CMAUP Plant Collective Molecular Activities

Plant Name: Piper longum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	1.450E-05	6.336E-04	CYP1A2; ALDH1A1; CYP3A4
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.736E-05	6.336E-04	MAOB; CYP1A2; CYP3A4
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	4.028E-04	7.352E-03	MAOB; CYP1A2
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	2.107E-04	5.127E-03	CYP1A2; CYP3A4
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.057E-03	1.221E-02	HTR2C; TRPV1; TSHR
hsa05218	Melanoma_Homo sapiens_hsa05218	1.266E-03	1.221E-02	MITF; TP53
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	8.471E-04	1.221E-02	CYP1A2; CYP3A4
hsa04750	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	2.394E-03	1.747E-02	HTR2C; TRPV1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.338E-03	1.221E-02	CYP1A2; CYP3A4
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	3.112E-03	2.065E-02	MAOB; HTR2C
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.684E-03	1.366E-02	CYP1A2; CYP3A4
hsa04210	Apoptosis_Homo sapiens_hsa04210	4.812E-03	2.509E-02	LMNA; TP53
hsa05162	Measles_Homo sapiens_hsa05162	4.548E-03	2.509E-02	RAB9A; TP53
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	7.831E-03	3.811E-02	HPGD; TP53
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	3.745E-03	2.278E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	HTR2C
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Acute or chronic pain	R52, G89	TRPV1
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	TRPV1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOB; HTR2C; HTR2C
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	MAOB
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT; MAOB
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1; TRPV1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pathological pain	R52, G89	TRPV1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT; MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Idiopathic parkinson's disease	F02.3, G20	MAOB
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOB; MAOB
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HTR2C; TRPV1; TRPV1
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR2C
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C
NA: NA	Primary insomnia	NA	HTR2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR2C
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	TRPV1
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	TRPV1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	MAOB; HTR2C; HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR2C
NA: NA	Esophagus sensitivity	NA	TRPV1
C00-D49: Neoplasms	Cancer	C00-C96	TP53
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive episode without melancholia	F30-F39	MAOB
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT; MAOB
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	TRPV1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	MAOB
J00-J99: Diseases of the respiratory system	Asthma	J45	TRPV1
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT; MAOB
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	TRPV1
NA: NA	Motor symptoms	NA	MAOB
I00-I99: Diseases of the circulatory system	Moderate to severe hypertension	I10-I16	MAOB
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOB; HTR2C
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOB; CYP3A4; HTR2C
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	TRPV1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	TRPV1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases