Plant Name: Abrus pulchellus
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; | |
| TSHR; | |
| BLM; | |
| GRIA4; GRIK2; GRIA1; GRIK5; GRIK3; GRIK1; | |
| TRPA1; | |
| MAPK1; | |
| CA2; CA1; CA7; CA9; CA12; CA14; | |
| ELANE; | |
| MAPT; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Ionotropic glutamate receptor | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | P48058 | CHEMBL3190 |
| Ionotropic glutamate receptor | GRIK2 | Glutamate receptor ionotropic kainate 2 | Q13002 | CHEMBL3683 |
| Ionotropic glutamate receptor | GRIA1 | Glutamate receptor ionotropic, AMPA 1 | P42261 | CHEMBL2009 |
| Ionotropic glutamate receptor | GRIK5 | Glutamate receptor ionotropic kainate 5 | Q16478 | CHEMBL2675 |
| Ionotropic glutamate receptor | GRIK3 | Glutamate receptor ionotropic kainate 3 | Q13003 | CHEMBL3684 |
| Ionotropic glutamate receptor | GRIK1 | Glutamate receptor ionotropic kainate 1 | P39086 | CHEMBL1918 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
| Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005215; transporter activity | GO:0005234; extracellularly glutamate-gated ion channel activity | 2.025E-14 | 1.470E-10 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0009987; cellular process | GO:0035235; ionotropic glutamate receptor signaling pathway | 1.710E-13 | 9.310E-10 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 5.181E-12 | 1.254E-08 | CA1, CA12, CA14, CA2, CA7, CA9 |
| MF | GO:0005215; transporter activity | GO:0015277; kainate selective glutamate receptor activity | 5.157E-12 | 1.254E-08 | GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0023052; signaling | GO:0060079; excitatory postsynaptic potential | 8.653E-11 | 1.175E-07 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.353E-10 | 3.476E-07 | CA1, CA12, CA2, CA7, CA9 |
| MF | GO:0005215; transporter activity | GO:0008381; mechanosensitive ion channel activity | 4.015E-08 | 2.650E-05 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TRPA1 |
| BP | GO:0065007; biological regulation | GO:0098771; inorganic ion homeostasis | 2.002E-07 | 1.090E-04 | CA12, CA2, CA7, ELANE, GRIA1, GRIK2, MAPK1, TRPA1 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 7.568E-07 | 3.169E-04 | GRIK2, GRIK3, MAPK1, MAPT |
| CC | GO:0044464; cell part | GO:0032839; dendrite cytoplasm | 2.508E-06 | 9.417E-04 | GRIK2, GRIK3, MAPK1 |
| CC | GO:0044456; synapse part | GO:0045211; postsynaptic membrane | 2.618E-06 | 9.661E-04 | GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 3.375E-06 | 1.167E-03 | CA2, CA7 |
| CC | GO:0032991; macromolecular complex | GO:0032983; kainate selective glutamate receptor complex | 3.375E-06 | 1.167E-03 | GRIK2, GRIK5 |
| MF | GO:0005215; transporter activity | GO:0098782; mechanosensitived potassium channel activity | 6.373E-06 | 2.041E-03 | GRIK1, GRIK2, GRIK3, GRIK5 |
| MF | GO:0005215; transporter activity | GO:0004971; AMPA glutamate receptor activity | 6.746E-06 | 2.069E-03 | GRIA1, GRIA4 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 6.598E-06 | 2.069E-03 | GRIK2, GRIK3, GRIK5, MAPK1 |
| CC | GO:0044464; cell part | GO:0044463; cell projection part | 8.522E-06 | 2.474E-03 | CA9, GRIA1, GRIA4, GRIK2, GRIK3, GRIK5, MAPK1, MAPT |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 1.684E-05 | 4.418E-03 | CA1, CA2 |
| BP | GO:0051179; localization | GO:0034220; ion transmembrane transport | 2.599E-05 | 6.431E-03 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TRPA1 |
| MF | Unclassified; | GO:0099600; transmembrane receptor activity | 2.945E-05 | 7.087E-03 | ADORA3, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TSHR |
| CC | GO:0044456; synapse part | GO:0043195; terminal bouton | 4.019E-05 | 9.310E-03 | GRIK2, GRIK3, GRIK5 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.745E-15 | 8.155E-11 | CA1, CA12, CA14, CA2, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 7.508E-15 | 8.709E-13 | CA12; CA1; CA2; CA7; CA9; CA14 |
| hsa04724 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.766E-11 | 1.024E-09 | GRIA1; GRIK5; GRIK3; MAPK1; GRIK1; GRIK2; GRIA4 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 2.131E-10 | 8.239E-09 | GRIA1; GRIK5; ADORA3; GRIK3; GRIK1; GRIK2; TSHR; GRIA4 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 4.985E-05 | 1.446E-03 | GRIA1; MAPK1; TSHR; GRIA4 |
| hsa04713 | Circadian entrainment_Homo sapiens_hsa04713 | 1.298E-04 | 3.009E-03 | GRIA1; MAPK1; GRIA4 |
| hsa04723 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.556E-04 | 3.009E-03 | GRIA1; MAPK1; GRIA4 |
| hsa05033 | Nicotine addiction_Homo sapiens_hsa05033 | 7.996E-04 | 1.325E-02 | GRIA1; GRIA4 |
| hsa04730 | Long-term depression_Homo sapiens_hsa04730 | 1.792E-03 | 2.585E-02 | GRIA1; MAPK1 |
| hsa05031 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.228E-03 | 2.585E-02 | GRIA1; GRIA4 |
| hsa04720 | Long-term potentiation_Homo sapiens_hsa04720 | 2.163E-03 | 2.585E-02 | GRIA1; MAPK1 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 2.498E-03 | 2.634E-02 | CA2; CYP3A4 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; MAPK1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | ELANE |
| NA: NA | Myocardial ischaemia-reperfusion injury | NA | ELANE |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| J00-J99: Diseases of the respiratory system | Pulmonary disease | J00-J99 | ELANE |
| J00-J99: Diseases of the respiratory system | Pulmonary emphysema | J43 | ELANE |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1; ADORA3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ADORA3 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| NA: NA | Acute respiratory distress syndrome | NA | ELANE; ELANE; ELANE |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | ADORA3 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | GRIK1 |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | GRIK1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Cystic fibrosis | E84 | ELANE; ELANE |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2 |
| J00-J99: Diseases of the respiratory system | Acute lung injury | J80 | ELANE; ELANE; ELANE |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Convulsions | R56.0 | GRIA1 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | GRIK1; TRPA1 |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | GRIA4 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | ADORA3 |
| NA: NA | Hepatitis C virus infection | NA | ADORA3 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| NA: NA | Edema | NA | CA2 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | GRIK1; GRIK1 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ADORA3 |
| J00-J99: Diseases of the respiratory system | Mucolytic | J00-J99 | ELANE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ELANE; ELANE |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | GRIK1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| J00-J99: Diseases of the respiratory system | Throat irritation | J39.2 | TRPA1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; CA1; MAPK1; ADORA3 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | ELANE |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | ELANE |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | ELANE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | GRIA1 |
| A00-B99: Certain infectious and parasitic diseases | Septic shock | A41.9 | ELANE |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | GRIA1 |
| J00-J99: Diseases of the respiratory system | Bronchiectasis | J47, Q33.4 | ELANE |