CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.148E-08	2.083E-05	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.278E-31	1.149E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.066E-06	5.902E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.917E-24	3.176E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.440E-22	7.838E-19	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	3.260E-30	1.271E-28	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.154E-04	6.150E-03	CA2; CA4
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	2.261E-03	2.940E-02	FUT7; MAOB; ALOX15; ALDH1A1; AKR1B1; XDH

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive episode without melancholia	F30-F39	MAOB
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	MAOB
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOB; MAOB
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Idiopathic parkinson's disease	F02.3, G20	MAOB
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOB
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOB
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
C00-D49: Neoplasms	Renal cancer	C64	CA9
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	MAOB
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; AKR1B1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH; AKR1B1
C00-D49: Neoplasms	Breast cancer	C50	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAOB; MAPT
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAOB; MAPT
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAOB; MAPT
NA: NA	Motor symptoms	NA	MAOB
I00-I99: Diseases of the circulatory system	Moderate to severe hypertension	I10-I16	MAOB
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
NA: NA	Edema	NA	CA2
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOB; MAPT

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Biancaea sappan

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases