CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.148E-15	1.121E-10	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.112E-12	5.162E-08	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.333E-10	1.348E-06	CA1, CA12, CA2, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.741E-09	1.631E-05	CA1, CA12, CA2, CA7, CA9, NR1H4, PPARA, PPARD, PTPN1, RORC
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	7.849E-08	1.676E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.585E-07	4.020E-04	NR1H4, PPARA, PPARD, RORC
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	5.511E-07	7.538E-04	NR1H4, PPARA, PPARD, RORC
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	3.368E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.712E-06	3.368E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.712E-06	3.368E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	7.420E-06	5.984E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	8.028E-06	6.243E-03	NR1H4, PPARA, PPARD, PTPN2
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.304E-05	9.467E-03	NR1H4, PPARA, PPARD, RORC

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	1.032E-14	5.056E-13	CA12; CA1; CA2; CA7; CA9; CA14
hsa04520	Adherens junction_Homo sapiens_hsa04520	7.119E-05	1.744E-03	PTPN1; ACP1; PTPRF
hsa04931	Insulin resistance_Homo sapiens_hsa04931	2.249E-04	3.673E-03	PTPN1; PPARA; PTPRF
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	2.592E-03	2.687E-02	PPARA; PPARD
hsa04976	Bile secretion_Homo sapiens_hsa04976	2.741E-03	2.687E-02	CA2; NR1H4
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	4.948E-03	4.041E-02	CA2; PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
C00-D49: Neoplasms	Renal cancer	C64	CA9
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1; PPARD
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1; PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; CDC25B
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
NA: NA	Dyslipidemia	NA	PPARD
C00-D49: Neoplasms	Breast cancer	C50	CA9
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9
NA: NA	Edema	NA	CA2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1; PPARD
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
NA: NA	Colour dead tissues	NA	PTPN1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aconitum campylorrhynchum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases