Plant Name: Skimmia japonica
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.870E-06 | 3.701E-03 | CA1, CA12, CA5A, CA5B, CA6, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.690E-19 | 8.035E-15 | CA1, CA12, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.746E-16 | 5.167E-12 | CA1, CA12, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.172E-15 | 1.576E-11 | CA1, CA12, CA5A, CA5B, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 8.735E-19 | 2.795E-17 | CA12; CA1; CA5B; CA5A; CA7; CA6; CA9 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.406E-04 | 3.849E-03 | CYP1A2; CYP2C19 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 8.693E-04 | 8.583E-03 | CASP7; CASP1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.212E-03 | 8.583E-03 | CYP1A2; ALDH1A1 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.364E-03 | 8.583E-03 | CYP1A2; CYP2C19 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 1.609E-03 | 8.583E-03 | CASP7; CASP1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.920E-03 | 8.776E-03 | CYP1A2; CYP2C19 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 5.475E-03 | 1.947E-02 | CASP7; LMNA |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 7.791E-03 | 2.493E-02 | CASP7; HSD17B10 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.464E-02 | 4.258E-02 | CYP1A2; ALDH1A1; CYP2C19; HSD17B10 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.994E-03 | 1.598E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA1 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; CA1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |