Plant Name: Annona muricata
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPR35; DRD4; | |
| NPSR1; CXCR1; | |
| RECQL; PLA2G1B; TDP1; APOBEC3G; CTDSP1; PIK3CG; PIK3R1; GLO1; HPGD; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; ALOX12; NOX4; USP2; TNKS; PARP1; TNKS2; PYGL; APEX1; POLB; CD38; | |
| ACHE; | |
| TOP2A; | |
| NEK6; AKT1; MET; CAMK2B; GSK3B; CSNK2A1; DAPK1; SYK; NEK2; FLT3; MYLK; SRC; IGF1R; PTK2; AURKB; INSR; CDK1; PIM1; NUAK1; ALK; AXL; KDR; PKN1; | |
| CA14; CA5B; CA5A; CA3; CA7; CA1; CA12; CA9; CA4; CA6; CA2; | |
| AR; | |
| ESRRA; | |
| ESR2; | |
| KDM4E; | |
| MAOA; ALOX5; TYR; XDH; | |
| MMP13; MMP12; MMP3; MMP2; MMP9; | |
| BACE1; | |
| AHR; STAT6; HIF1A; NFKB1; TP53; | |
| ABCC1; ABCG2; | |
| LMNA; MAPT; THPO; APP; TTR; | |
| L3MBTL1; SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | CD38 | Lymphocyte differentiation antigen CD38 | P28907 | CHEMBL4660 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Q9HC16 | CHEMBL1741217 |
| Enzyme_unclassified | CTDSP1 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Q9GZU7 | CHEMBL1795098 |
| Enzyme_unclassified | PIK3CG | PI3-kinase p110-gamma subunit | P48736 | CHEMBL3267 |
| Enzyme_unclassified | PIK3R1 | PI3-kinase p85-alpha subunit | P27986 | CHEMBL2506 |
| Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Enzyme_unclassified | TNKS | Tankyrase-1 | O95271 | CHEMBL6164 |
| Enzyme_unclassified | PARP1 | Poly [ADP-ribose] polymerase-1 | P09874 | CHEMBL3105 |
| Enzyme_unclassified | TNKS2 | Tankyrase-2 | Q9H2K2 | CHEMBL6154 |
| Enzyme_unclassified | PYGL | Liver glycogen phosphorylase | P06737 | CHEMBL2568 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Metallo protease | MMP13 | Matrix metalloproteinase 13 | P45452 | CHEMBL280 |
| Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Nuclear hormone receptor subfamily 3 group B | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
| Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Oxidoreductase | TYR | Tyrosinase | P14679 | CHEMBL1973 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Peptide receptor (family A GPCR) | CXCR1 | Interleukin-8 receptor A | P25024 | CHEMBL4029 |
| Protein Kinase | NEK6 | Serine/threonine-protein kinase NEK6 | Q9HC98 | CHEMBL4309 |
| Protein Kinase | AKT1 | Serine/threonine-protein kinase AKT | P31749 | CHEMBL4282 |
| Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Protein Kinase | CAMK2B | CaM kinase II beta | Q13554 | CHEMBL4121 |
| Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
| Protein Kinase | SYK | Tyrosine-protein kinase SYK | P43405 | CHEMBL2599 |
| Protein Kinase | NEK2 | Serine/threonine-protein kinase NEK2 | P51955 | CHEMBL3835 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | MYLK | Myosin light chain kinase, smooth muscle | Q15746 | CHEMBL2428 |
| Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | INSR | Insulin receptor | P06213 | CHEMBL1981 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | NUAK1 | NUAK family SNF1-like kinase 1 | O60285 | CHEMBL5784 |
| Protein Kinase | ALK | ALK tyrosine kinase receptor | Q9UM73 | CHEMBL4247 |
| Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Protein Kinase | PKN1 | Protein kinase N1 | Q16512 | CHEMBL3384 |
| Small molecule receptor (family A GPCR) | GPR35 | G-protein coupled receptor 35 | Q9HC97 | CHEMBL1293267 |
| Small molecule receptor (family A GPCR) | DRD4 | Dopamine D4 receptor | P21917 | CHEMBL219 |
| Transcription Factor | AHR | Aryl hydrocarbon receptor | P35869 | CHEMBL3201 |
| Transcription Factor | STAT6 | Signal transducer and activator of transcription 6 | P42226 | CHEMBL5401 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
| Unclassified | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
| Unclassified | TTR | Transthyretin | P02766 | CHEMBL3194 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.844E-12 | 8.544E-10 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, NOX4 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 4.094E-12 | 1.592E-09 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 5.199E-12 | 1.952E-09 | APOBEC3G, AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, ESRRA, GLO1, L3MBTL1, MMP12, MMP13, MMP2, MMP3, MMP9, PARP1, TNKS, TP53 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 5.496E-11 | 1.617E-08 | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, XDH |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 8.330E-11 | 2.296E-08 | ABCC1, ABCG2, AKT1, ALK, AURKB, AXL, CAMK2B, CDK1, CSNK2A1, DAPK1, FLT3, GSK3B, IGF1R, INSR, KDR, MET, MYLK, NEK2, NEK6, NUAK1, PIK3CG, PIM1, PKN1, PTK2, PYGL, RECQL, SRC, SYK, TOP2A, TP53 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 8.331E-11 | 2.296E-08 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, MPO, NOX4, SRC |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 7.625E-10 | 1.748E-07 | CYP1A2, CYP2C8, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.009E-09 | 2.242E-07 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.861E-09 | 3.787E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004674; protein serine/threonine kinase activity | 2.227E-09 | 4.448E-07 | AKT1, ALK, AURKB, CAMK2B, CDK1, CSNK2A1, DAPK1, GSK3B, MYLK, NEK2, NEK6, NUAK1, PIK3CG, PIM1, PKN1, SYK |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 3.005E-09 | 5.791E-07 | CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.134E-08 | 1.886E-06 | CYP1A2, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 1.875E-08 | 2.798E-06 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, NEK6, PKN1, SRC, SYK, TNKS |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 1.220E-07 | 1.369E-05 | AXL, INSR, MET, NOX4, PIK3CG, PIK3R1, PTK2, SRC, THPO |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 1.785E-07 | 1.915E-05 | IGF1R, INSR, KDR, PTK2, SRC, SYK |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 1.932E-07 | 2.052E-05 | AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, PKN1, TNKS |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 2.278E-07 | 2.397E-05 | AURKB, CA2, CA7, CD38, HIF1A, KDR, NEK2, NPSR1, PARP1, PLA2G1B, SRC, SYK, TNKS, TNKS2 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 3.596E-07 | 3.626E-05 | AURKB, CA2, CA7, HIF1A, NEK2, NPSR1, PLA2G1B, SYK, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 3.652E-07 | 3.648E-05 | CYP1A2, CYP2C8, CYP2C9, CYP3A4 |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 7.021E-07 | 6.735E-05 | AHR, CSNK2A1, HIF1A, KDR, MAPT |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 8.690E-07 | 8.086E-05 | AKR1B1, APEX1, AXL, CDK1, CYP1B1, STAT6 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 1.321E-06 | 1.170E-04 | ALOX12, ALOX15, ALOX5, HPGD |
| MF | GO:0003824; catalytic activity | GO:0101020; estrogen 16-alpha-hydroxylase activity | 1.461E-06 | 1.273E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 1.578E-06 | 1.358E-04 | HIF1A, MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| BP | GO:0065007; biological regulation | GO:1904355; positive regulation of telomere capping | 1.720E-06 | 1.458E-04 | AURKB, NEK2, TNKS, TNKS2 |
| BP | Unclassified; | GO:0044243; multicellular organismal catabolic process | 2.530E-06 | 2.087E-04 | MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 2.911E-06 | 2.348E-04 | CYP1A1, CYP2C8, CYP3A4 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 3.703E-06 | 2.890E-04 | AHR, AKR1B1, AKT1, ALOX5, APEX1, AR, AURKB, CAMK2B, CDK1, CSNK2A1, CTDSP1, ESR2, ESRRA, GSK3B, HIF1A, HPGD, L3MBTL1, LMNA, NEK2, NEK6, NFKB1, NUAK1, PARP1, PIM1, PKN1, POLB, RECQL, SMN1, SMN2, SRC, STAT6, TNKS, TOP2A, TP53, USP2 |
| BP | GO:0032502; developmental process | GO:0007568; aging | 4.053E-06 | 3.130E-04 | AKT1, APEX1, AURKB, CDK1, CYP1A1, MPO, NOX4, POLB, TP53 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 5.814E-06 | 4.336E-04 | AHR, AKR1B1, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, APOBEC3G, APP, AR, AURKB, CA1, CA2, CA3, CA7, CAMK2B, CDK1, CSNK2A1, FLT3, GLO1, GSK3B, HIF1A, HPGD, HSD17B1, LMNA, MAPT, MYLK, NEK2, NEK6, NFKB1, PIK3CG, PIK3R1, PIM1, PKN1, PLA2G1B, PTK2, PYGL, SMN1, SMN2, SRC, STAT6, SYK, TNKS, TNKS2, TP53, TYR, XDH |
| BP | Unclassified; | GO:0044259; multicellular organismal macromolecule metabolic process | 6.608E-06 | 4.845E-04 | HIF1A, MMP12, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0008152; metabolic process | GO:2000379; positive regulation of reactive oxygen species metabolic process | 8.601E-06 | 6.222E-04 | AKT1, INSR, MAPT, NOX4, TP53, XDH |
| BP | GO:0065007; biological regulation | GO:0000187; activation of MAPK activity | 1.152E-05 | 8.016E-04 | ALK, CDK1, DRD4, INSR, PKN1, PLA2G1B, SYK |
| MF | Unclassified; | GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity | 1.208E-05 | 8.353E-04 | INSR, KDR, SYK |
| BP | GO:0065007; biological regulation | GO:1904357; negative regulation of telomere maintenance via telomere lengthening | 1.218E-05 | 8.364E-04 | PARP1, SRC, TNKS, TNKS2 |
| BP | GO:0050896; response to stimulus | GO:1904646; cellular response to amyloid-beta | 1.218E-05 | 8.364E-04 | APP, GSK3B, IGF1R, PARP1 |
| MF | GO:0005488; binding | GO:0043548; phosphatidylinositol 3-kinase binding | 1.634E-05 | 1.095E-03 | AXL, IGF1R, INSR, PIK3R1 |
| CC | GO:0016020; membrane | GO:0005886; plasma membrane | 1.653E-05 | 1.104E-03 | ABCC1, ABCG2, ACHE, AKT1, ALK, ALOX12, ALOX15, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CAMK2B, CD38, CSNK2A1, CXCR1, DAPK1, DRD4, FLT3, GLO1, GPR35, GSK3B, HSD17B10, IGF1R, INSR, KDR, L3MBTL1, MAPT, MET, MMP2, NPSR1, PIK3CG, PIK3R1, PIM1, PKN1, PTK2, SRC, SYK, TDP1 |
| BP | GO:0032501; multicellular organismal process | GO:2000026; regulation of multicellular organismal development | 1.676E-05 | 1.116E-03 | AKT1, ALOX12, APP, AR, AXL, CA2, CAMK2B, CDK1, CTDSP1, CYP1B1, ESRRA, GSK3B, HIF1A, INSR, KDR, L3MBTL1, MAPT, PIK3R1, PIM1, PTK2, SRC, STAT6, SYK, THPO, XDH |
| BP | GO:0048511; rhythmic process | GO:0048511; rhythmic process | 2.123E-05 | 1.384E-03 | AHR, AXL, CSNK2A1, DRD4, GSK3B, SRC, TOP2A, TP53, USP2 |
| MF | GO:0005488; binding | GO:0043560; insulin receptor substrate binding | 2.355E-05 | 1.517E-03 | IGF1R, INSR, PIK3R1 |
| BP | GO:0008152; metabolic process | GO:0030574; collagen catabolic process | 2.505E-05 | 1.600E-03 | MMP12, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0009987; cellular process | GO:0030168; platelet activation | 2.715E-05 | 1.714E-03 | AKT1, AXL, PIK3CG, PIK3R1, SRC, SYK |
| BP | GO:0009987; cellular process | GO:0031334; positive regulation of protein complex assembly | 2.752E-05 | 1.732E-03 | ALOX15, GSK3B, MAPT, MET, MMP3, PARP1, SRC, TP53 |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 2.816E-05 | 1.732E-03 | APEX1, POLB |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.816E-05 | 1.732E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.816E-05 | 1.732E-03 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0045913; positive regulation of carbohydrate metabolic process | 3.122E-05 | 1.881E-03 | AKT1, HIF1A, INSR, NFKB1, SRC |
| BP | GO:0065007; biological regulation | GO:0032212; positive regulation of telomere maintenance via telomerase | 3.127E-05 | 1.881E-03 | AURKB, NEK2, TNKS, TNKS2 |
| BP | GO:0065007; biological regulation | GO:0098771; inorganic ion homeostasis | 3.736E-05 | 2.205E-03 | ABCG2, APP, CA12, CA2, CA7, CD38, DRD4, GPR35, HIF1A, NPSR1, PIK3CG, PLA2G1B, TP53 |
| BP | GO:0065007; biological regulation | GO:0045124; regulation of bone resorption | 3.939E-05 | 2.287E-03 | CA2, CD38, SRC, SYK |
| BP | GO:0008152; metabolic process | GO:0006703; estrogen biosynthetic process | 4.051E-05 | 2.334E-03 | CYP19A1, HSD17B1, HSD17B2 |
| BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 4.120E-05 | 2.361E-03 | AXL, KDR, PIK3R1, PTK2, SRC |
| BP | GO:0032502; developmental process | GO:0048638; regulation of developmental growth | 4.319E-05 | 2.462E-03 | AKT1, APP, AR, CDK1, INSR, MAPT, PIM1, PTK2, TNKS2 |
| BP | GO:0022610; biological adhesion | GO:0033628; regulation of cell adhesion mediated by integrin | 6.012E-05 | 3.257E-03 | CYP1B1, PIK3CG, PTK2, SYK |
| BP | GO:0009987; cellular process | GO:0022617; extracellular matrix disassembly | 6.444E-05 | 3.427E-03 | MMP12, MMP13, MMP2, MMP3, MMP9 |
| BP | GO:0032502; developmental process | GO:0009653; anatomical structure morphogenesis | 6.534E-05 | 3.462E-03 | APP, AR, AXL, CA2, CA9, CYP1B1, HIF1A, HPGD, INSR, MET, MMP13, MMP2, MYLK, NOX4, POLB, PTK2, SRC, STAT6, SYK |
| BP | GO:0051179; localization | GO:1900182; positive regulation of protein localization to nucleus | 6.939E-05 | 3.632E-03 | AKT1, APP, CDK1, PARP1, PIK3R1, SRC |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 8.418E-05 | 4.334E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 8.418E-05 | 4.334E-03 | CYP1A1, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 8.418E-05 | 4.334E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 8.418E-05 | 4.334E-03 | ALOX12, ALOX15 |
| BP | GO:0000003; reproduction | GO:0022414; reproductive process | 9.336E-05 | 4.739E-03 | AKR1B1, AKT1, APP, AR, AXL, CD38, CDK1, CYP19A1, CYP1A1, HIF1A, HPGD, HSD17B2, INSR, MMP2, MMP9, NEK2, PTK2, SRC, TOP2A |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 9.483E-05 | 4.780E-03 | CYP2C19, CYP2C8, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0035173; histone kinase activity | 9.483E-05 | 4.780E-03 | AURKB, CDK1, PKN1 |
| BP | GO:0009987; cellular process | GO:0043065; positive regulation of apoptotic process | 9.537E-05 | 4.785E-03 | AKT1, CYP1B1, DAPK1, GSK3B, HPGD, MAPT, MMP9, NOX4, SRC, TOP2A, TP53, XDH |
| BP | GO:0009987; cellular process | GO:0090199; regulation of release of cytochrome c from mitochondria | 9.603E-05 | 4.807E-03 | AKT1, LMNA, MMP9, TP53 |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 9.668E-05 | 4.828E-03 | AR, CYP3A4, ESR2, ESRRA, HSD17B1 |
| BP | GO:0008152; metabolic process | GO:0044283; small molecule biosynthetic process | 1.190E-04 | 5.810E-03 | AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, MPO, PLA2G1B, SYK |
| BP | Unclassified; | GO:2000021; regulation of ion homeostasis | 1.255E-04 | 6.073E-03 | CA2, CA7, KDR, NPSR1, PARP1, PLA2G1B, SRC |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.343E-04 | 6.415E-03 | AHR, AR, ESR2, ESRRA |
| BP | GO:0008152; metabolic process | GO:0016579; protein deubiquitination | 1.407E-04 | 6.690E-03 | AR, CDK1, HIF1A, POLB, TNKS, TNKS2, TP53, USP2 |
| BP | GO:0050896; response to stimulus | GO:0071320; cellular response to cAMP | 1.454E-04 | 6.855E-03 | APEX1, APP, NOX4, PIK3CG |
| CC | GO:0044464; cell part | GO:0005739; mitochondrion | 1.519E-04 | 7.128E-03 | AKT1, APEX1, CA5A, CA5B, CDK1, CYP1A1, CYP1B1, ESR2, GSK3B, HSD17B10, MAOA, MMP2, MPO, NFKB1, NOX4, PARP1, SRC, TP53 |
| BP | GO:0009987; cellular process | GO:0051983; regulation of chromosome segregation | 1.549E-04 | 7.221E-03 | AURKB, CSNK2A1, NEK2, NEK6, TNKS |
| BP | GO:0008152; metabolic process | GO:0070213; protein auto-ADP-ribosylation | 1.678E-04 | 7.691E-03 | TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 1.678E-04 | 7.691E-03 | CYP1A1, CYP1A2 |
| MF | GO:0005488; binding | GO:0051425; PTB domain binding | 1.678E-04 | 7.691E-03 | APP, INSR |
| MF | GO:0005488; binding | GO:0005497; androgen binding | 1.678E-04 | 7.691E-03 | ALDH1A1, AR |
| BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 1.826E-04 | 8.285E-03 | CYP1A1, POLB, TP53 |
| BP | GO:0008152; metabolic process | GO:1901575; organic substance catabolic process | 1.879E-04 | 8.505E-03 | ACHE, AKT1, ALDH1A1, APOBEC3G, AURKB, BACE1, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GSK3B, HSD17B10, MAOA, PLA2G1B, PYGL, TP53, USP2, XDH |
| BP | GO:0050896; response to stimulus | GO:0010332; response to gamma radiation | 1.965E-04 | 8.858E-03 | NOX4, PARP1, POLB, TP53 |
| BP | GO:0023052; signaling | GO:0050804; modulation of chemical synaptic transmission | 2.092E-04 | 9.277E-03 | ACHE, APP, BACE1, CA2, CA7, CAMK2B, CD38, DRD4 |
| BP | GO:0051179; localization | GO:0051924; regulation of calcium ion transport | 2.092E-04 | 9.277E-03 | CAMK2B, DRD4, GPR35, MYLK, NPSR1, PIK3CG, PLA2G1B |
| BP | GO:0065007; biological regulation | GO:0042593; glucose homeostasis | 2.096E-04 | 9.277E-03 | AKT1, HIF1A, INSR, NOX4, PIK3R1, PYGL |
| BP | GO:0008283; cell proliferation | GO:1904707; positive regulation of vascular smooth muscle cell proliferation | 2.106E-04 | 9.302E-03 | HPGD, MMP2, MMP9 |
| BP | GO:0008152; metabolic process | GO:0045740; positive regulation of DNA replication | 2.110E-04 | 9.302E-03 | CDK1, IGF1R, INSR, PLA2G1B |
| BP | GO:0022610; biological adhesion | GO:0001952; regulation of cell-matrix adhesion | 2.262E-04 | 9.916E-03 | GSK3B, KDR, PIK3R1, PTK2, SRC |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 2.262E-04 | 9.916E-03 | AKT1, AR, DAPK1, LMNA, SRC |
| BP | GO:0008152; metabolic process | GO:0045944; positive regulation of transcription from RNA polymerase II promoter | 2.283E-04 | 9.982E-03 | AHR, AKT1, APP, AR, ESRRA, HIF1A, MET, MMP12, NFKB1, PARP1, PIK3R1, PLA2G1B, STAT6, TNKS, TOP2A, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 7.668E-23 | 4.174E-19 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.794E-16 | 5.508E-13 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.691E-15 | 3.256E-12 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 4.704E-22 | 8.419E-20 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 3.966E-11 | 3.550E-09 | CAMK2B; SRC; MMP2; PIK3R1; HIF1A; MMP9; PTK2; PIK3CG; IGF1R; KDR; AKT1; TP53; MET |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.685E-10 | 7.542E-09 | HSD17B1; ALOX5; INSR; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.876E-09 | 6.715E-08 | GSK3B; FLT3; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; NFKB1; PIK3CG; PTK2; IGF1R; AR; AKT1; MET; TP53 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.111E-10 | 6.630E-09 | CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19 |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 2.207E-08 | 4.939E-07 | GSK3B; SYK; INSR; PIK3R1; PTK2; NFKB1; PIK3CG; IGF1R; KDR; AKT1; PKN1; TP53; MET |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.880E-08 | 4.845E-07 | GSK3B; AR; AKT1; PIK3R1; TP53; NFKB1; PIK3CG; IGF1R |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 3.047E-08 | 5.563E-07 | CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.895E-08 | 4.845E-07 | HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 3.108E-08 | 5.563E-07 | HPGD; FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 9.224E-08 | 1.101E-06 | GSK3B; SYK; CSNK2A1; CDK1; AKT1; CD38; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 5.277E-08 | 8.586E-07 | FLT3; AKT1; PIK3R1; TP53; MET; HIF1A; PIK3CG |
| hsa04510 | Focal adhesion_Homo sapiens_hsa04510 | 9.224E-08 | 1.101E-06 | GSK3B; SRC; KDR; AKT1; PIK3R1; MET; PTK2; PIK3CG; MYLK; IGF1R |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 5.965E-08 | 8.898E-07 | CAMK2B; INSR; AKT1; PIK3R1; HIF1A; NFKB1; PIK3CG; IGF1R |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 8.752E-08 | 1.101E-06 | GSK3B; SRC; AKT1; PIK3R1; NFKB1; ESR2; PIK3CG |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.148E-07 | 1.285E-06 | CYP2C9; APP; CYP2C8; MAOA; ALOX5; ALOX15; ALOX12; CYP2C19 |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 3.260E-07 | 3.241E-06 | CAMK2B; GSK3B; SRC; AKT1; PIK3R1; PTK2; PIK3CG |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 5.544E-07 | 4.962E-06 | INSR; AKT1; PIK3R1; TP53; NFKB1; PIK3CG; IGF1R |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 8.812E-07 | 6.858E-06 | SRC; AKT1; STAT6; PIK3R1; TP53; MMP9; NFKB1; PIK3CG |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.116E-06 | 7.683E-06 | PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; PYGL; CYP2C19; CYP3A4; TYR; CYP19A1; HSD17B10; CYP2C9; CYP2C8; HSD17B1; ALOX5; HSD17B2; CYP1A2; ALDH1A1; CYP1A1; CD38; XDH |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 4.724E-07 | 4.451E-06 | FLT3; PIM1; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 7.896E-07 | 6.425E-06 | SRC; MMP2; AKT1; PIK3R1; MMP9; ESR2; PIK3CG |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.166E-07 | 2.280E-06 | CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19 |
| hsa04370 | VEGF signaling pathway_Homo sapiens_hsa04370 | 7.110E-07 | 6.060E-06 | SRC; KDR; AKT1; PIK3R1; PTK2; PIK3CG |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 1.040E-06 | 7.448E-06 | CAMK2B; AKT1; PIK3R1; TP53; PIK3CG; IGF1R |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.515E-06 | 9.688E-06 | GSK3B; INSR; AKT1; PIK3R1; PYGL; NFKB1; PIK3CG |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 2.655E-06 | 1.440E-05 | PLA2G1B; INSR; KDR; AKT1; PIK3R1; MET; NFKB1; PIK3CG; IGF1R |
| hsa04662 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.074E-06 | 1.227E-05 | GSK3B; SYK; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.040E-06 | 7.448E-06 | CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 1.759E-06 | 1.086E-05 | AKT1; PIK3R1; TP53; MET; PIK3CG; IGF1R |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.582E-06 | 1.440E-05 | GSK3B; SRC; AKT1; PIK3R1; TP53; HIF1A; PIK3CG |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 2.889E-06 | 1.521E-05 | CAMK2B; GSK3B; AKT1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.485E-06 | 9.688E-06 | CYP2C9; CYP2C8; MAOA; CYP1A2; CYP3A4; CYP2C19 |
| hsa04062 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 5.605E-06 | 2.787E-05 | GSK3B; CXCR1; SRC; AKT1; PIK3R1; NFKB1; PTK2; PIK3CG |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 8.019E-06 | 3.681E-05 | PARP1; LMNA; AKT1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 6.627E-06 | 3.206E-05 | GSK3B; CSNK2A1; AKT1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.098E-05 | 4.795E-05 | POLB; SYK; SRC; CDK1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.354E-05 | 5.721E-05 | SRC; INSR; KDR; AKT1; PIK3R1; MET; PIK3CG; IGF1R |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 5.426E-06 | 2.775E-05 | AKT1; PIK3R1; TP53; NFKB1; PTK2; PIK3CG |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.374E-05 | 5.721E-05 | MMP2; PIM1; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.238E-05 | 8.533E-05 | MMP3; AKT1; PIK3R1; MMP9; NFKB1; PIK3CG |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 3.661E-05 | 1.312E-04 | ABCC1; AKT1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa04611 | Platelet activation_Homo sapiens_hsa04611 | 4.018E-05 | 1.357E-04 | SYK; SRC; AKT1; PIK3R1; PIK3CG; MYLK |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.019E-05 | 4.558E-05 | ALK; AKT1; PIK3R1; TP53; PIK3CG |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 7.045E-06 | 3.318E-05 | GSK3B; AKT1; PIK3R1; TP53; PIK3CG |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 2.125E-06 | 1.227E-05 | DAPK1; SRC; MMP2; MMP9; TP53 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.313E-04 | 3.982E-04 | GSK3B; INSR; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 6.512E-05 | 2.082E-04 | GSK3B; AKT1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.011E-04 | 3.121E-04 | SYK; CXCR1; INSR; AKT1; PIK3R1; PIK3CG |
| hsa04213 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.968E-05 | 7.828E-05 | INSR; AKT1; PIK3R1; PIK3CG; IGF1R |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 8.319E-05 | 2.613E-04 | GSK3B; INSR; AKT1; PIK3R1; PYGL; PIK3CG |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 1.684E-05 | 6.851E-05 | GSK3B; AKT1; PIK3R1; TP53; PIK3CG |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 3.738E-05 | 1.312E-04 | AKT1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 2.288E-05 | 8.533E-05 | AKT1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa04921 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.681E-04 | 4.776E-04 | CAMK2B; SRC; CD38; PIK3R1; PIK3CG; MYLK |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.681E-04 | 4.776E-04 | THPO; PIM1; AKT1; STAT6; PIK3R1; PIK3CG |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.526E-04 | 4.479E-04 | CDK1; AKT1; PIK3R1; PIK3CG; IGF1R |
| hsa05211 | Renal cell carcinoma_Homo sapiens_hsa05211 | 2.288E-05 | 8.533E-05 | AKT1; PIK3R1; MET; HIF1A; PIK3CG |
| hsa04750 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.526E-04 | 4.479E-04 | CAMK2B; SRC; ALOX12; PIK3R1; PIK3CG |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 3.992E-05 | 1.357E-04 | CSNK2A1; SRC; INSR; MET; IGF1R |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 3.789E-04 | 9.553E-04 | POLB; GSK3B; AKT1; PIK3R1; TP53; NFKB1; PIK3CG |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 3.738E-05 | 1.312E-04 | CYP2C9; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa05100 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 5.147E-05 | 1.706E-04 | SRC; PIK3R1; MET; PTK2; PIK3CG |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.733E-04 | 7.194E-04 | CAMK2B; ACHE; AKT1; PIK3R1; PIK3CG |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.017E-04 | 5.555E-04 | GSK3B; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 3.626E-04 | 9.273E-04 | ALOX5; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 8.720E-04 | 1.951E-03 | ABCC1; PIM1; CYP1B1; TP53; MMP9; MET; NFKB1 |
| hsa04670 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 3.626E-04 | 9.273E-04 | MMP2; PIK3R1; MMP9; PTK2; PIK3CG |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 6.057E-04 | 1.427E-03 | SYK; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa04152 | AMPK signaling pathway_Homo sapiens_hsa04152 | 4.554E-04 | 1.102E-03 | INSR; AKT1; PIK3R1; PIK3CG; IGF1R |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 5.456E-04 | 1.302E-03 | CAMK2B; GSK3B; MAOA; AKT1; DRD4 |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 6.268E-04 | 1.457E-03 | INSR; AKT1; PIK3R1; PIK3CG; IGF1R |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 8.426E-04 | 1.909E-03 | GSK3B; AKT1; PIK3R1; PIK3CG; IGF1R |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.732E-03 | 3.647E-03 | INSR; AKT1; PIK3R1; PIK3CG; MYLK |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 1.778E-03 | 3.665E-03 | BACE1; APP; GSK3B; MAPT; HSD17B10 |
| hsa05164 | Influenza A_Homo sapiens_hsa05164 | 2.125E-03 | 4.180E-03 | GSK3B; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa04810 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 5.019E-03 | 9.359E-03 | SRC; PIK3R1; PTK2; PIK3CG; MYLK |
| hsa04144 | Endocytosis_Homo sapiens_hsa04144 | 1.097E-02 | 1.907E-02 | CXCR1; SRC; KDR; MET; IGF1R |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 3.694E-03 | 7.034E-03 | CAMK2B; AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa05152 | Tuberculosis_Homo sapiens_hsa05152 | 2.288E-03 | 4.404E-03 | CAMK2B; SYK; SRC; AKT1; NFKB1 |
| hsa04060 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.202E-02 | 2.050E-02 | CXCR1; THPO; FLT3; KDR; MET |
| hsa04666 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.363E-03 | 2.940E-03 | SYK; AKT1; PIK3R1; PIK3CG |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 6.259E-03 | 1.132E-02 | CAMK2B; GSK3B; CSNK2A1; TP53 |
| hsa04261 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 7.228E-03 | 1.281E-02 | CAMK2B; AKT1; PIK3R1; PIK3CG |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.848E-03 | 3.758E-03 | AKT1; PIK3R1; HIF1A; PIK3CG |
| hsa04114 | Oocyte meiosis_Homo sapiens_hsa04114 | 3.769E-03 | 7.102E-03 | CAMK2B; AR; CDK1; IGF1R |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.541E-02 | 2.508E-02 | CSNK2A1; CDK1; TP53; NFKB1 |
| hsa05146 | Amoebiasis_Homo sapiens_hsa05146 | 1.781E-03 | 3.665E-03 | PIK3R1; NFKB1; PTK2; PIK3CG |
| hsa04620 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.204E-03 | 4.289E-03 | AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa04664 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 4.195E-04 | 1.029E-03 | SYK; AKT1; PIK3R1; PIK3CG |
| hsa05142 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 2.056E-03 | 4.090E-03 | AKT1; PIK3R1; NFKB1; PIK3CG |
| hsa04650 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.263E-02 | 5.000E-02 | SYK; PIK3R1; PIK3CG |
| hsa04064 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.363E-03 | 2.940E-03 | SYK; CSNK2A1; PARP1; NFKB1 |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 2.627E-02 | 4.145E-02 | GSK3B; CDK1; TP53 |
| hsa04360 | Axon guidance_Homo sapiens_hsa04360 | 2.793E-02 | 4.347E-02 | GSK3B; MET; PTK2 |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 2.592E-04 | 6.947E-04 | AKT1; PIK3R1; HIF1A; PIK3CG |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.984E-04 | 5.548E-04 | INSR; AKT1; PIK3R1; PIK3CG |
| hsa04916 | Melanogenesis_Homo sapiens_hsa04916 | 1.496E-02 | 2.479E-02 | CAMK2B; GSK3B; TYR |
| hsa04922 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.536E-02 | 2.508E-02 | CAMK2B; AKT1; PYGL |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.161E-02 | 1.999E-02 | CAMK2B; SRC; MMP2 |
| hsa04972 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.341E-02 | 2.265E-02 | CA2; PLA2G1B; CD38 |
| hsa04640 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.061E-02 | 1.862E-02 | THPO; FLT3; CD38 |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 4.195E-04 | 1.029E-03 | CXCR1; SRC; MET; NFKB1 |
| hsa04971 | Gastric acid secretion_Homo sapiens_hsa04971 | 6.599E-03 | 1.181E-02 | CAMK2B; CA2; MYLK |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 5.883E-03 | 1.086E-02 | CA2; CYP3A4; ABCG2 |
| hsa05217 | Basal cell carcinoma_Homo sapiens_hsa05217 | 3.268E-02 | 5.000E-02 | GSK3B; TP53 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 5.257E-05 | 1.711E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa05030 | Cocaine addiction_Homo sapiens_hsa05030 | 2.640E-02 | 4.145E-02 | MAOA; NFKB1 |
| hsa04973 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.609E-03 | 3.428E-03 | AKT1; PIK3R1; PIK3CG |
| hsa04930 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.939E-03 | 3.900E-03 | INSR; PIK3R1; PIK3CG |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.347E-02 | 3.750E-02 | CYP3A4; XDH |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 2.159E-02 | 3.482E-02 | ABCC1; ABCG2 |
| hsa04960 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.060E-03 | 2.341E-03 | INSR; PIK3R1; PIK3CG |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.399E-02 | 2.341E-02 | MAOA; TYR |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 6.468E-04 | 1.484E-03 | POLB; PARP1; APEX1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 6.193E-03 | 1.131E-02 | CA2; CA4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.600E-04 | 6.947E-04 | CYP1A2; XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET; PIK3CG; PIK3CG |
| H00-H59: Diseases of the eye and adnexa | Age related macular degeneration | H35.3 | APP |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1; ACHE |
| K00-K95: Diseases of the digestive system | Chemotherapy-induced mucositis | K12.3 | MET |
| H00-H59: Diseases of the eye and adnexa | Choroidal neovascularisation | H35 | ESRRA |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AKT1; MET; SYK; PIK3CG; FLT3; CA9; MMP2; SRC; IGF1R; AURKB; HIF1A; MMP9; PTK2; TP53; KDR; KDR; KDR; TOP2A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Amyloidosis | E85 | APP; TTR |
| NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3 |
| C00-D49: Neoplasms | Metastasis | C00-C97 | AXL |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | PIK3CG; KDR |
| C00-D49: Neoplasms | Mesothelioma | C45 | PTK2 |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B; ESRRA |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B; ALOX5; SYK |
| C00-D49: Neoplasms | AML | NA | FLT3; KDR |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | PARP1 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| I00-I99: Diseases of the circulatory system | Cerebrovascular disorders | I60-I69 | PARP1 |
| C00-D49: Neoplasms | Prostate cancer | C61 | AR; AR; PIK3CG; FLT3 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypoglycemia | E16.0-E16.2 | INSR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypogonadism | E23.0, E28.3, E29.1 | AR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| C00-D49: Neoplasms | Female androgenresponsive recurrent mammary cancer | C50 | AR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Myocardial reperfusion injury | T86.4 | AKT1 |
| J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3 |
| K00-K95: Diseases of the digestive system | Alcoholic hepatitis | K70.1 | AR |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | NPSR1; APP |
| C00-D49: Neoplasms | Metastatic prostate cancer | C61 | AR |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; KDR |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | PTK2; TP53 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1; INSR; GSK3B |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| Z00-Z99: Factors influencing health status and contact with health services | Contraception | Z30 | AR |
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3 |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | AR; IGF1R |
| C00-D49: Neoplasms | Hormone refractory prostate cancer | C61 | AR |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | MMP9 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | AKT1; FLT3 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | FLT3; IGF1R; MMP9; TP53; KDR |
| C00-D49: Neoplasms | Colon cancer | C50 | FLT3 |
| C00-D49: Neoplasms | Hematologic malignancies | C81-C86 | AKT1; PIK3CG |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SYK; SRC; CD38; AURKB; TP53 |
| NA: NA | Hematopoietic stem cell transplantation | NA | FLT3 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET; IGF1R; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | AR; AR; ESRRA; MMP2 |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | ALOX5; SYK |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR |
| C00-D49: Neoplasms | Ocular cancer | C69 | APEX1 |
| NA: NA | HIV infections | NA | AHR |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; CA4; CA2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | INSR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatological disease | L00-L99 | AR; ESRRA |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ESRRA; ALOX5 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperglycaemia in type 2 diabetes | E11, R73.9 | INSR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | INSR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hunter syndrome | E76.1 | INSR |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Permanent and transient stroke | G45.9, I61-I63 | PARP1 |
| C00-D49: Neoplasms | Glioma | C71 | PIK3CG; KDR; APP |
| C00-D49: Neoplasms | Glioblastoma | NA | FLT3 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAOA; INSR; MAPT; ACHE; ACHE; ACHE; GSK3B; APP |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Diagnostic imaging | G30, I73.9 | APP |
| L00-L99: Diseases of the skin and subcutaneous tissue | Alopecia | L65.9 | AR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1; ABCC1; ABCC1; XDH |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1; CA1; CA1; ACHE |
| NA: NA | Geographic retinal atrophy | NA | APP |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3 |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | SRC |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| I00-I99: Diseases of the circulatory system | Aortic aneurysm | I71 | MMP12 |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | MPO; MAOA; ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | AR; INSR; MMP13; ACHE; IGF1R; CDK1 |
| I00-I99: Diseases of the circulatory system | Cerebral amyloid angiopathy | I68.0 | APP |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | AKT1; FLT3; MMP2; KDR |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| K00-K95: Diseases of the digestive system | Gastrointestinal disease | K00-K93 | ESRRA |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | MPO |
| C00-D49: Neoplasms | Multiple myeloma | C90 | AHR; SRC; IGF1R; CD38 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Muscle atrophy | M62.5 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | MET |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | MMP2 |
| H00-H59: Diseases of the eye and adnexa | Macular degeneration | H35.3 | APP |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Testosterone deficiency | E29.1 | AR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis in post-menopausal women | M80-M81 | AR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | AR; SRC |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; GSK3B |
| C00-D49: Neoplasms | Ovarian cancer | C56 | MMP2; PARP1; KDR; KDR; KDR; KDR |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PLA2G1B; ESRRA; ALOX5; ALOX5; SYK; SYK; MMP12 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PLA2G1B; ABCC1; ESRRA; ALOX5; PIK3CG |
| G00-G99: Diseases of the nervous system G00-G99 | Ataxia telangiectasia | G11.3 | PARP1 |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | AR; PIK3CG; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Cystic fibrosis | E84 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; ACHE |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1; TP53; KDR; KDR |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| I00-I99: Diseases of the circulatory system | Heart disease | I00-I52 | MET |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | AR; XDH |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | ALOX5; MMP13; MMP3; MMP2 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Male hormonal deficiencies | E20-E35 | AR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | INSR; SYK |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | PIK3CG; CYP2C9 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory skin condition | L00-L99 | PARP1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R |
| H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
| NA: NA | Enthesopathy | NA | PIK3CG |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Erectile dysfunction | F52.2, N48.4 | DRD4 |
| NA: NA | Male hypogonadism | NA | AR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | INSR; ESRRA |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | SYK; PIK3CG; PIK3CG |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MET; AXL; IGF1R; IGF1R; KDR |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MPO; PLA2G1B; ALOX5; MMP13; SYK; PIK3CG; MMP12 |
| C00-D49: Neoplasms | Diffuse large B-cell lymphoma | C83.3 | PIK3CG |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Melanoma | C43 | PARP1; TYR; KDR; KDR |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | SRC; CYP19A1 |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CAMK2B; AKR1B1; PLA2G1B; ESRRA; ALOX5; SYK; MMP3; TYR |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA1; CA2; MYLK |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | AR; KDR |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | PIK3CG; MMP3; PARP1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | ESRRA; DRD4 |
| NA: NA | Edema | NA | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Endocrine disease | E00-E35 | AR |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| C00-D49: Neoplasms | Endometrial cancer | C54.1 | PIK3CG; PIK3CG |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Mild to moderate alzheimer disease | G30 | APP |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; APP |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3 |
| C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3 |
| C00-D49: Neoplasms | Castration-resistant prostate cancer | C61 | AR |
| I00-I99: Diseases of the circulatory system | Cardiomyopathy | I42.0 | TTR |
| C00-D49: Neoplasms | Recurrent epithelial ovarian or primary peritoneal cancer | C78 | PARP1 |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MMP9 |
| NA: NA | Upper abdominal bloating | NA | ACHE |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5; MMP12 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Melasma | L81.1 | TYR |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR |
| C00-D49: Neoplasms | Advanced prostate cancer | C61 | AR |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cachexia | R64 | AR; ESRRA |
| C00-D49: Neoplasms | Cancer | C00-C96 | AR; AKT1; MET; CSNK2A1; SYK; PIK3CG; CA1; FLT3; FLT3; CA9; MMP2; ACHE; SRC; IGF1R; CD38; GSK3B; HIF1A; CDK1; MMP9; NFKB1; PIM1; PARP1; PTK2; TP53; KDR; APP |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2; KDR; KDR |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | TTR amyloidosis | E85 | TTR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | INSR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | INSR; PIK3CG; PIK3CG; NFKB1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1/2 diabetes | E08-E13 | INSR |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SRC |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3 |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | SRC |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Brain injury | S09.90 | APP |
| G00-G99: Diseases of the nervous system G00-G99 | Brain ischaemia | G45.9, I67.8 | PARP1 |
| C00-D49: Neoplasms | Breast cancer | C50 | AR; INSR; PIK3CG; FLT3; FLT3; CA9; IGF1R; CYP19A1; CDK1; KDR; KDR; KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | ALOX5; FLT3 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| N00-N99: Diseases of the genitourinary system | Prostate hyperplasia | N40 | AR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B; ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA; TYR |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MPO; ALOX5; MMP12; MMP12 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR |
| C00-D49: Neoplasms | Liver cancer | C22 | IGF1R; KDR |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | FLT3; FLT3; AURKB; TP53; TP53 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3 |
| C00-D49: Neoplasms | Bladder cancer | C67 | AR; CYP19A1 |
| C00-D49: Neoplasms | B-cell lymphoma | C85.1 | SYK |
| K00-K95: Diseases of the digestive system | Crohn's disease | K50 | INSR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | AKT1; INSR; PIK3CG; PIK3CG; CA9; HIF1A |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; ACHE |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | MET |
| NA: NA | GIST | NA | FLT3 |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CAMK2B; MAOA; ACHE; CYP3A4 |
| NA: NA | Angioedema | NA | PIK3CG |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | SRC |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | SYK |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |