CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.412E-07	8.734E-04	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, TP53
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.821E-06	8.748E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.886E-24	2.153E-19	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.370E-18	1.492E-14	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.671E-17	3.632E-13	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	3.506E-23	3.120E-21	CA12; CA1; CA3; CA2; CA5A; CA7; CA6; CA9; CA14
hsa04210	Apoptosis_Homo sapiens_hsa04210	2.595E-05	1.155E-03	CASP7; LMNA; TP53; CTSD
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	5.966E-04	1.770E-02	CYP1A2; CYP2C19
hsa05214	Glioma_Homo sapiens_hsa05214	2.973E-03	3.306E-02	TP53; MTOR
hsa05014	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.842E-03	3.306E-02	CASP1; TP53
hsa05134	Legionellosis_Homo sapiens_hsa05134	2.139E-03	3.306E-02	CASP7; CASP1
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	3.156E-03	3.306E-02	TP53; MTOR
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	2.973E-03	3.306E-02	CYP1A2; ALDH1A1
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.343E-03	3.306E-02	CYP1A2; CYP2C19
hsa05215	Prostate cancer_Homo sapiens_hsa05215	5.496E-03	3.964E-02	TP53; MTOR
hsa04211	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	6.111E-03	3.964E-02	TP53; MTOR
hsa05133	Pertussis_Homo sapiens_hsa05133	3.936E-03	3.503E-02	CASP7; CASP1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	4.686E-03	3.791E-02	CYP1A2; CYP2C19
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	6.235E-03	3.964E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
C00-D49: Neoplasms	Breast cancer	C50	CA9
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MTOR
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
C00-D49: Neoplasms	Pancreatic cancer	C25	MTOR
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	MTOR
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MTOR
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Renal cancer	C64	MTOR; CA9
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Transplant rejection	D89.8, T86	MTOR
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
C00-D49: Neoplasms	Cancer	C00-C96	TP53; CA1; MTOR; CA9
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MTOR
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Lymphoma	C81-C86	MTOR; CA9
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; MTOR; CA9
C00-D49: Neoplasms	Solid tumors	NA	MTOR
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
C00-D49: Neoplasms	Sarcoma	C81-C86	MTOR
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	CTSD
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
C00-D49: Neoplasms	Bladder cancer	C67	MTOR
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
NA: NA	Coronary artery restenosis	NA	MTOR
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CTSD
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Multiple myeloma	C90	MTOR; MTOR
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR
C00-D49: Neoplasms	Advanced kidney cancer	C64	MTOR
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Organ rejection	D89.8, T86	MTOR
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
NA: NA	Edema	NA	CA2
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Asclepias subulata

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases