CMAUP Plant Collective Molecular Activities

Plant Name: Caesalpinia pulcherrima

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.346E-10	5.108E-06	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.003E-08	5.463E-05	CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.305E-08	1.004E-04	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.463E-06	3.185E-03	CA2, CA7
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.463E-06	3.185E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.924E-06	4.549E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.924E-06	4.549E-03	ADRA2A, ADRA2C

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	3.556E-10	3.734E-08	CA12; CA2; CA4; CA7
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.945E-04	5.138E-03	MAPK1; ADRA2C; ADRA2A
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.142E-04	5.138E-03	CA2; CA4
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.957E-04	5.138E-03	GAA; AKR1B1
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	8.543E-04	1.794E-02	NMUR2; ADRA2C; ADRA2A
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	2.659E-03	4.654E-02	ACHE; MAPK1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2A; ADRA2C; ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; MAPK1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
NA: NA	Upper abdominal bloating	NA	ACHE
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C; AKR1B1; ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4; ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases