Plant Name: Agave deserti
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 4.821E-06 | 8.748E-03 | CA2, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.370E-18 | 1.492E-14 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 6.671E-17 | 3.632E-13 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 4.412E-07 | 8.734E-04 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 9.886E-24 | 2.153E-19 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
Showing 1 to 5 of 5 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 6.235E-03 | 3.964E-02 | CYP1A2 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 5.966E-04 | 1.770E-02 | CYP1A2; CYP2C19 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 2.973E-03 | 3.306E-02 | CYP1A2; ALDH1A1 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.506E-23 | 3.120E-21 | CA12; CA1; CA3; CA2; CA5A; CA7; CA6; CA9; CA14 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 3.343E-03 | 3.306E-02 | CYP1A2; CYP2C19 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 2.595E-05 | 1.155E-03 | CASP7; LMNA; TP53; CTSD |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 6.111E-03 | 3.964E-02 | TP53; MTOR |
| hsa05014 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.842E-03 | 3.306E-02 | CASP1; TP53 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 3.936E-03 | 3.503E-02 | CASP7; CASP1 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 2.139E-03 | 3.306E-02 | CASP7; CASP1 |
Showing 1 to 10 of 14 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; MTOR; CA9 |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; CA1; MTOR; CA9 |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; CA9 |
Showing 1 to 10 of 48 entries