Plant Name: Christisonia bicolor
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| MGAM; | |
| TDP1; BLM; HSD17B1; ALOX15; AOX1; | |
| MAPK1; ABL1; EGFR; | |
| CA2; CA12; CA7; CA4; | |
| ESR1; ESR2; | |
| ESRRB; ESRRA; | |
| MAOA; | |
| HIF1A; TP53; | |
| ABCG2; ABCC1; | |
| SLCO1B3; SLCO1B1; | |
| NPC1; RAB9A; THPO; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Cytochrome P450 family 5 | TBXAS1 | Thromboxane-A synthase | P24557 | CHEMBL1835 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Showing 1 to 10 of 34 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.667E-09 | 4.538E-06 | CYP1A1, CYP1A2, CYP1B1, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.687E-08 | 4.639E-05 | CYP1A1, CYP1A2, CYP1B1, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 9.929E-08 | 7.722E-05 | CYP1A2, CYP2C9, CYP3A4 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 1.125E-07 | 8.444E-05 | ABL1, CA2, CA7, EGFR, HIF1A, MAPK1, NPC1 |
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 1.320E-07 | 9.255E-05 | ABL1, BLM, CYP1A1, CYP1B1, EGFR, ESR1, MAPK1, NPC1 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.527E-07 | 2.347E-04 | CA12, CA2, CA4, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.033E-06 | 4.499E-04 | CA12, CA2, CA4, CA7 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.084E-06 | 4.541E-04 | CYP1A2, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 1.084E-06 | 4.541E-04 | CYP1A2, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0034754; cellular hormone metabolic process | 1.217E-06 | 4.908E-04 | CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 |
Showing 1 to 10 of 36 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 4.487E-08 | 2.228E-06 | HSD17B1; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 8.472E-03 | 2.744E-02 | CYP1A2 |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.611E-03 | 6.318E-03 | MAOA; AOX1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 6.585E-09 | 9.811E-07 | MAOA; CYP1A2; CYP1A1; AOX1; CYP1B1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.585E-04 | 1.125E-03 | CYP2C9; ALOX15; TBXAS1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.604E-07 | 2.987E-06 | CYP2C9; CYP1A2; ALOX15; CYP3A4 |
| hsa00750 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.016E-02 | 3.089E-02 | AOX1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 8.019E-08 | 2.987E-06 | CYP2C9; CYP1A2; CYP1A1; AOX1; CYP3A4 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.630E-08 | 1.215E-06 | CA12; CA2; CA4; CA7 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.444E-07 | 2.987E-06 | CYP2C9; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
Showing 1 to 10 of 50 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| A00-B99: Certain infectious and parasitic diseases | Acquired immune deficiency syndrome | B20 | MGAM |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| A00-B99: Certain infectious and parasitic diseases | Dengue fever | A90 | MGAM |
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | ABL1; ABL1 |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | EGFR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; TP53; MAPK1; ABL1; EGFR |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | EGFR; EGFR |
Showing 1 to 10 of 135 entries