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Plant Name: Frullania tamarisci




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Peptide receptor (family A GPCR)
TSHR; NPSR1; CXCR1;
Small molecule receptor (family A GPCR)
ADRA2C; GPBAR1; DRD4;
Enzyme_unclassified
ALPL; RECQL; PLA2G1B; BLM; TDP1; GLA; CTDSP1; P4HB; PIK3R1; GLO1; HPGD; HSD11B1; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; ALOX12; AKR1B10; NOX4; PYGL; POLB;
Protein Phosphatase
PTPN1; PTPRF; PTPN2; ACP1;
Hydrolase
GAA;
Transient receptor potential channel
TRPA1;
Protein Kinase
MET; CAMK2B; CSNK2A1; AKT1; DAPK1; AXL; NEK2; FLT3; NEK6; SRC; IGF1R; PTK2; AURKB; GSK3B; CDK1; PIM1; NUAK1; ALK; KDR; PKN1;
Lyase
CA12; CA14; CA3; CA7; CA5A; CA9; CA4; CA6; CA2; CA1;
Nuclear hormone receptor subfamily 3 group C
AR;
Nuclear hormone receptor subfamily 1 group H
NR1H4;
Nuclear hormone receptor subfamily 3 group B
ESRRA;
Nuclear hormone receptor subfamily 1 group F
RORC;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; PTGS1; TYR; XDH;
Metallo protease
MMP13; MMP3; MMP2; MMP9;
Aspartic protease
BACE1;
Transcription Factor
AHR; STAT6; HIF1A; NFKB1; TP53;
ATP-binding cassette
ABCC1; ABCG2;
Unclassified
LMNA; MAPT; THPO;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP1A2; CYP19A1; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP2A6; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Showing 1 to 10 of 100 entries
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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO TypeGO CategoryEnriched GO Termsp-ValueAdjusted p-ValueEnriched Genes
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.551E-13 1.351E-10 CA1, CA12, CA2, CA3, CA4, CA5A, CA6, CA7, CA9
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 3.415E-12 1.814E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 8.823E-12 4.468E-09 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2C8, CYP2C9
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 1.490E-11 7.036E-09 CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 1.006E-08 2.029E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 3.242E-07 4.469E-05 CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 5.134E-07 6.694E-05 ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 1.173E-06 1.389E-04 ALOX12, ALOX15, ALOX5, HPGD
BP GO:0009987; cellular process GO:0071407; cellular response to organic cyclic compound 2.041E-06 2.245E-04 AKT1, ALPL, AR, BLM, CYP1A1, CYP1B1, FLT3, NFKB1, NOX4, RORC, SRC
BP GO:0008152; metabolic process GO:0018105; peptidyl-serine phosphorylation 2.285E-06 2.406E-04 AKT1, AURKB, CAMK2B, CDK1, GSK3B, NEK6, PKN1, SRC
Showing 1 to 10 of 85 entries
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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway IDPathway Namep-ValueAdjusted p-ValueEnriched Genes
hsa00040 Pentose and glucuronate interconversions_Homo sapiens_hsa00040 1.396E-02 2.779E-02 AKR1B10; AKR1B1
hsa00051 Fructose and mannose metabolism_Homo sapiens_hsa00051 1.113E-02 2.408E-02 AKR1B10; AKR1B1
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 1.459E-05 9.693E-05 AKR1B10; GAA; AKR1B1; GLA
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 4.583E-10 1.421E-08 HSD11B1; HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 1.204E-06 1.215E-05 CYP2A6; CYP1A2; XDH
hsa00350 Tyrosine metabolism_Homo sapiens_hsa00350 1.323E-02 2.765E-02 MAOA; TYR
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 4.683E-05 2.489E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa00561 Glycerolipid metabolism_Homo sapiens_hsa00561 3.219E-03 8.390E-03 AKR1B10; AKR1B1; GLA
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 7.953E-10 2.113E-08 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19; PTGS1
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 9.003E-11 8.373E-09 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
Showing 1 to 10 of 104 entries
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Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease CategoryDisease NameICD10 CodeLinked Targets
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Anthelmintic B89 ALPL
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
Showing 1 to 10 of 214 entries
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Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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