA; PPARG; PPARD;
Oxidoreductase
HMGCR; MAOA; ALOX5; PTGS1; XDH;
Lysine demethylase
KDM4E;
Metallo protease
MMP12; MMP2; MMP9;
Aspartic protease
BACE1;
Toll-like and Il-1 receptors
TLR2;
Transcription Factor
HIF1A; TP53;
Transferase
FUT7;
SLC superfamily of solute carriers
SLC22A6; SLCO1B3; SLCO1B1;
ATP-binding cassette
ABCG2;
Unclassified
SMAD3; LMNA; FABP5; FABP2; FABP4; MCL1; MAPT; HBB; FABP3; HSPA1A; APP; TTR;
Methyl-lysine/arginine binding protein
L3MBTL1; SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: TBXAS1; CYP1A2; CYP2C9; CYP2A6; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2A6 Cytochrome P450 2A6 P11509 CHEMBL5282
Cytochrome P450 family 5 TBXAS1 Thromboxane-A synthase P24557 CHEMBL1835
Enzyme_unclassified APEX1 DNA-(apurinic or apyrimidinic site) lyase P27695 CHEMBL5619
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Enzyme_unclassified CD38 Lymphocyte differentiation antigen CD38 P28907 CHEMBL4660
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified BLM Bloom syndrome protein P54132 CHEMBL1293237
Enzyme_unclassified GLA Alpha-galactosidase A P06280 CHEMBL2524
Enzyme_unclassified FAAH Anandamide amidohydrolase O00519 CHEMBL2243
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified TERT Telomerase reverse transcriptase O14746 CHEMBL2916
Enzyme_unclassified PKM Pyruvate kinase isozymes M1/M2 P14618 CHEMBL1075189
Enzyme_unclassified HKDC1 Putative hexokinase HKDC1 Q2TB90 CHEMBL1741200
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] P15428 CHEMBL1293255
Enzyme_unclassified AKR1B1 Aldose reductase P15121 CHEMBL1900
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified ALDH1A1 Aldehyde dehydrogenase 1A1 P00352 CHEMBL3577
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified GFER FAD-linked sulfhydryl oxidase ALR P55789 CHEMBL1741189
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified USP2 Ubiquitin carboxyl-terminal hydrolase 2 O75604 CHEMBL1293227
Enzyme_unclassified TNKS Tankyrase-1 O95271 CHEMBL6164
Enzyme_unclassified PARP1 Poly [ADP-ribose] polymerase-1 P09874 CHEMBL3105
Enzyme_unclassified TNKS2 Tankyrase-2 Q9H2K2 CHEMBL6154
Hydrolase GAA Lysosomal alpha-glucosidase P10253 CHEMBL2608
Isomerase TOP1 DNA topoisomerase I P11387 CHEMBL1781
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA3 Carbonic anhydrase III P07451 CHEMBL2885
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA5B Carbonic anhydrase VB Q9Y2D0 CHEMBL3969
Lyase CA5A Carbonic anhydrase VA P35218 CHEMBL4789
Lyase CA1 Carbonic anhydrase I P00915 CHEMBL261
Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Lyase CA13 Carbonic anhydrase XIII Q8N1Q1 CHEMBL3912
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lyase CA6 Carbonic anhydrase VI P23280 CHEMBL3025
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP12 Matrix metalloproteinase 12 P39900 CHEMBL4393
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Q9Y468 CHEMBL1287622
Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein Q16637 CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C PPARA Peroxisome proliferator-activated receptor alpha Q07869 CHEMBL239
Nuclear hormone receptor subfamily 1 group C PPARG Peroxisome proliferator-activated receptor gamma P37231 CHEMBL235
Nuclear hormone receptor subfamily 1 group C PPARD Peroxisome proliferator-activated receptor delta Q03181 CHEMBL3979
Nuclear hormone receptor subfamily 1 group I NR1I2 Pregnane X receptor O75469 CHEMBL3401
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Oxidoreductase HMGCR HMG-CoA reductase P04035 CHEMBL402
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase P09917 CHEMBL215
Oxidoreductase PTGS1 Cyclooxygenase-1 P23219 CHEMBL221
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Phosphodiesterase 5 PDE5A Phosphodiesterase 5A O76074 CHEMBL1827
Protein Kinase AKT1 Serine/threonine-protein kinase AKT P31749 CHEMBL4282
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase GSK3B Glycogen synthase kinase-3 beta P49841 CHEMBL262
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Protein Kinase BRAF Serine/threonine-protein kinase B-raf P15056 CHEMBL5145
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase AURKA Serine/threonine-protein kinase Aurora-A O14965 CHEMBL4722
Protein Kinase FLT4 Vascular endothelial growth factor receptor 3 P35916 CHEMBL1955
Protein Kinase EPHB4 Ephrin type-B receptor 4 P54760 CHEMBL5147
Protein Kinase MAP3K8 Mitogen-activated protein kinase kinase kinase 8 P41279 CHEMBL4899
Protein Kinase TEK Tyrosine-protein kinase TIE-2 Q02763 CHEMBL4128
Protein Kinase PDGFRB Platelet-derived growth factor receptor beta P09619 CHEMBL1913
Protein Kinase INSR Insulin receptor P06213 CHEMBL1981
Protein Kinase PLK4 Serine/threonine-protein kinase PLK4 O00444 CHEMBL3788
Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Protein Kinase MAPK14 MAP kinase p38 alpha Q16539 CHEMBL260
Protein Kinase MAPK3 MAP kinase ERK1 P27361 CHEMBL3385
Protein Kinase ERBB2 Receptor protein-tyrosine kinase erbB-2 P04626 CHEMBL1824
Protein Kinase EGFR Epidermal growth factor receptor erbB1 P00533 CHEMBL203
Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Protein Kinase LCK Tyrosine-protein kinase LCK P06239 CHEMBL258
Protein Kinase FYN Tyrosine-protein kinase FYN P06241 CHEMBL1841
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase PLK1 Serine/threonine-protein kinase PLK1 P53350 CHEMBL3024
Protein Phosphatase DUSP3 Dual specificity protein phosphatase 3 P51452 CHEMBL2635
SLC superfamily of solute carriers SLC22A6 Solute carrier family 22 member 6 Q4U2R8 CHEMBL1641347
SLC superfamily of solute carriers SLCO1B3 Solute carrier organic anion transporter family member 1B3 Q9NPD5 CHEMBL1743121
SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 Q9Y6L6 CHEMBL1697668
Small molecule receptor (family A GPCR) GPR35 G-protein coupled receptor 35 Q9HC97 CHEMBL1293267
Small molecule receptor (family A GPCR) FFAR1 Free fatty acid receptor 1 O14842 CHEMBL4422
Small molecule receptor (family A GPCR) FFAR4 G-protein coupled receptor 120 Q5NUL3 CHEMBL5339
Small molecule receptor (family A GPCR) ADRA2B Alpha-2b adrenergic receptor P18089 CHEMBL1942
Toll-like and Il-1 receptors TLR2 Toll-like receptor 2 O60603 CHEMBL4163
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 Q11130 CHEMBL3596077
Unclassified SMAD3 Mothers against decapentaplegic homolog 3 P84022 CHEMBL1293258
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified FABP5 Fatty acid binding protein epidermal Q01469 CHEMBL3674
Unclassified FABP2 Fatty acid binding protein intestinal P12104 CHEMBL4879
Unclassified FABP4 Fatty acid binding protein adipocyte P15090 CHEMBL2083
Unclassified MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Q07820 CHEMBL4361
Unclassified MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Unclassified HBB Hemoglobin beta chain P68871 CHEMBL4331
Unclassified FABP3 Fatty acid binding protein muscle P05413 CHEMBL3344
Unclassified HSPA1A Heat shock 70 kDa protein 1 P0DMV8 CHEMBL5460
Unclassified APP Beta amyloid A4 protein P05067 CHEMBL2487
Unclassified TTR Transthyretin P02766 CHEMBL3194
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 8.343E-12 1.366E-09 EGFR, FYN, IGF1R, INSR, KDR, LCK, MAPK3, PTK2, SRC
MF GO:0005488; binding GO:0008270; zinc ion binding 1.191E-11 1.921E-09 BLM, CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, L3MBTL1, MMP12, MMP2, MMP9, NR1I2, PARP1, PPARA, PPARD, PPARG, SMAD3, TNKS, TP53
BP GO:0009987; cellular process GO:0070374; positive regulation of ERK1 and ERK2 cascade 1.906E-10 2.455E-08 ALOX15, APP, BRAF, EGFR, FFAR4, FLT4, HMGCR, KDR, MAPK3, NOX4, PDGFRB, SRC, TEK
BP GO:0050896; response to stimulus GO:0034614; cellular response to reactive oxygen species 9.730E-10 1.070E-07 AKR1B1, AKT1, APEX1, CYP1B1, EGFR, MAPK1, MAPK3, MMP9, SRC, TP53
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 1.926E-09 2.026E-07 EGFR, ERBB2, FYN, INSR, LCK, MET, NOX4, PDGFRB, PTK2, SRC, TEK
MF GO:0005488; binding GO:0005506; iron ion binding 3.316E-09 3.358E-07 ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, HBB, TBXAS1, XDH
BP Unclassified; GO:0032844; regulation of homeostatic process 3.603E-09 3.632E-07 AURKB, CA2, CA7, CD38, EGFR, FYN, HIF1A, HMGCR, KDR, LCK, MAPK1, MAPK14, MAPK3, PARP1, SRC, TNKS, TNKS2
MF GO:0005488; binding GO:0020037; heme binding 5.157E-09 5.058E-07 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, HBB, NOX4, PTGS1, SRC, TBXAS1
CC GO:0016020; membrane GO:0016323; basolateral plasma membrane 1.604E-08 1.461E-06 CA2, CA4, CA9, EGFR, ERBB2, HPGD, SLC22A6, SLCO1B1, SLCO1B3, TEK, TSHR
BP GO:0050896; response to stimulus GO:0042060; wound healing 1.975E-08 1.734E-06 ALOX15, EGFR, ERBB2, PDGFRB, PPARA, PPARD, SMAD3, TP53
BP GO:0009987; cellular process GO:0071276; cellular response to cadmium ion 2.682E-08 2.299E-06 AKT1, CYP1A2, EGFR, MAPK1, MAPK3, MMP9
BP GO:0065007; biological regulation GO:1904355; positive regulation of telomere capping 4.183E-08 3.464E-06 AURKB, MAPK1, MAPK3, TNKS, TNKS2
MF GO:0005488; binding GO:0019901; protein kinase binding 6.420E-08 5.065E-06 AKT1, AURKA, BRAF, DUSP3, EGFR, GSK3B, HIF1A, LCK, MAPK1, MAPK14, PARP1, PDGFRB, PLK1, PTK2, SMAD3, SRC, TP53
CC GO:0044464; cell part GO:0005829; cytosol 6.603E-08 5.174E-06 AKR1B1, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, APP, AURKA, AURKB, BLM, BRAF, CA1, CA13, CA2, CA3, CA7, CSNK2A1, DUSP3, EPHB4, ERBB2, FABP2, FABP3, FABP4, FABP5, FLT3, FYN, GFER, GLO1, GSK3B, HBB, HIF1A, HKDC1, HPGD, HSPA1A, LCK, LMNA, MAP3K8, MAPK1, MAPK14, MAPK3, MAPT, MCL1, PDE5A, PKM, PLK1, PLK4, PPARG, PTK2, SMAD3, SMN1, SMN2, SRC, TNKS, TNKS2, TP53, XDH
BP GO:0050896; response to stimulus GO:0055093; response to hyperoxia 1.350E-07 9.895E-06 CYP1A1, PDGFRB, POLB, PPARG, TP53
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 1.350E-07 9.895E-06 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9
BP GO:0009987; cellular process GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling 1.364E-07 9.966E-06 FLT3, FYN, KDR, PDGFRB, PPARD, PTK2, TEK
MF Unclassified; GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity 1.520E-07 1.092E-05 EGFR, ERBB2, INSR, KDR
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 2.522E-07 1.738E-05 CYP1A1, CYP1A2, CYP1B1, CYP2C9
MF GO:0005488; binding GO:0019825; oxygen binding 2.771E-07 1.897E-05 CYP1A1, CYP1A2, CYP1B1, CYP2C9, HBB, NOX4
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 5.889E-07 3.794E-05 CYP1A2, CYP2A6, CYP2C9, NR1I2
CC GO:0044464; cell part GO:0005739; mitochondrion 5.883E-07 3.794E-05 AKT1, APEX1, BRAF, CA5A, CA5B, CYP1A1, CYP1B1, FYN, GFER, GSK3B, HKDC1, HSD17B10, HSPA1A, MAOA, MAPK1, MAPK14, MAPK3, MCL1, MMP2, NOX4, PARP1, PKM, SRC, TP53
MF GO:0005488; binding GO:0043548; phosphatidylinositol 3-kinase binding 7.580E-07 4.702E-05 FYN, IGF1R, INSR, LCK, PDGFRB
BP GO:0008152; metabolic process GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity 9.052E-07 5.552E-05 FLT3, PDGFRB, PTK2, SRC, TEK
BP GO:0009987; cellular process GO:0035690; cellular response to drug 1.070E-06 6.438E-05 AKR1B1, APEX1, BLM, BRAF, CYP1B1, EGFR, KDR, MAPK1, MAPK3, SRC, TP53
BP GO:0050896; response to stimulus GO:0031663; lipopolysaccharide-mediated signaling pathway 1.074E-06 6.443E-05 AKT1, MAPK1, MAPK14, MAPK3, TLR2
BP Unclassified; GO:0032846; positive regulation of homeostatic process 1.089E-06 6.499E-05 AURKB, CA2, CA7, EGFR, HIF1A, MAPK1, MAPK14, MAPK3, TNKS, TNKS2
BP GO:0009987; cellular process GO:1901796; regulation of signal transduction by p53 class mediator 1.166E-06 6.897E-05 AKT1, AURKA, AURKB, BLM, CSNK2A1, L3MBTL1, MAPK14, NUAK1, TP53
MF GO:0005488; binding GO:0019838; growth factor binding 1.171E-06 6.911E-05 EGFR, ERBB2, FLT4, IGF1R, INSR, KDR, PDGFRB, TEK
BP GO:0009987; cellular process GO:0038084; vascular endothelial growth factor signaling pathway 1.602E-06 9.250E-05 FLT3, FLT4, KDR, PDGFRB
BP GO:0009987; cellular process GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 1.734E-06 9.910E-05 AKT1, FYN, HSPA1A, MCL1, TERT
BP GO:0065007; biological regulation GO:0032212; positive regulation of telomere maintenance via telomerase 1.734E-06 9.910E-05 AURKB, MAPK1, MAPK3, TNKS, TNKS2
BP GO:0051179; localization GO:0042307; positive regulation of protein import into nucleus 2.069E-06 1.173E-04 APP, EGFR, MAPK1, MAPK14, PARP1, SMAD3, TLR2
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 2.126E-06 1.202E-04 ALOX12, ALOX15, ALOX5, HPGD
BP GO:0008152; metabolic process GO:0008202; steroid metabolic process 2.427E-06 1.348E-04 AKR1B1, APP, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, HMGCR, NR1I2, PPARD
MF GO:0003824; catalytic activity GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity 2.790E-06 1.538E-04 EGFR, ERBB2, FYN, LCK, MET, PDGFRB
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 3.084E-06 1.670E-04 AKT1, HIF1A, LMNA, PPARD, SRC, TERT, TP53
CC GO:0043226; organelle GO:0005654; nucleoplasm 4.070E-06 2.146E-04 AKR1B1, AKT1, ALOX5, APEX1, AURKA, AURKB, BLM, CSNK2A1, DUSP3, FABP5, GSK3B, HIF1A, HPGD, HSPA1A, L3MBTL1, LMNA, MAPK1, MAPK14, MAPK3, MCL1, NR1I2, NUAK1, PARP1, PLK1, POLB, PPARA, PPARD, PPARG, RECQL, SMAD3, SMN1, SMN2, SRC, TERT, TNKS, TOP1, TP53, USP2
BP GO:0009987; cellular process GO:0030168; platelet activation 4.485E-06 2.331E-04 ADRA2B, AKT1, FYN, LCK, MAPK1, MAPK3, SRC
BP GO:0008152; metabolic process GO:0045429; positive regulation of nitric oxide biosynthetic process 4.516E-06 2.336E-04 AKT1, EGFR, HBB, INSR, SMAD3
BP GO:0009987; cellular process GO:0048010; vascular endothelial growth factor receptor signaling pathway 4.659E-06 2.398E-04 FLT4, FYN, KDR, MAPK14, PTK2, SRC
MF Unclassified; GO:0032403; protein complex binding 5.273E-06 2.683E-04 APEX1, EGFR, FLT3, FYN, IGF1R, INSR, KDR, LCK, MMP12, MMP9, PKM, PLK1, PPARA, SMAD3, SRC, TLR2, TSHR
BP GO:0009987; cellular process GO:1901216; positive regulation of neuron death 6.900E-06 3.369E-04 FYN, GSK3B, MAPT, MCL1, PARP1, TP53
MF GO:0060089; molecular transducer activity GO:0005021; vascular endothelial growth factor-activated receptor activity 7.258E-06 3.528E-04 FLT3, FLT4, KDR
BP GO:0008152; metabolic process GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter 8.308E-06 3.976E-04 HIF1A, SMAD3, TERT, TP53
BP GO:0008283; cell proliferation GO:1904707; positive regulation of vascular smooth muscle cell proliferation 8.308E-06 3.976E-04 HPGD, MMP2, MMP9, TERT
BP GO:0050896; response to stimulus GO:0070542; response to fatty acid 8.618E-06 4.097E-04 AKT1, FABP3, FFAR1, PPARG, SRC, TLR2
BP GO:0009987; cellular process GO:1903376; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 1.156E-05 5.245E-04 HIF1A, MCL1, PARP1
BP GO:0032501; multicellular organismal process GO:0030878; thyroid gland development 1.196E-05 5.369E-04 BRAF, MAPK1, MAPK3, SMAD3
BP GO:0008152; metabolic process GO:0019433; triglyceride catabolic process 1.417E-05 6.246E-04 FABP2, FABP3, FABP4, FABP5
BP GO:0032501; multicellular organismal process GO:0048143; astrocyte activation 1.727E-05 7.372E-04 APP, EGFR, MAPT
BP GO:0009987; cellular process GO:0000733; DNA strand renaturation 1.727E-05 7.372E-04 BLM, RECQL, TP53
BP GO:0065007; biological regulation GO:1904357; negative regulation of telomere maintenance via telomere lengthening 1.948E-05 8.156E-04 PARP1, SRC, TNKS, TNKS2
BP GO:0050896; response to stimulus GO:1904646; cellular response to amyloid-beta 1.948E-05 8.156E-04 APP, GSK3B, IGF1R, PARP1
BP GO:0008283; cell proliferation GO:0008285; negative regulation of cell proliferation 2.074E-05 8.617E-04 APP, CYP1B1, ERBB2, FABP3, HSPA1A, LMNA, NOX4, PDE5A, PPARD, PPARG, SMAD3, TERT, TLR2, TP53, XDH
BP GO:0008152; metabolic process GO:0046320; regulation of fatty acid oxidation 2.262E-05 9.328E-04 AKT1, FABP3, PPARA, PPARG
MF GO:0005488; binding GO:0051721; protein phosphatase 2A binding 2.262E-05 9.328E-04 AKT1, HMGCR, MAPT, TP53
BP GO:0009987; cellular process GO:2001243; negative regulation of intrinsic apoptotic signaling pathway 2.317E-05 9.519E-04 AKT1, HIF1A, HSPA1A, MCL1, MMP9, SRC
BP GO:0008152; metabolic process GO:0051974; negative regulation of telomerase activity 2.456E-05 1.001E-03 PPARG, SRC, TP53
CC GO:0032991; macromolecular complex GO:0043235; receptor complex 2.469E-05 1.005E-03 ABCG2, APP, EGFR, ERBB2, FLT4, IGF1R, INSR, SMAD3, TLR2, TSHR
BP Unclassified; GO:0032845; negative regulation of homeostatic process 2.618E-05 1.052E-03 CD38, HMGCR, LCK, PARP1, SRC, TNKS, TNKS2
BP Unclassified; GO:0006461; protein complex assembly 2.655E-05 1.065E-03 BLM, BRAF, GSK3B, HBB, HMGCR, HSD17B10, HSPA1A, IGF1R, INSR, MAPK3, MAPT, PKM, PTK2, SLC22A6, SMAD3, SRC, TEK, TERT, TP53
BP GO:0009987; cellular process GO:0006974; cellular response to DNA damage stimulus 2.734E-05 1.094E-03 AKT1, APEX1, AURKA, BLM, MAPK1, MAPK14, MAPK3, MCL1, NUAK1, PARP1, PLK1, POLB, RECQL, TDP1, TP53
BP GO:0008152; metabolic process GO:0046854; phosphatidylinositol phosphorylation 2.930E-05 1.158E-03 EGFR, ERBB2, FYN, LCK, MET, PDGFRB
BP GO:0002376; immune system process GO:0043312; neutrophil degranulation 3.338E-05 1.296E-03 ALOX5, FABP5, GAA, GLA, HBB, HSPA1A, MAPK1, MAPK14, MMP9, PKM, TLR2, TTR
BP GO:0065007; biological regulation GO:0060249; anatomical structure homeostasis 3.384E-05 1.309E-03 AKR1B1, APEX1, BLM, GAA, HIF1A, NOX4, PARP1, SRC, TERT
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 3.428E-05 1.314E-03 ALOX12, ALOX15, ALOX5, TLR2
CC GO:0043226; organelle GO:0051233; spindle midzone 3.428E-05 1.314E-03 APP, AURKA, AURKB, PLK1
BP GO:0009987; cellular process GO:0006286; base-excision repair, base-free sugar-phosphate removal 3.576E-05 1.352E-03 APEX1, POLB
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 3.576E-05 1.352E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 3.576E-05 1.352E-03 ALOX12, ALOX15
MF GO:0005488; binding GO:0042610; CD8 receptor binding 3.576E-05 1.352E-03 FYN, LCK
BP GO:0032501; multicellular organismal process GO:0003007; heart morphogenesis 3.899E-05 1.451E-03 EPHB4, GAA, INSR, PTK2
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 3.899E-05 1.451E-03 CSNK2A1, HIF1A, KDR, MAPT
BP GO:0008152; metabolic process GO:0010907; positive regulation of glucose metabolic process 4.417E-05 1.608E-03 AKT1, INSR, PPARA, SRC
MF GO:0005488; binding GO:0046982; protein heterodimerization activity 4.491E-05 1.633E-03 AURKA, BRAF, EGFR, ERBB2, HIF1A, MCL1, PPARD, PPARG, SMAD3, TLR2, TP53, TTR
BP GO:0050896; response to stimulus GO:0042542; response to hydrogen peroxide 4.788E-05 1.729E-03 AKR1B1, APEX1, CYP1B1, HBB, PDGFRB, SRC
BP GO:0009987; cellular process GO:0070507; regulation of microtubule cytoskeleton organization 4.936E-05 1.771E-03 AURKA, GSK3B, HSPA1A, MAPT, MET, PLK1, PLK4
BP GO:0065007; biological regulation GO:0042593; glucose homeostasis 4.936E-05 1.771E-03 AKT1, FFAR1, HIF1A, HKDC1, INSR, NOX4, PPARG
BP GO:0065007; biological regulation GO:0032148; activation of protein kinase B activity 4.982E-05 1.784E-03 ADRA2B, AKT1, INSR, SRC
BP GO:0040011; locomotion GO:0014911; positive regulation of smooth muscle cell migration 6.270E-05 2.188E-03 NOX4, PDGFRB, SRC, TERT
BP GO:0065007; biological regulation GO:0045124; regulation of bone resorption 6.270E-05 2.188E-03 CA2, CD38, EGFR, SRC
MF GO:0005488; binding GO:0002039; p53 binding 6.350E-05 2.212E-03 BLM, GSK3B, HIF1A, NUAK1, TP53
BP GO:0009987; cellular process GO:0031334; positive regulation of protein complex assembly 6.462E-05 2.240E-03 ALOX15, GSK3B, HSPA1A, MAPT, MET, PARP1, SRC, TP53
BP GO:0050896; response to stimulus GO:0050728; negative regulation of inflammatory response 6.805E-05 2.341E-03 FFAR4, PPARA, PPARD, PPARG, SMAD3, TEK
CC GO:0016020; membrane GO:0005901; caveola 6.798E-05 2.341E-03 INSR, MAPK1, MAPK3, SLC22A6, SRC
BP GO:0050896; response to stimulus GO:0034405; response to fluid shear stress 6.998E-05 2.400E-03 AKT1, CA2, PDGFRB, SRC
BP GO:0050896; response to stimulus GO:0045471; response to ethanol 7.142E-05 2.445E-03 CA3, FYN, HMGCR, HPGD, POLB, TP53
CC GO:0044464; cell part GO:0031234; extrinsic component of cytoplasmic side of plasma membrane 7.271E-05 2.486E-03 ALOX15, FYN, LCK, PTK2, SRC
MF Unclassified; GO:0004707; MAP kinase activity 7.320E-05 2.498E-03 MAPK1, MAPK14, MAPK3
BP GO:0050896; response to stimulus GO:0043627; response to estrogen 7.769E-05 2.635E-03 CA2, MAPK1, PDGFRB, PPARG, TEK
BP GO:0051179; localization GO:0070198; protein localization to chromosome, telomeric region 9.110E-05 3.033E-03 TERT, TNKS, TNKS2
MF Unclassified; GO:0004708; MAP kinase kinase activity 9.110E-05 3.033E-03 MAPK1, MAPK14, MAPK3
BP GO:0009987; cellular process GO:1900034; regulation of cellular response to heat 1.066E-04 3.472E-03 GSK3B, HSPA1A, MAPK1, MAPK3, MAPT
BP GO:0032501; multicellular organismal process GO:0014005; microglia development 1.068E-04 3.472E-03 APP, TLR2
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.068E-04 3.472E-03 CA2, CA7
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.068E-04 3.472E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.068E-04 3.472E-03 ALOX12, ALOX15
BP GO:0009987; cellular process GO:2000811; negative regulation of anoikis 1.116E-04 3.612E-03 MCL1, PTK2, SRC
BP GO:0051179; localization GO:0046326; positive regulation of glucose import 1.272E-04 4.085E-03 AKT1, INSR, MAPK14, TERT
BP GO:0008152; metabolic process GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process 1.276E-04 4.085E-03 AKT1, AURKA, GSK3B, HSPA1A, PLK1
BP GO:0050896; response to stimulus GO:1901655; cellular response to ketone 1.276E-04 4.085E-03 AKR1B1, AKT1, EGFR, PPARG, SRC
BP GO:0065007; biological regulation GO:0031647; regulation of protein stability 1.307E-04 4.172E-03 AURKA, HSPA1A, MAPK1, PLK1, SMAD3, SRC, TERT, USP2
BP GO:0009987; cellular process GO:1901215; negative regulation of neuron death 1.321E-04 4.207E-03 AKT1, BRAF, FYN, GSK3B, HIF1A, PPARA, TERT
BP GO:0051179; localization GO:2000641; regulation of early endosome to late endosome transport 1.350E-04 4.260E-03 MAPK1, MAPK3, SRC
BP GO:0050896; response to stimulus GO:0033189; response to vitamin A 1.350E-04 4.260E-03 CYP1A1, PPARD, PPARG
BP GO:0065007; biological regulation GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process 1.352E-04 4.260E-03 LCK, MAPT, PPARG, SMAD3, XDH
CC GO:0044464; cell part GO:0048471; perinuclear region of cytoplasm 1.376E-04 4.325E-03 AKR1B1, APEX1, APP, AURKA, CA4, EGFR, ERBB2, HSPA1A, NOX4, PPARG, SRC, TNKS2, USP2
BP GO:0032501; multicellular organismal process GO:0043536; positive regulation of blood vessel endothelial cell migration 1.393E-04 4.363E-03 AKT1, HIF1A, KDR, MAPK14
BP GO:0009987; cellular process GO:0090199; regulation of release of cytochrome c from mitochondria 1.521E-04 4.699E-03 AKT1, LMNA, MMP9, TP53
BP GO:0032502; developmental process GO:0009888; tissue development 1.537E-04 4.741E-03 ALOX15, CYP1B1, FABP5, GAA, INSR, KDR, MAPK14, PDGFRB, PKM, PPARA, PPARD, SMAD3
BP GO:0008152; metabolic process GO:0051000; positive regulation of nitric-oxide synthase activity 1.612E-04 4.938E-03 AKT1, HIF1A, TERT
BP GO:0032502; developmental process GO:0060324; face development 1.612E-04 4.938E-03 BRAF, MAPK1, MAPK3
BP GO:0008283; cell proliferation GO:0001938; positive regulation of endothelial cell proliferation 1.693E-04 5.149E-03 AKT1, FLT4, HIF1A, KDR, TEK
BP GO:0048511; rhythmic process GO:0007623; circadian rhythm 1.716E-04 5.191E-03 EGFR, GSK3B, PPARA, TOP1, TP53, USP2
BP GO:0050896; response to stimulus GO:0009612; response to mechanical stimulus 1.769E-04 5.329E-03 AKT1, EGFR, FYN, MAPK14, MAPK3, PPARG, SRC
MF Unclassified; GO:0004872; receptor activity 1.855E-04 5.562E-03 ADRA2B, EGFR, EPHB4, ERBB2, FFAR1, FFAR4, FLT3, FLT4, GPR35, HPGD, IGF1R, INSR, KDR, MET, NR1I2, PDGFRB, PPARA, PPARD, PPARG, TEK, TLR2, TSHR
BP GO:0008152; metabolic process GO:0009895; negative regulation of catabolic process 1.900E-04 5.675E-03 AKT1, EGFR, FYN, MAPK14, MCL1, MET, PPARA, SMAD3
BP GO:0007610; behavior GO:0008542; visual learning 1.959E-04 5.821E-03 APP, BRAF, HIF1A, HMGCR
BP GO:0051179; localization GO:0051051; negative regulation of transport 1.989E-04 5.893E-03 ADRA2B, AKT1, APP, BRAF, FFAR4, GPR35, GSK3B, HMGCR, HSPA1A, MMP9, TLR2
BP GO:0009987; cellular process GO:0060282; positive regulation of oocyte development 2.128E-04 6.163E-03 AURKA, PDE5A
BP GO:0008152; metabolic process GO:0070213; protein auto-ADP-ribosylation 2.128E-04 6.163E-03 TNKS, TNKS2
BP GO:0009987; cellular process GO:0090170; regulation of Golgi inheritance 2.128E-04 6.163E-03 MAPK1, MAPK3
BP GO:0032501; multicellular organismal process GO:0032640; tumor necrosis factor production 2.128E-04 6.163E-03 APP, TLR2
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 2.128E-04 6.163E-03 CYP1A1, CYP1A2
MF GO:0140110; transcription regulator activity GO:0004879; nuclear receptor activity 2.124E-04 6.163E-03 NR1I2, PPARA, PPARD, PPARG
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 2.128E-04 6.163E-03 CYP1A2, CYP2C9
MF GO:0005488; binding GO:0051425; PTB domain binding 2.128E-04 6.163E-03 APP, INSR
CC GO:0043226; organelle GO:0000242; pericentriolar material 2.233E-04 6.398E-03 LCK, TNKS, TNKS2
MF GO:0003824; catalytic activity GO:0004715; non-membrane spanning protein tyrosine kinase activity 2.482E-04 7.037E-03 FYN, LCK, PTK2, SRC
BP GO:0009987; cellular process GO:0051262; protein tetramerization 2.617E-04 7.381E-03 HMGCR, HSD17B10, IGF1R, INSR, PKM, TP53
BP Unclassified; GO:2000021; regulation of ion homeostasis 2.626E-04 7.382E-03 CA2, CA7, FYN, KDR, LCK, PARP1, SRC
BP GO:0065007; biological regulation GO:0030641; regulation of cellular pH 2.699E-04 7.533E-03 CA2, CA7, MAPK1, MAPK3, TP53
CC GO:0044421; extracellular region part GO:0070062; extracellular exosome 2.779E-04 7.719E-03 AKR1B1, ALDH1A1, ALOX12, APP, CA1, CA2, CA4, CA6, CD38, DUSP3, EPHB4, FABP3, FABP4, FABP5, GAA, GLA, GLO1, HBB, HPGD, HSPA1A, INSR, LCK, MAPK1, MAPK14, MAPK3, MMP9, PDGFRB, PKM, PTGS1, SLC22A6, SRC, TTR
BP GO:0065007; biological regulation GO:0008217; regulation of blood pressure 2.815E-04 7.787E-03 ADRA2B, HBB, PPARA, PPARG, PTGS1, SMAD3
BP GO:0050896; response to stimulus GO:0051591; response to cAMP 2.833E-04 7.809E-03 APEX1, APP, BRAF, NOX4, TEK
CC GO:0043226; organelle GO:0005876; spindle microtubule 2.882E-04 7.912E-03 AURKA, AURKB, PLK1, POLB
MF GO:0005488; binding GO:0042803; protein homodimerization activity 2.952E-04 8.055E-03 ABCG2, AKT1, BLM, FLT3, FLT4, GLA, HMGCR, HPGD, MAPT, MCL1, SLC22A6, SMAD3, TERT, XDH
BP GO:0050896; response to stimulus GO:0010332; response to gamma radiation 3.098E-04 8.400E-03 NOX4, PARP1, POLB, TP53
BP GO:0032502; developmental process GO:0045766; positive regulation of angiogenesis 3.360E-04 9.055E-03 ALOX12, CYP1B1, HIF1A, KDR, TEK, TERT
BP GO:0008152; metabolic process GO:0009404; toxin metabolic process 3.424E-04 9.171E-03 CYP1A1, CYP1A2, CYP1B1
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 3.424E-04 9.171E-03 CYP1A1, CYP1A2, CYP1B1
BP GO:0051179; localization GO:0072584; caveolin-mediated endocytosis 3.534E-04 9.326E-03 MAPK1, MAPK3
BP GO:0032501; multicellular organismal process GO:0061308; cardiac neural crest cell development involved in heart development 3.534E-04 9.326E-03 MAPK1, MAPK3
BP GO:0008152; metabolic process GO:0051122; hepoxilin biosynthetic process 3.534E-04 9.326E-03 ALOX12, ALOX15
BP GO:0051179; localization GO:0010891; negative regulation of sequestering of triglyceride 3.534E-04 9.326E-03 PPARA, PPARG
MF GO:0005488; binding GO:0051525; NFAT protein binding 3.534E-04 9.326E-03 MAPK14, PPARA
MF GO:0003824; catalytic activity GO:0009378; four-way junction helicase activity 3.534E-04 9.326E-03 BLM, RECQL
CC GO:0032991; macromolecular complex GO:0032133; chromosome passenger complex 3.534E-04 9.326E-03 AURKA, AURKB
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 5.493E-25 1.196E-20 CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP GO:0051179; localization GO:0015701; bicarbonate transport 2.938E-19 4.376E-16 CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, HBB
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.195E-16 6.344E-14 CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF GO:0005488; binding GO:0005524; ATP binding 1.306E-13 3.159E-11 ABCG2, AKT1, AURKA, AURKB, BLM, BRAF, CSNK2A1, EGFR, EPHB4, ERBB2, FLT3, FLT4, FYN, GSK3B, HKDC1, HSPA1A, IGF1R, INSR, KDR, LCK, MAP3K8, MAPK1, MAPK14, MAPK3, MET, NUAK1, PDGFRB, PKM, PLK1, PLK4, PTK2, RECQL, SRC, TEK, TOP1, TP53
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 4.875E-24 9.652E-22 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14; CA13
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 2.775E-15 2.451E-13 SRC; MMP2; BRAF; MAPK14; HIF1A; MMP9; PTK2; EGFR; IGF1R; ERBB2; KDR; AKT1; MAPK1; TP53; MET; TLR2; MAPK3
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 3.713E-15 2.451E-13 PDGFRB; PKM; FLT3; HKDC1; ERBB2; AKT1; MAPK1; TP53; MET; HIF1A; EGFR; MAPK3
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 1.478E-12 4.596E-11 PDGFRB; GSK3B; SMAD3; FLT3; MMP2; BRAF; HIF1A; MMP9; EGFR; PTK2; IGF1R; ERBB2; AKT1; MAPK1; PPARG; MET; TP53; PPARD; MAPK3
hsa04510 Focal adhesion_Homo sapiens_hsa04510 7.742E-13 3.066E-11 PDGFRB; GSK3B; SRC; FLT4; BRAF; PTK2; EGFR; IGF1R; ERBB2; KDR; AKT1; MAPK1; FYN; MET; MAPK3
hsa04520 Adherens junction_Homo sapiens_hsa04520 4.737E-13 2.345E-11 SMAD3; CSNK2A1; SRC; INSR; ERBB2; MAPK1; FYN; MET; EGFR; IGF1R; MAPK3
hsa04015 Rap1 signaling pathway_Homo sapiens_hsa04015 2.157E-11 5.339E-10 PDGFRB; SRC; INSR; FLT4; BRAF; MAPK14; EGFR; IGF1R; KDR; AKT1; MAPK1; TEK; MET; MAPK3
hsa05219 Bladder cancer_Homo sapiens_hsa05219 1.625E-12 4.596E-11 SRC; MMP2; ERBB2; MAPK1; BRAF; MMP9; TP53; EGFR; MAPK3
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 1.335E-10 2.643E-09 PDGFRB; GSK3B; INSR; FLT4; PTK2; EGFR; IGF1R; KDR; AKT1; MAPK1; TEK; TP53; MET; TLR2; MCL1; MAPK3
hsa05215 Prostate cancer_Homo sapiens_hsa05215 1.006E-10 2.212E-09 PDGFRB; GSK3B; ERBB2; AKT1; MAPK1; BRAF; TP53; EGFR; IGF1R; MAPK3
hsa05218 Melanoma_Homo sapiens_hsa05218 2.988E-10 5.306E-09 PDGFRB; AKT1; MAPK1; BRAF; TP53; MET; EGFR; IGF1R; MAPK3
hsa04068 FoxO signaling pathway_Homo sapiens_hsa04068 3.216E-10 5.306E-09 PLK4; SMAD3; INSR; PLK1; AKT1; MAPK1; BRAF; MAPK14; EGFR; IGF1R; MAPK3
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 4.360E-10 6.641E-09 INSR; HKDC1; ERBB2; AKT1; MAPK1; TEK; HIF1A; EGFR; IGF1R; MAPK3
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 1.001E-09 1.322E-08 CYP2C9; APP; MAOA; ALOX5; ALOX15; MAPK1; BRAF; ALOX12; PTGS1; MAPK3
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 6.102E-10 8.629E-09 GSK3B; ERBB2; AKT1; MAPK1; BRAF; TP53; EGFR; MAPK3
hsa05214 Glioma_Homo sapiens_hsa05214 3.844E-09 4.478E-08 PDGFRB; AKT1; MAPK1; BRAF; TP53; EGFR; IGF1R; MAPK3
hsa04012 ErbB signaling pathway_Homo sapiens_hsa04012 1.905E-09 2.358E-08 GSK3B; SRC; ERBB2; AKT1; MAPK1; BRAF; EGFR; PTK2; MAPK3
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 3.033E-08 3.160E-07 PDGFRB; DUSP3; AKT1; MAPK1; BRAF; MAP3K8; MAPT; MAPK14; TP53; EGFR; HSPA1A; MAPK3
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 4.354E-09 4.789E-08 SMAD3; ERBB2; AKT1; MAPK1; BRAF; TP53; EGFR; MAPK3
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 8.738E-08 7.209E-07 PDGFRB; INSR; FLT4; KDR; AKT1; MAPK1; TEK; MET; EGFR; IGF1R; MAPK3
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 3.373E-08 3.339E-07 ERBB2; AKT1; MAPK1; BRAF; TP53; EGFR; MAPK3
hsa04370 VEGF signaling pathway_Homo sapiens_hsa04370 6.195E-08 5.841E-07 SRC; KDR; AKT1; MAPK1; MAPK14; PTK2; MAPK3
hsa05160 Hepatitis C_Homo sapiens_hsa05160 8.095E-08 6.969E-07 GSK3B; AKT1; MAPK1; BRAF; MAPK14; PPARA; TP53; EGFR; MAPK3
hsa04915 Estrogen signaling pathway_Homo sapiens_hsa04915 1.107E-07 8.770E-07 SRC; MMP2; AKT1; MAPK1; MMP9; EGFR; HSPA1A; MAPK3
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 6.950E-08 6.255E-07 GSK3B; SMAD3; AKT1; MAPK1; BRAF; TP53; MAPK3
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 1.626E-07 1.193E-06 GSK3B; LCK; AKT1; MAPK1; MAP3K8; FYN; MAPK14; MAPK3
hsa04611 Platelet activation_Homo sapiens_hsa04611 5.577E-07 3.943E-06 SRC; TBXAS1; AKT1; MAPK1; FYN; MAPK14; PTGS1; MAPK3
hsa04914 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 1.647E-06 1.019E-05 PLK1; AKT1; MAPK1; BRAF; MAPK14; IGF1R; MAPK3
hsa05161 Hepatitis B_Homo sapiens_hsa05161 2.174E-06 1.266E-05 SMAD3; SRC; AKT1; MAPK1; TP53; MMP9; TLR2; MAPK3
hsa03320 PPAR signaling pathway_Homo sapiens_hsa03320 1.475E-07 1.123E-06 FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 9.529E-07 6.289E-06 FLT3; AKT1; MAPK1; BRAF; PPARD; MAPK3
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 5.705E-06 2.896E-05 ALOX5; AKT1; MAPK1; MAPK14; HSPA1A; TLR2; MAPK3
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 5.705E-06 2.896E-05 GSK3B; SRC; AKT1; MAPK1; TP53; HIF1A; MAPK3
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 6.376E-06 3.156E-05 GSK3B; AKT1; MAPK1; BRAF; MAPK14; TP53; MAPK3
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 1.577E-06 1.007E-05 CYP2C9; ALOX5; ALOX15; TBXAS1; ALOX12; PTGS1
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 3.823E-06 2.103E-05 GSK3B; SRC; AKT1; MAPK1; MAPK14; MAPK3
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 4.146E-06 2.218E-05 SMAD3; AKT1; MAPK1; BRAF; TP53; MAPK3
hsa05211 Renal cell carcinoma_Homo sapiens_hsa05211 2.287E-06 1.294E-05 AKT1; MAPK1; BRAF; MET; HIF1A; MAPK3
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 1.023E-05 4.659E-05 HPGD; FLT3; PPARG; TP53; MMP9; MET; PTK2; IGF1R
hsa04360 Axon guidance_Homo sapiens_hsa04360 9.263E-06 4.367E-05 GSK3B; MAPK1; FYN; MET; PTK2; EPHB4; MAPK3
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 1.193E-05 5.249E-05 LCK; AKT1; MAPK1; PPARG; FYN; MAPK14; MAPK3
hsa05162 Measles_Homo sapiens_hsa05162 1.449E-05 6.239E-05 GSK3B; CSNK2A1; AKT1; FYN; TP53; HSPA1A; TLR2
hsa04210 Apoptosis_Homo sapiens_hsa04210 1.750E-05 7.072E-05 PARP1; LMNA; AKT1; MAPK1; TP53; MCL1; MAPK3
hsa04910 Insulin signaling pathway_Homo sapiens_hsa04910 1.670E-05 6.891E-05 GSK3B; INSR; HKDC1; AKT1; MAPK1; BRAF; MAPK3
hsa04912 GnRH signaling pathway_Homo sapiens_hsa04912 1.491E-05 6.283E-05 SRC; MMP2; MAPK1; MAPK14; EGFR; MAPK3
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 2.786E-05 9.679E-05 MAOA; GAA; ALOX15; AKR1B1; ALOX12; HMGCR; HSD17B10; PTGS1; CYP2C9; CYP2A6; FUT7; PKM; ALOX5; HKDC1; TBXAS1; CYP1A2; ALDH1A1; CYP1A1; CD38; XDH
hsa04072 Phospholipase D signaling pathway_Homo sapiens_hsa04072 2.100E-05 7.997E-05 PDGFRB; INSR; AKT1; MAPK1; FYN; EGFR; MAPK3
hsa04550 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 1.919E-05 7.449E-05 GSK3B; SMAD3; AKT1; MAPK1; MAPK14; IGF1R; MAPK3
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 2.705E-05 9.566E-05 SMAD3; MMP2; AKT1; MAPK1; MAPK14; MAPK3
hsa05231 Choline metabolism in cancer_Homo sapiens_hsa05231 2.705E-05 9.566E-05 PDGFRB; AKT1; MAPK1; HIF1A; EGFR; MAPK3
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 3.557E-05 1.194E-04 AKT1; MAPK1; MAP3K8; MAPK14; TLR2; MAPK3
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 5.916E-05 1.775E-04 PDGFRB; ERBB2; CYP1B1; MAPK1; TP53; MMP9; MET; EGFR; MCL1
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 4.383E-05 1.423E-04 AKT1; MAPK1; MAP3K8; MAPK14; MMP9; MAPK3
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 3.194E-05 1.090E-04 SMAD3; AKT1; MAPK1; MAPK14; TLR2; MAPK3
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 5.632E-05 1.742E-04 BACE1; APP; GSK3B; MAPK1; MAPT; HSD17B10; MAPK3
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 6.394E-07 4.366E-06 MAPK1; BRAF; PPARG; TP53; MAPK3
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 1.316E-04 3.620E-04 PDGFRB; POLB; GSK3B; SMAD3; TERT; LCK; AKT1; TP53
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 1.104E-04 3.122E-04 GSK3B; SRC; AKT1; MAPK1; BRAF; PTK2; MAPK3
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 1.779E-04 4.760E-04 GSK3B; CSNK2A1; AKT1; CD38; MAPK14; TP53; HSPA1A
hsa04930 Type II diabetes mellitus_Homo sapiens_hsa04930 8.445E-06 4.078E-05 PKM; INSR; HKDC1; MAPK1; MAPK3
hsa04810 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 2.532E-04 6.597E-04 PDGFRB; SRC; MAPK1; BRAF; PTK2; EGFR; MAPK3
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 7.132E-05 2.077E-04 AKT1; MAPK1; FYN; MAPK14; TP53; MAPK3
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 1.816E-05 7.189E-05 FABP4; INSR; AKT1; TSHR; PTGS1
hsa04913 Ovarian steroidogenesis_Homo sapiens_hsa04913 1.035E-05 4.659E-05 ALOX5; INSR; CYP1A1; CYP1B1; IGF1R
hsa04150 mTOR signaling pathway_Homo sapiens_hsa04150 2.548E-05 9.520E-05 AKT1; MAPK1; BRAF; HIF1A; MAPK3
hsa04022 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 4.310E-04 1.094E-03 INSR; AKT1; MAPK1; PDE5A; ADRA2B; MAPK3
hsa05164 Influenza A_Homo sapiens_hsa05164 5.520E-04 1.337E-03 GSK3B; AKT1; MAPK1; MAPK14; HSPA1A; MAPK3
hsa04664 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 4.688E-05 1.497E-04 AKT1; MAPK1; FYN; MAPK14; MAPK3
hsa04144 Endocytosis_Homo sapiens_hsa04144 7.919E-04 1.762E-03 SMAD3; SRC; KDR; MET; EGFR; HSPA1A; IGF1R
hsa05152 Tuberculosis_Homo sapiens_hsa05152 6.037E-04 1.440E-03 SRC; AKT1; MAPK1; MAPK14; TLR2; MAPK3
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 2.190E-04 5.782E-04 INSR; AKT1; PPARG; TP53; IGF1R
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 1.256E-03 2.618E-03 POLB; PKM; SRC; MAPK1; TP53; MAPK3
hsa04114 Oocyte meiosis_Homo sapiens_hsa04114 7.546E-04 1.717E-03 PLK1; MAPK1; AURKA; IGF1R; MAPK3
hsa04540 Gap junction_Homo sapiens_hsa04540 1.607E-04 4.358E-04 PDGFRB; SRC; MAPK1; EGFR; MAPK3
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 1.078E-03 2.296E-03 AKT1; MAPK1; BRAF; PPARA; TSHR; MAPK3
hsa04152 AMPK signaling pathway_Homo sapiens_hsa04152 7.827E-04 1.761E-03 INSR; AKT1; PPARG; HMGCR; IGF1R
hsa04060 Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 4.508E-03 8.582E-03 PDGFRB; FLT3; FLT4; KDR; MET; EGFR
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 3.766E-05 1.243E-04 CYP2C9; CYP2A6; CYP1A2; ALDH1A1; CYP1A1
hsa04921 Oxytocin signaling pathway_Homo sapiens_hsa04921 2.291E-03 4.628E-03 SRC; CD38; MAPK1; EGFR; MAPK3
hsa04310 Wnt signaling pathway_Homo sapiens_hsa04310 1.435E-03 2.959E-03 GSK3B; SMAD3; CSNK2A1; TP53; PPARD
hsa04650 Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 1.146E-03 2.414E-03 LCK; MAPK1; BRAF; FYN; MAPK3
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 1.150E-04 3.208E-04 CYP2C9; CYP2A6; CYP1A2; CYP1A1; CYP1B1
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 6.601E-05 1.951E-04 CYP2C9; CYP2A6; CYP1A2; CYP1A1; CYP1B1
hsa04976 Bile secretion_Homo sapiens_hsa04976 5.775E-05 1.759E-04 SLCO1B1; CA2; SLCO1B3; HMGCR; ABCG2
hsa04261 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 1.088E-02 1.906E-02 AKT1; MAPK1; MAPK14; MAPK3
hsa04932 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 1.164E-02 2.022E-02 GSK3B; INSR; AKT1; PPARA
hsa04931 Insulin resistance_Homo sapiens_hsa04931 3.744E-03 7.340E-03 GSK3B; INSR; AKT1; PPARA
hsa04020 Calcium signaling pathway_Homo sapiens_hsa04020 2.084E-02 3.327E-02 PDGFRB; ERBB2; CD38; EGFR
hsa05034 Alcoholism_Homo sapiens_hsa05034 2.047E-02 3.295E-02 MAOA; MAPK1; BRAF; MAPK3
hsa04725 Cholinergic synapse_Homo sapiens_hsa04725 3.995E-03 7.755E-03 AKT1; MAPK1; FYN; MAPK3
hsa04110 Cell cycle_Homo sapiens_hsa04110 5.909E-03 1.093E-02 GSK3B; SMAD3; PLK1; TP53
hsa04728 Dopaminergic synapse_Homo sapiens_hsa04728 6.784E-03 1.232E-02 GSK3B; MAOA; AKT1; MAPK14
hsa04670 Leukocyte transendothelial migration_Homo sapiens_hsa04670 4.963E-03 9.271E-03 MMP2; MAPK14; MMP9; PTK2
hsa04723 Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 2.847E-03 5.693E-03 FAAH; MAPK1; MAPK14; MAPK3
hsa04270 Vascular smooth muscle contraction_Homo sapiens_hsa04270 3.273E-02 4.985E-02 MAPK1; BRAF; MAPK3
hsa04916 Melanogenesis_Homo sapiens_hsa04916 2.047E-02 3.295E-02 GSK3B; MAPK1; MAPK3
hsa04750 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 1.941E-02 3.176E-02 SRC; ALOX12; MAPK14
hsa04922 Glucagon signaling pathway_Homo sapiens_hsa04922 2.100E-02 3.327E-02 PKM; AKT1; PPARA
hsa04666 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 1.691E-02 2.790E-02 AKT1; MAPK1; MAPK3
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 1.691E-02 2.790E-02 CSNK2A1; PARP1; LCK
hsa04350 TGF-beta signaling pathway_Homo sapiens_hsa04350 1.289E-02 2.219E-02 SMAD3; MAPK1; MAPK3
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 8.591E-04 1.869E-03 GSK3B; AKT1; MAPK1; MAPK3
hsa05132 Salmonella infection_Homo sapiens_hsa05132 1.373E-02 2.323E-02 MAPK1; MAPK14; MAPK3
hsa04213 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 5.220E-04 1.292E-03 INSR; AKT1; HSPA1A; IGF1R
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 1.373E-02 2.323E-02 AKT1; TP53; PTK2
hsa04730 Long-term depression_Homo sapiens_hsa04730 4.078E-04 1.049E-03 MAPK1; BRAF; IGF1R; MAPK3
hsa05100 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 1.055E-02 1.865E-02 SRC; MET; PTK2
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 8.591E-04 1.869E-03 MAPK1; MAPK14; TLR2; MAPK3
hsa05133 Pertussis_Homo sapiens_hsa05133 9.482E-03 1.691E-02 MAPK1; MAPK14; MAPK3
hsa05120 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 6.573E-04 1.531E-03 SRC; MAPK14; MET; EGFR
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 6.946E-04 1.599E-03 CYP2C9; CYP2A6; MAOA; CYP1A2
hsa05131 Shigellosis_Homo sapiens_hsa05131 5.538E-04 1.337E-03 SRC; MAPK1; MAPK14; MAPK3
hsa04720 Long-term potentiation_Homo sapiens_hsa04720 6.671E-03 1.223E-02 MAPK1; BRAF; MAPK3
hsa04621 NOD-like receptor signaling pathway_Homo sapiens_hsa04621 4.430E-03 8.515E-03 MAPK1; MAPK14; MAPK3
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 4.652E-03 8.772E-03 CYP1A2; CYP1A1; CYP1B1
hsa04973 Carbohydrate digestion and absorption_Homo sapiens_hsa04973 2.807E-02 4.377E-02 HKDC1; AKT1
hsa05144 Malaria_Homo sapiens_hsa05144 2.884E-03 5.711E-03 HBB; MET; TLR2
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 2.620E-05 9.566E-05 GAA; HKDC1; AKR1B1; GLA
hsa00983 Drug metabolism - other enzymes_Homo sapiens_hsa00983 2.924E-02 4.488E-02 CYP2A6; XDH
hsa05020 Prion diseases_Homo sapiens_hsa05020 4.896E-05 1.539E-04 MAPK1; FYN; HSPA1A; MAPK3
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 8.356E-05 2.398E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa04960 Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 1.492E-03 3.046E-03 INSR; MAPK1; MAPK3
hsa00620 Pyruvate metabolism_Homo sapiens_hsa00620 2.254E-02 3.541E-02 PKM; GLO1
hsa04320 Dorso-ventral axis formation_Homo sapiens_hsa04320 5.024E-04 1.259E-03 MAPK1; EGFR; MAPK3
hsa00051 Fructose and mannose metabolism_Homo sapiens_hsa00051 1.477E-02 2.478E-02 HKDC1; AKR1B1
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 6.223E-04 1.467E-03 CYP2C9; CYP1A2; ALOX15
hsa03410 Base excision repair_Homo sapiens_hsa03410 9.136E-04 1.966E-03 POLB; PARP1; APEX1
hsa04964 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 7.792E-03 1.403E-02 CA2; CA4
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 1.885E-06 1.131E-05 CYP2A6; CYP1A2; XDH
hsa00524 Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 2.867E-02 4.435E-02 HKDC1
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; IGF1R; IGF1R; PDGFRB; EGFR; EGFR; KDR
C00-D49: Neoplasms Non-small-cell lung cancer NA MMP2; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 FFAR1; INSR
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 PPARG; PPARD; PPARD
K00-K95: Diseases of the digestive system Non-alcoholic fatty liver disease K76.0 PPARG; PPARD
S00-T88: Injury, poisoning and certain other consequences of external causes Radiation sickness T66 TLR2
C00-D49: Neoplasms Recurrent epithelial ovarian or primary peritoneal cancer C78 PARP1
C00-D49: Neoplasms Refractory breast cancer C50 EGFR
C00-D49: Neoplasms Colon cancer C50 FLT3; EGFR
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR
C00-D49: Neoplasms Advanced cancers C00-C96 EGFR
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR; KDR
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA; PTGS1; ADRA2B
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 APP
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Nicotine dependence F17 PPARG
J00-J99: Diseases of the respiratory system Respiratory disease J00-J99 ALOX5
C00-D49: Neoplasms Renal cell carcinoma NA MMP2; KDR; KDR
C00-D49: Neoplasms Renal cancer C64 CA9; KDR
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA; ADRA2B
C00-D49: Neoplasms Glioblastoma multiforme C71 TOP1; SRC; ERBB2; EGFR; EGFR
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 ALOX5; MMP2; PTGS1
C00-D49: Neoplasms Cancer C00-C96 AKT1; MET; TLR2; TOP1; MCL1; GSK3B; CSNK2A1; CA1; FLT3; FLT3; CA9; MMP2; SRC; IGF1R; PTK2; BRAF; BRAF; AURKA; FLT4; EPHB4; TEK; HIF1A; MAPK1; MAPK14; MMP9; ERBB2; ERBB2; EGFR; PARP1; CD38; TP53; KDR; PLK1; APP
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 HMGCR; PDE5A; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 ALOX5
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAOA; GSK3B; MAPT; INSR; PPARG; PPARG; APP
C00-D49: Neoplasms Advanced ovarian cancer NA TOP1
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 CA4; CA4
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 CA4; CA2
H00-H59: Diseases of the eye and adnexa Ocular inflammation H16.229 TERT; PPARG
C00-D49: Neoplasms Ocular cancer C69 APEX1
E00-E89: Endocrine, nutritional and metabolic diseases Hypoglycemia E16.0-E16.2 INSR
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Drug abuse F10-F19 PPARG
C00-D49: Neoplasms Multiple myeloma C90 HMGCR; TERT; SRC; IGF1R; CD38
S00-T88: Injury, poisoning and certain other consequences of external causes Vulnerary S00-T98 EGFR
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
E00-E89: Endocrine, nutritional and metabolic diseases Amyloidosis E85 APP; TTR
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Anesthesia R20.0 FAAH
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; MAOA; FAAH
E00-E89: Endocrine, nutritional and metabolic diseases Fabry's disease E75.2 GLA
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 PKM; PTGS1; IGF1R; INSR; FAAH
C00-D49: Neoplasms Pancreatic cancer C25 AKT1; TLR2; TERT; FLT3; MMP2; EGFR; KDR; PLK1
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 MAOA; BRAF
C00-D49: Neoplasms Breast cancer C50 TERT; TOP1; FLT3; FLT3; CA9; IGF1R; INSR; ERBB2; ERBB2; ERBB2; EGFR; EGFR; EGFR; KDR; KDR; KDR
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; FLT4; KDR
C00-D49: Neoplasms Metastatic breast cancer C50 TOP1; TOP1; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic disorders E70-E89 PPARD
C00-D49: Neoplasms Mesothelioma C45 PTK2
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR
I00-I99: Diseases of the circulatory system Aortic aneurysm I71 MMP12
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 MAOA; FAAH
I00-I99: Diseases of the circulatory system Cerebral amyloid angiopathy I68.0 APP
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR
C00-D49: Neoplasms Gastric cancer C16 TOP1; ERBB2; EGFR; EGFR; KDR; KDR
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5
C00-D49: Neoplasms Osteosarcoma C40-C41 GSK3B; SRC
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 SRC
C00-D49: Neoplasms Ovarian cancer C56 TERT; TOP1; MMP2; EGFR; EGFR; PARP1; KDR; KDR; KDR; KDR
NA: NA Inflammatory diseases NA MAPK14
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET; AURKA; PLK1
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 TOP1; EGFR; KDR
C00-D49: Neoplasms Metastatic melanoma C43 BRAF; BRAF
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 APP
G00-G99: Diseases of the nervous system G00-G99 Mild to moderate alzheimer disease G30 APP
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA
J00-J99: Diseases of the respiratory system Asthma J45 TBXAS1; ALOX5; ALOX5; PDE5A; MMP12; ERBB2
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 ALOX5; TEK; MAPK14
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 HMGCR
I00-I99: Diseases of the circulatory system Atherosclerosis I70 HMGCR; NR1I2; ALOX5; MMP12; PPARD
G00-G99: Diseases of the nervous system G00-G99 Ataxia telangiectasia G11.3 PARP1
C00-D49: Neoplasms Non-hodgkin's lymphoma C85 ERBB2; PLK1
E00-E89: Endocrine, nutritional and metabolic diseases Type 1/2 diabetes E08-E13 INSR
S00-T88: Injury, poisoning and certain other consequences of external causes Postoperative inflammation T81 PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases Pompe's disease E74.02 GAA
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases Autoimmune diabetes E08-E13 TLR2; LCK; INSR
A00-B99: Certain infectious and parasitic diseases Cryptosporidium infection A07.2 EGFR
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR
I00-I99: Diseases of the circulatory system Thromboembolism I80-I82 TBXAS1
I00-I99: Diseases of the circulatory system Thrombosis I80-I82 HMGCR; TBXAS1; ALOX5
C00-D49: Neoplasms Thyroid cancer C73 BRAF; TSHR; KDR
C00-D49: Neoplasms Melanoma C43 TLR2; TERT; BRAF; EGFR; PARP1; KDR; KDR
C00-D49: Neoplasms Malignant tumor C00-C75, C7A, C7B EGFR
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 CA1
K00-K95: Diseases of the digestive system Chemotherapy or radiotherapy-induced mucositis K12.3, R52, G89 HMGCR
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 HMGCR; INSR; PPARD
C00-D49: Neoplasms Head and neck squamous cell carcinoma C44 EGFR
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1; TERT; EGFR; EGFR; EGFR; TP53; KDR; KDR
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET
I00-I99: Diseases of the circulatory system Heart failure I50 XDH
C00-D49: Neoplasms Liver cancer C22 TERT; IGF1R; KDR
C00-D49: Neoplasms Late-stage non-small cell lung cancer C33-C34 EPHB4
C00-D49: Neoplasms Leukemia C90-C95 AKT1; FLT3
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A TOP1; PTK2; BRAF; AURKA; TP53
J00-J99: Diseases of the respiratory system Rhinitis J00, J30, J31.0 ALOX5
G00-G99: Diseases of the nervous system G00-G99 Brain ischaemia G45.9, I67.8 PARP1
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 HMGCR; EGFR; PARP1
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R
C00-D49: Neoplasms Haematological malignancies C81-C86 AURKA
A00-B99: Certain infectious and parasitic diseases HBV infection B16, B18.0, B18.1 HMGCR
NA: NA Cardiovascular disease NA HMGCR
C00-D49: Neoplasms Locally advanced head and neck cancer C07-C14, C32, C33 EGFR
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET; FAAH
H00-H59: Diseases of the eye and adnexa Macular degeneration H35.3 APP
C00-D49: Neoplasms Lymphoma C81-C86 AKT1; CA9; INSR; HIF1A; ERBB2; EGFR; PLK1
I00-I99: Diseases of the circulatory system Cerebrovascular disorders I60-I69 PARP1
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT; PPARD
I00-I99: Diseases of the circulatory system Angina pectoris I20 TBXAS1; PDE5A
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 MAPT
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1; XDH; PPARG
C00-D49: Neoplasms Glioblastoma NA FLT3
C00-D49: Neoplasms Glioma C71 EGFR; EGFR; KDR; APP
C00-D49: Neoplasms Gliosarcoma NA FLT3
NA: NA Geographic retinal atrophy NA APP
NA: NA GIST NA FLT3
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1; CA1; CA1
E00-E89: Endocrine, nutritional and metabolic diseases Inflammation E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 ALOX5
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 TBXAS1; PTGS1; MAPK14; PPARG
C00-D49: Neoplasms Inflammatory breast cancer C50 EGFR
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 ALOX5; MMP12; PTGS1; MAPK14; FAAH
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory skin condition L00-L99 PARP1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CA2
G00-G99: Diseases of the nervous system G00-G99 Permanent and transient stroke G45.9, I61-I63 PARP1
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 ALOX5; PDE5A; MMP12; MMP12; MAPK14
C00-D49: Neoplasms Chronic myelogenous leukaemia C92.1 SRC
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 EGFR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Chronic pain R52.1-R52.2, G89 ERBB2
K00-K95: Diseases of the digestive system Gastrointestinal disease K00-K93 EGFR
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 ERBB2; KDR
I00-I99: Diseases of the circulatory system Ischemia I99.8 SRC; TEK
S00-T88: Injury, poisoning and certain other consequences of external causes Brain injury S09.90 PDGFRB; APP
C00-D49: Neoplasms Brain cancer C71, D33 TERT; SRC; EGFR; EGFR
C00-D49: Neoplasms Biliary cancer C22, C24 KDR
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Beta thalassemia D56.1 HBB
H00-H59: Diseases of the eye and adnexa Age related macular degeneration H35.3 APP
K00-K95: Diseases of the digestive system Crohn's disease K50 INSR
NA: NA Hyperlipidemia NA HMGCR
I00-I99: Diseases of the circulatory system Hypertension I10-I16 PDE5A; PDE5A
C00-D49: Neoplasms Lung cancer C33-C34 TOP1; MMP2; FLT4; EGFR
C00-D49: Neoplasms Bladder cancer C67 TOP1; ERBB2; EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 MAOA
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 ALOX5; PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 AKR1B1; GSK3B; FFAR1; PDGFRB; INSR; PPARG
E00-E89: Endocrine, nutritional and metabolic diseases Hyperglycaemia in type 2 diabetes E11, R73.9 INSR
E00-E89: Endocrine, nutritional and metabolic diseases Hypercholesterolemia E78 HMGCR; INSR
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 TOP1; FLT3
E00-E89: Endocrine, nutritional and metabolic diseases Hunter syndrome E76.1 INSR
NA: NA Miosis during ocular surgery NA PTGS1
I00-I99: Diseases of the circulatory system Cardiac arrhythmias I47-I49 TBXAS1
I00-I99: Diseases of the circulatory system Cardiomyopathy I42.0 TTR
G00-G99: Diseases of the nervous system G00-G99 Diagnostic imaging G30, I73.9 APP
H00-H59: Diseases of the eye and adnexa Diabetic retinopathy H36, E10.3, E11.3, E13.3 MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R
C00-D49: Neoplasms Refractory renal cell carcinoma C64 PKM
NA: NA Raynaud's disease NA PDE5A; PDE5A
E00-E89: Endocrine, nutritional and metabolic diseases Dietary shortage E40-E46 PTGS1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR
C00-D49: Neoplasms AML NA FLT3; KDR
C00-D49: Neoplasms Hematological malignancies C81-C86 SRC; AURKB; CD38; TP53
C00-D49: Neoplasms Hematologic malignancies C81-C86 AKT1
NA: NA Hematopoietic stem cell transplantation NA FLT3
C00-D49: Neoplasms HER2-positive urogenital cancer NA ERBB2
NA: NA Edema NA CA2
S00-T88: Injury, poisoning and certain other consequences of external causes Vascular restinosis following vascular graft surgery T82.858A FLT4
C00-D49: Neoplasms CLL NA FLT3
C00-D49: Neoplasms Myelodysplastic syndrome D46 TLR2; TOP1; TEK; KDR
NA: NA Rheumatold arthritis NA PTGS1; MAPK14
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 AKR1B1; ALOX5; MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Dyslipidaemias E78 HMGCR; PPARD; PPARD
NA: NA Dyslipidemia NA HMGCR; PPARD
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA1; CA2
N00-N99: Diseases of the genitourinary system Dysmenorrhea N94.4-N94.6 PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Elevated CRP E78.0 HMGCR
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2
N00-N99: Diseases of the genitourinary system Endometriosis N80 PPARG
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1; PTGS1
C00-D49: Neoplasms Esophageal cancer C15 TOP1; EGFR
K00-K95: Diseases of the digestive system Ulcerative colitis K51 PTGS1; MMP9
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R
H00-H59: Diseases of the eye and adnexa Retinal venous occlusion H34.8 ERBB2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Spasm R25.2 PDE5A
C00-D49: Neoplasms Solid tumours C00-D48 AKT1; MET; TLR2; TOP1; PKM; FLT3; CA9; MMP2; SRC; IGF1R; PTK2; AURKB; AURKA; FLT4; TEK; PDGFRB; HIF1A; MAPK1; MMP9; ERBB2; EGFR; TP53; KDR; KDR; KDR; PLK1; PLK1
C00-D49: Neoplasms Solid tumors NA BRAF
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR
G00-G99: Diseases of the nervous system G00-G99 Spinal muscular atrophy G00-G99 SMN1;SMN2
L00-L99: Diseases of the skin and subcutaneous tissue Diabetic foot ulcer L88-L89 EGFR
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 TBXAS1; FFAR1; INSR; PPARG; PPARG; PPARD
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR
E00-E89: Endocrine, nutritional and metabolic diseases Type 1 diabetes E10 INSR; PPARG; PPARD
C00-D49: Neoplasms Tumors C00-D48 TERT
E00-E89: Endocrine, nutritional and metabolic diseases TTR amyloidosis E85 TTR
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R
N00-N99: Diseases of the genitourinary system Nephritis N00-N19, N25-N29 TBXAS1
S00-T88: Injury, poisoning and certain other consequences of external causes Myocardial reperfusion injury T86.4 AKT1
I00-I99: Diseases of the circulatory system Myocardial infarction I21, I22 HMGCR; PARP1
I00-I99: Diseases of the circulatory system Coronary artery disease I20-I25 MAPK14; MAPK14
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 ALOX5
C00-D49: Neoplasms Prostate cancer C61 TLR2; TERT; FLT3; FLT4; ERBB2; EGFR; PLK1
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 ALOX5; FLT3; MAPK14; EGFR
J00-J99: Diseases of the respiratory system Acute lung injury J80 MAPK14
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3
C00-D49: Neoplasms Acute myeloid leukemia C92.0 TERT; FLT3; FLT3; AURKB; AURKA; TP53; TP53; PLK1
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3
C00-D49: Neoplasms Myeloid leukemia C92 FLT3
C00-D49: Neoplasms Colorectal cancer C18-C21 TOP1; PDE5A; FLT3; PTGS1; IGF1R; MMP9; ERBB2; EGFR; EGFR; TP53; KDR
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R
I00-I99: Diseases of the circulatory system Acute coronary syndrome I74 MAPK14
A00-B99: Certain infectious and parasitic diseases Acquired immune deficiency syndrome B20 TOP1
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 MMP2; PTGS1
NA: NA Acute respiratory distress syndrome NA MAPK14
C00-D49: Neoplasms Advanced breast cancer C50 SRC
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 PDE5A; PDE5A
C00-D49: Neoplasms Urethral cancer NA EGFR
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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Developer & Maintainer:
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