Plant Name: Buchenavia tetraphylla
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.571E-08 | 2.528E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 2.675E-08 | 3.641E-05 | FABP3, FFAR1, PPARG, PTGS2, TLR2 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 7.112E-07 | 3.872E-04 | ALOX15, HPGD, PTGS2 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 9.225E-07 | 4.783E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 5.383E-06 | 1.922E-03 | LMNA, PPARD, PTGS2, TERT |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 8.028E-06 | 2.649E-03 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0008283; cell proliferation | GO:0008285; negative regulation of cell proliferation | 8.761E-06 | 2.847E-03 | FABP3, LMNA, PPARD, PPARG, PTGS2, TERT, TLR2 |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.236E-05 | 3.686E-03 | PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 1.304E-05 | 3.838E-03 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 1.699E-05 | 4.742E-03 | FABP3, PPARA, PPARG, TLR2 |
Showing 1 to 10 of 25 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 4.189E-05 | 8.378E-04 | ALOX15; PTGS2; PTGS1 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 6.963E-13 | 4.178E-11 | FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.436E-04 | 3.654E-03 | ALOX15; PTGS2; PTGS1 |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 3.883E-07 | 1.165E-05 | FABP4; PTGS2; TSHR; PTGS1 |
| hsa05140 | Leishmaniasis_Homo sapiens_hsa05140 | 2.895E-03 | 3.474E-02 | PTGS2; TLR2 |
Showing 1 to 5 of 5 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | FAAH; PTGS2; PTGS1 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | PTGS1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | ABCB1; TLR2 |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2; TERT |
Showing 1 to 10 of 70 entries